Full Text Journal Articles by
Author Andrew S C Rice

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Efficacy and safety of EMA401 in peripheral neuropathic pain: results of 2 randomised, double-blind, phase 2 studies in patients with postherpetic neuralgia and painful diabetic neuropathy.

Andrew S C Rice, Robert H Dworkin, Nanna B Finnerup, Nadine Attal, Praveen Anand, Roy Freeman, Alessandro Piaia, Francesca Callegari, Christie Doerr, Subhayan Mondal, Nisha Narayanan, Laurent Ecochard, Yanina Flossbach, Shaloo Pandhi,

<h4>Abstract</h4>The analgesic efficacy and safety of 2 phase 2b studies of EMA401 (a highly selective angiotensin II type 2 receptor antagonist) in patients with postherpetic neuralgia (EMPHENE) and painful diabetic neuropathy (EMPADINE) were reported. These were multicentre, randomised, double-blind treatment studies conducted in participants with postherpetic neuralgia or type I/II ... Read more >>

Pain (Pain)
[2021, 162(10):2578-2589]

Cited: 1 time

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Societal issues and policy implications related to the use of cannabinoids, cannabis, and cannabis-based medicines for pain management.

Simon Haroutounian, Ian Gilron, Joletta Belton, Louisa Degenhardt, Marta Di Forti, David P Finn, Alexandra Fogarty, Eija Kalso, Elliot Krane, R Andrew Moore, Michael Rowbotham, Mark Wallace, Andrew S C Rice,

Pain (Pain)
[2021, 162(Suppl 1):S110-S116]

Cited: 0 times

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Cannabinoids, cannabis, and cannabis-based medicine for pain management: a systematic review of randomised controlled trials.

Emma Fisher, R Andrew Moore, Alexandra E Fogarty, David P Finn, Nanna B Finnerup, Ian Gilron, Simon Haroutounian, Elliot Krane, Andrew S C Rice, Michael Rowbotham, Mark Wallace, Christopher Eccleston,

<h4>Abstract</h4>Cannabinoids, cannabis, and cannabis-based medicines (CBMs) are increasingly used to manage pain, with limited understanding of their efficacy and safety. We summarised efficacy and adverse events (AEs) of these types of drugs for treating pain using randomised controlled trials: in people of any age, with any type of pain, and ... Read more >>

Pain (Pain)
[2021, 162(Suppl 1):S45-S66]

Cited: 2 times

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Cannabinoids, the endocannabinoid system, and pain: a review of preclinical studies.

David P Finn, Simon Haroutounian, Andrea G Hohmann, Elliot Krane, Nadia Soliman, Andrew S C Rice,

<h4>Abstract</h4>This narrative review represents an output from the International Association for the Study of Pain's global task force on the use of cannabis, cannabinoids, and cannabis-based medicines for pain management, informed by our companion systematic review and meta-analysis of preclinical studies in this area. Our aims in this review are ... Read more >>

Pain (Pain)
[2021, 162(Suppl 1):S5-S25]

Cited: 2 times

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International Association for the Study of Pain Presidential Task Force on Cannabis and Cannabinoid Analgesia: research agenda on the use of cannabinoids, cannabis, and cannabis-based medicines for pain management.

Simon Haroutounian, Lars Arendt-Nielsen, Joletta Belton, Fiona M Blyth, Louisa Degenhardt, Marta Di Forti, Christopher Eccleston, David P Finn, Nanna B Finnerup, Emma Fisher, Alexandra E Fogarty, Ian Gilron, Andrea G Hohmann, Eija Kalso, Elliot Krane, Mohammed Mohiuddin, R Andrew Moore, Michael Rowbotham, Nadia Soliman, Mark Wallace, Nantthasorn Zinboonyahgoon, Andrew S C Rice,

<h4>Abstract</h4>The President of the International Association for the Study of Pain established a task force on cannabis and cannabinoid analgesia to systematically examine the evidence on (1) analgesic pharmacology of cannabinoids and preclinical evidence on their efficacy in animal models of injury-related or pathological persistent pain; (2) the clinical efficacy ... Read more >>

Pain (Pain)
[2021, 162(Suppl 1):S117-S124]

Cited: 0 times

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General risks of harm with cannabinoids, cannabis, and cannabis-based medicine possibly relevant to patients receiving these for pain management: an overview of systematic reviews.

