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Transitions of Care After Critical Illness-Challenges to Recovery and Adaptive Problem Solving.

Kimberley J Haines, Elizabeth Hibbert, Nina Leggett, Leanne M Boehm, Tarli Hall, Rita N Bakhru, Anthony J Bastin, Brad W Butcher, Tammy L Eaton, Wendy Harris, Aluko A Hope, James Jackson, Annie Johnson, Janet A Kloos, Karen A Korzick, Pamela Mactavish, Joel Meyer, Ashley Montgomery-Yates, Tara Quasim, Andrew Slack, Dorothy Wade, Mary Still, Giora Netzer, Ramona O Hopkins, Theodore J Iwashyna, Mark E Mikkelsen, Joanne McPeake, Carla M Sevin, ,

<h4>Objectives</h4>Investigate the challenges experienced by survivors of critical illness and their caregivers across the transitions of care from intensive care to community, and the potential problem-solving strategies used to navigate these challenges.<h4>Design</h4>Qualitative design-data generation via interviews and data analysis via the framework analysis method.<h4>Setting</h4>Patients and caregivers from three continents, identified ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):1923-1931]

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Discharge Documentation and Follow-Up of Critically Ill Patients With Acute Kidney Injury Treated With Kidney Replacement Therapy: A Retrospective Cohort Study.

Xin Yi Choon, Nuttha Lumlertgul, Lynda Cameron, Andrew Jones, Joel Meyer, Andrew Slack, Helen Vollmer, Nicholas A Barrett, Richard Leach, Marlies Ostermann,

Leading organisations recommend follow-up of acute kidney injury (AKI) survivors, as these patients are at risk of long-term complications and increased mortality. Information transfer between specialties and from tertiary to primary care is essential to ensure timely and appropriate follow-up. Our aim was to examine the association between completeness of ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2021, 8:710228]

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Recovery, rehabilitation and follow-up services following critical illness: an updated UK national cross-sectional survey and progress report.

Bronwen Connolly, Rhian Milton-Cole, Claire Adams, Ceri Battle, Joanne McPeake, Tara Quasim, Jon Silversides, Andrew Slack, Carl Waldmann, Elizabeth Wilson, Joel Meyer, ,

<h4>Objective</h4>To comprehensively update and survey the current provision of recovery, rehabilitation and follow-up services for adult critical care patients across the UK.<h4>Design</h4>Cross-sectional, self-administered, predominantly closed-question, electronic, online survey.<h4>Setting</h4>Institutions providing adult critical care services identified from national databases.<h4>Participants</h4>Multiprofessional critical care clinicians delivering services at each site.<h4>Results</h4>Responses from 176 UK hospital sites ... Read more >>

BMJ Open (BMJ open)
[2021, 11(10):e052214]

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Growth and defense inform large sugar pine (Pinus lambertiana) mortality in a fire‐excluded forest of the central Sierra Nevada

Andrew W Slack, Jeffrey M Kane, Eric E Knapp,

KEY MESSAGE: Large sugar pine mortality was associated with recent growth and defense measures. Many old-growth pine forests across the western United States have encountered widespread and concerning increases in tree mortality attributed to increased competition and reduced vigor associated with prolonged fire exclusion that can make trees more vulnerable ... Read more >>

Trees (Berl West) (Trees (Berlin, Germany : West))
[2021, 35(3):1053-1063]

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Optimizing Critical Illness Recovery: Perspectives and Solutions From the Caregivers of ICU Survivors.

Carla M Sevin, Leanne M Boehm, Elizabeth Hibbert, Anthony J Bastin, James C Jackson, Joel Meyer, Tara Quasim, Rita N Bakhru, Ashley Montgomery-Yates, Andrew Slack, Mary Still, Giora Netzer, Mark E Mikkelsen, Theodore J Iwashyna, Kimberley J Haines, Joanne McPeake,

<h4>Objectives</h4>To understand the unmet needs of caregivers of ICU survivors, how they accessed support post ICU, and the key components of beneficial ICU recovery support systems as identified from a caregiver perspective.<h4>Design</h4>International, qualitative study.<h4>Subjects</h4>We conducted 20 semistructured interviews with a diverse group of caregivers in the United States, the United ... Read more >>

Crit Care Explor (Critical care explorations)
[2021, 3(5):e0420]

Cited: 1 time

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Restrictive fluid management versus usual care in acute kidney injury (REVERSE-AKI): a pilot randomized controlled feasibility trial.

