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Author Andrew Georgiou

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Potentially redundant repeat liver function test ordering practices in Australian hospitals: a 5-year multicentre retrospective observational study.

Nasir Wabe, Rae-Anne Hardie, Robert Lindeman, Craig Scowen, Alex Eigenstetter, Andrew Georgiou,

<h4>Background</h4>Repeat Liver Function Tests (LFTs) are often necessary for monitoring purposes, but retesting within a short-time-interval may suggest potentially redundant repeat test (PRRT) ordering practices. We aimed to determine the proportion of potentially redundant repeat LFT ordering and identify associated factors in hospitals.<h4>Methods</h4>A 5-year (2014-2018) retrospective cohort study in six ... Read more >>

Int J Clin Pract (International journal of clinical practice)
[2021, :e14004]

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COVID-19 – Protocol for Observational Studies Utilising Near Real-Time Electronic Australian General Practice Data to Promote Effective Care and Best-Practice Policy – A Design Thinking Approach

Andrew Georgiou, Julie Li, Christopher Pearce, Adam McLeod, Nasir Wabe, Rae-Anne Hardie, Guilherme Saffi Franco, Chisato Imai, Gorkem Sezgin, Judith Thomas, Zhaoli Dai, Muhammad Kashif Sheikh, Amanda Proposch, Stephen Weeding, Brendon Wickham, Tony Badrick, Darnel Murgatroyd,

<h4>Background: </h4> Health systems around the world have been forced to make choices about how to prioritise care, manage infection control and maintain reserve capacity for future disease outbreaks. Primary health care has moved into the frontline as COVID-19 testing transitions from hospitals to multiple providers, where tracking testing behaviours ... Read more >>

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COVID-19 – Protocol for Observational Studies Utilising Near Real-Time Electronic Australian General Practice Data to Promote Effective Care and Best-Practice Policy – A Design Thinking Approach

Andrew Georgiou, Julie Li, Christopher Pearce, Adam McLeod, Nasir Wabe, Rae-Anne Hardie, Guilherme Saffi Franco, Chisato Imai, Gorkem Sezgin, Judith Thomas, Zhaoli Dai, Muhammad Kashif Sheikh, Amanda Proposch, Stephen Weeding, Brendon Wickham, Tony Badrick, Darnel Murgatroyd,

<h4>Background: </h4> Health systems around the world have been forced to make choices about how to prioritise care, manage infection control and maintain reserve capacity for future disease outbreaks. Primary health care has moved into the frontline as COVID-19 testing transitions from hospitals to multiple providers, where tracking testing behaviours ... Read more >>

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Understanding the work of case managers in Australian community aged care: a longitudinal time and motion study.

Mirela Prgomet, Scott Walter, Mikaela Jorgensen, Andrew Georgiou, Johanna Westbrook,

Objective The aim of this study was to quantify the work activities of community aged care case managers and assess changes following consumer-directed policy reforms. Methods A longitudinal, time and motion study was performed, with direct observation (n=339h) of case managers undertaking work in the office or in the community. ... Read more >>

Aust Health Rev (Australian health review : a publication of the Australian Hospital Association)
[2020, 44(6):853-861]

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Differences in Antibiotic and Antiviral Use in People With Confirmed Influenza: a Retrospective Comparison of Rapid Influenza PCR and Multiplex Respiratory Virus PCR Tests.

Victor Au Yeung, Kiran Thapa, William Rawlinson, Andrew Georgiou, Jeffrey Post, Kristen Overton,

BACKGROUND Influenza is a highly contagious respiratory virus with clinical impacts on patient morbidity, mortality and hospital bed management. The effect of rapid nucleic acid testing (RPCR) in comparison to standard multiplex PCR (MPCR) diagnosis in treatment decisions is unclear. This study aimed to determine whether RPCR influenza testing in ... Read more >>

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Investigating the association between blood transfusion and clinical outcomes in patients with acute coronary syndromes: a data linkage approach to Patient Blood Management.

Guilherme S Franco, Julie Li, Ling Li, Mark Dean, Grant Shalaby, Andrew Georgiou,

<h4>Background</h4>The appropriateness of the use of blood transfusion in patients with acute coronary syndromes (ACS) remains contested. In general, studies addressing this issue were based on data from clinical trials, registries, or electronic medical records, and were conducted across different settings. Our study aimed to use a linked patient blood ... Read more >>

Blood Transfus (Blood transfusion = Trasfusione del sangue)
[2020, :]

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Can patients contribute to enhancing the safety and effectiveness of test-result follow-up? Qualitative outcomes from a health consumer workshop.

