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Author Andreas Kronbichler

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COVID-19: implications for immunosuppression in kidney disease and transplantation.

Andreas Kronbichler, Philipp Gauckler, Martin Windpessl, Jae Il Shin, Vivekanand Jha, Brad H Rovin, Rainer Oberbauer,

Nat Rev Nephrol (Nature reviews. Nephrology)
[2020, :]

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A Review of Pre-Exposure Prophylaxis Adherence among Female Sex Workers.

Ramy Abou Ghayda, Sung Hwi Hong, Jae Won Yang, Gwang Hun Jeong, Keum Hwa Lee, Andreas Kronbichler, Marco Solmi, Brendon Stubbs, Ai Koyanagi, Louis Jacob, Hans Oh, Jong Yeob Kim, Jae Il Shin, Lee Smith,

Globally and in Africa specifically, female sex workers (FSWs) are at an extraordinarily high risk of contracting human immunodeficiency virus (HIV). Pre-exposure prophylaxis (PrEP) has emerged as an effective and ethical method with which to prevent HIV infection among FSWs. PrEP efficacy is, however, closely linked to adherence, and adherence ... Read more >>

Yonsei Med. J. (Yonsei medical journal)
[2020, 61(5):349-358]

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Comorbidities in ANCA-associated vasculitis.

Andreas Kronbichler, Johannes Leierer, Philipp Gauckler, Jae Il Shin,

The prognosis of patients with ANCA-associated vasculitis has improved over the past decades, but overall survival rates are still unsatisfactory. Recent research has focused on complications of immunosuppressive measures and comorbidities of ANCA-associated vasculitis. This review focuses on thromboembolic and cardiovascular events. A considerably increased risk of thromboembolic events has ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2020, 59(Supplement_3):iii79-iii83]

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Anthropometric Variables as Predictors of Semen Parameters and Fertility Outcomes after Varicocelectomy.

Ramy Abou Ghayda, Robert Zakhia El-Doueihi, Jun Young Lee, Muhammad Bulbul, Nassib Abou Heidar, Jad Bulbul, Samer Asmar, Sung Hwi Hong, Jae Won Yang, Andreas Kronbichler, Jae Il Shin,

Varicocele is the most common correctable male infertility factor and varicocelectomy has been a mainstay in the management of infertility. However, the role of varicocelectomy as a treatment option has been controversial, and the scientific debate around it is still ongoing. Our study aimed to explore the role of anthropometric ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(4):]

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Association of the COVID-19 pandemic with Internet Search Volumes: A Google TrendsTM Analysis.

Maria Effenberger, Andreas Kronbichler, Jae Il Shin, Gert Mayer, Herbert Tilg, Paul Perco,

OBJECTIVES:To assess the association of public interest in coronavirus infections with the actual number of infected cases for selected countries across the globe. METHODS:We performed a Google TrendsTM search for "Coronavirus" and compared Relative Search Volumes (RSV) indices to the number of reported COVID-19 cases by the European Center for ... Read more >>

Int. J. Infect. Dis. (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2020, 95:192-197]

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Is There Decreasing Public Interest in Renal Transplantation? A Google TrendsTM Analysis.

Andreas Kronbichler, Maria Effenberger, Jae Il Shin, Christian Koppelstätter, Sara Denicolò, Michael Rudnicki, Hannes Neuwirt, Maria José Soler, Kate Stevens, Annette Bruchfeld, Herbert Tilg, Gert Mayer, Paul Perco,

BACKGROUND AND OBJECTIVES:Renal transplantation is the preferred form of renal replacement therapy for the majority of patients with end stage renal disease (ESRD). The Internet is a key tool for people seeking healthcare-related information. This current work explored the interest in kidney transplantation based on Internet search queries using Google ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(4):]

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Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome: A systematic review.

Jae Hyon Park, Keum Hwa Lee, Bokyoung Jeon, Hans D Ochs, Joon Suk Lee, Heon Yung Gee, Seeun Seo, Dongil Geum, Ciriaco A Piccirillo, Michael Eisenhut, Hans J van der Vliet, Jiwon M Lee, Andreas Kronbichler, Younhee Ko, Jae Il Shin,

BACKGROUND:Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a monogenic disorder characterized by early onset fatal multi-system autoimmunity due to loss-of-function mutations in the gene encoding the forkhead box P3 (FOXP3) transcription factor which is crucial for the development, maturation, and maintenance of CD4+ regulatory T (T-reg) cells. Various autoimmune ... Read more >>

Autoimmun Rev (Autoimmunity reviews)
[2020, 19(6):102526]

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Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta-analysis.

