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Author Andrea Marrari

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Discrepancies between UICC and AJCC TNM classifications for oral cavity tumors in the 8th editions and following versions.

Giuseppe Mercante, Francesca Gaino, Caterina Giannitto, Fabio Ferreli, Armando De Virgilio, Ciro Franzese, Andrea Marrari, Luca Malvezzi, Giovanni Colombo, Marta Scorsetti, Giuseppe Spriano,

<h4>Purpose</h4>To underline discrepancies between the Union for International Cancer Control (UICC) and the American Joint Committee on Cancer (AJCC) Tumor-Node-Metastasis (TNM) classifications in oral cavity cancer.<h4>Methods</h4>Comparison between the UICC and AJCC TNM classifications of oral cavity cancer in their 8th editions and following versions.<h4>Results</h4>The most important update was the introduction ... Read more >>

Eur Arch Otorhinolaryngol (European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery)
[2021, :]

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Impact of active cancer on COVID-19 survival: a matched-analysis on 557 consecutive patients at an Academic Hospital in Lombardy, Italy.

Alexia F Bertuzzi, Michele Ciccarelli, Andrea Marrari, Nicolò Gennaro, Andrea Dipasquale, Laura Giordano, Umberto Cariboni, Vittorio Lorenzo Quagliuolo, Marco Alloisio, Armando Santoro,

<h4>Background</h4>The impact of active cancer in COVID-19 patients is poorly defined; however, most studies showed a poorer outcome in cancer patients compared to the general population.<h4>Methods</h4>We analysed clinical data from 557 consecutive COVID-19 patients. Uni-multivariable analysis was performed to identify prognostic factors of COVID-19 survival; propensity score matching was used ... Read more >>

Br J Cancer (British journal of cancer)
[2021, :]

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Multi-Step Combined Upfront Surgery for Locally Advanced Paravertebral Sarcoma: A Case Report.

Umberto Cariboni, Nicolò Gennaro, Francesco Costa, Salvatore Lorenzo Renne, Pierluigi Novellis, Andrea Marrari, Alexia Francesca Bertuzzi, Efrem Civilini,

<b>Background:</b> Paravertebral localization of primary undifferentiated pleomorphic sarcoma (UPS) with bone and vascular involvement is infrequent and challenging. Multi-step surgical procedure has been described as a feasible and effective option to achieve sustained local tumor control. <b>Methods:</b> We report on a 62-year old man with paravertebral UPS infiltrating the aortic ... Read more >>

Front Surg (Frontiers in surgery)
[2021, 8:664089]

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It was hard enough: the spectre of COVID-19 on the management of sarcoma patients.

Andrea Marrari, Nicolò Gennaro, Umberto Cariboni, Vittorio Lorenzo Quagliuolo, Federico D'Orazio, Ferdinando Cananzi, Armando Santoro, Alexia Francesca Bertuzzi,

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2021, :]

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Determinants of enhanced vulnerability to coronavirus disease 2019 in UK patients with cancer: a European study.

David J Pinato, Lorenza Scotti, Alessandra Gennari, Emeline Colomba-Blameble, Saoirse Dolly, Angela Loizidou, John Chester, Uma Mukherjee, Alberto Zambelli, Juan Aguilar-Company, Mark Bower, Myria Galazi, Ramon Salazar, Alexia Bertuzzi, Joan Brunet, Ricard Mesia, Ailsa Sita-Lumsden, Johann Colomba, Fanny Pommeret, Elia Seguí, Federica Biello, Daniele Generali, Salvatore Grisanti, Gianpiero Rizzo, Michela Libertini, Charlotte Moss, Joanne S Evans, Beth Russell, Rachel Wuerstlein, Bruno Vincenzi, Rossella Bertulli, Diego Ottaviani, Raquel Liñan, Andrea Marrari, M C Carmona-García, Christopher C T Sng, Carlo Tondini, Oriol Mirallas, Valeria Tovazzi, Vittoria Fotia, Claudia A Cruz, Nadia Saoudi-Gonzalez, Eudald Felip, Ariadna R Lloveras, Alvin J X Lee, Thomas Newsom-Davis, Rachel Sharkey, Chris Chung, David García-Illescas, Roxana Reyes, Yien N Sophia Wong, Daniela Ferrante, Javier Marco-Hernández, Isabel Ruiz-Camps, Gianluca Gaidano, Andrea Patriarca, Anna Sureda, Clara Martinez-Vila, Ana Sanchez de Torre, Lorenza Rimassa, Lorenzo Chiudinelli, Michela Franchi, Marco Krengli, Armando Santoro, Aleix Prat, Josep Tabernero, Mieke V Hemelrijck, Nikolaos Diamantis, Alessio Cortellini, ,