Judith Thomas, Maria R Dahm, Julie Li, Andrew Georgiou,

<h4>Background</h4>Missed test-results and failure to follow-up test-results are major patient safety concerns. Strategies to improve test-results management have predominantly focused on clinician-based interventions, with patients principally involved in studies of test-result communication preferences, the impact of patient portals or experiences with reporting processes in primary care.<h4>Objective</h4>To identify consumer perspectives and ... Read more >>

Health Expect (Health expectations : an international journal of public participation in health care and health policy)
[2020, :]

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Evaluating the long-term effects of a data-driven approach to reduce variation in emergency department pathology investigations: study protocol for evaluation of the NSW Health Pathology Atlas of variation.

Craig Scowen, Nasir Wabe, Alex Eigenstetter, Robert Lindeman, Melissa Miao, Johanna I Westbrook, Andrew Georgiou,

<h4>Introduction</h4>Variation in test ordering is a major issue in Australia and globally with significant financial and clinical impacts. There is currently a lack of research identifying and remediating variation in the use of pathology tests in emergency departments (EDs). In 2019, NSW Health Pathology introduced the Pathology Atlas of Variation ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e039437]

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Measuring the prevalence of 60 health conditions in older Australians in residential aged care with electronic health records: a retrospective dynamic cohort study.

Kimberly E Lind, Magdalena Z Raban, Lindsey Brett, Mikaela L Jorgensen, Andrew Georgiou, Johanna I Westbrook,

<h4>Background</h4>The number of older Australians using aged care services is increasing, yet there is an absence of reliable data on their health. Multimorbidity in this population has not been well described. A clear picture of the health status of people using aged care is essential for informing health practice and ... Read more >>

Popul Health Metr (Population health metrics)
[2020, 18(1):25]

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Clinical thresholds for diagnosing iron deficiency: comparison of functional assessment of serum ferritin to population based centiles.

Gorkem Sezgin, Paul Monagle, Tze Ping Loh, Vera Ignjatovic, Monsurul Hoq, Christopher Pearce, Adam McLeod, Johanna Westbrook, Ling Li, Andrew Georgiou,

Low serum ferritin is diagnostic of iron deficiency, yet its published lower cut-off values are highly variable, particularly for pediatric populations. Lower cut-off values are commonly reported as 2.5th percentiles, and is based on the variation of ferritin values in the population. Our objective was to determine whether a functional ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):18233]

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Reducing preventable harm to residents in aged care: A systems approach.

Peter D Hibbert, Robyn Clay-Williams, Johanna Westbrook, Richard L Reed, Andrew Georgiou, Louise K Wiles, Charlotte J Molloy, Jeffrey Braithwaite,

Residents in Australian aged care facilities can suffer serious preventable harm from incidents ('adverse events' (AEs)). An inadequate response to AEs by aged care facilities can compound distress to residents and their families/carers. Facilities have an obligation to respond to and investigate AEs involving residents, learn from them, and take ... Read more >>

Australas J Ageing (Australasian journal on ageing)
[2020, :]

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Measuring the prevalence of 60 health conditions in older Australians in residential aged care with electronic health records: a retrospective dynamic cohort study

Kimberly Lind, Magdalena Raban, Lindsey Brett, Mikaela Jorgensen, Andrew Georgiou, Johanna Westbrook,

<h4>Background: </h4> : The number of older Australians using aged care services is increasing, yet there is an absence of reliable data on their health. Multimorbidity in this population has not been well described. A clear picture of the health status of people using aged care is essential for informing ... Read more >>

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Unmet Needs for Transdermal Patch Management in Electronic Medication Administration Records: An Analysis of Data from 66 Aged Care Facilities.

Magdalena Z Raban, Melissa T Baysari, Mikaela L Jorgensen, Amina Tariq, Andrew Georgiou, Johanna I Westbrook,

<h4>Background</h4>Transdermal medication patches have caused serious adverse events in residential aged care facilities (RACFs). Preliminary research suggests that facilities are using a workaround consisting of manually entered reminders in their electronic medication administration records (eMARs) to prompt staff to check and remove patches, because the eMAR does not support these ... Read more >>

Appl Clin Inform (Applied clinical informatics)
[2020, 11(5):812-820]

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Evaluation of Digital Health & Information Technology in Primary Care.