Suvi T Vaara, Marlies Ostermann, Laurent Bitker, Antoine Schneider, Elettra Poli, Eric Hoste, Jan Fierens, Michael Joannidis, Alexander Zarbock, Frank van Haren, John Prowle, Tuomas Selander, Minna Bäcklund, Ville Pettilä, Rinaldo Bellomo, ,

<h4>Purpose</h4>We compared a restrictive fluid management strategy to usual care among critically ill patients with acute kidney injury (AKI) who had received initial fluid resuscitation.<h4>Methods</h4>This multicenter feasibility trial randomized 100 AKI patients 1:1 in seven ICUs in Europe and Australia. Restrictive fluid management included targeting negative or neutral daily fluid ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(6):665-673]

Cited: 3 times

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Benefits of Peer Support for Intensive Care Unit Survivors: Sharing Experiences, Care Debriefing, and Altruism.

Joanne McPeake, Theodore J Iwashyna, Leanne M Boehm, Elizabeth Hibbert, Rita N Bakhru, Anthony J Bastin, Brad W Butcher, Tammy L Eaton, Wendy Harris, Aluko A Hope, James Jackson, Annie Johnson, Janet A Kloos, Karen A Korzick, Joel Meyer, Ashley Montgomery-Yates, Mark E Mikkelsen, Andrew Slack, Dorothy Wade, Mary Still, Giora Netzer, Ramona O Hopkins, Tara Quasim, Carla M Sevin, Kimberley J Haines,

<h4>Background</h4>After critical illness, patients are often left with impairments in physical, social, emotional, and cognitive functioning. Peer support interventions have been implemented internationally to ameliorate these issues.<h4>Objective</h4>To explore what patients believed to be the key mechanisms of effectiveness of peer support programs implemented during critical care recovery.<h4>Methods</h4>In a secondary analysis ... Read more >>

Am J Crit Care (American journal of critical care : an official publication, American Association of Critical-Care Nurses)
[2021, 30(2):145-149]

Cited: 2 times

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An International Study Exploring the Experience of Survivors of Critical Illness as Volunteers Within ICU Recovery Services.

Carly Robinson, Elizabeth Hibbert, Anthony J Bastin, Joel Meyer, Ashley Montgomery-Yates, Tara Quasim, Andrew Slack, Mark E Mikkelsen, Theodore J Iwashyna, Kimberley J Haines, Carla M Sevin, Joanne McPeake, Leanne M Boehm,

Many clinicians have implemented follow-up and aftercare to support patients following ICU. Some of this care is supported and facilitated by peer volunteers. There is limited contemporary work that has explicitly explored volunteer roles within ICU recovery services or the experience of volunteers undertaking these roles. We sought to explore ... Read more >>

Crit Care Explor (Critical care explorations)
[2020, 2(11):e0273]

Cited: 0 times

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Airway, voice and swallow outcomes following endotracheal intubation and mechanical ventilation for COVID-19 pneumonitis: preliminary results of a prospective cohort study

Benjamin Miller, Chrysostomos Tornari, Kelvin Miu, Andrew Slack, Patrick Murphy, Imran Ahmed, Victoria Burnay, Asit Arora, Ricard Simo, Yakubu Karagama,

<h4>Introduction: </h4> The coronavirus pandemic has resulted in unprecedented rates of patients requiring intubation and ventilation over a short period of time. The authors present 3-month data on airway, voice and swallow outcomes for this cohort to better understand the impact of COVID-19 critical illness on laryngotracheal morbidity. <h4>Methods: </h4>: ... Read more >>

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Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury.

