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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

Cited: 0 times

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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

Cited: 0 times

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The relationship between adrenocortical candidate gene expression and clinical response to hydrocortisone in patients with septic shock.

Jeremy Cohen, Antje Blumenthal, Gabriel Cuellar-Partida, David M Evans, Simon Finfer, Qiang Li, Johanna Ljungberg, John Myburgh, Elizabeth Peach, Joseph Powell, Dorrilyn Rajbhandari, Andrew Rhodes, Anne Senabouth, Balasubramanian Venkatesh,

<h4>Purpose</h4>To determine if adrenocortical gene expression is associated with clinical outcomes or response to corticosteroid treatment in septic shock.<h4>Methods</h4>A pre-specified nested cohort study of a randomised controlled trial of hydrocortisone compared to placebo in septic shock. Blood was collected for RNAseq analysis prior to treatment with hydrocortisone or placebo. The ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(9):974-983]

Cited: 1 time

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Postoperative continuous positive airway pressure to prevent pneumonia, re-intubation, and death after major abdominal surgery (PRISM): a multicentre, open-label, randomised, phase 3 trial.

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<h4>Background</h4>Respiratory complications are an important cause of postoperative morbidity. We aimed to investigate whether continuous positive airway pressure (CPAP) administered immediately after major abdominal surgery could prevent postoperative morbidity.<h4>Methods</h4>PRISM was an open-label, randomised, phase 3 trial done at 70 hospitals across six countries. Patients aged 50 years or older who ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2021, :]

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Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study.

Jakub Fronczek, Kamil Polok, Dylan W de Lange, Christian Jung, Michael Beil, Andrew Rhodes, Jesper Fjølner, Jacek Górka, Finn H Andersen, Antonio Artigas, Maurizio Cecconi, Steffen Christensen, Michael Joannidis, Susannah Leaver, Brian Marsh, Alessandro Morandi, Rui Moreno, Sandra Oeyen, Christina Agvald-Öhman, Bernardo Bollen Pinto, Joerg C Schefold, Andreas Valentin, Sten Walther, Ximena Watson, Tilemachos Zafeiridis, Sigal Sviri, Peter Vernon van Heerden, Hans Flaatten, Bertrand Guidet, Wojciech Szczeklik, , ,

<h4>Background</h4>The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after admission to the ICU. This study aimed to evaluate the influence of modelling approach on the association ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):231]

Cited: 0 times

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The Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness.

Craig M Coopersmith, Massimo Antonelli, Seth R Bauer, Clifford S Deutschman, Laura E Evans, Ricard Ferrer, Judith Hellman, Sameer Jog, Jozef Kesecioglu, Niranjan Kissoon, Ignacio Martin-Loeches, Mark E Nunnally, Hallie C Prescott, Andrew Rhodes, Daniel Talmor, Pierre Tissieres, Daniel De Backer,

<h4>Objectives</h4>To identify research priorities in the management, pathophysiology, and host response of coronavirus disease 2019 in critically ill patients.<h4>Design</h4>The Surviving Sepsis Research Committee, a multiprofessional group of 17 international experts representing the European Society of Intensive Care Medicine and Society of Critical Care Medicine, was virtually convened during the coronavirus ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(4):598-622]

Cited: 6 times

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The Surviving Sepsis Campaign: Fluid Resuscitation and Vasopressor Therapy Research Priorities in Adult Patients.

Ishaq Lat, Craig M Coopersmith, Daniel De Backer, , , , , , , , , , , , , , , , , ,

<h4>Objective</h4>Expand upon the priorities of fluid resuscitation and vasopressor therapy research priorities identified by a group of experts assigned by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine.<h4>Data sources</h4>Original article, literature search.<h4>Study selection</h4>Several members of the original task force with expertise specific to the ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(4):623-635]

Cited: 3 times

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Temporal changes in the epidemiology, management, and outcome from acute respiratory distress syndrome in European intensive care units: a comparison of two large cohorts.

Yasser Sakr, Bruno François, Jordi Solé-Violan, Katarzyna Kotfis, Ulrich Jaschinski, Angel Estella, Marc Leone, Stephan M Jakob, Xavier Wittebole, Luis E Fontes, Miguel de Melo Gurgel, Thais Midega, Jean-Louis Vincent, V Marco Ranieri, ,

<h4>Background</h4>Mortality rates for patients with ARDS remain high. We assessed temporal changes in the epidemiology and management of ARDS patients requiring invasive mechanical ventilation in European ICUs. We also investigated the association between ventilatory settings and outcome in these patients.<h4>Methods</h4>This was a post hoc analysis of two cohorts of adult ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):87]

Cited: 2 times

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The surviving sepsis campaign: fluid resuscitation and vasopressor therapy research priorities in adult patients.

