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A Multicentered Study of the Clinical and Molecular Epidemiology of TEM- and SHV-type Extended-Spectrum Beta-Lactamase Producing Enterobacterales Infections in Children.

Latania K Logan, Jared R Rispens, Rachel L Medernach, T Nicholas Domitrovic, Andrea M Hujer, Steven H Marshall, Susan D Rudin, Nadia K Qureshi, Xiaotian Zheng, Mary K Hayden, Robert A Weinstein, Robert A Bonomo,

<h4>Background</h4>Extended-spectrum β-lactamase (ESBL)-producing Enterobacterales-(Ent) infections are increasing in pediatrics. Before CTX-M ESBL emerged, the most common infection-associated ESBL genes were TEM and SHV-type ESBLs. We sought to define the current epidemiology of Ent infections in children due to blaTEM and blaSHV (TEM-SHV-Ent).<h4>Methods</h4>A retrospective case-control analysis of children with TEM-SHV-Ent infections ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):39-43]

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A comprehensive and contemporary "snapshot" of β-lactamases in carbapenem resistant Acinetobacter baumannii.

Andrea M Hujer, Kristine M Hujer, David A Leonard, Rachel A Powers, Bradley J Wallar, Andrew R Mack, Magdalena A Taracila, Philip N Rather, Paul G Higgins, Fabio Prati, Emilia Caselli, Steven H Marshall, Thomas Clarke, Christopher Greco, Pratap Venepally, Lauren Brinkac, Barry N Kreiswirth, Derrick E Fouts, Robert A Bonomo, ,

Successful treatment of Acinetobacter baumannii infections require early and appropriate antimicrobial therapy. One of the first steps in this process is understanding which β-lactamase (bla) alleles are present and in what combinations. Thus, we performed WGS on 98 carbapenem-resistant A. baumannii (CR Ab). In most isolates, an acquired bla<sub>OXA</sub> carbapenemase ... Read more >>

Diagn Microbiol Infect Dis (Diagnostic microbiology and infectious disease)
[2020, 99(2):115242]

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1256. In Vivo Activity and Structural Characterization of a New Generation γ-Lactam Siderophore Antibiotic Against Multidrug-Resistant Gram-Negative Bacteria and Acinetobacter spp

Joel Goldberg, Christopher Bethel, Andrea M Hujer, Steven Marshall, Magdalena A Taracila, Krisztina M Papp-Wallce, Vijay Kumar, Focco van den Akker, Mark Plummer, Robert A Bonomo,

Abstract <h4>Background</h4> Multidrug-resistant (MDR) A. baumannii presents a critical need for innovative antibacterial development. We have identified a new series of γ-lactam (oxopyrazole) antibiotics that target penicillin binding proteins (PBPs) and incorporate a siderophore moiety to facilitate periplasmic uptake. YU253911, an advanced iteration of this class shows potent in vitro ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(Suppl 1):S645-S645]

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Monitoring Ceftazidime-Avibactam and Aztreonam Concentrations in the Treatment of a Bloodstream Infection Caused by a Multidrug-Resistant Enterobacter sp. Carrying Both Klebsiella pneumoniae Carbapenemase-4 and New Delhi Metallo-β-Lactamase-1.

Mohamad Yasmin, Derrick E Fouts, Michael R Jacobs, Hanan Haydar, Steven H Marshall, Richard White, Roshan D'Souza, Thomas P Lodise, Daniel D Rhoads, Andrea M Hujer, Laura J Rojas, Claudia Hoyen, Federico Perez, Amy Edwards, Robert A Bonomo,

In an infection with an Enterobacter sp. isolate producing Klebsiella pneumoniae Carbapenemase-4 and New Delhi Metallo-β-Lactamase-1 in the United States, recognition of the molecular basis of carbapenem resistance allowed for successful treatment by combining ceftazidime-avibactam and aztreonam. Antimicrobial synergy testing and therapeutic drug monitoring assessed treatment adequacy. ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 71(4):1095-1098]

Cited: 2 times

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Predicting β-lactam resistance using whole genome sequencing in Klebsiella pneumoniae: the challenge of β-lactamase inhibitors.

Andrea M Hujer, S Wesley Long, Randall J Olsen, Magdalena A Taracila, Laura J Rojas, James M Musser, Robert A Bonomo,

Although multiple antimicrobial resistance (AMR) determinants can confer the same in vitro antimicrobial susceptibility testing (AST) phenotype, their differing effect on optimal therapeutic choices is uncertain. Using a large population-based collection of clinical strains spanning a 3.5-year period, we applied WGS to detect inhibitor resistant (IR), extended-spectrum β-lactamase (ESBL), and ... Read more >>

Diagn Microbiol Infect Dis (Diagnostic microbiology and infectious disease)
[2020, 98(3):115149]

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A γ-Lactam Siderophore Antibiotic Effective against Multidrug-Resistant Gram-Negative Bacilli.