Siaw-Teng Liaw, Andrew Georgiou, Heimar Marin,

Int J Med Inform (International journal of medical informatics)
[2020, 144:104285]

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Cepheid Xpert® Flu/RSV and Seegene Allplex RP1 show high diagnostic agreement for the detection of influenza A/B and respiratory syncytial viruses in clinical practice.

Nasir Wabe, Robert Lindeman, Jeffrey J Post, William Rawlinson, Melissa Miao, Johanna I Westbrook, Andrew Georgiou,

<h4>Background</h4>Molecular assays based on reverse transcription-polymerase chain reaction (RT-PCR) provide reliable results for the detection of respiratory pathogens, although diagnostic agreement varies. This study determined the agreement between the RT-PCR assays (Xpert<sup>®</sup> Flu/RSV vs Allplex<sup>™</sup> RP1) in detecting influenza A, influenza B, and respiratory syncytial viruses (RSVs) in clinical practice.<h4>Methods</h4>We ... Read more >>

Influenza Other Respir Viruses (Influenza and other respiratory viruses)
[2020, :]

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Improving Patients' Medication Adherence and Outcomes in Nonhospital Settings Through eHealth: Systematic Review of Randomized Controlled Trials.

Zoie Sy Wong, Braylien Siy, Katharina Da Silva Lopes, Andrew Georgiou,

<h4>Background</h4>Electronic health (eHealth) refers to the use of information and communication technologies for health. It plays an increasingly important role in patients' medication management.<h4>Objective</h4>To assess evidence on (1) whether eHealth for patients' medication management can improve drug adherence and health outcomes in nonhospital settings and (2) which eHealth functions are ... Read more >>

J Med Internet Res (Journal of medical Internet research)
[2020, 22(8):e17015]

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Characteristics of older Australian community aged care clients who fall: Incidents reported by care staff.

Lindsey Brett, Mikaela Jorgensen, Rimma Myton, Andrew Georgiou, Johanna I Westbrook,

Falls are the leading cause of injury and hospitalisation for older adults (aged 65 years or older) worldwide. Data collected by community aged care providers are an underutilised source of information about precipitating risk factors and consequences of falls for older adults living in the community. The objective of this longitudinal, ... Read more >>

Health Soc Care Community (Health & social care in the community)
[2020, :]

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Translation of evidence into kidney transplant clinical practice: managing drug-lab interactions by a context-aware clinical decision support system.

Zahra Niazkhani, Mahsa Fereidoni, Parviz Rashidi Khazaee, Afshin Shiva, Khadijeh Makhdoomi, Andrew Georgiou, Habibollah Pirnejad,

<h4>Background</h4>Drug-laboratory (lab) interactions (DLIs) are a common source of preventable medication errors. Clinical decision support systems (CDSSs) are promising tools to decrease such errors by improving prescription quality in terms of lab values. However, alert fatigue counteracts their impact. We aimed to develop a novel user-friendly, evidence-based, clinical context-aware CDSS ... Read more >>

BMC Med Inform Decis Mak (BMC medical informatics and decision making)
[2020, 20(1):196]

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Variation in electronic test results management and its implications for patient safety: A multisite investigation.

Judith Thomas, Maria R Dahm, Julie Li, Peter Smith, Jacqui Irvine, Johanna I Westbrook, Andrew Georgiou,

<h4>Objective</h4>The management and follow-up of diagnostic test results is a major patient safety concern. The aim of this qualitative study was to explore how clinicians manage test results on an everyday basis (work-as-done) in a health information technology-enabled emergency department setting. The objectives were to identify (1) variations in work-as-done ... Read more >>

J Am Med Inform Assoc (Journal of the American Medical Informatics Association : JAMIA)
[2020, 27(8):1214-1224]

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Barriers to patient, provider, and caregiver adoption and use of electronic personal health records in chronic care: a systematic review.

