Full Text Journal Articles by
Author Andreas von Knethen

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Editorial: The Roles of Checkpoint Inhibitors in Inflammatory Diseases.

Andreas von Knethen, Jose-Ignacio Rodriguez-Barbosa,

Front Immunol (Frontiers in immunology)
[2021, 12:795495]

Cited: 0 times

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Plasma RIPK3 And HMGB1 Predict Severe COVID-19 Progression In ICU Patients: A Single-Center Cohort Study

Katharina Ruskowski, Holger Neb, Steven Talbot, Suma Choorapoikayil, Elisabeth Adam, Andreas von Knethen, Kai Zacharowski, Ulrike Heinicke,

<h4>Background: </h4> Severe progression of coronavirus disease 2019 (COVID‑19) causes respiratory failure and critical illness. Recently, these pathologies have been associated with necroptosis, a receptor‑interacting serine/threonine‑protein kinase 3 (RIPK3) dependent regulated form of inflammatory cell death. Investigations of indicator necroptosis proteins like RIPK3, mixed lineage kinase domain‑like pseudokinase (MLKL), receptor‑interacting ... Read more >>

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Nrf2-A Molecular Target for Sepsis Patients in Critical Care.

Sandra Gunne, Ulrike Heinicke, Michael J Parnham, Volker Laux, Kai Zacharowski, Andreas von Knethen,

The transcription factor NF-E2 p45-related factor 2 (Nrf2) is an established master regulator of the anti-oxidative and detoxifying cellular response. Thus, a role in inflammatory diseases associated with the generation of large amounts of reactive oxygen species (ROS) seems obvious. In line with this, data obtained in cell culture experiments ... Read more >>

Biomolecules (Biomolecules)
[2020, 10(12):]

Cited: 2 times

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Macrophage-Derived Iron-Bound Lipocalin-2 Correlates with Renal Recovery Markers Following Sepsis-Induced Kidney Damage.

Christina Mertens, Laura Kuchler, Anna Sola, Roser Guiteras, Stephan Grein, Bernhard Brüne, Andreas von Knethen, Michaela Jung,

During the course of sepsis in critically ill patients, kidney dysfunction and damage are among the first events of a complex scenario toward multi-organ failure and patient death. Acute kidney injury triggers the release of lipocalin-2 (Lcn-2), which is involved in both renal injury and recovery. Taking into account that ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(20):]

Cited: 5 times

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Angiotensin II treatment in COVID-19 patients: more risk than benefit? A single-center experience.

Ulrike Heinicke, Elisabeth Adam, Michael Sonntagbauer, Andreas von Knethen, Kai Zacharowski, Holger Neb,

Crit Care (Critical care (London, England))
[2020, 24(1):409]

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One score to rule them all: severity assessment in laboratory mice

Steven Talbot, Birgitta Struve, Laura Wassermann, Miriam Heider, Nora Weegh, Tilo Knape, Martine Hofmann, Andreas von Knethen, Paulin Jirkof, Lydia Keubler, André Bleich, Christine Häger,

Animal welfare and the refinement of experimental procedures are fundamental aspects of biomedical research. They provide the basis for robust experimental designs and reproducibility of results. In many countries, the determination of welfare is a mandatory legal requirement and implies the assessment of the degree of the severity that an ... Read more >>

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Histone Deacetylation Inhibitors as Modulators of Regulatory T Cells.

Andreas von Knethen, Ulrike Heinicke, Andreas Weigert, Kai Zacharowski, Bernhard Brüne,

Regulatory T cells (T<sub>regs</sub>) are important mediators of immunological self-tolerance and homeostasis. Being cluster of differentiation 4<sup>+</sup>Forkhead box protein3<sup>+</sup> (CD4<sup>+</sup>FOXP3<sup>+</sup>), these cells are a subset of CD4<sup>+</sup> T lymphocytes and can originate from the thymus (tT<sub>regs</sub>) or from the periphery (pT<sub>regs</sub>). The malfunction of CD4<sup>+</sup> T<sub>regs</sub> is associated with autoimmune ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(7):]

Cited: 5 times

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Structure optimization of a new class of PPARγ antagonists.

