Full Text Journal Articles by
Author Andrea Mariani

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Sequencing chemotherapy before radiotherapy for women with stage IIIC endometrial cancer.

Deepa Maheswari Narasimhulu, Matthew S Block, Amy L Weaver, Michaela McGree, Amanika Kumar, Carrie Langstraat, Ivy Petersen, Andrea Mariani, Gretchen Glaser,

<h4>Objective</h4>It is unclear how to best sequence adjuvant chemotherapy and radiotherapy for advanced endometrial cancer. We studied the outcomes for women treated with chemotherapy before radiotherapy in a chemotherapy-first (chemotherapy for 6 cycles followed radiotherapy) or 'sandwich' approach (chemotherapy for 3 cycles followed by radiotherapy and subsequently chemotherapy for 3 ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, :]

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In search for biomarkers and potential drug targets for uterine serous endometrial cancer.

Giorgia Dinoi, Andrea Mariani, Enrica Martinelli, Alessandra Ciucci, Gian Franco Zannoni, Amy L Weaver, Gary L Keeney, George Vasmatzis, Panos Z Anastasiadis, Francesco Fanfani, Giovanni Scambia, Daniela Gallo,

<h4>Objective</h4>Serous endometrial cancer (USC) is a challenging malignancy associated with metastasis, recurrence and poor outcome. To identify clinically relevant prognostic biomarkers, we focused on a panel of proteins selected after a comprehensive literature review, for tumour profiling of a homogeneous cohort of USC patients.<h4>Methods</h4>Protein levels and localization were assessed by ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2021, :]

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The shift from inpatient to outpatient hysterectomy for endometrial cancer in the United States: trends, enabling factors, cost, and safety.

Serena Cappuccio, Yanli Li, Chao Song, Emeline Liu, Gretchen Glaser, Jvan Casarin, Tommaso Grassi, Kristina Butler, Paul Magtibay, Javier F Magrina, Giovanni Scambia, Andrea Mariani, Carrie Langstraat,

<h4>Objective</h4>To evaluate trends in outpatient versus inpatient hysterectomy for endometrial cancer and assess enabling factors, cost and safety.<h4>Methods</h4>In this retrospective cohort study, patients aged 18 years or older who underwent hysterectomy for endometrial cancer between January 2008 and September 2015 were identified in the Premier Healthcare Database. The surgical approach ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, :]

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Development of a surgical competency assessment tool for sentinel lymph node dissection by minimally invasive surgery for endometrial cancer.

Kristen Moloney, Monika Janda, Michael Frumovitz, Mario Leitao, Nadeem R Abu-Rustum, Emma Rossi, James L Nicklin, Marie Plante, Fabrice R Lecuru, Alessandro Buda, Andrea Mariani, Yee Leung, Sarah Elizabeth Ferguson, Rene Pareja, Rainer Kimmig, Pearl Shuang Ye Tong, Orla McNally, Naven Chetty, Kaijiang Liu, Ken Jaaback, Julio Lau, Soon Yau Joseph Ng, Henrik Falconer, Jan Persson, Russell Land, Fabio Martinelli, Andrea Garrett, Alon Altman, Adam Pendlebury, David Cibula, Roberto Altamirano, Donal Brennan, Thomas Edward Ind, Cornelis De Kroon, Ka Yu Tse, George Hanna, Andreas Obermair,

<h4>Introduction</h4>Sentinel lymph node dissection is widely used in the staging of endometrial cancer. Variation in surgical techniques potentially impacts diagnostic accuracy and oncologic outcomes, and poses barriers to the comparison of outcomes across institutions or clinical trial sites. Standardization of surgical technique and surgical quality assessment tools are critical to ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, :]

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Controversies in the Management of Early-stage Serous Endometrial Cancer.

Alyssa Larish, Andrea Mariani, Carrie Langstraat,

<h4>Background/aim</h4>Early-stage uterine serous carcinoma (USC) has one of the highest recurrence rates and mortality among early-stage uterine epithelial cancers. Research into the clinical management of USC has begun to progress, guided by surgical and pathological advances. This article summarizes the available literature regarding diagnosis, management, and possible future uses of ... Read more >>

In Vivo (In vivo (Athens, Greece))
[2021, 35(2):671-680]

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Lumping and splitting: The need for precision medicine and "personomics" in endometrial cancer.

Fiorella E Reyes-Baez, Simone Garzon, Andrea Mariani,

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e38]

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Adjuvant chemotherapy in early-stage endometrioid endometrial cancer with >50% myometrial invasion and negative lymph nodes.