Joel A Goldberg, Ha Nguyen, Vijay Kumar, Elizabeth J Spencer, Denton Hoyer, Emma K Marshall, Anna Cmolik, Margaret O'Shea, Steven H Marshall, Andrea M Hujer, Kristine M Hujer, Susan D Rudin, T Nicholas Domitrovic, Christopher R Bethel, Krisztina M Papp-Wallace, Latania K Logan, Federico Perez, Michael R Jacobs, David van Duin, Barry M Kreiswirth, Robert A Bonomo, Mark S Plummer, Focco van den Akker,

Treatment of multidrug-resistant Gram-negative bacterial pathogens represents a critical clinical need. Here, we report a novel γ-lactam pyrazolidinone that targets penicillin-binding proteins (PBPs) and incorporates a siderophore moiety to facilitate uptake into the periplasm. The MIC values of γ-lactam YU253434, 1, are reported along with the finding that 1 is ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2020, 63(11):5990-6002]

Cited: 1 time

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ARGONAUT II Study of the In Vitro Activity of Plazomicin against Carbapenemase-Producing Klebsiella pneumoniae.

Michael R Jacobs, Caryn E Good, Andrea M Hujer, Ayman M Abdelhamed, Daniel D Rhoads, Kristine M Hujer, Susan D Rudin, T Nicholas Domitrovic, Lynn E Connolly, Kevin M Krause, Robin Patel, Cesar A Arias, Barry N Kreiswirth, Laura J Rojas, Roshan D'Souza, Richard C White, Lauren M Brinkac, Kevin Nguyen, Indresh Singh, Derrick E Fouts, David van Duin, Robert A Bonomo, ,

Plazomicin was tested against 697 recently acquired carbapenem-resistant Klebsiella pneumoniae isolates from the Great Lakes region of the United States. Plazomicin MIC50 and MIC90 values were 0.25 and 1 mg/liter, respectively; 680 isolates (97.6%) were susceptible (MICs of ≤2 mg/liter), 9 (1.3%) intermediate (MICs of 4 mg/liter), and 8 (1.1%) resistant (MICs of >32 mg/liter). ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2020, 64(5):]

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A Standard Numbering Scheme for Class C β-Lactamases.

Andrew R Mack, Melissa D Barnes, Magdalena A Taracila, Andrea M Hujer, Kristine M Hujer, Gabriel Cabot, Michael Feldgarden, Daniel H Haft, William Klimke, Focco van den Akker, Alejandro J Vila, Andrea Smania, Shozeb Haider, Krisztina M Papp-Wallace, Patricia A Bradford, Gian Maria Rossolini, Jean-Denis Docquier, Jean-Marie Frère, Moreno Galleni, Nancy D Hanson, Antonio Oliver, Patrick Plésiat, Laurent Poirel, Patrice Nordmann, Timothy G Palzkill, George A Jacoby, Karen Bush, Robert A Bonomo,

Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2020, 64(3):]

Cited: 2 times

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Molecular and clinical epidemiology of carbapenem-resistant Enterobacterales in the USA (CRACKLE-2): a prospective cohort study.

David van Duin, Cesar A Arias, Lauren Komarow, Liang Chen, Blake M Hanson, Gregory Weston, Eric Cober, Omai B Garner, Jesse T Jacob, Michael J Satlin, Bettina C Fries, Julia Garcia-Diaz, Yohei Doi, Sorabh Dhar, Keith S Kaye, Michelle Earley, Andrea M Hujer, Kristine M Hujer, T Nicholas Domitrovic, William C Shropshire, An Dinh, Claudia Manca, Courtney L Luterbach, Minggui Wang, David L Paterson, Ritu Banerjee, Robin Patel, Scott Evans, Carol Hill, Rebekka Arias, Henry F Chambers, Vance G Fowler, Barry N Kreiswirth, Robert A Bonomo, ,

<h4>Background</h4>Carbapenem-resistant Enterobacterales (CRE) are a global threat. We aimed to describe the clinical and molecular characteristics of Centers for Disease Control and Prevention (CDC)-defined CRE in the USA.<h4>Methods</h4>CRACKLE-2 is a prospective, multicentre, cohort study. Patients hospitalised in 49 US hospitals, with clinical cultures positive for CDC-defined CRE between April 30, ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, 20(6):731-741]

Cited: 2 times

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Carbapenem-Susceptible Klebsiella pneumoniae and Escherichia coli Isolates Carrying a Truncated KPC Carbapenemase: a Challenge for Rapid Molecular Diagnostics.

