Full Text Journal Articles by
Author Andrew P McGovern

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Trends in 28-Day Mortality of Critical Care Patients With Coronavirus Disease 2019 in the United Kingdom: A National Cohort Study, March 2020 to January 2021.

John M Dennis, Andrew P McGovern, Nicholas J Thomas, Harrison Wilde, Sebastian J Vollmer, Bilal A Mateen,

<h4>Objectives</h4>To determine whether the previously described trend of improving mortality in people with coronavirus disease 2019 in critical care during the first wave was maintained, plateaued, or reversed during the second wave in United Kingdom, when B117 became the dominant strain.<h4>Design</h4>National retrospective cohort study.<h4>Setting</h4>All English hospital trusts (i.e., groups of ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):1895-1900]

Cited: 1 time

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A national retrospective study of the association between serious operational problems and COVID-19 specific intensive care mortality risk.

Harrison Wilde, John M Dennis, Andrew P McGovern, Sebastian J Vollmer, Bilal A Mateen,

<h4>Objectives</h4>To describe the relationship between reported serious operational problems (SOPs), and mortality for patients with COVID-19 admitted to intensive care units (ICUs).<h4>Design</h4>English national retrospective cohort study.<h4>Setting</h4>89 English hospital trusts (i.e. small groups of hospitals functioning as single operational units).<h4>Patients</h4>All adults with COVID-19 admitted to ICU between 2nd April and 1st ... Read more >>

PLoS One (PloS one)
[2021, 16(7):e0255377]

Cited: 1 time

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Improving Survival of Critical Care Patients With Coronavirus Disease 2019 in England: A National Cohort Study, March to June 2020.

John M Dennis, Andrew P McGovern, Sebastian J Vollmer, Bilal A Mateen,

<h4>Objectives</h4>To measure temporal trends in survival over time in people with severe coronavirus disease 2019 requiring critical care (high dependency unit or ICU) management, and to assess whether temporal variation in mortality was explained by changes in patient demographics and comorbidity burden over time.<h4>Design</h4>Retrospective observational cohort; based on data reported ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(2):209-214]

Cited: 46 times

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Prescribing in Type 2 Diabetes Patients With and Without Cardiovascular Disease History: A Descriptive Analysis in the UK CPRD.

Ruth E Farmer, Ivan Beard, Syed I Raza, Nicholas D Gollop, Niraj Patel, Abigail Tebboth, Andrew P McGovern, Naresh Kanumilli, Andrew Ternouth,

<h4>Purpose</h4>Some classes of glucose-lowering medications, including sodium-glucose co-transporter 2 inhibitors (SGLT2is) and glucagon-like peptide 1-receptor agonists (GLP1-RAs) have cardio-protective benefit, but it is unclear whether this influences prescribing in the United Kingdom (UK). This study aims to describe class-level prescribing in adults with type 2 diabetes mellitus (T2DM) by cardiovascular ... Read more >>

Clin Ther (Clinical therapeutics)
[2021, 43(2):320-335]

Cited: 1 time

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The disproportionate excess mortality risk of COVID-19 in younger people with diabetes warrants vaccination prioritisation.

Andrew P McGovern, Nick J Thomas, Sebastian J Vollmer, Andrew T Hattersley, Bilal A Mateen, John M Dennis,

Diabetologia (Diabetologia)
[2021, 64(5):1184-1186]

Cited: 3 times

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Type 2 Diabetes and COVID-19-Related Mortality in the Critical Care Setting: A National Cohort Study in England, March-July 2020.

John M Dennis, Bilal A Mateen, Raphael Sonabend, Raphael Sonabend, Nicholas J Thomas, Kashyap A Patel, Andrew T Hattersley, Spiros Denaxas, Spiros Denaxas, Andrew P McGovern, Sebastian J Vollmer,

<h4>Objective</h4>To describe the relationship between type 2 diabetes and all-cause mortality among adults with coronavirus disease 2019 (COVID-19) in the critical care setting.<h4>Research design and methods</h4>This was a nationwide retrospective cohort study in people admitted to hospital in England with COVID-19 requiring admission to a high dependency unit (HDU) or ... Read more >>

Diabetes Care (Diabetes care)
[2021, 44(1):50-57]

Cited: 26 times

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Risk factors for genital infections in people initiating SGLT2 inhibitors and their impact on discontinuation.

Andrew P McGovern, Michael Hogg, Beverley M Shields, Naveed A Sattar, Rury R Holman, Ewan R Pearson, Andrew T Hattersley, Angus G Jones, John M Dennis, ,

<h4>Introduction</h4>To identify risk factors, absolute risk, and impact on treatment discontinuation of genital infections with sodium-glucose co-transporter-2 inhibitors (SGLT2i).<h4>Research design and methods</h4>We assessed the relationship between baseline characteristics and genital infection in 21 004 people with type 2 diabetes initiating SGLT2i and 55 471 controls initiating dipeptidyl peptidase-4 inhibitors (DPP4i) in a ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2020, 8(1):]

Cited: 4 times

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What to do with diabetes therapies when HbA1c lowering is inadequate: add, switch, or continue? A MASTERMIND study.

Andrew P McGovern, John M Dennis, Beverley M Shields, Andrew T Hattersley, Ewan R Pearson, Angus G Jones, ,

<h4>Background</h4>It is unclear what to do when people with type 2 diabetes have had no or a limited glycemic response to a recently introduced medication. Intra-individual HbA1c variability can obscure true response. Some guidelines suggest stopping apparently ineffective therapy, but no studies have addressed this issue.<h4>Methods</h4>In a retrospective cohort analysis ... Read more >>

BMC Med (BMC medicine)
[2019, 17(1):79]

Cited: 1 time

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Time trends in prescribing of type 2 diabetes drugs, glycaemic response and risk factors: A retrospective analysis of primary care data, 2010-2017.