Zahra Niazkhani, Esmaeel Toni, Mojgan Cheshmekaboodi, Andrew Georgiou, Habibollah Pirnejad,

<h4>Background</h4>Electronic personal health records (ePHRs) are defined as electronic applications through which individuals can access, manage, and share health information in a private, secure, and confidential environment. Existing evidence shows their benefits in improving outcomes, especially for chronic disease patients. However, their use has not been as widespread as expected ... Read more >>

BMC Med Inform Decis Mak (BMC medical informatics and decision making)
[2020, 20(1):153]

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Social Participation Among Older Adults Receiving Community Care Services.

Joyce Siette, Helen Berry, Mikaela Jorgensen, Lindsey Brett, Andrew Georgiou, Tom McClean, Johanna Westbrook,

Aged care services have the potential to support social participation for the growing number of adults aging at home, but little is known about the types of social activities older adults in community care are engaged in. We used cluster analysis to examine the current profiles of social participation across ... Read more >>

J Appl Gerontol (Journal of applied gerontology : the official journal of the Southern Gerontological Society)
[2020, :733464820938973]

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Publisher Correction: A clonal expression biomarker associates with lung cancer mortality.

Dhruva Biswas, Nicolai J Birkbak, Rachel Rosenthal, Crispin T Hiley, Emilia L Lim, Krisztian Papp, Stefan Boeing, Marcin Krzystanek, Dijana Djureinovic, Linnea La Fleur, Maria Greco, Balázs Döme, János Fillinger, Hans Brunnström, Yin Wu, David A Moore, Marcin Skrzypski, Christopher Abbosh, Kevin Litchfield, Maise Al Bakir, Thomas B K Watkins, Selvaraju Veeriah, Gareth A Wilson, Mariam Jamal-Hanjani, Judit Moldvay, Johan Botling, Arul M Chinnaiyan, Patrick Micke, Allan Hackshaw, Jiri Bartek, Istvan Csabai, Zoltan Szallasi, Javier Herrero, Nicholas McGranahan, Charles Swanton, ,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Med (Nature medicine)
[2020, 26(7):1148]

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Publisher Correction: Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer.

Kroopa Joshi, Marc Robert de Massy, Mazlina Ismail, James L Reading, Imran Uddin, Annemarie Woolston, Emine Hatipoglu, Theres Oakes, Rachel Rosenthal, Thomas Peacock, Tahel Ronel, Mahdad Noursadeghi, Virginia Turati, Andrew J S Furness, Andrew Georgiou, Yien Ning Sophia Wong, Assma Ben Aissa, Mariana Werner Sunderland, Mariam Jamal-Hanjani, Selvaraju Veeriah, Nicolai J Birkbak, Gareth A Wilson, Crispin T Hiley, Ehsan Ghorani, José Afonso Guerra-Assunção, Javier Herrero, Tariq Enver, Sine R Hadrup, Allan Hackshaw, Karl S Peggs, Nicholas McGranahan, Charles Swanton, , Sergio A Quezada, Benny Chain,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Med (Nature medicine)
[2020, 26(7):1148]

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Barriers to patient, provider, and caregiver adoption and use of electronic personal health records in chronic care: a systematic review

Zahra Niazkhani, Esmaeel Toni, Mojgan Cheshmekaboodi, Andrew Georgiou, Habibollah Pirnejad,

<h4>Background: </h4> Electronic personal health records (ePHRs) are defined as electronic applications through which individuals can access, manage, and share health information in a private, secure, and confidential environment. Existing evidence shows their benefits in improving outcomes, especially for chronic disease patients. However, their use has not been as widespread ... Read more >>

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Publisher Correction: Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse.

Francesca Chemi, Dominic G Rothwell, Nicholas McGranahan, Sakshi Gulati, Chris Abbosh, Simon P Pearce, Cong Zhou, Gareth A Wilson, Mariam Jamal-Hanjani, Nicolai Birkbak, Jackie Pierce, Chang Sik Kim, Saba Ferdous, Deborah J Burt, Daniel Slane-Tan, Fabio Gomes, David Moore, Rajesh Shah, Maise Al Bakir, Crispin Hiley, Selvaraju Veeriah, Yvonne Summers, Philip Crosbie, Sophia Ward, Barbara Mesquita, Marek Dynowski, Dhruva Biswas, Jonathan Tugwood, Fiona Blackhall, Crispin Miller, Allan Hackshaw, Ged Brady, Charles Swanton, Caroline Dive, ,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Med (Nature medicine)
[2020, 26(7):1147]

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