, , , , , , Sean M Bagshaw, Ron Wald, Neill K J Adhikari, Rinaldo Bellomo, Bruno R da Costa, Didier Dreyfuss, Bin Du, Martin P Gallagher, Stéphane Gaudry, Eric A Hoste, François Lamontagne, Michael Joannidis, Giovanni Landoni, Kathleen D Liu, Daniel F McAuley, Shay P McGuinness, Javier A Neyra, Alistair D Nichol, Marlies Ostermann, Paul M Palevsky, Ville Pettilä, Jean-Pierre Quenot, Haibo Qiu, Bram Rochwerg, Antoine G Schneider, Orla M Smith, Fernando Thomé, Kevin E Thorpe, Suvi Vaara, Matthew Weir, Amanda Y Wang, Paul Young, Alexander Zarbock,

<h4>Background</h4>Acute kidney injury is common in critically ill patients, many of whom receive renal-replacement therapy. However, the most effective timing for the initiation of such therapy remains uncertain.<h4>Methods</h4>We conducted a multinational, randomized, controlled trial involving critically ill patients with severe acute kidney injury. Patients were randomly assigned to receive an ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 383(3):240-251]

Cited: 40 times

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The Australasian COVID-19 Trial (ASCOT) to assess clinical outcomes in hospitalised patients with SARS-CoV-2 infection (COVID-19) treated with lopinavir/ritonavir and/or hydroxychloroquine compared to standard of care: A structured summary of a study protocol for a randomised controlled trial.

Justin T Denholm, Joshua Davis, David Paterson, Jason Roberts, Susan Morpeth, Thomas Snelling, Dominica Zentner, Megan Rees, Matthew O'Sullivan, David Price, Asha Bowen, Steven Y C Tong, ,

<h4>Objectives</h4>To determine if lopinavir/ritonavir +/- hydroxychloroquine will reduce the proportion of participants who survive without requiring ventilatory support, 15 days after enrolment, in adult participants with non-critically ill SARS-CoV-2 infection.<h4>Trial design</h4>ASCOT is an investigator-initiated, multi-centre, open-label, randomised controlled trial. Participants will have been hospitalised with confirmed COVID-19, and will be ... Read more >>

Trials (Trials)
[2020, 21(1):646]

Cited: 3 times

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Key Components of ICU Recovery Programs: What Did Patients Report Provided Benefit?

Joanne McPeake, Leanne M Boehm, Elizabeth Hibbert, Rita N Bakhru, Anthony J Bastin, Brad W Butcher, Tammy L Eaton, Wendy Harris, Aluko A Hope, James Jackson, Annie Johnson, Janet A Kloos, Karen A Korzick, Pamela MacTavish, Joel Meyer, Ashley Montgomery-Yates, Tara Quasim, Andrew Slack, Dorothy Wade, Mary Still, Giora Netzer, Ramona O Hopkins, Mark E Mikkelsen, Theodore J Iwashyna, Kimberley J Haines, Carla M Sevin,

To understand from the perspective of patients who did, and did not attend ICU recovery programs, what were the most important components of successful programs and how should they be organized. Design:International, qualitative study. Setting:Fourteen hospitals in the United States, United Kingdom, and Australia. Patients:We conducted 66 semi-structured interviews with ... Read more >>

Crit Care Explor (Critical care explorations)
[2020, 2(4):e0088]

Cited: 7 times

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Response to: Is high volume Haemofiltration really necessary to remove Ammonia?

Andrew J Slack, William Bernal,

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2020, 40(3):728]

Cited: 0 times

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Enablers and Barriers to Implementing ICU Follow-Up Clinics and Peer Support Groups Following Critical Illness: The Thrive Collaboratives.

Kimberley J Haines, Joanne McPeake, Elizabeth Hibbert, Leanne M Boehm, Krishna Aparanji, Rita N Bakhru, Anthony J Bastin, Sarah J Beesley, Lynne Beveridge, Brad W Butcher, Kelly Drumright, Tammy L Eaton, Thomas Farley, Penelope Firshman, Andrew Fritschle, Clare Holdsworth, Aluko A Hope, Annie Johnson, Michael T Kenes, Babar A Khan, Janet A Kloos, Erin K Kross, Pamela Mactavish, Joel Meyer, Ashley Montgomery-Yates, Tara Quasim, Howard L Saft, Andrew Slack, Joanna Stollings, Gerald Weinhouse, Jessica Whitten, Giora Netzer, Ramona O Hopkins, Mark E Mikkelsen, Theodore J Iwashyna, Carla M Sevin,

<h4>Objectives</h4>Data are lacking regarding implementation of novel strategies such as follow-up clinics and peer support groups, to reduce the burden of postintensive care syndrome. We sought to discover enablers that helped hospital-based clinicians establish post-ICU clinics and peer support programs, and identify barriers that challenged them.<h4>Design</h4>Qualitative inquiry. The Consolidated Framework ... Read more >>

Crit Care Med (Critical care medicine)
[2019, 47(9):1194-1200]

Cited: 12 times

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Glucocorticoids in elite sport: current status, controversies and innovative management strategies-a narrative review.