Francesco Multinu, Simone Garzon, Amy L Weaver, Michaela E McGree, Enrico Sartori, Fabio Landoni, Paolo Zola, Giorgia Dinoi, Giovanni Aletti, Matthew S Block, Angiolo Gadducci, Andrea Mariani,

<h4>Objective</h4>The role of adjuvant chemotherapy as an addition or alternative to radiotherapy for early-stage high-risk endometrioid endometrial cancer is controversial. This study aimed to investigate the role of adjuvant chemotherapy in early-stage high-risk endometrioid endometrial cancer.<h4>Methods</h4>We identified patients with stage I or II endometrioid grade 2 or 3 endometrial cancer ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, 31(4):537-544]

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Extent of Cardiac Damage and Mortality in Patients Undergoing Transcatheter Aortic Valve Implantation

Marisa Avvedimento, Anna Franzone, Attilio Leone, Raffaele Piccolo, Domenico Simone Castiello, Andrea Mariani, Federica Ilardi, Roberta Esposito, Cristina Iapicca, Domenico Angellotti, Maria Scalamogna, Ciro Santoro, Plinio Cirillo, Giovanni Esposito,

PurposeWe sought to assess the prognostic role of the extent of cardiac damage among real-world patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI).MethodsA staging classification was applied to 262 patients from the EffecTAVI Registry at baseline and re-assessed within 30-day after TAVI. All-cause mortality at 1-year ... Read more >>

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Adjuvant brachytherapy for FIGO stage I serous or clear cell endometrial cancer.

Elizabeth B Jeans, William G Breen, Trey C Mullikin, Brittany A Looker, Andrea Mariani, Gary L Keeney, Michael G Haddock, Ivy A Petersen,

<h4>Objectives</h4>Optimal adjuvant treatment for early-stage clear cell and serous endometrial cancer remains unclear. We report outcomes for women with surgically staged International Federation of Gynecology and Obstetrics (FIGO) stage I clear cell, serous, and mixed endometrial cancers following adjuvant vaginal cuff brachytherapy with or without chemotherapy.<h4>Methods</h4>From April 1998 to January ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, :]

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Skill-Oriented and Performance-Driven Adaptive Curricula for Training in Robot-Assisted Surgery Using Simulators: A Feasibility Study.

Andrea Mariani, Edoardo Pellegrini, Elena De Momi,

<h4>Objective</h4>Virtual Reality (VR) simulators represent a remarkable educational opportunity in order to acquire and refine surgical practical skills. Nevertheless, there exists no consensus regarding a standard curriculum of simulation-based training. This study introduces an automatic, adaptive curriculum where the training session is real-time scheduled on the basis of the trainee's ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2021, 68(2):685-694]

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Reduced lymphedema after sentinel lymph node biopsy versus lymphadenectomy for endometrial cancer.

Gretchen Glaser, Giorgia Dinoi, Francesco Multinu, Kathleen Yost, Mariam Al Hilli, Alyssa Larish, Amanika Kumar, Michaela McGree, Amy L Weaver, Andrea Cheville, Sean Dowdy, Andrea Mariani,

<h4>Objective</h4>Endometrial cancer surgical staging includes lymph node assessment which can lead to lower extremity lymphedema. The aim of this study was to estimate prevalence after sentinel lymph node biopsy versus lymphadenectomy.<h4>Methods</h4>Consecutive patients who underwent minimally invasive surgery at the Mayo Clinic, Rochester, Minnesota, USA, between January 2009 and June 2016 ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, 31(1):85-91]

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Fertility-sparing management for endometrial cancer: review of the literature.

Simone Garzon, Stefano Uccella, Pier Carlo Zorzato, Mariachiara Bosco, Massimo P Franchi, Vladimir Student, Andrea Mariani,

<h4>Introduction</h4>Primary surgery is effective in low-risk endometrial cancer (EC). However, in young women, this approach compromises fertility. Therefore, fertility-sparing management in the case of atypical endometrial hyperplasia, or grade 1 EC limited to the endometrium can be considered.<h4>Evidence acquisition</h4>We performed a literature review to identify studies involving women with EC ... Read more >>

Minerva Med (Minerva medica)
[2021, 112(1):55-69]

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Sentinel lymph node for endometrial cancer treatment: review of the literature.

Pier C Zorzato, Mariachiara Bosco, Massimo P Franchi, Andrea Mariani, Stefano Cianci, Simone Garzon, Stefano Uccella,

<h4>Introduction</h4>Endometrial cancer is the most common gynecologic malignancy and in two thirds of patients it is apparently uterine confined at presentation. Lymph nodal status represents one of the main prognostic factors. Nodal evaluation with sentinel lymph node (SLN) mapping has gained more ground in clinical practice after the publication of ... Read more >>

Minerva Med (Minerva medica)
[2021, 112(1):70-80]

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Acoustic Coupling Quantification in Ultrasound-Guided Focused Ultrasound Surgery: Simulation-Based Evaluation and Experimental Feasibility Study.

