Full Text Journal Articles by
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Diabetic Ketoacidosis at Manifestation of Type 1 Diabetes in Childhood and Adolescence—Incidence and Risk Factors.

Hugo Segerer, Michael Wurm, Julia M Grimsmann, Beate Karges, Andreas Neu, Marina Sindichakis, Katharina Warncke, Axel Dost, Reinhard W Holl,

<h4>Background</h4>Diabetic ketoacidosis (DKA) is a potentially life-threatening metabolic disorder that can occur with manifestation of type 1 diabetes mellitus (T1D). The aim of this study was to analyze the incidence of DKA at the time of the diagnosis of T1D in childhood and adolescence, the risk factors, and regional approaches ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Praktische Empfehlungen der Deutschen Diabetes Gesellschaft zum Diabetesmanagement bei Patientinnen und Patienten mit einer COVID-19-Erkrankung Practical recommendations of the German Diabetes Society for the management of diabetes in patients with COVID-19

Stefan R. Bornstein, Baptist Gallwitz, Monika Kellerer, Barbara Ludwig, Dirk Müller-Wieland, Andreas Neu, Hans-Martin Reuter, Michael Roden, Jochen Seufert,

Bei Menschen mit einer Infektion mit dem neuartigen Coronavirus SARS-CoV-2 und einer COVID-19-Erkrankung sind Diabetes mellitus und kardiovaskuläre Erkrankungen sehr häufige Komorbiditäten. Patienten mit Diabetes und Begleit- beziehungsweise Folgeerkrankungen scheinen ein erhöhtes Risiko für einen schweren Krankheitsverlauf bei COVID-19 einschließlich ARDS und Multiorganversagen zu haben. Die genauen Zusammenhänge zwischen Diabetes ... Read more >>

(Der Diabetologe)
[2021, :1-6]

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Use of insulin pump therapy is associated with reduced hospital-days in the long-term: a real-world study of 48,756 pediatric patients with type 1 diabetes.

Marie Auzanneau, Beate Karges, Andreas Neu, Thomas Kapellen, Stefan A Wudy, Corinna Grasemann, Gabriele Krauch, Eva Maria Gerstl, Gerhard Däublin, Reinhard W Holl,

In pediatric diabetes, insulin pump therapy is associated with less acute complications but inpatient pump education may lead to more hospital days. We investigated the number of hospital days associated with pump vs. injection therapy between 2009 and 2018 in 48,756 patients with type 1 diabetes < 20 years of ... Read more >>

Eur J Pediatr (European journal of pediatrics)
[2021, 180(2):597-606]

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Additional Insulin for Coping with Fat- and Protein-Rich Meals in Adolescents with Type 1 Diabetes: The Protein Unit.

Roland Schweizer, Susann Herrlich, Martina Lösch-Binder, Michaela Glökler, Magdalena Heimgärtner, Franziska Liebrich, Katja Meßner, Tina Muckenhaupt, Angelika Schneider, Julian Ziegler, Andreas Neu,

OBJECTIVE:Dietary proteins raise blood glucose levels; dietary fats delay this rise. We sought to assess the insulin amount required to normalize glucose levels after a fat- and protein-rich meal (FPRM). METHODS:Sixteen adolescents (5 female) with type 1 diabetes (median age: 18.2 years; range: 15.2-24.0; duration: 7.1 years; 2.3-14.3; HbA1c: 7.2%; ... Read more >>

Exp Clin Endocrinol Diabetes (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association)
[2020, :]

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Children with onset-ketoacidosis are admitted to the nearest hospital available, regardless of center size.

Katrin Nagl, Joachim Rosenbauer, Andreas Neu, Thomas M Kapellen, Beate Karges, Tanja Rojacher, Julia Hermann, Birgit Rami-Merhar, Reinhard W Holl, ,

Background To investigate longitudinal trends of admissions with diabetic ketoacidosis (DKA) in new-onset type 1 diabetes (T1D) and subsequent duration of hospitalization in association with structural health care properties, such as size of treatment facility, population density and linear distance between home and treatment centers. Methods Data from 24,321 German ... Read more >>

J Pediatr Endocrinol Metab (Journal of pediatric endocrinology & metabolism : JPEM)
[2020, 33(6):751-759]

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Diagnosis, Therapy and Follow-Up of Diabetes Mellitus in Children and Adolescents.