<h4>Background</h4>Despite high contagiousness and rapid spread, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to heterogeneous outcomes across affected nations. Within Europe (EU), the United Kingdom (UK) is the most severely affected country, with a death toll in excess of 100,000 as of January 2021. We aimed to compare ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2021, 150:190-202]

Cited: 1 time

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Systemic pro-inflammatory response identifies patients with cancer with adverse outcomes from SARS-CoV-2 infection: the OnCovid Inflammatory Score.

Gino M Dettorre, Saoirse Dolly, Angela Loizidou, John Chester, Amanda Jackson, Uma Mukherjee, Alberto Zambelli, Juan Aguilar-Company, Mark Bower, Christopher C T Sng, Ramon Salazar, Alexia Bertuzzi, Joan Brunet, Ricard Mesia, Ailsa Sita-Lumsden, Elia Seguí, Federica Biello, Daniele Generali, Salvatore Grisanti, Pavetha Seeva, Gianpiero Rizzo, Michela Libertini, Antonio Maconi, Charlotte Moss, Beth Russell, Nadia Harbeck, Bruno Vincenzi, Rossella Bertulli, Diego Ottaviani, Raquel Liñan, Andrea Marrari, M Carmen Carmona-García, Neha Chopra, Carlo Alberto Tondini, Oriol Mirallas, Valeria Tovazzi, Vittoria Fotia, Claudia Andrea Cruz, Nadia Saoudi-Gonzalez, Eudald Felip, Ariadna Roqué, Alvin J X Lee, Tom Newsom-Davis, David García-Illescas, Roxana Reyes, Yien Ning Sophia Wong, Daniela Ferrante, Lorenza Scotti, Javier Marco-Hernández, Isabel Ruiz-Camps, Andrea Patriarca, Lorenza Rimassa, Lorenzo Chiudinelli, Michela Franchi, Armando Santoro, Aleix Prat, Alessandra Gennari, Mieke Van Hemelrijck, Josep Tabernero, Nikolaos Diamantis, David J Pinato, ,

<h4>Background</h4>Patients with cancer are particularly susceptible to SARS-CoV-2 infection. The systemic inflammatory response is a pathogenic mechanism shared by cancer progression and COVID-19. We investigated systemic inflammation as a driver of severity and mortality from COVID-19, evaluating the prognostic role of commonly used inflammatory indices in SARS-CoV-2-infected patients with cancer ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2021, 9(3):]

Cited: 1 time

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The radiologist empowerment through virtual multidisciplinary tumor boards: The commitment of oncologic care during COVID-19 pandemic.

Nicolò Gennaro, Andrea Marrari, Alexia F Bertuzzi, Luca Balzarini, Armando Santoro, Letterio S Politi,

Clin Imaging (Clinical imaging)
[2021, 70:49-50]

Cited: 1 time

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Low Incidence of SARS-CoV-2 in Patients with Solid Tumours on Active Treatment: An Observational Study at a Tertiary Cancer Centre in Lombardy, Italy.

Alexia Francesca Bertuzzi, Andrea Marrari, Nicolò Gennaro, Umberto Cariboni, Michele Ciccarelli, Laura Giordano, Vittorio Lorenzo Quagliuolo, Armando Santoro,

<b>Background:</b> The incidence and prognosis of SARS-CoV-2-positive cancer patients on active oncologic treatment remain unknown. Retrospective data from China reported higher incidence and poorer outcomes with respect to the general population. We aimed to describe the real-word incidence of SARS-CoV-2 in cancer patients and the impact of oncologic therapies on ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(9):]

Cited: 6 times

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Clinical portrait of the SARS-CoV-2 epidemic in European cancer patients.