Ishaq Lat, Craig M Coopersmith, Daniel De Backer, Craig M Coopersmith, ,

<h4>Objective</h4>To expand upon the priorities of fluid resuscitation and vasopressor therapy research priorities identified by a group of experts assigned by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine.<h4>Data sources</h4>Original paper and literature search.<h4>Study selection</h4>Several members of the original task force with expertise specific ... Read more >>

Intensive Care Med Exp (Intensive care medicine experimental)
[2021, 9(1):10]

Cited: 1 time

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Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update.

Waleed Alhazzani, Laura Evans, Fayez Alshamsi, Morten Hylander Møller, Marlies Ostermann, Hallie C Prescott, Yaseen M Arabi, Mark Loeb, Michelle Ng Gong, Eddy Fan, Simon Oczkowski, Mitchell M Levy, Lennie Derde, Amy Dzierba, Bin Du, Flavia Machado, Hannah Wunsch, Mark Crowther, Maurizio Cecconi, Younsuck Koh, Lisa Burry, Daniel S Chertow, Wojciech Szczeklik, Emilie Belley-Cote, Massimiliano Greco, Malgorzata Bala, Ryan Zarychanski, Jozef Kesecioglu, Allison McGeer, Leonard Mermel, Manoj J Mammen, Sheila Nainan Myatra, Amy Arrington, Ruth Kleinpell, Giuseppe Citerio, Kimberley Lewis, Elizabeth Bridges, Ziad A Memish, Naomi Hammond, Frederick G Hayden, Muhammed Alshahrani, Zainab Al Duhailib, Greg S Martin, Lewis J Kaplan, Craig M Coopersmith, Massimo Antonelli, Andrew Rhodes,

<h4>Background</h4>The coronavirus disease 2019 pandemic continues to affect millions worldwide. Given the rapidly growing evidence base, we implemented a living guideline model to provide guidance on the management of patients with severe or critical coronavirus disease 2019 in the ICU.<h4>Methods</h4>The Surviving Sepsis Campaign Coronavirus Disease 2019 panel has expanded to ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(3):e219-e234]

Cited: 37 times

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How the COVID-19 pandemic will change the future of critical care.

Yaseen M Arabi, Elie Azoulay, Hasan M Al-Dorzi, Jason Phua, Jorge Salluh, Alexandra Binnie, Carol Hodgson, Derek C Angus, Maurizio Cecconi, Bin Du, Rob Fowler, Charles D Gomersall, Peter Horby, Nicole P Juffermans, Jozef Kesecioglu, Ruth M Kleinpell, Flavia R Machado, Greg S Martin, Geert Meyfroidt, Andrew Rhodes, Kathryn Rowan, Jean-François Timsit, Jean-Louis Vincent, Giuseppe Citerio,

Coronavirus disease 19 (COVID-19) has posed unprecedented healthcare system challenges, some of which will lead to transformative change. It is obvious to healthcare workers and policymakers alike that an effective critical care surge response must be nested within the overall care delivery model. The COVID-19 pandemic has highlighted key elements ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(3):282-291]

Cited: 7 times

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β-Lactam antimicrobial  pharmacokinetics and target attainment in critically ill patients aged 1 day to 90 years: the ABDose study.

Dagan O Lonsdale, Karin Kipper, Emma H Baker, Charlotte I S Barker, Isobel Oldfield, Barbara J Philips, Atholl Johnston, Andrew Rhodes, Mike Sharland, Joseph F Standing,

<h4>Background</h4>The pharmacokinetics of β-lactam antibiotics in critical illness remain poorly characterized, particularly in neonates, children and the elderly. We undertook a pharmacokinetic study of commonly used β-lactam antibiotics in critically ill patients of all ages. The aims were to produce a whole-life β-lactam pharmacokinetic model and describe the extent to ... Read more >>

J Antimicrob Chemother (The Journal of antimicrobial chemotherapy)
[2020, 75(12):3625-3634]

Cited: 0 times

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The wave of very old people in the intensive care unit-A challenge in decision-making.