Victor Hernandez-Olmos, Tilo Knape, Jan Heering, Andreas von Knethen, Whitney Kilu, Astrid Kaiser, Mario Wurglics, Moritz Helmstädter, Daniel Merk, Manfred Schubert-Zsilavecz, Michael J Parnham, Dieter Steinhilber, Ewgenij Proschak,

Peroxisome proliferator-activated receptor gamma (PPARγ) modulators have found wide application for the treatment of cancers, metabolic disorders and inflammatory diseases. Contrary to PPARγ agonists, PPARγ antagonists have been much less studied and although they have shown immunomodulatory effects, there is still no therapeutically useful PPARγ antagonist on the market. In ... Read more >>

Bioorg Med Chem (Bioorganic & medicinal chemistry)
[2019, 27(21):115082]

Cited: 0 times

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Macrophage S1PR1 Signaling Alters Angiogenesis and Lymphangiogenesis During Skin Inflammation.

Shahzad Nawaz Syed, Rebecca Raue, Andreas Weigert, Andreas von Knethen, Bernhard Brüne,

The bioactive lipid sphingosine-1-phosphate (S1P), along with its receptors, modulates lymphocyte trafficking and immune responses to regulate skin inflammation. Macrophages are important in the pathogenesis of psoriasiform skin inflammation and express various S1P receptors. How they respond to S1P in skin inflammation remains unknown. We show that myeloid specific S1P ... Read more >>

Cells (Cells)
[2019, 8(8):]

Cited: 6 times

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PD-L1 in the palm of your hand: palmitoylation as a target for immuno-oncology.

Andreas von Knethen, Bernhard Brüne,

Signal Transduct Target Ther (Signal transduction and targeted therapy)
[2019, 4:18]

Cited: 4 times

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Sphingosine kinase 2 is a negative regulator of inflammatory macrophage activation.

Andreas Weigert, Andreas von Knethen, Dominique Thomas, Isabel Faria, Dmitry Namgaladze, Ekaterina Zezina, Dominik Fuhrmann, Anton Petcherski, Dagmar Meyer Zu Heringdorf, Heinfried H Radeke, Bernhard Brüne,

Sphingosine kinases (SPHK) generate the sphingolipid sphingosine-1-phosphate, which, among other functions, is a potent regulator of inflammation. While SPHK1 produces S1P to promote inflammatory signaling, the role of SPHK2 is unclear due to divergent findings in studies utilizing gene depletion versus inhibition of catalytic activity. We sought to clarify how ... Read more >>

Biochim Biophys Acta Mol Cell Biol Lipids (Biochimica et biophysica acta. Molecular and cell biology of lipids)
[2019, 1864(9):1235-1246]

Cited: 11 times

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Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones.

Perihan A Elzahhar, Rana Alaaeddine, Tamer M Ibrahim, Rasha Nassra, Azza Ismail, Benjamin S K Chua, Rebecca L Frkic, John B Bruning, Nadja Wallner, Tilo Knape, Andreas von Knethen, Hala Labib, Ahmed F El-Yazbi, Ahmed S F Belal,

In search for effective multi-targeting drug ligands (MTDLs) to address low-grade inflammatory changes of metabolic disorders, we rationally designed some novel glitazones-like compounds. This was achieved by incorporating prominent pharmacophoric motifs from previously reported COX-2, 15-LOX and PPARγ ligands. Challenging our design with pre-synthetic docking experiments on PPARγ showed encouraging ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2019, 167:562-582]

Cited: 6 times

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Histone Deacetylation Inhibitors as Therapy Concept in Sepsis.

Andreas von Knethen, Bernhard Brüne,

Sepsis is characterized by dysregulated gene expression, provoking a hyper-inflammatory response occurring in parallel to a hypo-inflammatory reaction. This is often associated with multi-organ failure, leading to the patient's death. Therefore, reprogramming of these pro- and anti-inflammatory, as well as immune-response genes which are involved in acute systemic inflammation, is ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(2):]

Cited: 9 times

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Lipocalin-2 abrogates epithelial cell cycle arrest by PPARγ inhibition.

Michaela Jung, Bernhard Brüne, Andreas von Knethen, Roser Guiteras, Josep Maria Cruzado, Georgina Hotter, Anna Sola,

Macrophage-epithelial cross-talk regulates cell cycle progression and represents an important factor in rescuing epithelial cells from cell cycle arrest in order to maintain a healthy epithelial phenotype. However, the underlying mechanisms are still not well defined. We provide evidence that macrophage-secreted lipocalin-2 (Lcn-2) plays a key role during this process. ... Read more >>

Lab Invest (Laboratory investigation; a journal of technical methods and pathology)
[2018, 98(11):1408-1422]

Cited: 3 times

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Redox-signals and macrophage biology.