Mohammed Mohiuddin, Fiona M Blyth, Louisa Degenhardt, Marta Di Forti, Christopher Eccleston, Simon Haroutounian, Andrew Moore, Andrew S C Rice, Mark Wallace, Rex Park, Ian Gilron,

<h4>Abstract</h4>The growing demand for improved pain treatments together with expanding legalization of, and access to, cannabinoids, cannabis, and cannabis-based medicines has intensified the focus on risk-benefit considerations in pain management. Given limited harms data from analgesic clinical trials, we conducted an overview of systematic reviews focused on all harms possibly ... Read more >>

Pain (Pain)
[2021, 162(Suppl 1):S80-S96]

Cited: 0 times

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Presenting the outputs of the IASP Presidential Task Force on Cannabis and Cannabinoid Analgesia.

Andrew S C Rice, Joletta Belton, Lars Arendt Nielsen,

Pain (Pain)
[2021, 162(Suppl 1):S3-S4]

Cited: 0 times

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Medicinal cannabis in Thailand: 1-year experience after legalization.

Nantthasorn Zinboonyahgoon, Sahaphume Srisuma, Wirun Limsawart, Andrew S C Rice, Chuthamanee Suthisisang,

Pain (Pain)
[2021, 162(Suppl 1):S105-S109]

Cited: 0 times

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Systematic review and meta-analysis of cannabinoids, cannabis-based medicines, and endocannabinoid system modulators tested for antinociceptive effects in animal models of injury-related or pathological persistent pain.

Nadia Soliman, Simon Haroutounian, Andrea G Hohmann, Elliot Krane, Jing Liao, Malcolm Macleod, Daniel Segelcke, Christopher Sena, James Thomas, Jan Vollert, Kimberley Wever, Harutyun Alaverdyan, Ahmed Barakat, Tyler Barthlow, Amber L Harris Bozer, Alexander Davidson, Marta Diaz-delCastillo, Antonina Dolgorukova, Mehnaz I Ferdousi, Catherine Healy, Simon Hong, Mary Hopkins, Arul James, Hayley B Leake, Nathalie M Malewicz, Michael Mansfield, Amelia K Mardon, Darragh Mattimoe, Daniel P McLoone, Gith Noes-Holt, Esther M Pogatzki-Zahn, Emer Power, Bruno Pradier, Eleny Romanos-Sirakis, Astra Segelcke, Rafael Vinagre, Julio A Yanes, Jingwen Zhang, Xue Ying Zhang, David P Finn, Andrew S C Rice,

<h4>Abstract</h4>We report a systematic review and meta-analysis of studies that assessed the antinociceptive efficacy of cannabinoids, cannabis-based medicines, and endocannabinoid system modulators on pain-associated behavioural outcomes in animal models of pathological or injury-related persistent pain. In April 2019, we systematically searched 3 online databases and used crowd science and machine ... Read more >>

Pain (Pain)
[2021, 162(Suppl 1):S26-S44]

Cited: 1 time

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Cannabinoids, cannabis, and cannabis-based medicines for pain management: an overview of systematic reviews.

R Andrew Moore, Emma Fisher, David P Finn, Nanna B Finnerup, Ian Gilron, Simon Haroutounian, Elliot Krane, Andrew S C Rice, Michael Rowbotham, Mark Wallace, Christopher Eccleston,

<h4>Abstract</h4>Cannabinoids, cannabis, and cannabis-based medicines (CBM) are increasingly used to manage pain, with limited understanding of their efficacy and safety. We assessed methodological quality, scope, and results of systematic reviews of randomised controlled trials of these treatments. Several search strategies sought self-declared systematic reviews. Methodological quality was assessed using both ... Read more >>

Pain (Pain)
[2021, 162(Suppl 1):S67-S79]

Cited: 0 times

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Pragmatic trials of pain therapies: a systematic review of methods.

