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Author Andrew G Day

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Relationship Between Nutrition Intake and Outcome After Subarachnoid Hemorrhage: Results From the International Nutritional Survey.

Neeraj Badjatia, Alice Ryan, H Alex Choi, Gunjan Y Parikh, Xuran Jiang, Andrew G Day, Daren K Heyland,

<h4>Background</h4>A previous study suggested an association between low caloric intake(CI), negative nitrogen balance, and poor outcome after subarachnoid hemorrhage(SAH). Objective of this multinational, multicenter study was to investigate whether clinical outcomes vary by protein intake(PI) or CI in SAH patients adjusting for the nutritional risk as judged by the modified ... Read more >>

J Intensive Care Med (Journal of intensive care medicine)
[2021, 36(10):1141-1148]

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Identifying neurocognitive outcomes and cerebral oxygenation in critically ill adults on acute kidney replacement therapy in the intensive care unit: the INCOGNITO-AKI study protocol.

Natasha Arianne Jawa, Rachel M Holden, Samuel A Silver, Stephen H Scott, Andrew G Day, Patrick A Norman, Benjamin Y M Kwan, David M Maslove, John Muscedere, John Gordon Boyd,

<h4>Introduction</h4>Initiation of acute kidney replacement therapy (KRT) is common in critically ill adults admitted to the intensive care unit (ICU), and associated with increased morbidity and mortality. KRT has been linked to poor neurocognitive outcomes, leading to reduced quality of life and increased utilisation of healthcare resources. Adults on dialysis ... Read more >>

BMJ Open (BMJ open)
[2021, 11(8):e049250]

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Characteristics of Clinicians Are Associated With Their Beliefs About ICD Deactivation: Insight From the DECIDE-HF Study.

Florence Landry-Hould, Blandine Mondésert, Andrew G Day, Heather J Ross, Judith Brouillette, Brian Clarke, Shelley Zieroth, Mustafa Toma, Marie-Claude Parent, Robert A Fowler, John J You, Anique Ducharme, ,

<h4>Background</h4>Discussing goals of care with heart failure patients is recommended but is not done systematically, due to factors such as time and personal beliefs. A recent survey showed that one-fifth of clinicians believe that implantable cardioverter defibrillator deactivation (ICDD) is unethical or constitutes physician-assisted suicide. We investigated whether individuals' characteristics ... Read more >>

CJC Open (CJC open)
[2021, 3(8):994-1001]

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The effect of higher versus lower protein delivery in critically ill patients: a systematic review and meta-analysis of randomized controlled trials.

Zheng-Yii Lee, Cindy Sing Ling Yap, M Shahnaz Hasan, Julia Patrick Engkasan, Mohd Yusof Barakatun-Nisak, Andrew G Day, Jayshil J Patel, Daren K Heyland,

<h4>Background</h4>The optimal protein dose in critical illness is unknown. We aim to conduct a systematic review of randomized controlled trials (RCTs) to compare the effect of higher versus lower protein delivery (with similar energy delivery between groups) on clinical and patient-centered outcomes in critically ill patients.<h4>Methods</h4>We searched MEDLINE, EMBASE, CENTRAL ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):260]

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Correlation between gastric residual volumes and markers of gastric emptying: A post hoc analysis of a randomized clinical trial.

Charles Chin Han Lew, Zheng-Yii Lee, Andrew G Day, Daren K Heyland,

<h4>Background</h4>The correlation between gastric residual volumes (GRVs) and markers of gastric emptying (GE) in critically ill patients is unclear. This particularly applies to critically ill surgical patients, as they are underrepresented in previous studies.<h4>Methods</h4>We conducted a post hoc analysis of a multicenter trial that investigated the effectiveness of a promotility ... Read more >>

JPEN J Parenter Enteral Nutr (JPEN. Journal of parenteral and enteral nutrition)
[2021, :]

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Initial development and validation of a novel nutrition risk, sarcopenia, and frailty assessment tool in mechanically ventilated critically ill patients: The NUTRIC-SF score.

Zheng-Yii Lee, M Shahnaz Hasan, Andrew G Day, Ching Choe Ng, Su Ping Ong, Cindy Sing Ling Yap, Julia Patrick Engkasan, Mohd Yusof Barakatun-Nisak, Daren K Heyland,

<h4>Background</h4>Nutrition risk, sarcopenia, and frailty are interrelated. They may be due to suboptimal or prevented by optimal nutrition intake. The combination of nutrition risk (modified nutrition risk in the critically ill [mNUTRIC]), sarcopenia (SARC-F combined with calf circumference [SARC-CALF]), and frailty (clinical frailty scale [CFS]) in a single score may ... Read more >>

JPEN J Parenter Enteral Nutr (JPEN. Journal of parenteral and enteral nutrition)
[2021, :]

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Validation of the modified NUTrition Risk Score (mNUTRIC) in mechanically ventilated, severe burn patients: A prospective multinational cohort study.