Andreas Neu, Jutta Bürger-Büsing, Thomas Danne, Axel Dost, Martin Holder, Reinhard W Holl, Paul-Martin Holterhus, Thomas Kapellen, Beate Karges, Olga Kordonouri, Karin Lange, Susanne Müller, Klemens Raile, Roland Schweizer, Simone von Sengbusch, Rainer Stachow, Verena Wagner, Susanna Wiegand, Ralph Ziegler,

Exp Clin Endocrinol Diabetes (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association)
[2019, 127(S 01):S39-S72]

Cited: 1 time

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Hospitalization in Pediatric Diabetes: A Nationwide Analysis of all Admission Causes for Germany in 2015.

Marie Auzanneau, Joachim Rosenbauer, Andrea Icks, Beate Karges, Andreas Neu, Ralph Ziegler, Wolfgang Marg, Thomas Kapellen, Paul-Martin Holterhus, Reinhard W Holl,

<h4>Introduction</h4>Regarding pediatric diabetes, hospital admission for acute complications of type 1 diabetes (T1D) has often been investigated, but little is known about other causes of hospitalization. This study aimed to explore the total burden of hospitalization in individuals with diabetes<20 years of age in Germany.<h4>Methods</h4>Using the German Diagnosis-Related Groups data ... Read more >>

Exp Clin Endocrinol Diabetes (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association)
[2020, 128(9):615-623]

Cited: 1 time

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Diagnosis, Therapy and Follow-up of Diabetes Mellitus in Children and Adolescents.

Andreas Neu, Jutta Bürger-Büsing, Thomas Danne, Axel Dost, Martin Holder, Reinhard W Holl, Paul-Martin Holterhus, Thomas Kapellen, Beate Karges, Olga Kordonouri, Karin Lange, Susanne Müller, Klemens Raile, Roland Schweizer, Simone von Sengbusch, Rainer Stachow, Verena Wagner, Susanna Wiegand, Ralph Ziegler,

Exp Clin Endocrinol Diabetes (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association)
[2019, 127(6):341-352]

Cited: 1 time

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Trends and cyclical variation in the incidence of childhood type 1 diabetes in 26 European centres in the 25 year period 1989-2013: a multicentre prospective registration study.

Christopher C Patterson, Valma Harjutsalo, Joachim Rosenbauer, Andreas Neu, Ondrej Cinek, Torild Skrivarhaug, Birgit Rami-Merhar, Gyula Soltesz, Jannet Svensson, Roger C Parslow, Conxa Castell, Eugen J Schoenle, Polly J Bingley, Gisela Dahlquist, Przemysława K Jarosz-Chobot, Dalė Marčiulionytė, Edna F Roche, Ulrike Rothe, Natasa Bratina, Constantin Ionescu-Tirgoviste, Ilse Weets, Mirjana Kocova, Valentino Cherubini, Natasa Rojnic Putarek, Carine E deBeaufort, Mira Samardzic, Anders Green,

<h4>Aims/hypothesis</h4>Against a background of a near-universally increasing incidence of childhood type 1 diabetes, recent reports from some countries suggest a slowing in this increase. Occasional reports also describe cyclical variations in incidence, with periodicities of between 4 and 6 years.<h4>Methods</h4>Age/sex-standardised incidence rates for the 0- to 14-year-old age group are reported ... Read more >>

Diabetologia (Diabetologia)
[2019, 62(3):408-417]

Cited: 46 times

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Diabetes in Childhood and Adolescence.

Ralph Ziegler, Andreas Neu,

BACKGROUND:The incidence of type 1 diabetes mellitus in childhood and adolescence is steadily rising and now stands at 22.9 new cases per year per 100 000 persons up to age 15. METHODS:This review is based on pertinent publications retrieved by a selective literature search, with special attention to the current ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2018, 115(9):146-156]

Cited: 4 times

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Targets and teamwork: Understanding differences in pediatric diabetes centers treatment outcomes.

Timothy C Skinner, Karin S Lange, Hilary Hoey, Henrik B Mortensen, Henk-Jan Aanstoot, Luis Castaňo, Soren Skovlund, Peter Gf Swift, Fergus J Cameron, Harry R Dorchy, Mark R Palmert, Eero Kaprio, Jean-Jacques Robert, Thomas Danne, Andreas Neu, Shlomit Shalitin, Francesco Chiarelli, Giovanni Chiari, Tatsuhiko Urakami, Pål R Njølstad, Premyslawa K Jarosz-Chobot, Edna F Roche, Cintia G Castro-Correia, Mirjana Kocova, Jan Åman, Eugen Schönle, Timothy G Barrett, Lynda Fisher, Carine E de Beaufort, ,

OBJECTIVE:The reason for center differences in metabolic control of childhood diabetes is still unknown. We sought to determine to what extent the targets, expectations, and goals that diabetes care professionals have for their patients is a determinant of center differences in metabolic outcomes. RESEARCH DESIGN AND METHODS:Children, under the age ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2018, 19(3):559-565]

Cited: 2 times

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Low association between fasting and OGTT stimulated glucose levels with HbA1c in overweight children and adolescents.