David Hohenschurz-Schmidt, Bethea A Kleykamp, Jerry Draper-Rodi, Jan Vollert, Jessica Chan, McKenzie Ferguson, Ewan McNicol, Jules Phalip, Scott R Evans, Dennis C Turk, Robert H Dworkin, Andrew S C Rice,

<h4>Abstract</h4>Pragmatic randomised clinical trials aim to directly inform clinical or health policy decision making. Here, we systematically review methods and design of pragmatic trials of pain therapies to examine methods, identify common challenges, and areas for improvement. Seven databases were searched for pragmatic randomised controlled clinical trials that assessed pain ... Read more >>

Pain (Pain)
[2021, :]

Cited: 0 times

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Chronic pain and cognitive impairment: a cross-sectional study in people living with HIV.

Harriet I Kemp, Donna L Kennedy, Jan Vollert, Nicholas W S Davies, Whitney Scott, Andrew S C Rice,

Cognitive impairment and chronic pain are amongst the most prevalent neurological sequelae of HIV infection, yet little is understood about the potential bidirectional relationship between the two conditions. Cognitive dysfunction can occur in chronic pain populations whilst those with cognitive impairment can display modified responses to experimentally induced painful stimuli. ... Read more >>

AIDS Care (AIDS care)
[2021, :1-14]

Cited: 0 times

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Performing and interpreting randomized clinical trials.

David Hohenschurz-Schmidt, Jan Vollert, Steven Vogel, Andrew S C Rice, Jerry Draper-Rodi,

J Osteopath Med (Journal of osteopathic medicine)
[2021, 121(4):443-445]

Cited: 0 times

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No pain, still gain (of function): the relation between sensory profiles and the presence or absence of self-reported pain in a large multicenter cohort of patients with neuropathy.

Julia Forstenpointner, Ruth Ruscheweyh, Nadine Attal, Ralf Baron, Didier Bouhassira, Elena K Enax-Krumova, Nanna B Finnerup, Rainer Freynhagen, Janne Gierthmühlen, Per Hansson, Troels S Jensen, Christoph Maier, Andrew S C Rice, Märta Segerdahl, Thomas Tölle, Rolf-Detlef Treede, Jan Vollert,

<h4>Abstract</h4>The pathophysiology of pain in neuropathy is complex and may be linked to sensory phenotypes. Quantitative sensory testing, a standardized method to evaluate sensory profiles in response to defined stimuli, assesses functional integrity of small and large nerve fiber afferents and central somatosensory pathways. It has revealed detailed insights into ... Read more >>

Pain (Pain)
[2021, 162(3):718-727]

Cited: 1 time

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Health-related quality of life and pain interference in two patient cohorts with neuropathic pain: breast cancer survivors and HIV patients.

Reetta Sipilä, Harriet Kemp, Hanna Harno, Andrew S C Rice, Eija Kalso,

<h4>Objectives</h4>Persistent pain is common in HIV patients and breast cancer (BC) survivors. The aim of this study was to compare two patient groups with neuropathic pain (NP) regarding several psychological variables and Health-related Quality of Life. Although, treatment of pain is always planned individually, the knowledge of the differences and ... Read more >>

Scand J Pain (Scandinavian journal of pain)
[2021, 21(3):512-521]

Cited: 1 time

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Acceptability of psychologically-based pain management and online delivery for people living with HIV and chronic neuropathic pain: a qualitative study.

