Full Text Journal Articles by
Author Andrew Duncan

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Randomised Controlled Trial of Intravenous Nafamostat Mesylate in COVID Pneumonitis: Phase 1b/2a Experimental Study to Investigate Safety, Pharmacokinetics and Pharmacodynamics

Tom Michael Quinn, Erin Gaughan, Annya Bruce, Jean Antonelli, Richard O'Connor, Feng Li, Sarah McNamara, Oliver Koch, Claire MacKintosh, David Dockrell, Timothy Walsh, Kevin Blyth, Colin Church, Jürgen Schwarze, Cecilia Boz, Asta Valanciute, Matthew Burgess, Philip Emanuel, Bethany Mills, Giulia Rinaldi, Gareth Hardisty, Ross Mills, Emily Findlay, Sunny Jabball, Andrew Duncan, Sinéad Plant, Adam Marshall, Irene Young, Kay Russell, Emma Scholefield, Alastair Nimmo, Islom Nazarov, Grant Churchill, James McCullagh, Kourosh Ebrahimi, Colin Ferrett, Kate Templeton, Steve Rannard, Andrew Owen, Anne Moore, Keith Finlayson, Manu Shankar-Hari, John Norrie, Richard Parker, Ahsan Akram, Daniel Anthony, James Dear, Nik Hirani, Kev Dhaliwal,

Background: Many repurposed drugs have progressed rapidly to Phase 2 and 3 trials in COVID19 without characterisation of Pharmacokinetics /Pharmacodynamics including safety data. One such drug is Nafamostat Mesylate.<br><br>Methods: We present the findings of a phase Ib/II open label, platform randomised controlled trial of intravenous Nafamostat in hospitalised patients with ... Read more >>

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Quantifying changes in the British cattle movement network.

Andrew J Duncan, Aaron Reeves, George J Gunn, Roger W Humphry,

The modelling of disease spread is crucial to the farming industry and policy makers. In some of these industries, excellent data exist on animal movements, along with the networks that these movements create, and allow researchers to model spread of disease (both epidemic and endemic). The Cattle Tracing System is ... Read more >>

Prev Vet Med (Preventive veterinary medicine)
[2021, 198:105524]

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A novel humanized model of NASH and its treatment with META4 a potent agonist of MET.

Jihong Ma, Xinping Tan, Yongkook Kwon, Evan R Delgado, Arman Zarnegar, Marie C DeFrances, Andrew W Duncan, Reza Zarnegar,

<h4>Background & aims</h4>Non-alcoholic fatty liver disease (NAFLD) is a frequent cause of hepatic dysfunction and is now a global epidemic. This ailment can progress to an advanced form called NASH (non-alcoholic steatohepatitis) and end-stage liver disease. Currently, the molecular basis of NASH pathogenesis is poorly understood, and no effective therapies ... Read more >>

Cell Mol Gastroenterol Hepatol (Cellular and molecular gastroenterology and hepatology)
[2021, :]

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Income Deprivation and Groin Wound Surgical Site Infection: Cross-Sectional Analysis from the Groin Wound Infection after Vascular Exposure Multicenter Cohort Study.

Brenig Llwyd Gwilym, Ravi Maheswaran, Adrian Edwards, Emma Thomas-Jones, Jonathan Michaels, David Charles Bosanquet, ,

<b><i>Background:</i></b> Living in deprived areas is associated with poorer outcomes after certain vascular procedures and surgical site infection in other specialties. Our primary objective was to determine whether living in more income-deprived areas was associated with groin wound surgical site infection after arterial intervention. Secondary objectives were to determine whether ... Read more >>

Surg Infect (Larchmt) (Surgical infections)
[2021, :]

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METTL3 Regulates Liver Homeostasis, Hepatocyte Ploidy, and Circadian Rhythm-Controlled Gene Expression in Mice.

