Full Text Journal Articles by
Author Andrew Beck

Advertisement

Find full text journal articles






Human-interpretable image features derived from densely mapped cancer pathology slides predict diverse molecular phenotypes.

James A Diao, Jason K Wang, Wan Fung Chui, Victoria Mountain, Sai Chowdary Gullapally, Ramprakash Srinivasan, Richard N Mitchell, Benjamin Glass, Sara Hoffman, Sudha K Rao, Chirag Maheshwari, Abhik Lahiri, Aaditya Prakash, Ryan McLoughlin, Jennifer K Kerner, Murray B Resnick, Michael C Montalto, Aditya Khosla, Ilan N Wapinski, Andrew H Beck, Hunter L Elliott, Amaro Taylor-Weiner,

Computational methods have made substantial progress in improving the accuracy and throughput of pathology workflows for diagnostic, prognostic, and genomic prediction. Still, lack of interpretability remains a significant barrier to clinical integration. We present an approach for predicting clinically-relevant molecular phenotypes from whole-slide histopathology images using human-interpretable image features (HIFs). ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):1613]

Cited: 1 time

View full text PDF listing >>



Rapid, Bottom-Up Design of a Regional Learning Health System in Response to COVID-19.

Andrew F Beck, David M Hartley, Robert S Kahn, Stuart C Taylor, Elizabeth Bishop, Kate Rich, Myra S Saeed, Christine L Schuler, Michael Seid, Susan C Cronin, Laura Raney, Muhammad A Zafar, Peter A Margolis,

Mayo Clin Proc (Mayo Clinic proceedings)
[2021, 96(4):849-855]

Cited: 0 times

View full text PDF listing >>



Advertisement

Cultivating social relationships and disrupting social isolation in low-income, high-disparity neighbourhoods in Ohio, USA.

Allison A Parsons, Dawna Leggett, Daniela Vollmer, Valerie Perez, Rachel Smith, Emily Goodman, Crystal Mayes, Chellie McLellan, Nancy Laird, Andrew F Beck, Robert Kahn, Carley Riley,

Social isolation undermines health. Inequities in social networks exist due to historical and contemporary practices of socioeconomic and racial segregation. Thus, lower income and minority families are less likely to have the number, strength, and variety of social connections as higher income and white families. Therefore, social isolation may contribute ... Read more >>

Health Soc Care Community (Health & social care in the community)
[2021, :]

Cited: 0 times

View full text PDF listing >>



A Machine Learning Approach Enables Quantitative Measurement of Liver Histology and Disease Monitoring in NASH.

Amaro Taylor-Weiner, Harsha Pokkalla, Ling Han, Catherine Jia, Ryan Huss, Chuhan Chung, Hunter Elliott, Benjamin Glass, Kishalve Pethia, Oscar Carrasco-Zevallos, Chinmay Shukla, Urmila Khettry, Robert Najarian, Ross Taliano, G Mani Subramanian, Robert P Myers, Ilan Wapinski, Aditya Khosla, Murray Resnick, Michael C Montalto, Quentin M Anstee, Vincent Wai-Sun Wong, Michael Trauner, Eric J Lawitz, Stephen A Harrison, Takeshi Okanoue, Manuel Romero-Gomez, Zachary Goodman, Rohit Loomba, Andrew H Beck, Zobair M Younossi,

<h4>Background & aims</h4>Manual histologic assessment is currently the accepted standard for diagnosing and monitoring disease progression in nonalcoholic steatohepatitis (NASH), but is limited by variability in interpretation and insensitivity to change. Thus, there is a critical need for improved tools to assess liver pathology in order to risk stratify NASH ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2021, :]

Cited: 0 times

View full text PDF listing >>



Center variation in long-term outcomes for socioeconomically deprived children.

Sharad I Wadhwani, Chiung-Yu Huang, Laura Gottlieb, Andrew F Beck, John Bucuvalas, Uma Kotagal, Courtney Lyles, Jennifer C Lai,

Neighborhood socioeconomic deprivation is associated with adverse outcomes after pediatric liver transplant. We sought to determine if this relationship varies by transplant center. Using SRTR, we included patients <18 years transplanted 2008-2013 (N = 2804). We matched patient ZIP codes to a deprivation index (range [0,1]; higher values indicate increased socioeconomic deprivation). A ... Read more >>

Am J Transplant (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Combination Therapies Including Cilofexor and Firsocostat for Bridging Fibrosis and Cirrhosis Attributable to NASH.