Jae Hyon Park, Gwang Hun Jeong, Kwang Seob Lee, Keum Hwa Lee, Jin-Soon Suh, Michael Eisenhut, Hans J van der Vliet, Andreas Kronbichler, Brendon Stubbs, Marco Solmi, Elena Dragioti, Ai Koyanagi, Jae Il Shin, Gabriele Gamerith,

BACKGROUND:Cancer risk has been associated with certain gene variations in microRNA (miRNA), but conflicting evidence warrants re-assessing of significant results in meta-analyses. We summarized published meta-analyses that assess the associations between miRNA polymorphism and cancers to show the validity of the findings. METHOD:We searched PubMed and investigated the results of ... Read more >>

Eur. J. Clin. Invest. (European journal of clinical investigation)
[2020, 50(4):e13203]

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Lessons learned from immunoadsorption for hyperviscosity in IgM multiple myeloma-A case report.

Philipp Gauckler, Johannes Leierer, Florian Kocher, Clemens Feistritzer, Wolfgang Willenbacher, Eberhard Gunsilius, Dominik Wolf, Hannes Neuwirt, Gert Mayer, Andreas Kronbichler,

We report the case of a 63-year-old Caucasian woman with multiple relapsed IgM multiple myeloma (MM) and elevated free kappa light chains (fκLC). Due to hyperviscosity syndrome with visual impairment, regular plasma exchanges were performed. As part of her 11th line of therapy, an experimental protocol consisting of pembrolizumab, pomalidomide, ... Read more >>

J Clin Apher (Journal of clinical apheresis)
[2020, :]

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Clinical associations of renal involvement in ANCA-associated vasculitis.

Andreas Kronbichler, Jae Il Shin, Keum Hwa Lee, Daiki Nakagomi, Luis F Quintana, Martin Busch, Anthea Craven, Raashid A Luqmani, Peter A Merkel, Gert Mayer, David R W Jayne, Richard A Watts,

OBJECTIVE:Renal involvement in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis is associated with significant morbidity and higher mortality rates. This study examined clinical manifestations associated with renal involvement in ANCA-associated vasculitis within a large, international cross-sectional cohort. METHODS:Univariate and multivariate analyses were performed to identify clinical factors associated with renal disease, which ... Read more >>

Autoimmun Rev (Autoimmunity reviews)
[2020, 19(4):102495]

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Is There a Role for LAMP-2 Autoantibodies in Patients with Antineutrophil Cytoplasmic Antibody-associated Vasculitis?

Sergey Moiseev, Anastasiia Zykova, Nikolay Bulanov, Evgeny Gitel, Pavel Novikov, Mayra Bulanova, Andreas Kronbichler, David Jayne,

J. Rheumatol. (The Journal of rheumatology)
[2020, 47(4):636-638]

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Current understandings in treating children with steroid-resistant nephrotic syndrome.

Jiwon M Lee, Andreas Kronbichler, Jae Il Shin, Jun Oh,

Steroid-resistant nephrotic syndrome (SRNS) remains a challenge for paediatric nephrologists. SRNS is viewed as a heterogeneous disease entity including immune-based and monogenic aetiologies. Because SRNS is rare, treatment strategies are individualized and vary among centres of expertise. Calcineurin inhibitors (CNI) have been effectively used to induce remission in patients with ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, :]

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Statin and Cancer Mortality and Survival: An Umbrella Systematic Review and Meta-Analysis.

Gwang Hun Jeong, Keum Hwa Lee, Jong Yeob Kim, Michael Eisenhut, Andreas Kronbichler, Hans J van der Vliet, Jae Il Shin, Gabriele Gamerith,

The aim of this study is to provide an overview and understand the strength of evidence and the extent of potential biases and the validity of claimed associations between the use of statins and cancer mortality or survival. We performed a comprehensive umbrella review of meta-analyses and systematically appraised the ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(2):]

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Clinical Interventions and All-Cause Mortality of Patients with Chronic Kidney Disease: An Umbrella Systematic Review of Meta-Analyses.