Whitney Scott, James Badenoch, Maite Garcia Calderon Mendoza Del Solar, Darren A Brown, Harriet Kemp, Lance M McCracken, Amanda C de C Williams, Andrew S C Rice,

<h4>Objectives</h4>Chronic neuropathic pain is common in people living with HIV. Psychological treatments can improve quality of life for people with chronic pain in general, and online delivery can increase access to these treatments. However, the acceptability of psychological treatment and online delivery have not been investigated in-depth in people living ... Read more >>

Scand J Pain (Scandinavian journal of pain)
[2021, 21(2):296-307]

Cited: 0 times

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Axonal swellings are related to type 2 diabetes, but not to distal diabetic sensorimotor polyneuropathy.

Pall Karlsson, Sandra S Gylfadottir, Alexander G Kristensen, Juan D Ramirez, Pedro Cruz, Nhu Le, Pallai R Shillo, Solomon Tesfaye, Andrew S C Rice, Hatice Tankisi, Nanna B Finnerup, Jens R Nyengaard, Troels S Jensen, David L H Bennett, Andreas C Themistocleous,

<h4>Aims/hypothesis</h4>Distal diabetic sensorimotor polyneuropathy (DSP) is a common complication of diabetes with many patients showing a reduction of intraepidermal nerve fibre density (IENFD) from skin biopsy, a validated and sensitive diagnostic tool for the assessment of DSP. Axonal swelling ratio is a morphological quantification altered in DSP. It is, however, ... Read more >>

Diabetologia (Diabetologia)
[2021, 64(4):923-931]

Cited: 1 time

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Mechanical detection and pain thresholds: comparability of devices using stepped and ramped stimuli.

Doreen B Pfau, Omer Haroun, Diana N Lockwood, Christoph Maier, Marc Schmitter, Jan Vollert, Andrew S C Rice, Rolf-Detlef Treede,

Quantitative sensory testing is used to assess somatosensory function in humans. The protocol of the German Research Network on Neuropathic Pain (DFNS) provides comprehensive normative values using defined tools; however, some of these may not be feasible in low-resource settings.<h4>Objectives</h4>To compare the standard DFNS devices for assessment of mechanosensory function ... Read more >>

Pain Rep (Pain reports)
[2020, 5(6):e865]

Cited: 0 times

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An introduction to the Biennial Review of Pain.

Andrew S C Rice, Francis J Keefe,

Pain (Pain)
[2020, 161 Suppl 1:S1-S2]

Cited: 0 times

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The Utility of Corneal Nerve Fractal Dimension Analysis in Peripheral Neuropathies of Different Etiology.

Ioannis N Petropoulos, Abdulrahman Al-Mohammedi, Xin Chen, Maryam Ferdousi, Georgios Ponirakis, Harriet Kemp, Reena Chopra, Scott Hau, Marc Schargus, Jan Vollert, Dietrich Sturm, Tina Bharani, Christopher Kleinschnitz, Mark Stettner, Tunde Peto, Christoph Maier, Andrew S C Rice, Rayaz A Malik,

<h4>Purpose</h4>Quantification of corneal confocal microscopy (CCM) images has shown a significant reduction in corneal nerve fiber length (CNFL) in a range of peripheral neuropathies. We assessed whether corneal nerve fractal dimension (CNFrD) analysis, a novel metric to quantify the topological complexity of corneal subbasal nerves, can differentiate peripheral neuropathies of ... Read more >>

Transl Vis Sci Technol (Translational vision science & technology)
[2020, 9(9):43]

Cited: 2 times

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A practical guide to preclinical systematic review and meta-analysis.

Nadia Soliman, Andrew S C Rice, Jan Vollert,

Pain (Pain)
[2020, 161(9):1949-1954]

Cited: 0 times

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Reply to Banik.

Sophie W Kjær, Andrew S C Rice, Karolina Wartolowska, Lene Vase,

Pain (Pain)
[2020, 161(8):1939-1940]

Cited: 0 times

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Conditional expression of HIV-1 tat in the mouse alters the onset and progression of tonic, inflammatory and neuropathic hypersensitivity in a sex-dependent manner.