Rohit Loomba, Mazen Noureddin, Kris V Kowdley, Anita Kohli, Aasim Sheikh, Guy Neff, Bal Raj Bhandari, Nadege Gunn, Stephen H Caldwell, Zachary Goodman, Ilan Wapinski, Murray Resnick, Andrew H Beck, Dora Ding, Catherine Jia, Jen-Chieh Chuang, Ryan S Huss, Chuhan Chung, G Mani Subramanian, Robert P Myers, Keyur Patel, Brian B Borg, Reem Ghalib, Heidi Kabler, John Poulos, Ziad Younes, Magdy Elkhashab, Tarek Hassanein, Rajalakshmi Iyer, Peter Ruane, Mitchell L Shiffman, Simone Strasser, Vincent Wai-Sun Wong, Naim Alkhouri, ,

<h4>Background and aims</h4>Advanced fibrosis attributable to NASH is a leading cause of end-stage liver disease.<h4>Approach and results</h4>In this phase 2b trial, 392 patients with bridging fibrosis or compensated cirrhosis (F3-F4) were randomized to receive placebo, selonsertib 18 mg, cilofexor 30 mg, or firsocostat 20 mg, alone or in two-drug combinations, once-daily for 48 weeks. ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2021, 73(2):625-643]

Cited: 1 time

View full text PDF listing >>



Screening for depression in children and adolescents: a protocol for a systematic review update.

Andrew Beck, John C LeBlanc, Kate Morissette, Candyce Hamel, Becky Skidmore, Heather Colquhoun, Eddy Lang, Ainsley Moore, John J Riva, Brett D Thombs, Scott Patten, Heather Bragg, Ian Colman, Gary S Goldfield, Stuart Gordon Nicholls, Kathleen Pajer, Beth K Potter, Robert Meeder, Priya Vasa, Brian Hutton, Beverley J Shea, Eva Graham, Julian Little, David Moher, Adrienne Stevens,

<h4>Background</h4>Major depressive disorder is common, debilitating, and affects feelings, thoughts, mood, and behaviors. Childhood and adolescence are critical periods for the development of depression and adolescence is marked by an increased incidence of mental health disorders. This protocol outlines the planned scope and methods for a systematic review update that ... Read more >>

Syst Rev (Systematic reviews)
[2021, 10(1):24]

Cited: 0 times

View full text PDF listing >>



Correction to: The social, economic, political, and genetic value of race and ethnicity in 2020.

Tesfaye B Mersha, Andrew F Beck,

An amendment to this paper has been published and can be accessed via the original article. ... Read more >>

Hum Genomics (Human genomics)
[2020, 14(1):42]

Cited: 0 times

View full text PDF listing >>



Functional Characterization of Circulating Mumps Viruses with Stop Codon Mutations in the Small Hydrophobic Protein.

Rita Czakó Stinnett, Andrew S Beck, Elena N Lopareva, Rebecca J McNall, Donald R Latner, Carole J Hickman, Paul A Rota, Bettina Bankamp,

Between 2015 and 2017, routine molecular surveillance in the United States detected multiple mumps viruses (MuVs) with mutations in the small hydrophobic (SH) gene compared to a reference virus of the same genotype. These mutations include an unusual pattern of uracil-to-cytosine hypermutations and other mutations resulting in the generation of ... Read more >>

mSphere (mSphere)
[2020, 5(6):]

Cited: 0 times

View full text PDF listing >>



Can Baseline Characteristics be Used to Predict Liver Disease Outcomes in Pediatric Nonalcoholic Fatty Liver Disease?

Sarah Orkin, Toshifumi Yodoshi, Qin Sun, Lin Fei, Syeda Meryum, Ana Catalina Arce-Clachar, Kristin Bramlage, Andrew F Beck, Marialena Mouzaki,

<h4>Objective</h4>Longitudinal studies on childhood predictors of nonalcoholic fatty liver disease (NAFLD) progression are lacking. The objective of this study was to determine whether baseline clinical or laboratory measures predict liver disease outcomes in a pediatric NAFLD cohort.<h4>Methods</h4>A retrospective study of patients with presumed NAFLD was conducted using baseline and follow-up ... Read more >>

Obesity (Silver Spring) (Obesity (Silver Spring, Md.))
[2021, 29(1):171-176]

Cited: 0 times

View full text PDF listing >>



Euglycemic DKA (euDKA) as a presentation of COVID-19.

Bhagwan Dass, Andrew Beck, Cody Holmes, Glenville Morton,

COVID-19 in the setting of SGLT2 inhibitor use may precipitate euglycemic DKA separate from known acute viral illness and dehydration precipitants. There should be consideration of proactive discontinuation of these medications in these patients. ... Read more >>

Clin Case Rep (Clinical case reports)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Effect of Parental Adverse Childhood Experiences and Resilience on a Child's Healthcare Reutilization.