Jong Yeob Kim, Johanna Steingroever, Keum Hwa Lee, Jun Oh, Min Jae Choi, Jiwon Lee, Nicholas G Larkins, Franz Schaefer, Sung Hwi Hong, Gwang Hun Jeong, Jae Il Shin, Andreas Kronbichler,

Patients with chronic kidney disease (CKD) have altered physiologic processes, which result in different treatment outcomes compared with the general population. We aimed to systematically evaluate the efficacy of clinical interventions in reducing mortality of patients with CKD. We searched PubMed, MEDLINE, Embase, and Cochrane Database of Systematic Reviews for ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(2):]

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Treatment of refractory IgA vasculitis with dapsone: a systematic review.

Keum Hwa Lee, Sung Hwi Hong, Jinhae Jun, Youngheun Jo, Woogyeong Jo, Dayeon Choi, Jeongho Joo, Guhyun Jung, Sunghee Ahn, Andreas Kronbichler, Michael Eisenhut, Jae Il Shin,

IgA vasculitis, formerly known as Henoch-Schönlein purpura, is a systemic IgA-mediated vasculitis of the small vessels commonly seen in children. The natural history of IgA vasculitis is generally self-limiting; however, one-third of patients experience symptom recurrence and a refractory course. This systematic review examined the use of dapsone in refractory ... Read more >>

Clin Exp Pediatr (Clinical and experimental pediatrics)
[2020, 63(5):158-163]

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Corrigendum to "Association between Serum Matrix Metalloproteinase- (MMP-) 3 Levels and Systemic Lupus Erythematosus: A Meta-Analysis".

Jiwon M Lee, Andreas Kronbichler, Se Jin Park, Seong Heon Kim, Kyoung Hee Han, Hee Gyung Kang, Il Soo Ha, Hae Il Cheong, Ki Hwan Kim, Gaeun Kim, Dong Soo Kim, Hyun Wook Chae, Chul Ho Lee, Keum Hwa Lee, Jae Il Shin,

[This corrects the article DOI: 10.1155/2019/9796735.]. ... Read more >>

Dis. Markers (Disease markers)
[2020, 2020:5943216]

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Understanding the immunopathogenesis of autoimmune diseases by animal studies using gene modulation: A comprehensive review.

Keum Hwa Lee, Byung Soo Ahn, Dohyeon Cha, Won Woo Jang, Eugene Choi, Soohyun Park, Jun Hyeong Park, Junseok Oh, Da Eun Jung, Heeryun Park, Ju Ha Park, Youngsong Suh, Dongwan Jin, Siyeon Lee, Yong-Hwan Jang, Tehwook Yoon, Min-Kyu Park, Yoonje Seong, Jihoon Pyo, Sunmo Yang, Youngin Kwon, Hyunjean Jung, Chae Kwang Lim, Jun Beom Hong, Yeoeun Park, Eunjin Choi, Jae Il Shin, Andreas Kronbichler,

Autoimmune diseases are clinical syndromes that result from pathogenic inflammatory responses driven by inadequate immune activation by T- and B-cells. Although the exact mechanisms of autoimmune diseases are still elusive, genetic factors also play an important role in the pathogenesis. Recently, with the advancement of understanding of the immunological and ... Read more >>

Autoimmun Rev (Autoimmunity reviews)
[2020, 19(3):102469]

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Efficacy of Cancer Immunotherapy: An Umbrella Review of Meta-analyses of Randomized Controlled Trials.

Jong Yeob Kim, Keum Hwa Lee, Michael Eisenhut, Hans J van der Vliet, Andreas Kronbichler, Gwang Hun Jeong, Jae Il Shin, Gabriele Gamerith,

We conducted a systematic review for evidence of the clinical efficacy of cancer immunotherapies. We searched PubMed from inception to 14 February 2018 for meta-analyses of randomized controlled trials (RCTs) of cancer immunotherapies. Re-analyses were performed to estimate the summary effect size under random-effects, the 95% confidence interval (CI), heterogeneity, ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(11):]

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A hemodialysis patient with bone disease after pregnancy: a case report.

Hannelore Sprenger-Mähr, Emanuel Zitt, Andreas Kronbichler, Manfred Cejna, Karl Lhotta,

BACKGROUND:Pregnancy is rare in women on hemodialysis. Recommendations for the treatment of secondary hyperparathyroidism (sHPT) and preservation of bone health in pregnant dialysis patients are lacking. CASE PRESENTATION:We present the case of a young woman with end-stage kidney disease (ESKD) due to lupus nephritis, who developed multiple brown tumors while ... Read more >>

BMC Nephrol (BMC nephrology)
[2019, 20(1):425]

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Tumor Mutational Burden and Efficacy of Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis.