Laura Morchi, Andrea Mariani, Alessandro Diodato, Selene Tognarelli, Andrea Cafarelli, Arianna Menciassi,

Adequate acoustic coupling between the therapeutic transducer and the patient's body is essential for safe and efficient focused ultrasound surgery (FUS). There is currently no quantitative method for acoustic coupling verification in ultrasound-guided FUS. In this work, a quantitative method was developed and a related metric was introduced: the acoustic ... Read more >>

Ultrasound Med Biol (Ultrasound in medicine & biology)
[2020, 46(12):3305-3316]

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Impact of hysteroscopy on course of disease in high-risk endometrial carcinoma.

Alyssa Larish, Amanika Kumar, Amy Weaver, Andrea Mariani,

<h4>Objective</h4>Previous studies have investigated the impact of preoperative hysteroscopy on the staging and survival of predominantly grade 1 endometrial cancers. We sought to evaluate the effect of hysteroscopy on the peritoneal spread of tumor cells and disease course in a large series of patients with high-risk endometrial cancer.<h4>Methods</h4>Patients who underwent ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(10):1513-1519]

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Robotic-Assisted Colonoscopy Platform with a Magnetically-Actuated Soft-Tethered Capsule.

Mauro Verra, Andrea Firrincieli, Marcello Chiurazzi, Andrea Mariani, Giacomo Lo Secco, Edoardo Forcignanò, Anastasios Koulaouzidis, Arianna Menciassi, Paolo Dario, Gastone Ciuti, Alberto Arezzo,

<i>Background and Aims</i>: Colorectal cancer (CRC) is a major cause of morbidity and mortality worldwide. Despite offering a prime paradigm for screening, CRC screening is often hampered by invasiveness. Endoo is a potentially painless colonoscopy method with an active locomotion tethered capsule offering diagnostic and therapeutic capabilities. <i>Materials and Methods</i>: ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(9):]

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A prospective multicenter international single-arm observational study on the oncological safety of the sentinel lymph node algorithm in stage I intermediate-risk endometrial cancer (SELECT, SEntinel Lymph node Endometrial Cancer Trial).

Tommaso Grassi, Andrea Mariani, David Cibula, Pamela T Soliman, Vera J Suman, Amy L Weaver, Silvana Pedra Nobre, Britta Weigelt, Gretchen E Glaser, Serena Cappuccio, Nadeem R Abu-Rustum,

<h4>Background</h4>In the primary treatment of apparent uterine-confined endometrial carcinoma, pelvic ± para-aortic lymphadenectomy has been considered the standard of care. Although some retrospective data suggest that the sentinel lymph node algorithm without complete lymphadenectomy can be used without jeopardizing oncologic outcome, prospective data are lacking.<h4>Primary objectives</h4>To assess the 36 month incidence ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(10):1627-1632]

Cited: 1 time

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Role of adjuvant therapy in stage IIIC2 endometrial cancer.

Giorgio Bogani, Serena Cappuccio, Jvan Casarin, Deepa Maheswari M Narasimhulu, William A Cilby, Gretchen E Glaser, Amy L Weaver, Michaela E McGree, Gary L Keeney, John Weroha, Ivy A Petersen, Andrea Mariani,

<h4>Objective</h4>The role of the different types of adjuvant treatments in endometrial cancer with para-aortic node metastases is unclear. The aim of this study was to report oncologic outcomes after adjuvant therapy in patients with stage IIIC2 endometrial cancer.<h4>Methods</h4>This retrospective single-institution study assessed patients with stage IIIC2 endometrial cancer who underwent ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(8):1169-1176]

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NCCN Guidelines Insights: Cervical Cancer, Version 1.2020.