Hossein Salimnia, Jennifer Veltman, Pranatharthi H Chandrasekar, Jason M Pogue, Ryan Mynatt, Tanaz Salimnia, Steven H Marshall, Andrea M Hujer, Robert A Bonomo,

J Clin Microbiol (Journal of clinical microbiology)
[2020, 58(3):]

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Core genome MLST and resistome analysis of Klebsiella pneumoniae using a clinically amenable workflow.

Madiha Fida, Scott A Cunningham, Matthew P Murphy, Robert A Bonomo, Kristine M Hujer, Andrea M Hujer, Barry N Kreiswirth, Nicholas Chia, Patricio R Jeraldo, Heidi Nelson, Nicole M Zinsmaster, Nikhil Toraskar, Weizhong Chang, Robin Patel, ,

Whole genome sequencing (WGS) is replacing traditional microbiological typing methods for investigation of outbreaks in clinical settings. Here, we used a clinical microbiology laboratory core genome multilocus sequence typing (cgMLST) workflow to analyze 40 isolates of K. pneumoniae which are part of the Antimicrobial Resistance Leadership Group (ARLG) isolate collection, ... Read more >>

Diagn Microbiol Infect Dis (Diagnostic microbiology and infectious disease)
[2020, 97(1):114996]

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Evaluation of in vitro activity of ceftazidime/avibactam and ceftolozane/tazobactam against MDR Pseudomonas aeruginosa isolates from Qatar.

Mazen A Sid Ahmed, Hamad Abdel Hadi, Abubaker A I Hassan, Sulieman Abu Jarir, Muna A Al-Maslamani, Nahla Omer Eltai, Khalid M Dousa, Andrea M Hujer, Ali A Sultan, Bo Soderquist, Robert A Bonomo, Emad Bashir Ibrahim, Jana Jass, Ali S Omrani,

OBJECTIVES:To investigate the in vitro activity of ceftazidime/avibactam and ceftolozane/tazobactam against clinical isolates of MDR Pseudomonas aeruginosa from Qatar, as well as the mechanisms of resistance. METHODS:MDR P. aeruginosa isolated between October 2014 and September 2015 from all public hospitals in Qatar were included. The BD PhoenixTM system was used ... Read more >>

J Antimicrob Chemother (The Journal of antimicrobial chemotherapy)
[2019, 74(12):3497-3504]

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698. In vitro Activity of a New Generation Oxopyrazole Antibiotic Against Multidrug-Resistant Gram-Negative Bacilli

Joel Goldberg, Christopher Bethel, Andrea M Hujer, Kristine Hujer, Steven Marshall, Krisztina M Papp-Wallace, Federico Perez, Elizabeth Spencer, Denton Hoyer, Mark Plummer, Robert A Bonomo,

Abstract <h4>Background</h4> Multidrug-resistant Gram-negative bacilli (MDRGNB) are emerging as a challenging cause of hospital-acquired infections and represent a critical need for innovative antibacterial development. New oxopyrazole agents targeting penicillin-binding proteins (PBPs) based on a non-β-lactam core and incorporating a siderophore moiety (Figure 1) which facilitates transport to the periplasm are ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S315-S316]

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687. In vitro Activity of a New Generation Oxopyrazole Antibiotic Against Acinetobacter spp.

Joel Goldberg, Christopher Bethel, Andrea M Hujer, Kristine Hujer, Steven Marshall, Krisztina M Papp-Wallace, Federico Perez, Elizabeth Spencer, Denton Hoyer, Mark Plummer, Robert A Bonomo,

Abstract Background Acinetobacter spp. resistant to common antibiotics have become a worrying cause of hospital-acquired infections and represent a critical need for innovative antibacterial development. New oxopyrazole agents targeting penicillin-binding proteins (PBPs) based on a non-β-lactam core and incorporating a siderophore moiety (figure) which facilitates transport to the periplasm are ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S312-S312]

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594. A Multi-Centered Study of the Clinical and Molecular Epidemiology of AmpC Cephalosporinase-Producing (AmpC) Enterobacteriaceae (Ent) Infections in Children

Rachel L Medernach, T Nicholas Domitrovic, Karen C Hayani, Andrea M Hujer, Nadia K Qureshi, Steven H Marshall, David C Nguyen, Susan D Rudin, Jared R Rispens, Xiaotian Zheng, Robert A Weinstein, Robert A Bonomo, Latania K Logan,