Anita N Shah, Katherine A Auger, Heidi J Sucharew, Colleen Mangeot, Kelsey Childress, Julianne Haney, Samir S Shah, Jeffrey M Simmons, Andrew F Beck, ,

<h4>Background</h4>Adverse childhood experiences (ACEs) are associated with poor health outcomes in adults. Resilience may mitigate this effect. There is limited evidence regarding how parents' ACEs and resilience may be associated with their children's health outcomes.<h4>Objective</h4>To determine the association of parental ACEs and resilience with their child's risk of unanticipated healthcare ... Read more >>

J Hosp Med (Journal of hospital medicine)
[2020, 15(11):645-651]

Cited: 0 times

View full text PDF listing >>



Association Between Neighborhood-level Socioeconomic Deprivation and the Medication Level Variability Index for Children Following Liver Transplantation.

Sharad I Wadhwani, John C Bucuvalas, Cole Brokamp, Ravinder Anand, Ashutosh Gupta, Stuart Taylor, Eyal Shemesh, Andrew F Beck,

<h4>Background</h4>Neighborhood socioeconomic deprivation is associated with adverse health outcomes. We sought to determine if neighborhood socioeconomic deprivation was associated with adherence to immunosuppressive medications after liver transplantation.<h4>Methods</h4>We conducted a secondary analysis of a multicenter, prospective cohort of children enrolled in the medication adherence in children who had a liver transplant ... Read more >>

Transplantation (Transplantation)
[2020, 104(11):2346-2353]

Cited: 0 times

View full text PDF listing >>



The social, economic, political, and genetic value of race and ethnicity in 2020.

Tesfaye B Mersha, Andrew F Beck,

Disparities across racial and ethnic groups are present for a range of health outcomes. In this opinion piece, we consider the origin of racial and ethnic groupings, a history that highlights the sociopolitical nature of these terms. Indeed, the terms race and ethnicity exist purely as social constructs and must ... Read more >>

Hum Genomics (Human genomics)
[2020, 14(1):37]

Cited: 2 times

View full text PDF listing >>



A National Prescription for Health: Tax Credits.

Lucy E Marcil, Andrew F Beck,

Pediatrics (Pediatrics)
[2020, 146(5):]

Cited: 0 times

View full text PDF listing >>



Risk factors for severe outcomes of COVID-19: a rapid review

Aireen Wingert, Jennifer Pillay, Michelle Gates, Samantha Guitard, Sholeh Rahman, Andrew Beck, Ben Vandermeer, Lisa Hartling,

<h4>ABSTRACT</h4> <h4>Background</h4> Identification of high-risk groups is needed to inform COVID-19 vaccine prioritization strategies in Canada. A rapid review was conducted to determine the magnitude of association between potential risk factors and risk of severe outcomes of COVID-19. <h4>Methods</h4> <h4>Methods: </h4> , inclusion criteria, and outcomes were prespecified in a ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



A first-in-class CDK4 inhibitor demonstrates in vitro, ex-vivo and in vivo efficacy against ovarian cancer.

Laychiluh Bantie, Solomon Tadesse, Jimma Likisa, Mingfeng Yu, Benjamin Noll, Gary Heinemann, Noor A Lokman, Carmela Ricciardelli, Martin K Oehler, Andrew Beck, Rupal Pradhan, Robert Milne, Hugo Albrecht, Shudong Wang,

<h4>Introduction</h4>Cyclin-dependent kinases 4 and 6 (CDK4/6) are fundamental drivers of the cell cycle and are involved in the initiation and progression of various cancers. Deregulation of the CDK4/6-cyclin D-retinoblastoma (Rb) pathway is common in ovarian cancer and is associated with an aggressive phenotype and poor prognosis. Patients with advanced ovarian ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 159(3):827-838]

Cited: 0 times

View full text PDF listing >>



A Qualitative Study of Increased Pediatric Reutilization After a Postdischarge Home Nurse Visit.

Sarah W Riddle, Susan N Sherman, Margo J Moore, Allison M Loechtenfeldt, Heather L Tubbs-Cooley, Jennifer M Gold, Susan Wade-Murphy, Andrew F Beck, Angela M Statile, Samir S Shah, Jeffrey M Simmons, Katherine A Auger, ,

<h4>Background</h4>The Hospital to Home Outcomes (H2O) trial was a 2-arm, randomized controlled trial that assessed the effects of a nurse home visit after a pediatric hospital discharge. Children randomized to the intervention had higher 30-day postdischarge reutilization rates compared with those with standard discharge. We sought to understand perspectives on ... Read more >>

J Hosp Med (Journal of hospital medicine)
[2020, 15(9):518-525]

Cited: 0 times

View full text PDF listing >>



Neighborhood socioeconomic deprivation, racial segregation, and organ donation across 5 states.