L Alfonso Ortiz, Xuran Jiang, Alexis F Turgeon, Lucy Wibbenmeyer, Jonathan Pollack, Samuel P Mandell, Andrew G Day, Daren K Heyland,

<h4>Background</h4>Whether nutrition therapy benefits all burn victims equally is unknown. To identify patients who will benefit the most from optimal nutrition, the modified Nutrition Risk in Critically Ill (mNUTRIC) Score has been validated in the Intensive Care Unit. However, the utility of mNUTRIC in severe burn victims is unknown. We ... Read more >>

Burns (Burns : journal of the International Society for Burn Injuries)
[2021, :]

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Determining the psychometric properties of a novel questionnaire to measure "preparedness for the future" (Prep FQ).

Daren K Heyland, J Paige Pope, Xuran Jiang, Andrew G Day,

<h4>Background</h4>People are living longer than ever before. However, with living longer comes increased problems that negatively impact on quality of life and the quality of death. Tools are needed to help individuals assess whether they are practicing the best attitudes and behaviors that are associated with a future long life, ... Read more >>

Health Qual Life Outcomes (Health and quality of life outcomes)
[2021, 19(1):122]

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Longitudinal Outcomes in Octogenarian Critically Ill Patients with a Focus on Frailty and Cardiac Surgery.

Aileen Hill, Daren K Heyland, Rolf Rossaint, Rakesh C Arora, Daniel T Engelman, Andrew G Day, Christian Stoppe,

Cardiac surgery (CSX) can be lifesaving in elderly patients (age ≥ 80 years) but may still be associated with complications and functional decline. Frailty represents a determinant to outcomes in critically ill patients, but little is known about its influence on elderly CSX-patients. This is a secondary exploratory analysis of ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 10(1):]

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Incidence, Risk Factors, and Clinical Consequence of Enteral Feeding Intolerance in the Mechanically Ventilated Critically Ill: An Analysis of a Multicenter, Multiyear Database.

Daren K Heyland, Alfonso Ortiz, Christian Stoppe, Jayshil J Patel, D Dante Yeh, George Dukes, Yaozhu J Chen, Cristina Almansa, Andrew G Day,

<h4>Objectives</h4>To determine the incidence of enteral feed intolerance, identify factors associated with enteral feed intolerance, and assess the relationship between enteral feed intolerance and key nutritional and clinical outcomes in critically ill patients.<h4>Design</h4>Analysis of International Nutrition Survey database collected prospectively from 2007 to 2014.<h4>Setting</h4>Seven-hundred eighty-five ICUs from around the world.<h4>Patients</h4>Mechanically ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(1):49-59]

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Translating Evidence-Based Guidelines into Practice-Are We Getting It Right? A Multi-Centre Prospective International Audit of Nutrition Care in Patients with Foregut Tumors (INFORM).

Merran Findlay, Judith D Bauer, Rupinder Dhaliwal, Marian de van der Schueren, Alessandro Laviano, Adrianne Widaman, Lisa Martin, Andrew G Day, Leah M Gramlich,

Malnutrition is highly prevalent in patients with foregut tumors comprising head and neck (HNC) and esophageal (EC) cancers, negatively impacting outcomes. International evidence-based guidelines (EBGs) for nutrition care exist; however, translation of research evidence into practice commonly presents considerable challenges and consequently lags. This study aimed to describe and evaluate ... Read more >>

Nutrients (Nutrients)
[2020, 12(12):]

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Application of the modified Nutrition Risk in Critically Ill score to nutritional risk stratification of trauma victims: A multicenter observational study.

Chinenye Iwuchukwu, Grant E O'Keefe, Andrew G Day, Xuran Jiang, Daren K Heyland,

<h4>Background</h4>The modified Nutrition Risk in Critically Ill (mNUTRIC) score was developed to identify patients most likely to benefit from nutritional therapies and to stratify or select study subjects for clinical trials. The score is not validated in trauma victims in whom adequate nutritional support is important and difficult to achieve. ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2020, 89(6):1143-1148]

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Intravenous Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC): A Randomized, Controlled Trial.