Abstract Background AmpC producing Ent are an important cause of multidrug-resistant (MDR) infections in pediatrics. Since most AmpC Ent studies have been conducted in adults, we characterized the molecular epidemiology of AmpC Ent strains with transmissible resistance and identified factors associated with AmpC Ent infections in children. Methods A case–control ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S280-S280]

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609. Differing Genotypic Contexts Between E. coli and A. baumannii Modulate the Role of blaADC-7 in the Development of Antibiotic Collateral Sensitivity

Erin McClure, Julia Newman, Nikhil Krishnan, Joseph Rutter, Andrea M Hujer, Mark D Adams, Jacob Scott, Robert A Bonomo,

Abstract Background Antibiotic resistance is a global health crisis. While persistent drug discovery of novel antibiotics has previously been relied upon to thwart resistance, evolution inevitably perseveres. While genes conferring antibiotic resistance have previously been characterized, it is unclear how varying genetic contexts can change the antibiotic resistance phenotype a ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S284-S285]

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A Multi-Centered Case-Case-Control Study of Factors Associated With Klebsiella pneumoniae Carbapenemase-Producing Enterobacteriaceae Infections in Children and Young Adults.

Latania K Logan, David C Nguyen, Felicia A Scaggs Huang, Nadia K Qureshi, Angella Charnot-Katsikas, Allison H Bartlett, Xiaotian Zheng, Andrea M Hujer, T Nicholas Domitrovic, Steven H Marshall, Robert A Bonomo, Robert A Weinstein,

<h4>Background</h4>Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae (KPC-CRE) are multidrug-resistant organisms causing morbidity and mortality worldwide. KPC-CRE prevalence is increasing in pediatric populations, though multi-centered data are lacking. Identifying risk factors for KPC-CRE infection in children and classifying genotypes is a priority in this vulnerable population.<h4>Methods</h4>A case-case-control study of patients (0-22 years) ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(5):490-495]

Cited: 3 times

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Community Origins and Regional Differences Highlight Risk of Plasmid-mediated Fluoroquinolone Resistant Enterobacteriaceae Infections in Children.

Latania K Logan, Rachel L Medernach, Jared R Rispens, Steven H Marshall, Andrea M Hujer, T Nicholas Domitrovic, Susan D Rudin, Xiaotian Zheng, Nadia K Qureshi, Sreenivas Konda, Mary K Hayden, Robert A Weinstein, Robert A Bonomo,

<h4>Background</h4>Fluoroquinolones are uncommonly prescribed in children, yet pediatric multidrug resistant (MDR) enterobacteriaceae (Ent) infections often reveal fluoroquinolone resistance (FQR). We sought to define the molecular epidemiology of FQR and MDR-Ent in children.<h4>Methods</h4>A case-control analysis of children with MDR-Ent infections at 3 Chicago hospitals was performed. Cases were children with third-generation ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(6):595-599]

Cited: 2 times

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Rapid Molecular Diagnostics to Inform Empiric Use of Ceftazidime/Avibactam and Ceftolozane/Tazobactam Against Pseudomonas aeruginosa: PRIMERS IV.

Scott R Evans, Thuy Tien T Tran, Andrea M Hujer, Carol B Hill, Kristine M Hujer, Jose R Mediavilla, Claudia Manca, T Nicholas Domitrovic, Federico Perez, Michael Farmer, Kelsey M Pitzer, Brigid M Wilson, Barry N Kreiswirth, Robin Patel, Michael R Jacobs, Liang Chen, Vance G Fowler, Henry F Chambers, Robert A Bonomo, ,

<h4>Background</h4>Overcoming β-lactam resistance in pathogens such as Pseudomonas aeruginosa is a major clinical challenge. Rapid molecular diagnostics (RMDs) have the potential to inform selection of empiric therapy in patients infected by P. aeruginosa.<h4>Methods</h4>In this study, we used a heterogeneous collection of 197 P. aeruginosa that included multidrug-resistant isolates to determine ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2019, 68(11):1823-1830]

Cited: 8 times

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Targeting Multidrug-Resistant Acinetobacter spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent.

Melissa D Barnes, Vijay Kumar, Christopher R Bethel, Samir H Moussa, John O'Donnell, Joseph D Rutter, Caryn E Good, Kristine M Hujer, Andrea M Hujer, Steve H Marshall, Barry N Kreiswirth, Sandra S Richter, Philip N Rather, Michael R Jacobs, Krisztina M Papp-Wallace, Focco van den Akker, Robert A Bonomo,

Multidrug-resistant (MDR) <i>Acinetobacter</i> spp. poses a significant therapeutic challenge in part due to the presence of chromosomally encoded β-lactamases, including class C <i>Acinetobacter</i>-derived cephalosporinases (ADC) and class D oxacillinases (OXA), as well as plasmid-mediated class A β-lactamases. Importantly, OXA-like β-lactamases represent a gap in the spectrum of inhibition by recently ... Read more >>

mBio (mBio)
[2019, 10(2):]

Cited: 10 times

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The Clinical and Molecular Epidemiology of CTX-M-9 Group Producing Enterobacteriaceae Infections in Children.