David J Pinato, Alberto Zambelli, Juan Aguilar-Company, Mark Bower, Christopher Sng, Ramon Salazar, Alexia Bertuzzi, Joan Brunet, Ricard Mesia, Elia Segui, Federica Biello, Daniele Generali, Salvatore Grisanti, Gianpiero Rizzo, Michela Libertini, Antonio Maconi, Nadia Harbeck, Bruno Vincenzi, Rossella Bertulli, Diego Ottaviani, Anna Carbo, Riccardo Bruna, Sarah Benafif, Andrea Marrari, Rachel Wuerstlein, M Carmen Carmona-Garcia, Neha Chopra, Carlo Tondini, Oriol Mirallas, Valeria Tovazzi, Marta Betti, Salvatore Provenzano, Vittoria Fotia, Claudia Andrea Cruz, Alessia Dalla Pria, Francesca D'Avanzo, Joanne S Evans, Nadia Saoudi-Gonzalez, Eudald Felip, Myria Galazi, Isabel Garcia-Fructuoso, Alvin J X Lee, Thomas Newsom-Davis, Andrea Patriarca, David Garcia-Illescas, Roxana Reyes, Palma Dileo, Rachel Sharkey, Yien Ning Sophia Wong, Daniela Ferrante, Javier Marco-Hernandez, Anna Sureda, Clara Maluquer, Isabel Ruiz-Camps, Gianluca Gaidano, Lorenza Rimassa, Lorenzo Chiudinelli, Macarena Izuzquiza, Alba Cabirta, Michela Franchi, Armando Santoro, Aleix Prat, Josep Tabernero, Alessandra Gennari,

The SARS-Cov-2 pandemic significantly impacted on oncology practice across the globe. There is uncertainty as to the contribution of patients' demographics and oncological features on severity and mortality from Covid-19 and little guidance as to the role of anti-cancer and anti-Covid-19 therapy in this population. In a multi-center study of ... Read more >>

Cancer Discov (Cancer discovery)
[2020, :]

Cited: 37 times

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Event-free survival in Desmoid-Type fibromatosis (DTF): A pre-post comparison of upfront surgery versus wait-and-see approach.

Laura Ruspi, Ferdinando Carlo Maria Cananzi, Federico Sicoli, Laura Samà, Salvatore Lorenzo Renne, Andrea Marrari, Nicolò Gennaro, Piergiuseppe Colombo, Luca Cozzaglio, Letterio Salvatore Politi, Alexia Bertuzzi, Vittorio Quagliuolo,

<h4>Background</h4>Desmoid-Type Fibromatosis (DTF) is a rare mesenchymal neoplasm with a locally invasive pattern and high risk of local recurrence after surgery. Historically, the standard treatment for DTF was surgical resection. However, considering the difficulty of achieving surgical eradication, the possible unnecessary morbidity and the unpredictability of the natural history, a ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2021, 47(5):1196-1200]

Cited: 0 times

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Activity of regorafenib in advanced pretreated soft tissue sarcoma: Results of a single-center phase II study.

Andrea Marrari, Alexia Bertuzzi, Silvia Bozzarelli, Nicolò Gennaro, Laura Giordano, Vittorio Quagliuolo, Rita De Sanctis, Simona Sala, Luca Balzarini, Armando Santoro,

<h4>Background</h4>Regorafenib, a multitargeted tyrosine kinase inhibitor, proved to be active in patients with soft tissue sarcomas (STS).<h4>Methods</h4>We conducted an open-label, non-randomized, single-center phase II study in advanced pretreated STS patients. Patients received regorafenib 160 mg daily on days 1 enrule 21 of a 28-day cycle. The primary endpoint was the progression-free ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(26):e20719]

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Multimodality imaging of adult rhabdomyosarcoma: the added value of hybrid imaging.