Nadeem R Abu-Rustum, Catheryn M Yashar, Sarah Bean, Kristin Bradley, Susana M Campos, Hye Sook Chon, Christina Chu, David Cohn, Marta Ann Crispens, Shari Damast, Christine M Fisher, Peter Frederick, David K Gaffney, Robert Giuntoli, Ernest Han, Warner K Huh, John R Lurain Iii, Andrea Mariani, David Mutch, Christa Nagel, Larissa Nekhlyudov, Amanda Nickles Fader, Steven W Remmenga, R Kevin Reynolds, Rachel Sisodia, Todd Tillmanns, Stefanie Ueda, Renata Urban, Emily Wyse, Nicole R McMillian, Angela D Motter,

The NCCN Guidelines for Cervical Cancer provide recommendations for diagnostic workup, staging, and treatment of patients with the disease. These NCCN Guidelines Insights focus on recent updates to the guidelines, including changes to first- and second-line systemic therapy recommendations for patients with recurrent or metastatic disease, and emerging evidence on ... Read more >>

J Natl Compr Canc Netw (Journal of the National Comprehensive Cancer Network : JNCCN)
[2020, 18(6):660-666]

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Signals from the Metastatic Niche Regulate Early and Advanced Ovarian Cancer Metastasis through miR-4454 Downregulation.

Subramanyam Dasari, Taruni Pandhiri, Tommaso Grassi, Daniel W Visscher, Francesco Multinu, Komal Agarwal, Andrea Mariani, Viji Shridhar, Anirban K Mitra,

Treatment of ovarian cancer is limited by extensive metastasis and yet it remains poorly understood. We have studied the critical step of metastatic colonization in the context of the productive interactions with the metastatic microenvironment with a goal of identifying key regulators. By combining miRNA expression analysis using an organotypic ... Read more >>

Mol Cancer Res (Molecular cancer research : MCR)
[2020, 18(8):1202-1217]

Cited: 2 times

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A case of multi-agent drug resistant choriocarcinoma treated with Pembrolizumab.

Jennifer A Goldfarb, Giorgia Dinoi, Andrea Mariani, Carrie L Langstraat,

•High-risk multi-agent drug resistant GTN is a life threatening disease.•Majority of choriocarcinomas show intense PD-L1 immunoreactivity.•Pembrolizumab increases antitumor activity.•Effectiveness of Pembrolizumab in treating patients with high-risk multi-agent drug resistant GTN. ... Read more >>

Gynecol Oncol Rep (Gynecologic oncology reports)
[2020, 32:100574]

Cited: 1 time

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Being a Doctor Will Never Be the Same After the COVID-19 Pandemic.

Mari Giulio, Dario Maggioni, Isacco Montroni, Giampaolo Ugolini, Patrizio Capelli, Lorenzo Ceppi, Paolo Bonfanti, Andrea Mariani, Felice Achilli,

Am J Med (The American journal of medicine)
[2020, 133(6):652]

Cited: 6 times

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External beam radiotherapy versus vaginal brachytherapy in patients with stage II endometrial cancer: a systematic review and meta-analysis.

Deepa Maheswari Narasimhulu, Adela Cope, Irbaz Bin Riaz, Ivy Petersen, William Cilby, Carrie Langstraat, Gretchen Glaser, Amanika Kumar, Serena Cappuccio, Mohammad Hassan Murad, Colin West, Andrea Mariani,

<h4>Objective</h4>The choice of adjuvant treatment for women with stage II endometrial cancer is challenging, given the known increase in morbidity with external beam radiation compared with vaginal brachytherapy, and the lack of consensus on its benefits. We summarized the evidence on survival and recurrence for stage II endometrial cancer, defined ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(6):797-805]

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Sentinel Lymph Nodes and Precision Surgery in Gynecologic Cancer.

Khaled Ghoniem, Sherif A Shazly, Giorgia Dinoi, Valentina Zanfagnin, Gretchen E Glaser, Andrea Mariani,

Besides histologic features, the presence of nodal metastasis is the most crucial prognostic factor for recurrence and survival for patients with gynecologic cancer. Conventionally, lymphadenectomy has been performed routinely to assess lymphatic metastasis. However, lymphadenectomy may be unnecessary in early-stage gynecologic cancer, because the percentage of patients with lymph node ... Read more >>

Clin Obstet Gynecol (Clinical obstetrics and gynecology)
[2020, 63(1):12-23]

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Adjuvant therapy for grade 3, deeply invasive endometrioid adenocarcinoma of the uterus.

Michaela Onstad, Jennifer Ducie, Bryan M Fellman, Nadeem R Abu-Rustum, Mario Leitao, Andrea Mariani, Francesco Multinu, Karen H Lu, Pamela Soliman,

<h4>Background</h4>Patients with grade 3, deeply invasive endometrioid adenocarcinoma are typically managed with primary surgery. The role and type of adjuvant therapy used is controversial. We sought to evaluate the role of adjuvant radiation and/or chemotherapy in women with deeply invasive grade 3 endometrioid tumors.<h4>Methods</h4>A multi-center retrospective chart review was performed ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(4):485-490]

Cited: 1 time

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