Peter Vernon van Heerden, Sigal Sviri, Michael Beil, Wojciech Szczeklik, Dylan de Lange, Christian Jung, Bertrand Guidet, Susannah Leaver, Andrew Rhodes, Ariane Boumendil, Hans Flaatten,

In this paper the authors express the opinion that there is much to be learned about the 80+ year old age group as it relates to critical care and end-of-life matters. We need to learn how to better predict outcome, we need to learn our limitations and deal with uncertainties, ... Read more >>

J Crit Care (Journal of critical care)
[2020, 60:290-293]

Cited: 3 times

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Plasma Cortisol, Aldosterone, and Ascorbic Acid Concentrations in Patients with Septic Shock Do Not Predict Treatment Effect of Hydrocortisone on Mortality. A Nested Cohort Study.

Jeremy Cohen, Rinaldo Bellomo, Laurent Billot, Louise M Burrell, David M Evans, Simon Finfer, Naomi E Hammond, Qiang Li, David Liu, Colin McArthur, Brett McWhinney, John Moore, John Myburgh, Sandra Peake, Carel Pretorius, Dorrilyn Rajbhandari, Andrew Rhodes, Manoj Saxena, Jacobus P J Ungerer, Morag J Young, Balasubramanian Venkatesh,

<b>Rationale:</b> Whether biomarkers can identify subgroups of patients with septic shock with differential treatment responses to hydrocortisone is unknown.<b>Objectives:</b> To determine if there is heterogeneity in effect for hydrocortisone on mortality, shock resolution, and other clinical outcomes based on baseline cortisol, aldosterone, and ascorbic acid concentrations.<b>Methods:</b> From May 2014 to ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 202(5):700-707]

Cited: 2 times

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Treatment variables associated with outcome in emergency department patients with suspected sepsis.

Narani Sivayoham, Lesley A Blake, Shafi E Tharimoopantavida, Saad Chughtai, Adil N Hussain, Andrew Rhodes,

<h4>Background</h4>Early treatment is advocated in the management of patients with suspected sepsis in the emergency department (ED). We sought to understand the association between the ED treatments and outcome in patients admitted with suspected sepsis. The treatments studied were: (i) the time to antibiotics, where time zero is the time ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2020, 10(1):136]

Cited: 2 times

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Dynamic Arterial Elastance During Experimental Endotoxic Septic Shock: A Potential Marker of Cardiovascular Efficiency.

Manuel Ignacio Monge Garcia, Pedro Guijo González, Paula Saludes Orduña, Manuel Gracia Romero, Anselmo Gil Cano, Antonio Messina, Andrew Rhodes, Maurizio Cecconi,

Dynamic arterial elastance (Ea<sub>dyn</sub>), the ratio between pulse pressure variation (PPV) and stroke volume variation (SVV), has been suggested as a dynamic parameter relating pressure and flow. We aimed to determine the effects of endotoxic septic shock and hemodynamic resuscitation on Ea<sub>dyn</sub> in an experimental study in 18 New Zealand ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:562824]

Cited: 0 times

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On predictions in critical care: The individual prognostication fallacy in elderly patients.

Michael Beil, Sigal Sviri, Hans Flaatten, Dylan W De Lange, Christian Jung, Wojciech Szczeklik, Susannah Leaver, Andrew Rhodes, Bertrand Guidet, P Vernon van Heerden,

Predicting the future course of critical conditions involves personal experience, heuristics and statistical models. Although these methods may perform well for some cases and population averages, they suffer from substantial shortcomings when applied to individual patients. The reasons include methodological problems of statistical modeling as well as limitations of cross-sectional ... Read more >>

J Crit Care (Journal of critical care)
[2021, 61:34-38]

Cited: 2 times

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The surviving sepsis campaign: basic/translational science research priorities.

Clifford S Deutschman, Judith Hellman, Ricard Ferrer Roca, Daniel De Backer, Craig M Coopersmith, ,

<h4>Objectives</h4>Expound upon priorities for basic/translational science identified in a recent paper by a group of experts assigned by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine.<h4>Data sources</h4>Original paper, search of the literature.<h4>Study selection</h4>This study is selected by several members of the original task force ... Read more >>

Intensive Care Med Exp (Intensive care medicine experimental)
[2020, 8(1):31]

Cited: 2 times

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Septic Shock: A Genomewide Association Study and Polygenic Risk Score Analysis.