Nicolò Gennaro, Andrea Marrari, Salvatore Lorenzo Renne, Ferdinando Carlo Maria Cananzi, Vittorio Lorenzo Quagliuolo, Lucia Di Brina, Marta Scorsetti, Giovanna Pepe, Arturo Chiti, Armando Santoro, Luca Balzarini, Letterio Salvatore Politi, Alexia Francesca Bertuzzi,

Rhabdomyosarcoma (RMS) represents more than 50% of paediatric soft tissue tumours. Conversely, it is extremely rare among adults, where it shows peculiar biological and clinical features that are still poorly investigated. RMS patients should be referred to a Sarcoma Centre, where the contribution of experienced radiologists plays a relevant role ... Read more >>

Br J Radiol (The British journal of radiology)
[2020, 93(1112):20200250]

Cited: 3 times

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The blurred line between the art and science of medicine.

Alexia Francesca Bertuzzi, Nicolò Gennaro, Andrea Marrari, Armando Santoro,

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2020, 150:61]

Cited: 1 time

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Neoadjuvant Chemotherapy in High-Risk Soft Tissue Sarcomas: Final Results of a Randomized Trial From Italian (ISG), Spanish (GEIS), French (FSG), and Polish (PSG) Sarcoma Groups.

Alessandro Gronchi, Emanuela Palmerini, Vittorio Quagliuolo, Javier Martin Broto, Antonio Lopez Pousa, Giovanni Grignani, Antonella Brunello, Jean-Yves Blay, Oscar Tendero, Robert Diaz Beveridge, Virginia Ferraresi, Iwona Lugowska, Domenico Franco Merlo, Valeria Fontana, Emanuela Marchesi, Luca Braglia, Davide Maria Donati, Elena Palassini, Giuseppe Bianchi, Andrea Marrari, Carlo Morosi, Silvia Stacchiotti, Silvia Bagué, Jean Michel Coindre, Angelo Paolo Dei Tos, Piero Picci, Paolo Bruzzi, Paolo Giovanni Casali,

<h4>Purpose</h4>To determine whether the administration of histology-tailored neoadjuvant chemotherapy (HT) was superior to the administration of standard anthracycline plus ifosfamide neoadjuvant chemotherapy (A+I) in high-risk soft tissue sarcoma (STS) of an extremity or the trunk wall.<h4>Patients and methods</h4>This was a randomized, open-label, phase III trial. Patients had localized high-risk STS ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2020, 38(19):2178-2186]

Cited: 10 times

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Adjuvant volumetric modulated arc therapy compared to 3D conformal radiation therapy for newly diagnosed soft tissue sarcoma of the extremities: outcome and toxicity evaluation.

Lucia Di Brina, Antonella Fogliata, Pierina Navarria, Giuseppe D'Agostino, Ciro Franzese, Davide Franceschini, Fiorenza De Rose, Tiziana Comito, Alexia Bertuzzi, Andrea Marrari, Piergiuseppe Colombo, Vittorio Quagliuolo, Armando Santoro, Marta Scorsetti,

<h4>Objective</h4>To assess the impact of adjuvant volumetric modulated arc therapy (VMAT) compared with three-dimensional conformal radiation therapy (3DCRT) in terms of toxicity and local control (LC) in patients with soft tissue sarcoma of the extremities.<h4>Methods</h4>From 2004 to 2016, 109 patients were treated, initially using 3DCRT and subsequently with VMAT. Clinical ... Read more >>

Br J Radiol (The British journal of radiology)
[2019, 92(1102):20190252]

Cited: 0 times

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Soft tissue sarcoma in Italy: From epidemiological data to clinical networking to improve patient care and outcomes.