Sharad I Wadhwani, Cole Brokamp, Erika Rasnick, John C Bucuvalas, Jennifer C Lai, Andrew F Beck,

One in 10 people die awaiting transplantation from donor shortage. Only half of Americans register as organ donors. In this cross-sectional study, we evaluated population-level associations of neighborhood socioeconomic deprivation and racial segregation on organ donor registration rates. We analyzed state identification card demographic and organ donor registration data from ... Read more >>

Am J Transplant (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2021, 21(3):1206-1214]

Cited: 1 time

View full text PDF listing >>



Muscle Mass Is Linked to Liver Disease Severity in Pediatric Nonalcoholic Fatty Liver Disease.

Toshifumi Yodoshi, Sarah Orkin, Ana-Catalina Arce Clachar, Kristin Bramlage, Qin Sun, Lin Fei, Andrew F Beck, Stavra A Xanthakos, Andrew T Trout, Marialena Mouzaki,

<h4>Objective</h4>To investigate the association between muscle mass and liver disease severity in pediatric patients with non-alcoholic fatty liver disease (NAFLD).<h4>Study design</h4>This was a retrospective study of patients aged <20 years followed from 2009 to 2018. Muscle mass was estimated in all patients by measuring magnetic resonance imaging-based total psoas muscle surface ... Read more >>

J Pediatr (The Journal of pediatrics)
[2020, 223:93-99.e2]

Cited: 0 times

View full text PDF listing >>



Dense, high-resolution mapping of cells and tissues from pathology images for the interpretable prediction of molecular phenotypes in cancer

James Diao, Wan Fung Chui, Jason Wang, Richard Mitchell, Sudha Rao, Murray Resnick, Abhik Lahiri, Chirag Maheshwari, Benjamin Glass, Victoria Mountain, Jennifer Kerner, Michael Montalto, Aditya Khosla, Ilan Wapinski, Andrew Beck, Amaro Taylor-Weiner, Hunter Elliott,

While computational methods have made substantial progress in improving the accuracy and throughput of pathology workflows for diagnostic, prognostic, and genomic prediction, lack of interpretability remains a significant barrier to clinical integration. In this study, we present a novel approach for predicting clinically-relevant molecular phenotypes from histopathology whole-slide images (WSIs) ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Seeking Normalcy as the Curve Flattens: Ethical Considerations for Pediatricians Managing Collateral Damage of Coronavirus Disease-2019.

Dalia M Feltman, Gregory P Moore, Andrew F Beck, Emily Siffermann, Carlo Bellieni, John Lantos,

J Pediatr (The Journal of pediatrics)
[2020, 225:233-238]

Cited: 1 time

View full text PDF listing >>



Medical-Legal-Psychology Partnerships - Innovation in Addressing Social Determinants of Health in Pediatric Primary Care.

Rachel Lawton, Monica Whitehead, Adrienne Henize, Elaine Fink, Melissa Salamon, Robert Kahn, Andrew F Beck, Melissa Klein,

Acad Pediatr (Academic pediatrics)
[2020, 20(7):902-904]

Cited: 0 times

View full text PDF listing >>



Environmental Toxic Exposures Using Companion Animals as an Indicator of Human Toxicity: A Case Report and Discussion.

Andrew C Beck, Erica M Lash, Jason B Hack,

<h4>Background</h4>Hundreds of years ago, humans realized that animals could be used as surrogate indicators of toxic environmental exposures, as a tool to measure risk to human health. The classic example is coal miners bringing canaries into coal mines. The respiratory rate and metabolism of the animal resulted in toxic signs ... Read more >>

J Emerg Med (The Journal of emergency medicine)
[2020, 59(1):e1-e7]

Cited: 1 time

View full text PDF listing >>



Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials.

Jan Hudeček, Leonie Voorwerk, Maartje van Seijen, Iris Nederlof, Michiel de Maaker, Jose van den Berg, Koen K van de Vijver, Karolina Sikorska, Sylvia Adams, Sandra Demaria, Giuseppe Viale, Torsten O Nielsen, Sunil S Badve, Stefan Michiels, William Fraser Symmans, Christos Sotiriou, David L Rimm, Stephen M Hewitt, Carsten Denkert, Sibylle Loibl, Sherene Loi, John M S Bartlett, Giancarlo Pruneri, Deborah A Dillon, Maggie C U Cheang, Andrew Tutt, Jacqueline A Hall, Zuzana Kos, Roberto Salgado, Marleen Kok, Hugo M Horlings, ,

Stromal tumor-infiltrating lymphocytes (sTILs) are a potential predictive biomarker for immunotherapy response in metastatic triple-negative breast cancer (TNBC). To incorporate sTILs into clinical trials and diagnostics, reliable assessment is essential. In this review, we propose a new concept, namely the implementation of a risk-management framework that enables the use of ... Read more >>

NPJ Breast Cancer (NPJ breast cancer)
[2020, 6:15]

Cited: 1 time

View full text PDF listing >>



Advertisement

Disclaimer
1.064 s