John M Dennis, William E Henley, Andrew P McGovern, Andrew J Farmer, Naveed Sattar, Rury R Holman, Ewan R Pearson, Andrew T Hattersley, Beverley M Shields, Angus G Jones, ,

<h4>Aim</h4>To describe population-level time trends in prescribing patterns of type 2 diabetes therapy, and in short-term clinical outcomes (glycated haemoglobin [HbA1c], weight, blood pressure, hypoglycaemia and treatment discontinuation) after initiating new therapy.<h4>Materials and methods</h4>We studied 81 532 people with type 2 diabetes initiating a first- to fourth-line drug in primary care ... Read more >>

Diabetes Obes Metab (Diabetes, obesity & metabolism)
[2019, 21(7):1576-1584]

Cited: 11 times

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Type 2 diabetes: A protective factor for COPD?

Louise H Rayner, Andrew P McGovern, Julian Sherlock, Piers Gatenby, Ana Correa, Ben Creagh-Brown, Simon de Lusignan,

BACKGROUND:Chronic obstructive pulmonary disease (COPD) and type 2 diabetes (T2DM) are common comorbidities. COPD is a known risk factor for incident T2DM, however few studies have examined the relationship in reverse. The primary aim of this study was to compare the incidence of COPD in people with and without T2DM. ... Read more >>

Prim Care Diabetes (Primary care diabetes)
[2018, 12(5):438-444]

Cited: 3 times

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Incidence, Demographics, and Clinical Characteristics of Diabetes of the Exocrine Pancreas (Type 3c): A Retrospective Cohort Study.

Chris Woodmansey, Andrew P McGovern, Katherine A McCullough, Martin B Whyte, Neil M Munro, Ana C Correa, Piers A C Gatenby, Simon A Jones, Simon de Lusignan,

<h4>Objective</h4>This study was conducted to describe the incidence of diabetes following pancreatic disease, assess how these patients are classified by clinicians, and compare clinical characteristics with type 1 and type 2 diabetes.<h4>Research design and methods</h4>Primary care records in England (<i>n</i> = 2,360,631) were searched for incident cases of adult-onset diabetes ... Read more >>

Diabetes Care (Diabetes care)
[2017, 40(11):1486-1493]

Cited: 38 times

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Physician Associate and General Practitioner Consultations: A Comparative Observational Video Study.

Simon de Lusignan, Andrew P McGovern, Mohammad Aumran Tahir, Simon Hassan, Simon Jones, Mary Halter, Louise Joly, Vari M Drennan,

<h4>Background</h4>Physician associates, known internationally as physician assistants, are a mid-level practitioner, well established in the United States of America but new to the United Kingdom. A small number work in primary care under the supervision of general practitioners, where they most commonly see patients requesting same day appointments for new ... Read more >>

PLoS One (PloS one)
[2016, 11(8):e0160902]

Cited: 1 time

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Infection risk in elderly people with reduced glycaemic control.

Andrew P McGovern, Julia Hine, Simon de Lusignan,

Lancet Diabetes Endocrinol (The lancet. Diabetes & endocrinology)
[2016, 4(4):303-304]

Cited: 3 times

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Identification of people with autosomal dominant polycystic kidney disease using routine data: a cross sectional study.

Andrew P McGovern, Simon Jones, Jeremy van Vlymen, Anand K Saggar, Richard Sandford, Simon de Lusignan,

<h4>Background</h4>Autosomal dominant polycystic kidney disease (ADPKD) causes progressive renal damage and is a leading cause of end-stage renal failure. With emerging therapies it is important to devise a method for early detection. We aimed to identify factors from routine clinical data which can be used to distinguish people with a ... Read more >>

BMC Nephrol (BMC nephrology)
[2014, 15:182]

Cited: 9 times

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Association of chronic kidney disease (CKD) and failure to monitor renal function with adverse outcomes in people with diabetes: a primary care cohort study.

Andrew P McGovern, Benjamin Rusholme, Simon Jones, Jeremy N van Vlymen, Harshana Liyanage, Hugh Gallagher, Charles R V Tomson, Kamlesh Khunti, Kevin Harris, Simon de Lusignan,

<h4>Background</h4>Chronic kidney disease (CKD) is a known risk factor for cardiovascular events and all-cause mortality. We investigate the relationship between CKD stage, proteinuria, hypertension and these adverse outcomes in the people with diabetes. We also study the outcomes of people who did not have monitoring of renal function.<h4>Methods</h4>A cohort of ... Read more >>

BMC Nephrol (BMC nephrology)
[2013, 14:198]

Cited: 11 times

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DNMT3A mutations at R882 hotspot are only found in major clones of acute myeloid leukemia.

Kathrin E Bisling, John N Brewin, Andrew P McGovern, Gillian A Horne, Tom Rider, Helen J Stewart, Bernard H Ramsahoye, Timothy J Chevassut,

Leuk Lymphoma (Leukemia & lymphoma)
[2014, 55(3):711-714]

Cited: 2 times

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A dynamic multi-compartmental model of DNA methylation with demonstrable predictive value in hematological malignancies.

Andrew P McGovern, Benjamin E Powell, Timothy J T Chevassut,

Recent advances have highlighted the central role of DNA methylation in leukemogenesis and have led to clinical trials of epigenetic therapy, notably hypomethylating agents, in myelodysplasia and acute myeloid leukemia. However, despite these advances, our understanding of the dynamic regulation of the methylome remains poor. We have attempted to address ... Read more >>

J Theor Biol (Journal of theoretical biology)
[2012, 310:14-20]

Cited: 11 times

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