Annalisa Trama, Giuseppe Badalamenti, Giacomo Giulio Baldi, Antonella Brunello, Morena Caira, Nora Drove, Andrea Marrari, Emanuela Palmerini, Bruno Vincenzi, Angelo Paolo Dei Tos, Giovanni Grignani,

Sarcomas are rare malignant neoplasms that develop from mesenchymal cells and include a heterogeneous and large group of histological subtypes that may occur at any anatomical site. Soft tissue sarcomas (STS), the focus of this review, account for ≈70‒80% of sarcomas and represent <1% of all cancers. The heterogeneity of ... Read more >>

Cancer Epidemiol (Cancer epidemiology)
[2019, 59:258-264]

Cited: 3 times

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Survival Outcome and Prognostic Factors After Pulmonary Metastasectomy in Sarcoma Patients: A 18-Year Experience at a Single High-volume Referral Center.

Umberto Cariboni, Rita De Sanctis, Marta Giaretta, Emanuele Voulaz, Emanuela Morenghi, Piergiuseppe Colombo, Pierluigi Novellis, Edoardo Bottoni, Valentina Errico, Alessandro Crepaldi, Andrea Marrari, Pierina Navarria, Anna M Ascolese, Alberto Testori, Marta Scorsetti, Vittorio Quagliuolo, Armando Santoro, Marco Alloisio,

<h4>Background</h4>Metastatic sarcoma patients have a poor prognosis with 3-year survival rate of 25%. About 30% of them present isolated lung metastases. We aimed to analyze the clinical outcome of sarcoma patients undergoing pulmonary metastasectomy (PM) and prognostic factors associated with local control, disease-free, and overall survival (OS).<h4>Patients and methods</h4>All sarcoma ... Read more >>

Am J Clin Oncol (American journal of clinical oncology)
[2019, 42(1):6-11]

Cited: 3 times

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Sporadic desmoid tumors of the abdominal wall: the results of surgery.

Chiara E Mussi, Piergiuseppe Colombo, Chiara Lo Russo, Anaid Kasangian, Ferdinando Cananzi, Andrea Marrari, Emanuela Morenghi, Rita De Sanctis, Vittorio Quagliuolo,

<h4>Purpose</h4>Before the wait-and-see policy became the standard approach in abdominal wall desmoid tumors, surgery was performed on a systematic basis. Surgery remains indicated for progressing tumors but its extent is debatable. The abdominal wall is a common site of origin of sporadic desmoids, usually associated with a favorable prognosis. We ... Read more >>

Tumori (Tumori)
[2016, 102(6):582-587]

Cited: 2 times

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Solitary fibrous tumour presenting with a single bone metastasis: report of six cases and literature review.

Vittoria Colia, Salvatore Provenzano, Carlo Morosi, Paola Collini, Salvatore Lorenzo Renne, Paolo G Dagrada, Claudia Sangalli, Angelo Paolo Dei Tos, Andrea Marrari, Paolo G Casali, Silvia Stacchiotti,

<h4>Background</h4>Solitary fibrous tumour (SFT) is a rare soft tissue sarcoma with a low metastatic potential. A higher metastatic rate is observed in the high-grade/dedifferentiated variant. The most common expected site of distant spread are the lungs and the liver. Bone involvement is generally viewed as a late stage of disease ... Read more >>

Clin Sarcoma Res (Clinical sarcoma research)
[2016, 6(1):16]

Cited: 3 times

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Trabectedin for the treatment of soft tissue sarcomas.

Rita De Sanctis, Andrea Marrari, Armando Santoro,

<h4>Introduction</h4>Trabectedin, a marine-derived DNA-binding antineoplastic agent, has been registered by the EMA and recently also by the FDA for the treatment of patients with advanced soft-tissue sarcoma (STS), a rare and heterogeneous disease.<h4>Areas covered</h4>The antitumor activity of trabectedin is related both to direct effects on cancer cells, such as growth ... Read more >>

Expert Opin Pharmacother (Expert opinion on pharmacotherapy)
[2016, 17(11):1569-1577]

Cited: 9 times

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Role of surgery in the multimodal treatment of primary and recurrent leiomyosarcoma of the inferior vena cava.

