Full Text Journal Articles by
Author Andrea R Levine


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The Impact of Corticosteroids on Secondary Infection and Mortality in Critically Ill COVID-19 Patients.

Lindsay A Ritter, Noel Britton, Emily L Heil, William A Teeter, Sarah B Murthi, Jonathan H Chow, Emily Ricotta, Daniel S Chertow, Alison Grazioli, Andrea R Levine,

<h4>Background</h4>Corticosteroids are part of the treatment guidelines for COVID-19 and have been shown to improve mortality. However, the impact corticosteroids have on the development of secondary infection in COVID-19 is unknown. We sought to define the rate of secondary infection in critically ill patients with COVID-19 and determine the effect ... Read more >>

J Intensive Care Med (Journal of intensive care medicine)
[2021, 36(10):1201-1208]

Cited: 0 times

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Renin Kinetics Are Superior to Lactate Kinetics for Predicting In-Hospital Mortality in Hypotensive Critically Ill Patients.

Maniraj Jeyaraju, Michael T McCurdy, Andrea R Levine, Prasad Devarajan, Michael A Mazzeffi, Kristin E Mullins, Michaella Reif, David N Yim, Christopher Parrino, Allison S Lankford, Jonathan H Chow,

<h4>Objectives</h4>Whole blood lactate concentration is widely used in shock states to assess perfusion. We aimed to determine if the change in plasma renin concentration over time would be superior to the change in lactate concentration for predicting in-hospital mortality in hypotensive patients on vasopressors.<h4>Design</h4>Prospective, observational cohort study.<h4>Setting</h4>Tertiary academic ICU.<h4>Patients</h4>Adult patients ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

Cited: 0 times

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Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction.

Taijyu Satoh, Longfei Wang, Cristina Espinosa-Diez, Bing Wang, Scott A Hahn, Kentaro Noda, Elizabeth R Rochon, Matthew R Dent, Andrea R Levine, Jeffrey J Baust, Samuel Wyman, Yijen L Wu, Georgios A Triantafyllou, Ying Tang, Mike Reynolds, Sruti Shiva, Cynthia St Hilaire, Delphine Gomez, Dmitry A Goncharov, Elena A Goncharova, Stephen Y Chan, Adam C Straub, Yen-Chun Lai, Charles F McTiernan, Mark T Gladwin,

<h4>Background</h4>Many patients with heart failure with preserved ejection fraction have metabolic syndrome and develop exercise-induced pulmonary hypertension (EIPH). Increases in pulmonary vascular resistance in patients with heart failure with preserved ejection fraction portend a poor prognosis; this phenotype is referred to as combined precapillary and postcapillary pulmonary hypertension (CpcPH). Therapeutic ... Read more >>

Circulation (Circulation)
[2021, 144(8):615-637]

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SARS-CoV-2 infection of the oral cavity and saliva.

Ni Huang, Paola Pérez, Takafumi Kato, Yu Mikami, Kenichi Okuda, Rodney C Gilmore, Cecilia Domínguez Conde, Billel Gasmi, Sydney Stein, Margaret Beach, Eileen Pelayo, Jose O Maldonado, Bernard A Lafont, Shyh-Ing Jang, Nadia Nasir, Ricardo J Padilla, Valerie A Murrah, Robert Maile, William Lovell, Shannon M Wallet, Natalie M Bowman, Suzanne L Meinig, Matthew C Wolfgang, Saibyasachi N Choudhury, Mark Novotny, Brian D Aevermann, Richard H Scheuermann, Gabrielle Cannon, Carlton W Anderson, Rhianna E Lee, Julie T Marchesan, Mandy Bush, Marcelo Freire, Adam J Kimple, Daniel L Herr, Joseph Rabin, Alison Grazioli, Sanchita Das, Benjamin N French, Thomas Pranzatelli, John A Chiorini, David E Kleiner, Stefania Pittaluga, Stephen M Hewitt, Peter D Burbelo, Daniel Chertow, , , Karen Frank, Janice Lee, Richard C Boucher, Sarah A Teichmann, Blake M Warner, Kevin M Byrd,

Despite signs of infection-including taste loss, dry mouth and mucosal lesions such as ulcerations, enanthema and macules-the involvement of the oral cavity in coronavirus disease 2019 (COVID-19) is poorly understood. To address this, we generated and analyzed two single-cell RNA sequencing datasets of the human minor salivary glands and gingiva ... Read more >>

Nat Med (Nature medicine)
[2021, 27(5):892-903]

Cited: 32 times

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Seven-Year Follow-Up of an Online Critical Care Curriculum.