Aaron J Ruberto, Marco L A Sivilotti, Savannah Forrester, Andrew K Hall, Frances M Crawford, Andrew G Day,

<h4>Study objective</h4>Little is known about the cause or optimal treatment of hyperemesis in habitual cannabis users. Anecdotal evidence supports the use of haloperidol over traditional antiemetics for this newly recognized disorder. We compare haloperidol with ondansetron for cannabis hyperemesis syndrome.<h4>Methods</h4>We randomized cannabis users with active emesis to either haloperidol (with ... Read more >>

Ann Emerg Med (Annals of emergency medicine)
[2021, 77(6):613-619]

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Methacholine-Induced Cough in the Absence of Asthma: Insights From Impulse Oscillometry.

Nilita Sood, Nastasia V Wasilewski, Andrew G Day, Taylar Wall, Thomas Fisher, John T Fisher, M Diane Lougheed,

<h4>Introduction</h4>The pathophysiologic differences between methacholine-induced cough but normal airway sensitivity (COUGH) and healthy individuals (CONTROL) are incompletely understood and may be due to differences in the bronchodilating effect of deep inspirations (DIs). The purpose of this study is to compare the bronchodilating effect of DIs in individuals with classic asthma ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:554679]

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The initial validation of a novel outcome measure in severe burns- the Persistent Organ Dysfunction +Death: Results from a multicenter evaluation.

Christian Stoppe, Aileen Hill, Andrew G Day, Arnold S Kristof, Gabriel Hundeshagen, Ulrich Kneser, Justus Beier, David Lumenta, Bong-Sung Kim, Jan Plock, Declan P Collins, Jochen Gille, Xuran Jiang, Daren K Heyland,

<h4>Introduction</h4>A need exists to improve the efficiency of clinical trials in burn care. The objective of this study was to validate "Persistent Organ Dysfunction" plus death as endpoint in burn patients and to demonstrate its statistical efficiency.<h4>Methods</h4>This secondary outcome analysis of a dataset from a prospective international multicenter RCT (RE-ENERGIZE) ... Read more >>

Burns (Burns : journal of the International Society for Burn Injuries)
[2021, 47(4):765-775]

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Waist circumference does not improve established cardiovascular disease risk prediction modeling.

Matthew W Nelms, Andrew G Day, Xuemei Sui, Steven N Blair, Robert Ross,

Despite considerable evidence demonstrating that waist circumference (WC) is independently associated with cardiovascular disease (CVD) and/or all-cause mortality, whether the addition of WC improves risk prediction models is unclear. The objective was to evaluate the improvement in risk prediction with the addition of WC, alone or in combination with BMI, ... Read more >>

PLoS One (PloS one)
[2020, 15(10):e0240214]

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Simultaneous glomerular filtration rate determination using inulin, iohexol, and 99mTc-DTPA demonstrates the need for customized measurement protocols.

Christine A White, Ayub Akbari, Celine Allen, Andrew G Day, Patrick A Norman, David Holland, Michael A Adams, Greg A Knoll,

Urinary inulin clearance is considered the gold standard of glomerular filtration rate (GFR) measurement but plasma clearance of less expensive and more accessible tracers is more commonly performed. Many plasma sampling protocols exist but little is known about their accuracy. Here, the study objectives were to compare plasma iohexol and ... Read more >>

Kidney Int (Kidney international)
[2021, 99(4):957-966]

Cited: 3 times

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Promotion of Regular Oesophageal Motility to Prevent Regurgitation and Enhance Nutrition Intake in Long-Stay ICU Patients. A Multicenter, Phase II, Sham-Controlled, Randomized Trial: The PROPEL Study.

Daren K Heyland, Francois Marquis, Francois Lamontagne, Martin Albert, Alexis F Turgeon, Kosar A Khwaja, Allan Garland, Richard Hall, Martin G Chapman, Demetrios J Kutsiogannis, Claudio Martin, Daniel I Sessler, Andrew G Day,

OBJECTIVES:To evaluate the effect of esophageal stimulation on nutritional adequacy in critically ill patients at risk for enteral feeding intolerance. DESIGN:A multicenter randomized sham-controlled clinical trial. SETTING:Twelve ICUs in Canada. PATIENTS:We included mechanically ventilated ICU patients who were given moderate-to-high doses of opioids and expected to remain alive and ventilated ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(3):e219-e226]

Cited: 1 time

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Individual Response to Standardized Exercise: Total and Abdominal Adipose Tissue.