Stefan Ehehalt, Susanna Wiegand, Antje Körner, Roland Schweizer, Klaus-Peter Liesenkötter, Carl-Joachim Partsch, Gunnar Blumenstock, Ulrike Spielau, Christian Denzer, Michael B Ranke, Andreas Neu, Gerhard Binder, Martin Wabitsch, Wieland Kiess, Thomas Reinehr,

<h4>Background</h4>Diabetes and prediabetes are defined based on different methods such as fasting glucose, glucose at 2-hour in oral glucose tolerance test (OGTT), and glycated hemoglobin A1c (HbA1c). These parameters probably describe different deteriorations in glucose metabolism limiting the exchange between each other in definitions of diabetes.<h4>Objective</h4>To investigate the relationship between ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2017, 18(8):734-741]

Cited: 5 times

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Diabetes screening in overweight and obese children and adolescents: choosing the right test.

Stefan Ehehalt, Susanna Wiegand, Antje Körner, Roland Schweizer, Klaus-Peter Liesenkötter, Carl-Joachim Partsch, Gunnar Blumenstock, Ulrike Spielau, Christian Denzer, Michael B Ranke, Andreas Neu, Gerhard Binder, Martin Wabitsch, Wieland Kiess, Thomas Reinehr,

Type 2 diabetes can occur without any symptoms, and health problems associated with the disease are serious. Screening tests allowing an early diagnosis are desirable. However, optimal screening tests for diabetes in obese youth are discussed controversially. We performed an observational multicenter analysis including 4848 (2668 female) overweight and obese ... Read more >>

Eur J Pediatr (European journal of pediatrics)
[2017, 176(1):89-97]

Cited: 9 times

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The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus.

Simranjeet Kaur, Aashiq H Mirza, Caroline A Brorsson, Tina Fløyel, Joachim Størling, Henrik B Mortensen, Flemming Pociot, ,

The study aimed to explore the role of ERBB3 in type 1 diabetes (T1D). We examined whether genetic variation of ERBB3 (rs2292239) affects residual β-cell function in T1D cases. Furthermore, we examined the expression of ERBB3 in human islets, the effect of ERBB3 knockdown on apoptosis in insulin-producing INS-1E cells ... Read more >>

Mol Cell Endocrinol (Molecular and cellular endocrinology)
[2016, 419:83-91]

Cited: 13 times

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Trends in Incidence Rates during 1999-2008 and Prevalence in 2008 of Childhood Type 1 Diabetes Mellitus in Germany--Model-Based National Estimates.

Alexander Bendas, Ulrike Rothe, Wieland Kiess, Thomas Michael Kapellen, Thoralf Stange, Ulf Manuwald, Eckhard Salzsieder, Reinhard Walter Holl, Olaf Schoffer, Anna Stahl-Pehe, Guido Giani, Stefan Ehehalt, Andreas Neu, Joachim Rosenbauer,

<h4>Aims</h4>To estimate the national incidence rate and trend of type 1 diabetes (T1DM) in Germany from 1999 to 2008 and the national prevalence in 2008 in the age group 0-14 years.<h4>Methods</h4>Data were taken from a nationwide registry for incident cases of T1DM in the ages 0-4 years and 3 regional ... Read more >>

PLoS One (PloS one)
[2015, 10(7):e0132716]

Cited: 30 times

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Hospital admission for diabetic ketoacidosis or severe hypoglycemia in 31,330 young patients with type 1 diabetes.

Beate Karges, Joachim Rosenbauer, Paul-Martin Holterhus, Peter Beyer, Horst Seithe, Christian Vogel, Andreas Böckmann, Dirk Peters, Silvia Müther, Andreas Neu, Reinhard W Holl, ,

<h4>Objective</h4>To investigate rates and risk factors of hospital admission for diabetic ketoacidosis (DKA) or severe hypoglycemia in young patients with established type 1 diabetes.<h4>Design</h4>In total, 31,330 patients with type 1 diabetes (median age 12.7 years) from the Diabetes Patienten Verlaufsdokumentation (DPV) Prospective Diabetes Registry treated between 2011 and 2013 in ... Read more >>

Eur J Endocrinol (European journal of endocrinology)
[2015, 173(3):341-350]

Cited: 24 times

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Changes in whole-body fat distribution, intrahepatic lipids, and insulin resistance of obese adolescents during a low-level lifestyle intervention.