Latania K Logan, Rachel L Medernach, T Nicholas Domitrovic, Jared R Rispens, Andrea M Hujer, Nadia K Qureshi, Steven H Marshall, David C Nguyen, Susan D Rudin, Xiaotian Zheng, Sreenivas Konda, Robert A Weinstein, Robert A Bonomo,

<h4>Introduction</h4>The pandemic of extended-spectrum beta-lactamase-(ESBL)-producing Enterobacteriaceae (Ent) is strongly linked to the dissemination of CTX-M-type-ESBL-Ent. We sought to define the epidemiology of infections in children due to an emerging resistance type, CTX-M-9-group-producing-Ent (CTX-M-9-grp-Ent).<h4>Methods</h4>A retrospective matched case-control analysis of children with CTX-M-9-grp-Ent infections who received medical care at three Chicago area ... Read more >>

Infect Dis Ther (Infectious diseases and therapy)
[2019, 8(2):243-254]

Cited: 2 times

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ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases.

Michael R Jacobs, Ayman M Abdelhamed, Caryn E Good, Daniel D Rhoads, Kristine M Hujer, Andrea M Hujer, T Nicholas Domitrovic, Susan D Rudin, Sandra S Richter, David van Duin, Barry N Kreiswirth, Chris Greco, Derrick E Fouts, Robert A Bonomo,

The activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-resistant Gram-negative bacteria. In this study, the activity of cefiderocol against characterized carbapenem-resistant <i>Acinetobacter baumannii</i> complex, <i>Stenotrophomonas maltophilia</i>, <i>Pseudomonas aeruginosa</i>, and <i>Enterobacteriaceae</i> strains was determined by microdilution in iron-depleted Mueller-Hinton broth. The MIC<sub>90</sub>s against <i>A. baumannii</i>, <i>S. maltophilia</i>, and <i>P. ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2019, 63(1):]

Cited: 12 times

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The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae.

Courtney L Luterbach, Ashley Boshe, Heather I Henderson, Eric Cober, Sandra S Richter, Robert A Salata, Robert C Kalayjian, Richard R Watkins, Andrea M Hujer, Kristine M Hujer, Susan D Rudin, T Nicholas Domitrovic, Yohei Doi, Keith S Kaye, Scott Evans, Vance G Fowler, Robert A Bonomo, David van Duin,

In the Consortium on Resistance Against Carbapenems in <i>Klebsiella</i> and other <i>Enterobacteriaceae</i> (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant <i>Enterobacteriaceae</i> (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMP-SMX. Development of resistance further limits the use of ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(1):ofy351]

Cited: 1 time

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Antibiotic collateral sensitivity is contingent on the repeatability of evolution.

Daniel Nichol, Joseph Rutter, Christopher Bryant, Andrea M Hujer, Sai Lek, Mark D Adams, Peter Jeavons, Alexander R A Anderson, Robert A Bonomo, Jacob G Scott,

Antibiotic resistance represents a growing health crisis that necessitates the immediate discovery of novel treatment strategies. One such strategy is the identification of collateral sensitivities, wherein evolution under a first drug induces susceptibility to a second. Here, we report that sequential drug regimens derived from in vitro evolution experiments may ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):334]

Cited: 17 times

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Deciphering the Evolution of Cephalosporin Resistance to Ceftolozane-Tazobactam in Pseudomonas aeruginosa.

Melissa D Barnes, Magdalena A Taracila, Joseph D Rutter, Christopher R Bethel, Ioannis Galdadas, Andrea M Hujer, Emilia Caselli, Fabio Prati, John P Dekker, Krisztina M Papp-Wallace, Shozeb Haider, Robert A Bonomo,

<i>Pseudomonas aeruginosa</i> produces a class C β-lactamase (e.g., PDC-3) that robustly hydrolyzes early generation cephalosporins often at the diffusion limit; therefore, bacteria possessing these β-lactamases are resistant to many β-lactam antibiotics. In response to this significant clinical threat, ceftolozane, a 3' aminopyrazolium cephalosporin, was developed. Combined with tazobactam, ceftolozane promised ... Read more >>

mBio (mBio)
[2018, 9(6):]

Cited: 13 times

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