Andrea M Brennan, Andrew G Day, Theresa E Cowan, Gregory J Clarke, Benoit Lamarche, Robert Ross,

<h4>Purpose</h4>(1) Determine the effect of exercise amount and intensity on the proportion of individuals for whom the adipose tissue (AT) response is above the minimal clinically important difference (MCID); and (2) Examine whether clinically meaningful anthropometric changes reflect individual AT responses above the MCID.<h4>Methods</h4>Men (n = 41) and women (n ... Read more >>

Med Sci Sports Exerc (Medicine and science in sports and exercise)
[2020, 52(2):490-497]

Cited: 1 time

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Lessening Organ dysfunction with VITamin C (LOVIT): protocol for a randomized controlled trial.

Marie-Hélène Masse, Julie Ménard, Sheila Sprague, Marie-Claude Battista, Deborah J Cook, Gordon H Guyatt, Daren K Heyland, Salmaan Kanji, Ruxandra Pinto, Andrew G Day, Dian Cohen, Djillali Annane, Shay McGuinness, Rachael Parke, Anitra Carr, Yaseen Arabi, Bharath Kumar Tirupakuzhi Vijayaraghavan, Frédérick D'Aragon, Élaine Carbonneau, David Maslove, Miranda Hunt, Bram Rochwerg, Tina Millen, Michaël Chassé, Martine Lebrasseur, Patrick Archambault, Estel Deblois, Christine Drouin, François Lellouche, Patricia Lizotte, Irene Watpool, Rebecca Porteous, France Clarke, Nicole Marinoff, Émilie Belley-Côté, Brigitte Bolduc, Scott Walker, John Iazzetta, Neill K J Adhikari, François Lamontagne, ,

BACKGROUND:Sepsis is a health problem of global importance; treatments focus on controlling infection and supporting failing organs. Recent clinical research suggests that intravenous vitamin C may decrease mortality in sepsis. We have designed a randomized controlled trial (RCT) to ascertain the effect of vitamin C on the composite endpoint of ... Read more >>

Trials (Trials)
[2020, 21(1):42]

Cited: 7 times

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Impact of a Specialized Ambulatory Clinic on Refractory Breathlessness in Subjects With Advanced COPD.

Amany F Elbehairy, Hannah McIsaac, Elizabeth Hill, Patrick A Norman, Andrew G Day, J Alberto Neder, Denis E O'Donnell, Ingrid A Harle,

<h4>Background</h4>Severe exertional dyspnea is a commonly reported symptom in patients with COPD, especially in the advanced stages. Our objective was to assess the preliminary impact of comprehensive, individualized management provided by a specialized tertiary center clinic on exertional dyspnea and patient-centered outcomes in patients with advanced COPD.<h4>Methods</h4>This retrospective analysis included ... Read more >>

Respir Care (Respiratory care)
[2020, 65(4):444-454]

Cited: 1 time

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Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery.

Imelda M Galvin, Ron Levy, Andrew G Day, Ian Gilron,

<h4>Background</h4>Pain following brain surgery can compromise recovery. Several pharmacological interventions have been used to prevent pain after craniotomy; however, there is currently a lack of evidence regarding which interventions are most effective.<h4>Objectives</h4>The objectives are to assess the effectiveness of pharmacological interventions for prevention of acute postoperative pain in adults undergoing ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2019, 2019(11):]

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Penalized estimation of complex, non-linear exposure-lag-response associations.

Andreas Bender, Fabian Scheipl, Wolfgang Hartl, Andrew G Day, Helmut Küchenhoff,

We propose a novel approach for the flexible modeling of complex exposure-lag-response associations in time-to-event data, where multiple past exposures within a defined time window are cumulatively associated with the hazard. Our method allows for the estimation of a wide variety of effects, including potentially smooth and smoothly time-varying effects ... Read more >>

Biostatistics (Biostatistics (Oxford, England))
[2019, 20(2):315-331]

Cited: 2 times

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Mediation Analysis of High Blood Pressure Targets, Arrhythmias, and Shock Mortality.

Allan J Walkey, Neill K J Adhikari, Andrew G Day, Peter Radermacher, Pierre Asfar, Francois Lamontagne,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2019, 199(6):802-805]

Cited: 3 times

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Individual Response to Standardized Exercise: Total and Abdominal Adipose Tissue.

Andrea M Brennan, Andrew G Day, Theresa E Cowan, Gregory J Clarke, Benoit Lamarche, Robert Ross,

<h4>Purpose</h4>(1) Determine the effect of exercise amount and intensity on the proportion of adipose tissue (AT) responses likely, very likely, and unlikely above the minimal clinically important difference (MCID); and (2) Examine whether clinically meaningful anthropometric changes reflect individual AT responses above the MCID.<h4>Methods</h4>Men (n=41) and women (n=62) (52.7 ± ... Read more >>

Med Sci Sports Exerc (Medicine and science in sports and exercise)
[2019, :]

Cited: 3 times

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