Jong Yeob Kim, Andreas Kronbichler, Michael Eisenhut, Sung Hwi Hong, Hans J van der Vliet, Jeonghyun Kang, Jae Il Shin, Gabriele Gamerith,

Tumor mutational burden (TMB) is a genomic biomarker that predicts favorable responses to immune checkpoint inhibitors (ICIs). Here, we set out to assess the predictive value of TMB on long-term survival outcomes in patients undergoing ICIs. We systematically searched PubMed, Embase, CENTRAL and clinicaltrials.gov from inception to 6 August 2019. ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(11):]

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The composition and functional protein subsystems of the human nasal microbiome in granulomatosis with polyangiitis: a pilot study.

Josef Wagner, Ewan M Harrison, Marcos Martinez Del Pero, Beth Blane, Gert Mayer, Johannes Leierer, Seerapani Gopaluni, Mark A Holmes, Julian Parkhill, Sharon J Peacock, David R W Jayne, Andreas Kronbichler,

BACKGROUND:Ear, nose and throat involvement in granulomatosis with polyangiitis (GPA) is frequently the initial disease manifestation. Previous investigations have observed a higher prevalence of Staphylococcus aureus in patients with GPA, and chronic nasal carriage has been linked with an increased risk of disease relapse. In this cross-sectional study, we investigated ... Read more >>

Microbiome (Microbiome)
[2019, 7(1):137]

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Review on long-term non-renal complications of childhood nephrotic syndrome.

Jiwon M Lee, Andreas Kronbichler, Jae Il Shin, Jun Oh,

BACKGROUND:Nephrotic syndrome (NS) is the most common glomerular childhood disease. A body of literature has described the long-term renal prognosis of childhood-onset idiopathic NS. However, the nonrenal outcomes have not been studied as much. AIM:We aimed to discuss the long-term non-renal outcomes of childhood NS, highlighting studies with a follow-up ... Read more >>

Acta Paediatr. (Acta paediatrica (Oslo, Norway : 1992))
[2020, 109(3):460-470]

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Hyperprogressive Disease during Anti-PD-1 (PDCD1) / PD-L1 (CD274) Therapy: A Systematic Review and Meta-Analysis.

Jong Yeob Kim, Keum Hwa Lee, Jeonghyun Kang, Edith Borcoman, Esma Saada-Bouzid, Andreas Kronbichler, Sung Hwi Hong, Leandro Fórnias Machado de Rezende, Shuji Ogino, Nana Keum, Mingyang Song, Claudio Luchini, Hans J van der Vliet, Jae Il Shin, Gabriele Gamerith,

Hyperprogressive disease (HPD) is a recently acknowledged pattern of rapid tumor progression after the initiation of immune checkpoint inhibitors. HPD has been observed across various types of tumors and has been associated with poor survival. We performed a meta-analysis to identify baseline (i.e., prior to programmed cell death 1 [PD-1, ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(11):]

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Rituximab in minimal change disease and focal segmental glomerulosclerosis.

Andreas Kronbichler, Philipp Gauckler, Annette Bruchfeld,

Nephrol. Dial. Transplant. (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2019, :]

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Association of Pulmonary Hemorrhage, Positive Proteinase 3, and Urinary Red Blood Cell Casts With Venous Thromboembolism in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

Andreas Kronbichler, Johannes Leierer, Jae Il Shin, Peter A Merkel, Robert Spiera, Philip Seo, Carol A Langford, Gary S Hoffman, Cees G M Kallenberg, E William St Clair, Paul Brunetta, Fernando C Fervenza, Duvuru Geetha, Karina A Keogh, Paul A Monach, Steven R Ytterberg, Gert Mayer, Ulrich Specks, John H Stone, ,

OBJECTIVE:To assess the frequency of venous thromboembolism (VTE) events in the Rituximab in Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis (RAVE) trial and identify novel potential risk factors. METHODS:VTE events in 197 patients enrolled in the RAVE trial were analyzed. Baseline demographic and clinical characteristics were recorded, and univariate and multivariate analyses ... Read more >>

(Arthritis & rheumatology (Hoboken, N.J.))
[2019, 71(11):1888-1893]

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