Juan M Barajas, Cho-Hao Lin, Hui-Lung Sun, Frances Alencastro, Allen C Zhu, Mona Aljuhani, Ladan Navari, Selen A Yilmaz, Lianbo Yu, Kara Corps, Chuan He, Andrew W Duncan, Kalpana Ghoshal,

N<sup>6</sup>-methyladenosine (m<sup>6</sup>A), the most abundant internal modifier of mRNAs that is installed by the methyltransferase 13 (METTL3) at the (G/A)(m<sup>6</sup>A)C motif, plays a critical role in gene expression regulation. METTL3 is essential for embryonic development, and its dysregulation is linked to various diseases. However, the role of METTL3 in liver ... Read more >>

Am J Pathol (The American journal of pathology)
[2021, :]

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Single-Cell DNA Sequencing Reveals Chromosomal Diversity in HCC and a Novel Model of HCC Evolution.

Sierra R Wilson, Andrew W Duncan,

Gastroenterology (Gastroenterology)
[2021, :]

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Pulmonary haemorrhage in neonates: Systematic review of management.

Melissa E Barnes, Emily Feeney, Andrew Duncan, Samher Jassim, Honora MacNamara, Joseph O'Hara, Beshoy Refila, John Allen, Danielle McCollum, Judith Meehan, Rachel Mullaly, Niamh O'Cathain, Edna Roche, Eleanor J Molloy,

<h4>Aim</h4>Pulmonary haemorrhage (PH) is an acute catastrophic event with low incidence yet high mortality among neonates. We aimed to systematically review the management of PH.<h4>Methods</h4>A search was carried out of the PubMed, EMBASE and Cochrane databases according to the PRISMA guidelines. Data were extracted on study design and size, patient ... Read more >>

Acta Paediatr (Acta paediatrica (Oslo, Norway : 1992))
[2021, :]

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Predictive semiology of psychogenic non-epileptic seizures in an epilepsy monitoring unit.

Andrew J Duncan, Ivana Peric, Ray Boston, Udaya Seneviratne,

<h4>Introduction</h4>The diagnosis of psychogenic nonepileptic seizures (PNES) is a common clinical dilemma. We sought to assess the diagnostic value of four ictal signs commonly used in differentiating PNES from epileptic seizures (ES).<h4>Methods</h4>We retrospectively reviewed consecutive adult video-electroencephalogram (VEM) studies conducted at a single tertiary epilepsy center between May 2009 and ... Read more >>

J Neurol (Journal of neurology)
[2021, :]

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The association between mechanical ventilator compatible bed occupancy and mortality risk in intensive care patients with COVID-19: a national retrospective cohort study.

Harrison Wilde, Thomas Mellan, Iwona Hawryluk, John M Dennis, Spiros Denaxas, Christina Pagel, Andrew Duncan, Samir Bhatt, Seth Flaxman, Bilal A Mateen, Sebastian J Vollmer,

<h4>Background</h4>The literature paints a complex picture of the association between mortality risk and ICU strain. In this study, we sought to determine if there is an association between mortality risk in intensive care units (ICU) and occupancy of beds compatible with mechanical ventilation, as a proxy for strain.<h4>Methods</h4>A national retrospective ... Read more >>

BMC Med (BMC medicine)
[2021, 19(1):213]

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Coordinated Cross-Talk Between the Myc and Mlx Networks in Liver Regeneration and Neoplasia

Huabo Wang, Jie Lu, Frances Alencastro, Alexander Roberts, Julia Fiedor, Patrick Carroll, Robert Eisenman, Sarangarajan Ranganathan, Michael Torbenson, Andrew Duncan, Edward Prochownik,

The Myc bHLH-ZIP transcription factor is deregulated by most cancers. As a heterodimer with the bHLH-ZIP protein Max, Myc regulates target genes that contribute to metabolism and proliferation. This “Myc Network” cross-talks with the “Mlx Network” comprised of the Myc-like bHLH-ZIP proteins MondoA and ChREBP and the Max-like bHLH-ZIP protein ... Read more >>

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Groin Wound Infection after Vascular Exposure (GIVE) Risk Prediction Models: Development, Internal Validation, and Comparison with Existing Risk Prediction Models Identified in a Systematic Literature Review.