Andreas Weigert, Andreas von Knethen, Dominik Fuhrmann, Nathalie Dehne, Bernhard Brüne,

Macrophages are known for their versatile role in biology. They sense and clear structures that contain exogenous or endogenous pathogen-associated molecular patterns. This process is tightly linked to the production of a mixture of potentially harmful oxidants and cytokines. Their inherent destructive behavior is directed against foreign material or structures ... Read more >>

Mol Aspects Med (Molecular aspects of medicine)
[2018, 63:70-87]

Cited: 14 times

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Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis.

Laura Kuchler, Lisa K Sha, Annika K Giegerich, Tilo Knape, Carlo Angioni, Nerea Ferreirós, Martina V Schmidt, Andreas Weigert, Bernhard Brüne, Andreas von Knethen,

Sepsis mouse models revealed thymus atrophy, characterised by decreased thymus weight and loss of thymocytes due to apoptosis. Mice suffered from lymphopenia, a lack of T cells in the periphery, which attenuates their ability to fight against recurring and secondary infections during sepsis progression. Key players in thymus atrophy are ... Read more >>

Mol Immunol (Molecular immunology)
[2017, 90:255-263]

Cited: 4 times

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Apoptotic Diminution of Immature Single and Double Positive Thymocyte Subpopulations Contributes to Thymus Involution During Murine Polymicrobial Sepsis.

Christoph Netzer, Tilo Knape, Laura Kuchler, Andreas Weigert, Kai Zacharowski, Waltraud Pfeilschifter, Gregory Sempowski, Michael J Parnham, Bernhard Brüne, Andreas von Knethen,

To generate and maintain functional T-cell receptor diversity, thymocyte development is tightly organized. Errors in this process may have dramatic consequences, provoking, for example, autoimmune diseases. Probably for this reason, the thymus reacts to septic stress with involution, decreasing the numbers of thymocytes. Because it is still unclear which thymocyte ... Read more >>

Shock (Shock (Augusta, Ga.))
[2017, 48(2):215-226]

Cited: 5 times

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Pparγ Expression in T Cells as a Prognostic Marker of Sepsis.

Marco Brenneis, Ramin Aghajaanpour, Tilo Knape, Lisa K Sha, Holger Neb, Patrick Meybohm, Kai Zacharowski, Ingeborg A Hauser, Stefan Büttner, Michael J Parnham, Bernhard Brüne, Andreas von Knethen,

Translating murine data to the human situation, we proposed that the level of peroxisome proliferator-activated receptor γ (PPARγ) expression in T cells from septic patients correlates with clinical outcome. In this preliminary report, we analyzed PPARγ mRNA expression in CD3 T cells derived from blood of a very small number ... Read more >>

Shock (Shock (Augusta, Ga.))
[2016, 45(6):591-597]

Cited: 2 times

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Contribution of Ninjurin1 to Toll-like receptor 4 signaling and systemic inflammation.

Carla Jennewein, Ralf Sowa, Anne C Faber, Madlen Dildey, Andreas von Knethen, Patrick Meybohm, Bertram Scheller, Stefan Dröse, Kai Zacharowski,

Nerve injury-induced protein (Ninjurin [Ninj]) 1 is an adhesion molecule originally identified in Schwann cells after nerve injury, whereas it is also expressed in leukocytes, epithelium, endothelium, and various organs, and is induced under inflammatory conditions. Its contribution to inflammation was so far restricted to the nervous system and exclusively ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2015, 53(5):656-663]

Cited: 19 times

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Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling.

Angelika F Winkel, Christian K Engel, Daniel Margerie, Aimo Kannt, Hauke Szillat, Heiner Glombik, Christopher Kallus, Sven Ruf, Stefan Güssregen, Jens Riedel, Andreas W Herling, Andreas von Knethen, Andreas Weigert, Bernhard Brüne, Dieter Schmoll,

The activation of the transcription factor NF-E2-related factor 2 (Nrf2) maintains cellular homeostasis in response to oxidative stress by the regulation of multiple cytoprotective genes. Without stressors, the activity of Nrf2 is inhibited by its interaction with the Keap1 (kelch-like ECH-associated protein 1). Here, we describe (3S)-1-[4-[(2,3,5,6-tetramethylphenyl) sulfonylamino]-1-naphthyl]pyrrolidine-3-carboxylic acid (RA839), ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2015, 290(47):28446-28455]

Cited: 28 times

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MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer.