Shannon D'Urso, Dorrilyn Rajbhandari, Elizabeth Peach, Erika de Guzman, Qiang Li, Sarah E Medland, Scott D Gordon, Nicholas G Martin, , Symen Ligthart, Matthew A Brown, Joseph Powell, Colin McArthur, Andrew Rhodes, Jason Meyer, Simon Finfer, John Myburgh, Antje Blumenthal, Jeremy Cohen, Balasubramanian Venkatesh, Gabriel Cuellar-Partida, David M Evans,

Previous genetic association studies have failed to identify loci robustly associated with sepsis, and there have been no published genetic association studies or polygenic risk score analyses of patients with septic shock, despite evidence suggesting genetic factors may be involved. We systematically collected genotype and clinical outcome data in the ... Read more >>

Twin Res Hum Genet (Twin research and human genetics : the official journal of the International Society for Twin Studies)
[2020, 23(4):204-213]

Cited: 0 times

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Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review.

W Joost Wiersinga, Andrew Rhodes, Allen C Cheng, Sharon J Peacock, Hallie C Prescott,

<h4>Importance</h4>The coronavirus disease 2019 (COVID-19) pandemic, due to the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a worldwide sudden and substantial increase in hospitalizations for pneumonia with multiorgan disease. This review discusses current evidence regarding the pathophysiology, transmission, diagnosis, and management of COVID-19.<h4>Observations</h4>SARS-CoV-2 is spread primarily via ... Read more >>

JAMA (JAMA)
[2020, 324(8):782-793]

Cited: 835 times

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Managing ICU surge during the COVID-19 crisis: rapid guidelines.

Shadman Aziz, Yaseen M Arabi, Waleed Alhazzani, Laura Evans, Giuseppe Citerio, Katherine Fischkoff, Jorge Salluh, Geert Meyfroidt, Fayez Alshamsi, Simon Oczkowski, Elie Azoulay, Amy Price, Lisa Burry, Amy Dzierba, Andrew Benintende, Jill Morgan, Giacomo Grasselli, Andrew Rhodes, Morten H Møller, Larry Chu, Shelly Schwedhelm, John J Lowe, Du Bin, Michael D Christian,

Given the rapidly changing nature of COVID-19, clinicians and policy makers require urgent review and summary of the literature, and synthesis of evidence-based guidelines to inform practice. The WHO advocates for rapid reviews in these circumstances. The purpose of this rapid guideline is to provide recommendations on the organizational management ... Read more >>

Intensive Care Med (Intensive care medicine)
[2020, 46(7):1303-1325]

Cited: 63 times

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Health-related quality of life in survivors of septic shock: 6-month follow-up from the ADRENAL trial.

Naomi E Hammond, Simon R Finfer, Qiang Li, Colman Taylor, Jeremy Cohen, Yaseen Arabi, Rinaldo Bellomo, Laurent Billot, Meg Harward, Christopher Joyce, Colin McArthur, John Myburgh, Anders Perner, Dorrilyn Rajbhandari, Andrew Rhodes, Kelly Thompson, Steve Webb, Balasubramanian Venkatesh, ,

<h4>Purpose</h4>To investigate the impact of hydrocortisone treatment and illness severity on health-related quality of life (HRQoL) at 6 months in septic shock survivors from the ADRENAL trial.<h4>Methods</h4>Using the EuroQol questionnaire (EQ-5D-5L) at 6 months after randomization we assessed HRQoL in patient subgroups defined by hydrocortisone or placebo treatment, gender, illness severity (APACHE II < or ≥ 25), ... Read more >>

Intensive Care Med (Intensive care medicine)
[2020, 46(9):1696-1706]

Cited: 2 times

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The good, the bad and the ugly: pandemic priority decisions and triage.

Hans Flaatten, Vernon Van Heerden, Christian Jung, Michael Beil, Susannah Leaver, Andrew Rhodes, Bertrand Guidet, Dylan W deLange,

In this analysis we discuss the change in criteria for triage of patients during three different phases of a pandemic like COVID-19, seen from the critical care point of view. Availability of critical care beds has become a hot topic, and in many countries, we have seen a huge increase ... Read more >>

J Med Ethics (Journal of medical ethics)
[2020, :]

Cited: 8 times

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Elective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans.

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<h4>Background</h4>The COVID-19 pandemic has disrupted routine hospital services globally. This study estimated the total number of adult elective operations that would be cancelled worldwide during the 12 weeks of peak disruption due to COVID-19.<h4>Methods</h4>A global expert response study was conducted to elicit projections for the proportion of elective surgery that would ... Read more >>

Br J Surg (The British journal of surgery)
[2020, 107(11):1440-1449]

Cited: 342 times

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