Full Text Journal Articles by
Author Andrew M Youssef

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Pain stickiness in pediatric complex regional pain syndrome: A role for the nucleus accumbens.

Andrew M Youssef, Ke Peng, Pearl Kijoo Kim, Alyssa Lebel, Navil F Sethna, Corey Kronman, David Zurakowski, David Borsook, Laura E Simons,

Some individuals with chronic pain experience improvement in their pain with treatment, whereas others do not. The neurobiological reason is unclear, but an understanding of brain structure and functional patterns may provide insights into pain's responsivity to treatment. In this investigation, we used magnetic resonance imaging (MRI) techniques to determine ... Read more >>

Neurobiol Pain (Neurobiology of pain (Cambridge, Mass.))
[2021, 9:100062]

Cited: 0 times

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Effect of Expectation on Pain Processing: A Psychophysics and Functional MRI Analysis.

Luke A Henderson, Flavia Di Pietro, Andrew M Youssef, Sinjeong Lee, Shirley Tam, R Akhter, Emily P Mills, Greg M Murray, Chris C Peck, Paul M Macey,

Pain is a complex phenomenon that is highly modifiable by expectation. Whilst the intensity of incoming noxious information plays a key role in the intensity of perceived pain, this intensity can be profoundly shaped by an individual's expectations. Modern brain imaging investigations have begun to detail the brain regions responsible ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:6]

Cited: 0 times

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Brain signatures of threat-safety discrimination in adolescent chronic pain.

Lauren C Heathcote, Inge Timmers, Corey A Kronman, Farah Mahmud, J Maya Hernandez, Jason Bentley, Andrew M Youssef, Daniel S Pine, David Borsook, Laura E Simons,

Approximately 1.7 million youth suffer from debilitating chronic pain in the US alone, conferring risk of continued pain in adulthood. Aberrations in threat-safety (T-S) discrimination are proposed to contribute to pain chronicity in adults and youth by interacting with pain-related distress. Yet, few studies have examined the neural circuitry underlying ... Read more >>

Pain (Pain)
[2020, 161(3):630-640]

Cited: 5 times

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Implications of the putamen in pain and motor deficits in complex regional pain syndrome.

Monica Azqueta-Gavaldon, Andrew M Youssef, Claudia Storz, Jordan Lemme, Heike Schulte-Göcking, Lino Becerra, Shahnaz C Azad, Anselm Reiners, Birgit Ertl-Wagner, David Borsook, Jaymin Upadhyay, Eduard Kraft,

Complex regional pain syndrome (CRPS) develops after-limb injury, with persistent pain and deficits in movement frequently co-occurring. The striatum is critical for mediating multiple mechanisms that are often aberrant in CRPS, which includes sensory and pain processing, motor function, and goal-directed behaviors associated with movement. Yet, much remains unknown with ... Read more >>

Pain (Pain)
[2020, 161(3):595-608]

Cited: 2 times

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Shifting brain circuits in pain chronicity.

Andrew M Youssef, Monica Azqueta-Gavaldon, Katie E Silva, Nadia Barakat, Natalia Lopez, Farah Mahmud, Alyssa Lebel, Navil F Sethna, David Zurakowski, Laura E Simons, Eduard Kraft, David Borsook,

The evaluation of brain changes to a specific pain condition in pediatric and adult patients allows for insights into potential mechanisms of pain chronicity and possibly long-term brain changes. Here we focused on the primary somatosensory system (SS) involved in pain processing, namely the ventroposterolateral thalamus (VPL) and the primary ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2019, 40(15):4381-4396]

Cited: 2 times

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Migraine in the Young Brain: Adolescents vs. Young Adults.

Elisabeth Colon, Allison Ludwick, Sophie L Wilcox, Andrew M Youssef, Amy Danehy, Damien A Fair, Alyssa A Lebel, Rami Burstein, Lino Becerra, David Borsook,

Migraine is a disease that peaks in late adolescence and early adulthood. The aim of this study was to evaluate age-related brain changes in resting state functional connectivity (rs-FC) in migraineurs vs. age-sex matched healthy controls at two developmental stages: adolescence vs. young adulthood. The effect of the disease was ... Read more >>

Front Hum Neurosci (Frontiers in human neuroscience)
[2019, 13:87]

Cited: 4 times

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When pain gets stuck: the evolution of pain chronification and treatment resistance.