Brenig L Gwilym, Graeme K Ambler, Athanasios Saratzis, David C Bosanquet, ,

<h4>Objective</h4>This study aimed to develop and internally validate risk prediction models for predicting groin wound surgical site infections (SSIs) following arterial intervention and to evaluate the utility of existing risk prediction models for this outcome.<h4>Methods</h4>Data from the Groin wound Infection after Vascular Exposure (GIVE) multicentre cohort study were used. The ... Read more >>

Eur J Vasc Endovasc Surg (European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery)
[2021, 62(2):258-266]

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The Dockstore: enhancing a community platform for sharing reproducible and accessible computational protocols.

Denis Yuen, Louise Cabansay, Andrew Duncan, Gary Luu, Gregory Hogue, Charles Overbeck, Natalie Perez, Walt Shands, David Steinberg, Chaz Reid, Nneka Olunwa, Richard Hansen, Elizabeth Sheets, Ash O'Farrell, Kim Cullion, Brian D O'Connor, Benedict Paten, Lincoln Stein,

Dockstore (https://dockstore.org/) is an open source platform for publishing, sharing, and finding bioinformatics tools and workflows. The platform has facilitated large-scale biomedical research collaborations by using cloud technologies to increase the Findability, Accessibility, Interoperability and Reusability (FAIR) of computational resources, thereby promoting the reproducibility of complex bioinformatics analyses. Dockstore supports ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2021, 49(W1):W624-W632]

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Porcine reproductive and respiratory syndrome virus seroprevalence in Scottish finishing pigs between 2006 and 2018.

Carla Correia-Gomes, Andrew Duncan, Allan Ward, Michael Pearce, Lysan Eppink, Grace Webster, Andy McGowan, Jill Thomson,

<h4>Background</h4>Porcine reproductive and respiratory syndrome (PRRS) is a major endemic pig disease worldwide and is associated with considerable economic costs.<h4>Methods</h4>In Scotland, three abattoir surveys were conducted in 2006 (158 farms), 2012-2013 (94 farms) and 2017-2018 (97 farms) to estimate seroprevalence to PRRS virus (PRRSV) in commercial finishing pigs. These surveys ... Read more >>

Vet Rec (The Veterinary record)
[2021, :e349]

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Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial.

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<h4>Background</h4>Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19.<h4>Methods</h4>This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised ... Read more >>

Lancet (Lancet (London, England))
[2021, 397(10289):2049-2059]

Cited: 49 times

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Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

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<h4>Background</h4>In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation.<h4>Methods</h4>This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those ... Read more >>

Lancet (Lancet (London, England))
[2021, 397(10285):1637-1645]

Cited: 147 times

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Scaffolding Protein IQGAP1 Is Dispensable, but Its Overexpression Promotes Hepatocellular Carcinoma via YAP1 Signaling.

Evan R Delgado, Hanna L Erickson, Junyan Tao, Satdarshan P Monga, Andrew W Duncan, Sayeepriyadarshini Anakk,

IQ motif-containing GTPase-activating protein 1 (IQGAP1) is a ubiquitously expressed scaffolding protein that is overexpressed in a number of cancers, including liver cancer, and is associated with protumorigenic processes, such as cell proliferation, motility, and adhesion. IQGAP1 can integrate multiple signaling pathways and could be an effective antitumor target. Therefore, ... Read more >>

Mol Cell Biol (Molecular and cellular biology)
[2021, 41(4):]

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A flexible repertoire of transcription factor binding sites and a diversity threshold determines enhancer activity in embryonic stem cells.

Gurdeep Singh, Shanelle Mullany, Sakthi D Moorthy, Richard Zhang, Tahmid Mehdi, Ruxiao Tian, Andrew G Duncan, Alan M Moses, Jennifer A Mitchell,

Transcriptional enhancers are critical for development and phenotype evolution and are often mutated in disease contexts; however, even in well-studied cell types, the sequence code conferring enhancer activity remains unknown. To examine the enhancer regulatory code for pluripotent stem cells, we identified genomic regions with conserved binding of multiple transcription ... Read more >>

Genome Res (Genome research)
[2021, 31(4):564-575]

Cited: 2 times

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Hospital bed capacity and usage across secondary healthcare providers in England during the first wave of the COVID-19 pandemic: a descriptive analysis.