Alan Vernec, Andrew Slack, Peter Rex Harcourt, Richard Budgett, Martine Duclos, Audrey Kinahan, Katja Mjøsund, Christian J Strasburger,

The use of systemic glucocorticoids (GCs), as well as local injections, continues to be a controversial issue in the sport/anti-doping community. There is widespread and legitimate use of GCs for numerous health conditions, yet there are concerns about side effects and the possibility of enhanced athletic performance in limited settings. ... Read more >>

Br J Sports Med (British journal of sports medicine)
[2020, 54(1):8-12]

Cited: 4 times

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Key mechanisms by which post-ICU activities can improve in-ICU care: results of the international THRIVE collaboratives.

Kimberley J Haines, Carla M Sevin, Elizabeth Hibbert, Leanne M Boehm, Krishna Aparanji, Rita N Bakhru, Anthony J Bastin, Sarah J Beesley, Brad W Butcher, Kelly Drumright, Tammy L Eaton, Thomas Farley, Penelope Firshman, Andrew Fritschle, Clare Holdsworth, Aluko A Hope, Annie Johnson, Michael T Kenes, Babar A Khan, Janet A Kloos, Erin K Kross, Belinda J MacLeod-Smith, Pamela Mactavish, Joel Meyer, Ashley Montgomery-Yates, Tara Quasim, Howard L Saft, Andrew Slack, Joanna Stollings, Gerald Weinhouse, Jessica Whitten, Giora Netzer, Ramona O Hopkins, Mark E Mikkelsen, Theodore J Iwashyna, Joanne McPeake,

<h4>Objective</h4>To identify the key mechanisms that clinicians perceive improve care in the intensive care unit (ICU), as a result of their involvement in post-ICU programs.<h4>Methods</h4>Qualitative inquiry via focus groups and interviews with members of the Society of Critical Care Medicine's THRIVE collaborative sites (follow-up clinics and peer support). Framework analysis ... Read more >>

Intensive Care Med (Intensive care medicine)
[2019, 45(7):939-947]

Cited: 12 times

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Models of Peer Support to Remediate Post-Intensive Care Syndrome: A Report Developed by the Society of Critical Care Medicine Thrive International Peer Support Collaborative.

Joanne McPeake, Eliotte L Hirshberg, Leeann M Christie, Kelly Drumright, Kimberley Haines, Catherine L Hough, Joel Meyer, Dorothy Wade, Adair Andrews, Rita Bakhru, Samantha Bates, John A Barwise, Julie Bastarache, Sarah J Beesley, Leanne M Boehm, Sheryl Brown, Alison S Clay, Penelope Firshman, Steven Greenberg, Wendy Harris, Christopher Hill, Carol Hodgson, Clare Holdsworth, Aluko A Hope, Ramona O Hopkins, David C J Howell, Anna Janssen, James C Jackson, Annie Johnson, Erin K Kross, Daniela Lamas, Belinda MacLeod-Smith, Ruth Mandel, John Marshall, Mark E Mikkelsen, Megan Nackino, Tara Quasim, Carla M Sevin, Andrew Slack, Rachel Spurr, Mary Still, Carol Thompson, Gerald Weinhouse, M Elizabeth Wilcox, Theodore J Iwashyna,

<h4>Objectives</h4>Patients and caregivers can experience a range of physical, psychologic, and cognitive problems following critical care discharge. The use of peer support has been proposed as an innovative support mechanism.<h4>Design</h4>We sought to identify technical, safety, and procedural aspects of existing operational models of peer support, among the Society of Critical ... Read more >>

Crit Care Med (Critical care medicine)
[2019, 47(1):e21-e27]

Cited: 15 times

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Activity of Ceftolozane-Tazobactam against Burkholderia pseudomallei.