Fabian Springer, Verena Ballweg, Roland Schweizer, Fritz Schick, Michael B Ranke, Gerhard Binder, Stefan Ehehalt, ,

<h4>Unlabelled</h4>The aim of this study was to analyze changes in adipose tissue (AT) distribution, intrahepatic lipids (IHL), and insulin resistance (IR) among a group of obese adolescents undergoing a 7-months low-level lifestyle intervention. Thirty-nine obese Caucasian adolescents (mean age 13.9 years, body mass index standard deviation score (BMI-SDSLMS) 2.14) were ... Read more >>

Eur J Pediatr (European journal of pediatrics)
[2015, 174(12):1603-1612]

Cited: 2 times

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Optimizing insulin pump therapy: the potential advantages of using a structured diabetes management program.

Karin Lange, Ralph Ziegler, Andreas Neu, Thomas Reinehr, Iris Daab, Marion Walz, Michael Maraun, Oliver Schnell, Bernhard Kulzer, Andreas Reichel, Lutz Heinemann, Christopher G Parkin, Thomas Haak,

Use of continuous subcutaneous insulin infusion (CSII) therapy improves glycemic control, reduces hypoglycemia and increases treatment satisfaction in individuals with diabetes. As a number of patient- and clinician-related factors can hinder the effectiveness and optimal usage of CSII therapy, new approaches are needed to address these obstacles. Ceriello and colleagues ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2015, 31(3):477-485]

Cited: 1 time

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Higher glucose concentrations following protein- and fat-rich meals - the Tuebingen Grill Study: a pilot study in adolescents with type 1 diabetes.

Andreas Neu, Fabian Behret, Regina Braun, Susann Herrlich, Franziska Liebrich, Martina Loesch-Binder, Angelika Schneider, Roland Schweizer,

Traditionally insulin dosage is focused on the carbohydrate amount of meals. We investigated the influence of a fat- and protein-rich meal in the evening on glucose concentration over night in adolescents with type 1 diabetes.Fifteen patients, mean age 16.8 [standard deviation (SD) 2.9] yr participated in the study. Mean glycated ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2015, 16(8):587-591]

Cited: 14 times

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GAD-treatment of children and adolescents with recent-onset type 1 diabetes preserves residual insulin secretion after 30 months.

Johnny Ludvigsson, Mikael Chéramy, Stina Axelsson, Mikael Pihl, Linda Akerman, Rosaura Casas, ,

<h4>Background</h4>This study aimed to analyse data from two different studies (phase II and phase III) regarding the safety and efficacy of treatment with alum formulated glutamic acid decarboxylase GAD65 (GAD-alum) at 30 months after administration to children and adolescents with type 1 diabetes.<h4>Methods</h4>The phase II trial was a double-blind, randomised ... Read more >>

Diabetes Metab Res Rev (Diabetes/metabolism research and reviews)
[2014, 30(5):405-414]

Cited: 16 times

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Do eating behaviors in the general population account for country variance in glycemic control among adolescents with diabetes: the Hvidoere Study Group and the Health Behaviour in School-Aged Children study.

Pernille Due, Carine de Beaufort, Mogens Trab Damsgaard, Henrik Bindesbøl Mortensen, Mette Rasmussen, Naman Ahluwalia, Timothy Skinner, Peter Swift, ,

<h4>Background</h4>The Hvidoere Study Group (HSG) has demonstrated major differences in glycemic control between pediatric diabetes centers which remain largely unexplained. This study investigates whether these differences are partly attributable to healthy eating norms in the background population.<h4>Methods</h4>The study involved adolescents from 18 countries from (i) the Health Behaviour in School-Aged ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2013, 14(8):554-561]

Cited: 2 times

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Metabolic outcomes in young children with type 1 diabetes differ between treatment centers: the Hvidoere Study in Young Children 2009.