Ali Tabatabai, John C Greenwood, James H Lantry, Andrea R Levine, Nirav G Shah, William C Chiu, Nicholas A Morris, Jonathan H Chow, Samuel A Tisherman, Michael T McCurdy,

<b>Background:</b> In July of 2013, the University of Maryland launched MarylandCCProject.com. This free-access educational website delivers asynchronous high-quality multidisciplinary critical care education targeted at critical care trainees. The lectures, presented in real time on-site, are recorded and available on the website or as a podcast on iTunes or Android. Thus, ... Read more >>

ATS Sch (ATS scholar)
[2021, 2(2):224-235]

Cited: 0 times

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Impact of Sex and Metabolic Comorbidities on COVID-19 Mortality Risk Across Age Groups: 66,646 Inpatients Across 613 U.S. Hospitals.

Katherine E Goodman, Laurence S Magder, Jonathan D Baghdadi, Lisa Pineles, Andrea R Levine, Eli N Perencevich, Anthony D Harris,

<h4>Background</h4>The relationship between common patient characteristics, such as sex and metabolic comorbidities, and mortality from COVID-19 remains incompletely understood. Emerging evidence suggests that metabolic risk factors may also vary by age. This study aimed to determine the association between common patient characteristics and mortality across age-groups among COVID-19 inpatients.<h4>Methods</h4>We performed ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

Cited: 19 times

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Real-Time Remote Tele-Mentored Echocardiography: A Systematic Review.

Alexis Salerno, Diane Kuhn, Rayan El Sibai, Andrea R Levine, Michael T McCurdy,

<i>Background and Objectives</i>: Real-time remote tele-mentored echocardiography (RTMUS echo) involves the transmission of clinical ultrasound (CU) cardiac images with direct feedback from a CU expert at a different location. In this review, we summarize the current uses of RTMUS to diagnose and manage cardiovascular dysfunction and discuss expanded and future ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2020, 56(12):]

Cited: 0 times

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Initiation of a survey of healthcare worker distress and moral injury at the onset of the COVID-19 surge.

Stella E Hines, Katherine H Chin, Andrea R Levine, Emerson M Wickwire,

Am J Ind Med (American journal of industrial medicine)
[2020, 63(9):830-833]

Cited: 4 times

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Argument for Personalized Vasopressors in Septic Shock.

Andrea R Levine, Jonathan H Chow, Michael T McCurdy,

Crit Care Med (Critical care medicine)
[2020, 48(5):e439]

Cited: 0 times

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A Simple But Often Ignored Formula to Improve Critical Care: "Telemedicine + Ultrasound = Tele-Ultrasound".

Andrea R Levine, Avelino C Verceles, Michael T McCurdy,

Crit Care Med (Critical care medicine)
[2020, 48(6):e540]

Cited: 2 times

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Tele-Ultrasound in Resource-Limited Settings: A Systematic Review.

Noel Britton, Michael A Miller, Sami Safadi, Ariel Siegel, Andrea R Levine, Michael T McCurdy,

Background: Telemedicine, or healthcare delivery from a distance, has evolved over the past 50 years and helped alter health care delivery to patients around the globe. Its integration into numerous domains has permitted high quality care that transcends obstacles of geographic distance, lack of access to health care providers, and ... Read more >>

Front Public Health (Frontiers in public health)
[2019, 7:244]

Cited: 16 times

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AMP Kinase Activation Attenuates Cardiac Remodeling in Pulmonary Hypertension due to Heart Failure with Preserved Ejection Fraction; Lung Epithelial Progenitor Cells in Alveolar Regeneration; and Drug Discovery and Novel Therapies for Lung Cancer.