Andrew Slack, Fiona Parsonson, Katie Cronin, Cathy Engler, Robert Norton,

We investigated the in vitro activity of a novel fifth-generation cephalosporin-tazobactam combination, ceftolozane-tazobactam against Burkholderia pseudomallei, the etiological agent of melioidosis. Using both disc diffusion and minimum inhibitory concentration (MIC) strip techniques against 56 clinical isolates and an national collection of type cultures (NCTC) strain, the MIC to ceftolozane-tazobactam was ... Read more >>

Am J Trop Med Hyg (The American journal of tropical medicine and hygiene)
[2018, 99(2):281-282]

Cited: 2 times

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Acute Hepatic Failure

Andrew Slack, Brian J. Hogan, Julia Wendon,

(Liver Anesthesiology and Critical Care Medicine)
[2018, :41-62]

Cited: 0 times

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Interferon-gamma release assay for the diagnosis of latent tuberculosis infection: A latent-class analysis.

Tan N Doan, Damon P Eisen, Morgan T Rose, Andrew Slack, Grace Stearnes, Emma S McBryde,

<h4>Background</h4>Accurate diagnosis and subsequent treatment of latent tuberculosis infection (LTBI) is essential for TB elimination. However, the absence of a gold standard test for diagnosing LTBI makes assessment of the true prevalence of LTBI and the accuracy of diagnostic tests challenging. Bayesian latent class models can be used to make ... Read more >>

PLoS One (PloS one)
[2017, 12(11):e0188631]

Cited: 20 times

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A painful dilemma? Analgesic use in sport and the role of anti-doping.

Alan Vernec, Andrew Pipe, Andrew Slack,

Br J Sports Med (British journal of sports medicine)
[2017, 51(17):1243-1244]

Cited: 2 times

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Intensive care in the very old: how gently should we go into that good night?

Luigi Camporota, Andrew Slack,

Minerva Anestesiol (Minerva anestesiologica)
[2017, 83(6):549-552]

Cited: 0 times

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Contingent resistance in longleaf pine (Pinus palustris) growth and defense 10years following smoldering fires

Andrew W Slack, J. Morgan Varner, Jeffrey M. Kane, Nickolas E. Zeibig-Kichas,

In many fire-prone woodlands and forests, fire exclusion has resulted in substantial litter and duff accumulations capable of long-duration smoldering once fire is reintroduced. While previous research has shown that the soil heating from smoldering fires resulted in short-term reductions in coarse root non-structural carbohydrates and latewood growth, information on ... Read more >>

For Ecol Manage (Forest ecology and management)
[2016, 364:130-138]

Cited: 0 times

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Improving Care after Acute Kidney Injury: A Prospective Time Series Study.

Samuel A Silver, Ziv Harel, Andrea Harvey, Neill K Adhikari, Andrew Slack, Rey Acedillo, Arsh K Jain, Robert M Richardson, Christopher T Chan, Glenn M Chertow, Chaim M Bell, Ron Wald,

Acute kidney injury (AKI) complicates 15-20% of hospitalizations, and AKI survivors are at increased risk of chronic kidney disease and death. However, less than 20% of patients see a nephrologist within 3 months of discharge, even though a nephrologist visit within 90 days of discharge is associated with enhanced survival. ... Read more >>

Nephron (Nephron)
[2015, 131(1):43-50]

Cited: 19 times

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Ammonia clearance with haemofiltration in adults with liver disease.

Andrew J Slack, Georg Auzinger, Chris Willars, Tracy Dew, Rebecca Musto, Daniel Corsilli, Roy Sherwood, Julia A Wendon, William Bernal,

<h4>Background & aims</h4>Ammonia is recognized as a toxin central to complications of liver failure. Hyperammonaemia has important clinical consequences, but optimal means to reduce circulating levels are uncertain. In patients with liver disease, continuous renal replacement therapy (CRRT) with haemofiltration (HF) is often required to treat concurrent kidney injury, but ... Read more >>

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2014, 34(1):42-48]

Cited: 40 times

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