Carine E de Beaufort, Karin Lange, Peter G F Swift, Jan Aman, Fergus Cameron, Luis Castano, Harry Dorchy, Lynda K Fisher, Hilary Hoey, Eero Kaprio, Mirjana Kocova, Andreas Neu, Pal R Njolstad, Moshe Phillip, Eugen Schoenle, Jean J Robert, Tatsuhiko Urukami, Maurizio Vanelli, Thomas Danne, Tim Barrett, Franco Chiarelli, Henk J Aanstoot, Henrik B Mortensen, ,

<h4>Objective</h4>To investigate whether center differences in glycemic control are present in prepubertal children <11 yr with type 1 diabetes mellitus.<h4>Research design and methods</h4>This cross-sectional study involved 18 pediatric centers worldwide. All children, <11 y with a diabetes duration ≥12 months were invited to participate. Case Record Forms included information on clinical characteristics, ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2013, 14(6):422-428]

Cited: 25 times

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GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus.

Johnny Ludvigsson, David Krisky, Rosaura Casas, Tadej Battelino, Luis Castaño, James Greening, Olga Kordonouri, Timo Otonkoski, Paolo Pozzilli, Jean-Jacques Robert, Henk J Veeze, Jerry Palmer, Ulf Samuelsson, Helena Elding Larsson, Jan Åman, Gunilla Kärdell, Jan Neiderud Helsingborg, Göran Lundström, Eva Albinsson, Annelie Carlsson, Maria Nordvall, Hans Fors, Carl-Göran Arvidsson, Stig Edvardson, Ragnar Hanås, Karin Larsson, Björn Rathsman, Henrik Forsgren, Helena Desaix, Gun Forsander, Nils-Östen Nilsson, Carl-Göran Åkesson, Päivi Keskinen, Riitta Veijola, Timo Talvitie, Klemens Raile, Thomas Kapellen, Walter Burger, Andreas Neu, Ilse Engelsberger, Bettina Heidtmann, Suzanne Bechtold, David Leslie, Francesco Chiarelli, Alesandro Cicognani, Giuseppe Chiumello, Franco Cerutti, Gian Vincenzo Zuccotti, Ana Gomez Gila, Itxaso Rica, Raquel Barrio, Maria Clemente, Maria José López Garcia, Mercedes Rodriguez, Isabel Gonzalez, Juan Pedro Lopez, Mirentxu Oyarzabal, H M Reeser, Roos Nuboer, Pauline Stouthart, Natasa Bratina, Nina Bratanic, Marc de Kerdanet, Jacques Weill, Nicole Ser, Pascal Barat, Anne Marie Bertrand, Jean-Claude Carel, Rachel Reynaud, Regis Coutant, Sabine Baron,

<h4>Background</h4>The 65-kD isoform of glutamic acid decarboxylase (GAD65) is a major autoantigen in type 1 diabetes. We hypothesized that alum-formulated GAD65 (GAD-alum) can preserve beta-cell function in patients with recent-onset type 1 diabetes.<h4>Methods</h4>We studied 334 patients, 10 to 20 years of age, with type 1 diabetes, fasting C-peptide levels of ... Read more >>

N Engl J Med (The New England journal of medicine)
[2012, 366(5):433-442]

Cited: 155 times

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Variants of the FTO gene in obese children and their impact on body composition and metabolism before and after lifestyle intervention.

J Schum, G Blumenstock, K Weber, R Schweizer, C Pfaff, N Schurr, M B Ranke, G Binder, S Ehehalt, ,

<h4>Objective</h4>To investigate the impact of variants of the FTO gene (rs1421085, rs17817449, rs9939609) in obese children before and after lifestyle intervention.<h4>Method</h4><h4>Design</h4>Longitudinal, clinical intervention study with an increase in physical activity, and nutritional recommendations based on the 'Optimized Mixed Diet for German Children and Adolescents' (Research Institute of Child Nutrition, Germany).<h4>Study ... Read more >>

Exp Clin Endocrinol Diabetes (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association)
[2012, 120(3):128-131]

Cited: 5 times

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Prediction model for the incidence and prevalence of type 1 diabetes in childhood and adolescence: evidence for a cohort-dependent increase within the next two decades in Germany.

Stefan Ehehalt, Klaus Dietz, Andre Manfred Willasch, Andreas Neu, ,

<h4>Objective</h4>To provide data on type 1 diabetes (T1D) epidemiology in childhood over a period of 20 years and to predict prevalence and cohort-age-specific incidence rates (IRs) for the next two decades in Germany.<h4>Methods</h4>The Baden-Wuerttemberg Diabetes Incidence Registry (DIARY) includes children and adolescents below 15 years of age with new onset ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2012, 13(1):15-20]

Cited: 21 times

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