Ferdinando Carlo Maria Cananzi, Chiara Mussi, Maria Grazia Bordoni, Andrea Marrari, Rita De Sanctis, Piergiuseppe Colombo, Vittorio Quagliuolo,

<h4>Background</h4>The optimal treatment of leiomyosarcoma (LMS) of the inferior vena cava (IVC) is still unclear, especially in the metastatic and/or recurrent setting. We herein evaluated the long-term outcome after aggressive management.<h4>Methods</h4>Eleven patients underwent surgery for primary LMS of the IVC between 2000 and 2012. The clinical, pathological, and survival data ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2016, 114(1):44-49]

Cited: 10 times

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Efficacy of trabectedin in advanced soft tissue sarcoma: beyond lipo- and leiomyosarcoma.

Rita De Sanctis, Andrea Marrari, Silvia Marchetti, Chiara Mussi, Luca Balzarini, Fabio Romano Lutman, Primo Daolio, Stefano Bastoni, Alexia Francesca Bertuzzi, Vittorio Quagliuolo, Armando Santoro,

<h4>Objective</h4>Trabectedin is effective in leiomyosarcoma and liposarcoma, especially the myxoid variant, related to the presence of the FUS-CHOP transcript. We evaluated the efficacy of trabectedin in specific subgroups of patients with soft tissue sarcomas (STS).<h4>Methods</h4>Seventy-two patients with advanced anthracycline-pretreated STS, who received trabectedin at a dose of 1.5 mg/m(2) every ... Read more >>

Drug Des Devel Ther (Drug design, development and therapy)
[2015, 9:5785-5791]

Cited: 9 times

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Non-pegylated liposomal doxorubicin plus ifosfamide in metastatic soft tissue sarcoma: results from a phase-II trial.

Rita De Sanctis, Alexia Bertuzzi, Umberto Basso, Alessandro Comandone, Silvia Marchetti, Andrea Marrari, Piergiuseppe Colombo, Romano Fabio Lutman, Laura Giordano, Armando Santoro,

<h4>Background/aim</h4>Non-pegylated liposomal doxorubicin (NPLD) has demonstrated antitumour activity equivalent to conventional doxorubicin and a significantly lower risk of cardiotoxicity. This phase II trial was performed to evaluate the activity and the safety of NPLD and ifosfamide combination in patients with metastatic soft tissue sarcoma.<h4>Patients and methods</h4>Thirty-four patients received NPLD 40 ... Read more >>

Anticancer Res (Anticancer research)
[2015, 35(1):543-547]

Cited: 9 times

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Stereotactic body radiation therapy for lung metastases from soft tissue sarcoma.

Pierina Navarria, Anna Maria Ascolese, Luca Cozzi, Stefano Tomatis, Giuseppe Roberto D'Agostino, Fiorenza De Rose, Rita De Sanctis, Andrea Marrari, Armando Santoro, Antonella Fogliata, Umberto Cariboni, Marco Alloisio, Vittorio Quagliuolo, Marta Scorsetti,

<h4>Purpose</h4>To appraise the role of stereotactic body radiation therapy (SBRT) in patients with lung metastasis from primary soft tissue sarcoma.<h4>Methods</h4>Twenty-eight patients (51 lesions) were analysed. All patients were in good performance status (1-2 eastern cooperative oncology group (ECOG)), unsuitable for surgical resection, with controlled primary tumour and the number of ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2015, 51(5):668-674]

Cited: 19 times

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High-dose continuous-infusion ifosfamide in advanced well-differentiated/dedifferentiated liposarcoma.

Roberta Sanfilippo, Rossella Bertulli, Andrea Marrari, Elena Fumagalli, Silvana Pilotti, Carlo Morosi, Antonella Messina, Angelo Paolo Dei Tos, Alessandro Gronchi, Paolo Giovanni Casali,

<h4>Background</h4>Liposarcomas represent the most common histological type of soft-tissue sarcomas (STS). Its main subgroups, WD/DD, is known to be poorly sensitive to chemotherapy, with few active agents, i.e., anthracyclines +/- ifosfamide and trabectedin. High-dose ifosfamide (HDIFX >12 g/m2) is active in STS pts pretreated with standard-dose IFX, though with greater toxicity. ... Read more >>

Clin Sarcoma Res (Clinical sarcoma research)
[2014, 4(1):16]

Cited: 18 times

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