David Borsook, Andrew M Youssef, Laura Simons, Igor Elman, Christopher Eccleston,

It is well-recognized that, despite similar pain characteristics, some people with chronic pain recover, whereas others do not. In this review, we discuss possible contributions and interactions of biological, social, and psychological perturbations that underlie the evolution of treatment-resistant chronic pain. Behavior and brain are intimately implicated in the production ... Read more >>

Pain (Pain)
[2018, 159(12):2421-2436]

Cited: 34 times

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Subliminal (latent) processing of pain and its evolution to conscious awareness.

David Borsook, Andrew M Youssef, Nadia Barakat, Christine B Sieberg, Igor Elman,

By unconscious or covert processing of pain we refer to nascent interactions that affect the eventual deliverance of pain awareness. Thus, internal processes (viz., repeated nociceptive events, inflammatory kindling, reorganization of brain networks, genetic) or external processes (viz., environment, socioeconomic levels, modulation of epigenetic status) contribute to enhancing or inhibiting ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2018, 88:1-15]

Cited: 3 times

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In child and adult migraineurs the somatosensory cortex stands out … again: An arterial spin labeling investigation.

Andrew M Youssef, Allison Ludwick, Sophie L Wilcox, Alyssa Lebel, Ke Peng, Elisabeth Colon, Amy Danehy, Rami Burstein, Lino Becerra, David Borsook,

Over the past decade, human brain imaging investigations have reported altered regional cerebral blood flow (rCBF) in the interictal phase of migraine. However, there have been conflicting findings across different investigations, making the use of perfusion imaging in migraine pathophysiology more difficult to define. These inconsistencies may reflect technical constraints ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2017, 38(8):4078-4087]

Cited: 11 times

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Cortical influences on brainstem circuitry responsible for conditioned pain modulation in humans.

Andrew M Youssef, Vaughan G Macefield, Luke A Henderson,

Conditioned pain modulation (CPM) is a powerful endogenous analgesic mechanism which can completely inhibit incoming nociceptor signals at the primary synapse. The circuitry responsible for CPM lies within the brainstem and involves the subnucleus reticularis dorsalis (SRD). While the brainstem is critical for CPM, the cortex can significantly modulate its ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2016, 37(7):2630-2644]

Cited: 24 times

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Chronic Neuropathic Pain: It's about the Rhythm.

Zeynab Alshelh, Flavia Di Pietro, Andrew M Youssef, Jenna M Reeves, Paul M Macey, E Russell Vickers, Christopher C Peck, Greg M Murray, Luke A Henderson,

The neural mechanisms underlying the development and maintenance of chronic neuropathic pain remain unclear. Evidence from human investigations suggests that neuropathic pain is associated with altered thalamic burst firing and thalamocortical dysrhythmia. Additionally, experimental animal investigations show that neuropathic pain is associated with altered infra-slow (<0.1 Hz) frequency oscillations within ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2016, 36(3):1008-1018]

Cited: 42 times

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Differential brain activity in subjects with painful trigeminal neuropathy and painful temporomandibular disorder.

Andrew M Youssef, Sylvia M Gustin, Paul G Nash, Jenna M Reeves, Esben T Petersen, Chris C Peck, Greg M Murray, Luke A Henderson,

Human brain imaging investigations have revealed that acute pain is associated with coactivation of numerous brain regions, including the thalamus, somatosensory, insular, and cingulate cortices. Surprisingly, a similar set of brain structures is not activated in all chronic pain conditions, particularly chronic neuropathic pain, which is associated with almost exclusively ... Read more >>

Pain (Pain)
[2014, 155(3):467-475]

Cited: 34 times

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Chronic pain: lost inhibition?

Luke A Henderson, Chris C Peck, Esben T Petersen, Caroline D Rae, Andrew M Youssef, Jenna M Reeves, Sophie L Wilcox, Rahena Akhter, Rahena Akhter, Greg M Murray, Sylvia M Gustin,

Human brain imaging has revealed that acute pain results from activation of a network of brain regions, including the somatosensory, insular, prefrontal, and cingulate cortices. In contrast, many investigations report little or no alteration in brain activity associated with chronic pain, particularly neuropathic pain. It has been hypothesized that neuropathic ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2013, 33(17):7574-7582]

Cited: 68 times

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