Deniz Bagdas, Jason J Paris, Moriah Carper, Rachel Wodarski, Andrew S C Rice, Pamela E Knapp, Kurt F Hauser, M Imad Damaj,

<h4>Background</h4>At least one-third of HIV-1-afflicted individuals experience peripheral neuropathy. Although the underlying mechanisms are not known, they may involve neurotoxic HIV-1 proteins.<h4>Methods</h4>We assessed the influence of the neurotoxic HIV-1 regulatory protein, Tat, on inflammatory and neuropathic nociceptive behaviours using transgenic male and female mice that conditionally expressed (or did not ... Read more >>

Eur J Pain (European journal of pain (London, England))
[2020, 24(8):1609-1623]

Cited: 4 times

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Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort.

James E D Thaventhiran, Hana Lango Allen, Oliver S Burren, William Rae, Daniel Greene, Emily Staples, Zinan Zhang, James H R Farmery, Ilenia Simeoni, Elizabeth Rivers, Jesmeen Maimaris, Christopher J Penkett, Jonathan Stephens, Sri V V Deevi, Alba Sanchis-Juan, Nicholas S Gleadall, Moira J Thomas, Ravishankar B Sargur, Pavels Gordins, Helen E Baxendale, Matthew Brown, Paul Tuijnenburg, Austen Worth, Steven Hanson, Rachel J Linger, Matthew S Buckland, Paula J Rayner-Matthews, Kimberly C Gilmour, Crina Samarghitean, Suranjith L Seneviratne, David M Sansom, Andy G Lynch, Karyn Megy, Eva Ellinghaus, David Ellinghaus, Silje F Jorgensen, Tom H Karlsen, Kathleen E Stirrups, Antony J Cutler, Dinakantha S Kumararatne, Anita Chandra, J David M Edgar, Archana Herwadkar, Nichola Cooper, Sofia Grigoriadou, Aarnoud P Huissoon, Sarah Goddard, Stephen Jolles, Catharina Schuetz, Felix Boschann, , Paul A Lyons, Matthew E Hurles, Sinisa Savic, Siobhan O Burns, Taco W Kuijpers, Ernest Turro, Willem H Ouwehand, Adrian J Thrasher, Kenneth G C Smith,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nature (Nature)
[2020, 584(7819):E2]

Cited: 3 times

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Whole-genome sequencing of patients with rare diseases in a national health system.

Ernest Turro, William J Astle, Karyn Megy, Stefan Gräf, Daniel Greene, Olga Shamardina, Hana Lango Allen, Alba Sanchis-Juan, Mattia Frontini, Chantal Thys, Jonathan Stephens, Rutendo Mapeta, Oliver S Burren, Kate Downes, Matthias Haimel, Salih Tuna, Sri V V Deevi, Timothy J Aitman, David L Bennett, Paul Calleja, Keren Carss, Mark J Caulfield, Patrick F Chinnery, Peter H Dixon, Daniel P Gale, Roger James, Ania Koziell, Michael A Laffan, Adam P Levine, Eamonn R Maher, Hugh S Markus, Joannella Morales, Nicholas W Morrell, Andrew D Mumford, Elizabeth Ormondroyd, Stuart Rankin, Augusto Rendon, Sylvia Richardson, Irene Roberts, Noemi B A Roy, Moin A Saleem, Kenneth G C Smith, Hannah Stark, Rhea Y Y Tan, Andreas C Themistocleous, Adrian J Thrasher, Hugh Watkins, Andrew R Webster, Martin R Wilkins, Catherine Williamson, James Whitworth, Sean Humphray, David R Bentley, , Nathalie Kingston, Neil Walker, John R Bradley, Sofie Ashford, Christopher J Penkett, Kathleen Freson, Kathleen E Stirrups, F Lucy Raymond, Willem H Ouwehand,

Most patients with rare diseases do not receive a molecular diagnosis and the aetiological variants and causative genes for more than half such disorders remain to be discovered<sup>1</sup>. Here we used whole-genome sequencing (WGS) in a national health system to streamline diagnosis and to discover unknown aetiological variants in the ... Read more >>

Nature (Nature)
[2020, 583(7814):96-102]

Cited: 47 times

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