Andrea R Levine, William Bain, Joseph S Bednash, Mark T Gladwin, Bryan J McVerry,

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2019, 60(2):244-247]

Cited: 0 times

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Brief training increases nurses' comfort using tele-ultrasound: A feasibility study.

Taylor M Douglas, Andrea R Levine, Peter P Olivieri, Michael T McCurdy, Alfred Papali, Marc T Zubrow, Karen M Rodick, Julie M Hurley, Avelino C Verceles,

<h4>Background</h4>Nurses and other non-physician providers have demonstrated proficiency at obtaining images in the tele-ultrasound system. However, use of this skill requires comfort with the procedure and willingness to incorporate it into practice.<h4>Objectives</h4>To assess 1) level of comfort of non-physician providers performing tele-ultrasound before and after brief training and 2) feasibility ... Read more >>

Intensive Crit Care Nurs (Intensive & critical care nursing)
[2019, 51:45-49]

Cited: 1 time

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Pulmonary vascular disease in the setting of heart failure with preserved ejection fraction.

Andrea R Levine, Marc A Simon, Mark T Gladwin,

Heart failure with preserved ejection fraction (HFpEF) is defined as clinical features of heart failure, ideally with biomarker evidence such as elevated plasma natriuretic peptide levels, in the setting of an ejection fraction (EF) greater than 50% and imaging evidence of diastolic left ventricular dysfunction [1,2]. In the absence of ... Read more >>

Trends Cardiovasc Med (Trends in cardiovascular medicine)
[2019, 29(4):207-217]

Cited: 5 times

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Remote tele-mentored ultrasound for non-physician learners using FaceTime: A feasibility study in a low-income country.

Thomas E Robertson, Andrea R Levine, Avelino C Verceles, Jessica A Buchner, James H Lantry, Alfred Papali, Marc T Zubrow, L Nathalie Colas, Marc E Augustin, Michael T McCurdy, ,

<h4>Purpose</h4>Ultrasound (US) is a burgeoning diagnostic tool and is often the only available imaging modality in low- and middle-income countries (LMICs). However, bedside providers often lack training to acquire or interpret US images. We conducted a study to determine if a remote tele-intensivist could mentor geographically removed LMIC providers to ... Read more >>

J Crit Care (Journal of critical care)
[2017, 40:145-148]

Cited: 10 times

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Tele-Medicine and Point-of-Care Ultrasound: A New Paradigm for Resource-Constrained Settings.

Andrea R Levine, Thomas E Robertson, Alfred Papali, Avelino C Verceles, Michael T McCurdy,

Chest (Chest)
[2016, 149(6):1580-1581]

Cited: 2 times

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Ultrasound images transmitted via FaceTime are non-inferior to images on the ultrasound machine.

Andrea R Levine, Jessica A Buchner, Avelino C Verceles, Marc T Zubrow, Haney A Mallemat, Alfred Papali, Michael T McCurdy,

<h4>Purpose</h4>Remote telementored ultrasound (RTMUS) systems can deliver ultrasound (US) expertise to regions lacking highly trained bedside ultrasonographers and US interpreters. To date, no studies have evaluated the quality and clinical utility of US images transmitted using commercially available RTMUS systems.<h4>Methods</h4>This prospective pilot evaluated the quality of US images (right internal ... Read more >>

J Crit Care (Journal of critical care)
[2016, 33:51-55]

Cited: 9 times

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Tele-intensivists can instruct non-physicians to acquire high-quality ultrasound images.

Andrea R Levine, Michael T McCurdy, Marc T Zubrow, Alfred Papali, Haney A Mallemat, Avelino C Verceles,

<h4>Purpose</h4>Intensive care unit telemedicine (tele-ICU) uses audiovisual systems to remotely monitor and manage patients. Intensive care unit ultrasound can augment an otherwise limited bedside evaluation. To date, no studies have utilized tele-ICU technology to assess the quality and clinical use of real-time ultrasound images. We assessed whether tele-intensivists can instruct ... Read more >>

J Crit Care (Journal of critical care)
[2015, 30(5):871-875]

Cited: 14 times

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