Bilal Akhter Mateen, Harrison Wilde, John M Dennis, Andrew Duncan, Nick Thomas, Andrew McGovern, Spiros Denaxas, Matt Keeling, Sebastian Vollmer,

<h4>Objective</h4>In this study, we describe the pattern of bed occupancy across England during the peak of the first wave of the COVID-19 pandemic.<h4>Design</h4>Descriptive survey.<h4>Setting</h4>All non-specialist secondary care providers in England from 27 March27to 5 June 2020.<h4>Participants</h4>Acute (non-specialist) trusts with a type 1 (ie, 24 hours/day, consultant-led) accident and emergency department (n=125), ... Read more >>

BMJ Open (BMJ open)
[2021, 11(1):e042945]

Cited: 7 times

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Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

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<h4>Background</h4>Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.<h4>Methods</h4>In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), several possible treatments were ... Read more >>

Lancet (Lancet (London, England))
[2021, 397(10274):605-612]

Cited: 44 times

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A national retrospective cohort study of mechanical ventilator availability and its association with mortality risk in intensive care patients with COVID-19

Harrison Wilde, Thomas Mellan, Iwona Hawryluk, John Dennis, Spiros Denaxas, Christina Pagel, Andrew Duncan, Samir Bhatt, Seth Flaxman, Bilal Mateen, Sebastian Vollmer,

<h4>Objectives: </h4> To determine if there is an association between survival rates in intensive care units (ICU) and occupancy of the unit on the day of admission. <h4>Design:</h4> National retrospective observational cohort study during the COVID-19 pandemic. <h4>Setting:</h4> 90 English hospital trusts (i.e. groups of hospitals functioning as single operational ... Read more >>

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Differential Roles for Diploid and Polyploid Hepatocytes in Acute and Chronic Liver Injury.

Patrick D Wilkinson, Andrew W Duncan,

Hepatocytes are the primary functional cells of the liver that perform essential roles in homeostasis, regeneration, and injury. Most mammalian somatic cells are diploid and contain pairs of each chromosome, but there are also polyploid cells containing additional sets of chromosomes. Hepatocytes are among the best described polyploid cells, with ... Read more >>

Semin Liver Dis (Seminars in liver disease)
[2021, 41(1):42-49]

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Hepatocyte ploidy modulation in liver cancer.

Andrew W Duncan,

Polyploidy, a balanced amplification of the genome, is common in the liver. The function of hepatic polyploidy is not entirely clear, but growing evidence shows that polyploidy can protect the liver from tumor formation. In this issue of EMBO Reports, Sladky and colleagues identify the PIDDosome as a polyploidy sensor ... Read more >>

EMBO Rep (EMBO reports)
[2020, 21(12):e51922]

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Groin wound infection after vascular exposure (GIVE) multicentre cohort study.

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Surgical site infections (SSIs) of groin wounds are a common and potentially preventable cause of morbidity, mortality, and healthcare costs in vascular surgery. Our aim was to define the contemporaneous rate of groin SSIs, determine clinical sequelae, and identify risk factors for SSI. An international multicentre prospective observational cohort study ... Read more >>

Int Wound J (International wound journal)
[2021, 18(2):164-175]

Cited: 1 time

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Global impact of the first coronavirus disease 2019 (COVID-19) pandemic wave on vascular services.

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This online structured survey has demonstrated the global impact of the COVID-19 pandemic on vascular services. The majority of centres have documented marked reductions in operating and services provided to vascular patients. In the months during recovery from the resource restrictions imposed during the pandemic peaks, there will be a ... Read more >>

Br J Surg (The British journal of surgery)
[2020, 107(11):1396-1400]

Cited: 8 times

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Quinine exposure and the risk of acute kidney injury: a population-based observational study of older people.

Andrew D S Duncan, Simona Hapca, Nicosha De Souza, Daniel Morales, Samira Bell,

<h4>Objectives</h4>to establish and quantify any observable association between the exposure to community prescriptions for quinine and acute kidney injury (AKI) events in a population of older adults.<h4>Design</h4>two observational studies using the same dataset, a retrospective longitudinal cohort study and a self-controlled case series (SCCS).<h4>Setting</h4>NHS health board in Scotland.<h4>Participants</h4>older adults (60+ ... Read more >>

Age Ageing (Age and ageing)
[2020, 49(6):1042-1047]

Cited: 1 time

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