Catherine Olesch, Weixiao Sha, Carlo Angioni, Lisa Katharina Sha, Elias Açaf, Paola Patrignani, Per-Johan Jakobsson, Heinfried H Radeke, Sabine Grösch, Gerd Geisslinger, Andreas von Knethen, Andreas Weigert, Bernhard Brüne,

Prostaglandin E2 (PGE2) favors multiple aspects of tumor development and immune evasion. Therefore, microsomal prostaglandin E synthase (mPGES-1/-2), is a potential target for cancer therapy. We explored whether inhibiting mPGES-1 in human and mouse models of breast cancer affects tumor-associated immunity. A new model of breast tumor spheroid killing by ... Read more >>

Oncotarget (Oncotarget)
[2015, 6(12):10284-10296]

Cited: 22 times

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Identification and characterisation of a prototype for a new class of competitive PPARγ antagonists.

Tilo Knape, Daniel Flesch, Laura Kuchler, Lisa K Sha, Annika K Giegerich, Sandra Labocha, Nerea Ferreirós, Tobias Schmid, Mario Wurglics, Manfred Schubert-Zsilavecz, Eugen Proschak, Bernhard Brüne, Michael J Parnham, Andreas von Knethen,

Understanding of the physiological role of peroxisome proliferator-activated receptor gamma (PPARγ) offers new opportunities for the treatment of cancers, immune disorders and inflammatory diseases. In contrast to PPARγ agonists, few PPARγ antagonists have been studied, though they do exert immunomodulatory effects. Currently, no therapeutically useful PPARγ antagonist is commercially available. ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2015, 755:16-26]

Cited: 1 time

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Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8(+) T cell function by limiting GSH and Cys availability.

Lisa K Sha, Weixiao Sha, Laura Kuchler, Andreas Daiber, Annika K Giegerich, Andreas Weigert, Tilo Knape, Ryan Snodgrass, Katrin Schröder, Ralf P Brandes, Bernhard Brüne, Andreas von Knethen,

NF-E2-related factor 2 (Nrf2), known to protect against reactive oxygen species, has recently been reported to resolve acute inflammatory responses in activated macrophages. Consequently, disruption of Nrf2 promotes a proinflammatory macrophage phenotype. In the current study, we addressed the impact of this macrophage phenotype on CD8(+) T cell activation by ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2015, 83:77-88]

Cited: 16 times

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Activation of the peroxisome proliferator-activated receptor γ counteracts sepsis-induced T cell cytotoxicity toward alloantigenic target cells.

Andreas von Knethen, Lisa Katharina Sha, Tilo Knape, Laura Kuchler, Annika Klara Giegerich, Martin Schulz, Ingeborg A Hauser, Bernhard Brüne,

<h4>Unlabelled</h4>Sepsis still emerges as a major cause of patient death in intensive care units. Therefore, new therapeutic approaches are mandatory. Because during sepsis progression cytotoxic T lymphocytes (CTLs) can be activated in an autoimmune fashion contributing to multiorgan damage, it remains unclear whether CTLs are activated toward alloantigenic cells. This ... Read more >>

J Mol Med (Berl) (Journal of molecular medicine (Berlin, Germany))
[2015, 93(6):633-644]

Cited: 1 time

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Cytokines induce protein kinase A-mediated signalling by a redox-dependent mechanism in rat renal mesangial cells.

Karl-Friedrich Beck, Johannes Euler, Florian Eisel, Martina Beck, Yvette Köhler, Lisa Katharina Sha, Andreas von Knethen, Sebastian Longen, Josef Pfeilschifter,

Glomerular mesangial cells are smooth muscle cell-like pericytes and are regarded as key players in kidney diseases. In an inflammatory setting, these cells produce high amounts of inflammatory cytokines, chemokines and redox mediators such as reactive oxygen species or nitric oxide (NO). The temporal production of ROS, NO and other ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2015, 93(3):362-369]

Cited: 2 times

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