Full Text Journal Articles by
Author Andrea Levine


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The Impact of Corticosteroids on Secondary Infection and Mortality in Critically Ill COVID-19 Patients.

Lindsay A Ritter, Noel Britton, Emily L Heil, William A Teeter, Sarah B Murthi, Jonathan H Chow, Emily Ricotta, Daniel S Chertow, Alison Grazioli, Andrea R Levine,

<h4>Background</h4>Corticosteroids are part of the treatment guidelines for COVID-19 and have been shown to improve mortality. However, the impact corticosteroids have on the development of secondary infection in COVID-19 is unknown. We sought to define the rate of secondary infection in critically ill patients with COVID-19 and determine the effect ... Read more >>

J Intensive Care Med (Journal of intensive care medicine)
[2021, 36(10):1201-1208]

Cited: 2 times

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Renin Kinetics Are Superior to Lactate Kinetics for Predicting In-Hospital Mortality in Hypotensive Critically Ill Patients.

Maniraj Jeyaraju, Michael T McCurdy, Andrea R Levine, Prasad Devarajan, Michael A Mazzeffi, Kristin E Mullins, Michaella Reif, David N Yim, Christopher Parrino, Allison S Lankford, Jonathan H Chow,

<h4>Objectives</h4>Whole blood lactate concentration is widely used in shock states to assess perfusion. We aimed to determine if the change in plasma renin concentration over time would be superior to the change in lactate concentration for predicting in-hospital mortality in hypotensive patients on vasopressors.<h4>Design</h4>Prospective, observational cohort study.<h4>Setting</h4>Tertiary academic ICU.<h4>Patients</h4>Adult patients ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

Cited: 1 time

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Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction.

Taijyu Satoh, Longfei Wang, Cristina Espinosa-Diez, Bing Wang, Scott A Hahn, Kentaro Noda, Elizabeth R Rochon, Matthew R Dent, Andrea R Levine, Jeffrey J Baust, Samuel Wyman, Yijen L Wu, Georgios A Triantafyllou, Ying Tang, Mike Reynolds, Sruti Shiva, Cynthia St Hilaire, Delphine Gomez, Dmitry A Goncharov, Elena A Goncharova, Stephen Y Chan, Adam C Straub, Yen-Chun Lai, Charles F McTiernan, Mark T Gladwin,

<h4>Background</h4>Many patients with heart failure with preserved ejection fraction have metabolic syndrome and develop exercise-induced pulmonary hypertension (EIPH). Increases in pulmonary vascular resistance in patients with heart failure with preserved ejection fraction portend a poor prognosis; this phenotype is referred to as combined precapillary and postcapillary pulmonary hypertension (CpcPH). Therapeutic ... Read more >>

Circulation (Circulation)
[2021, 144(8):615-637]

Cited: 0 times

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Aspirin Use Is Associated With Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients With Coronavirus Disease 2019.

Jonathan H Chow, Ashish K Khanna, Shravan Kethireddy, David Yamane, Andrea Levine, Amanda M Jackson, Michael T McCurdy, Ali Tabatabai, Gagan Kumar, Paul Park, Ivy Benjenk, Jay Menaker, Nayab Ahmed, Evan Glidewell, Elizabeth Presutto, Shannon Cain, Naeha Haridasa, Wesley Field, Jacob G Fowler, Duy Trinh, Kathleen N Johnson, Aman Kaur, Amanda Lee, Kyle Sebastian, Allison Ulrich, Salvador Peña, Ross Carpenter, Shruti Sudhakar, Pushpinder Uppal, Benjamin T Fedeles, Aaron Sachs, Layth Dahbour, William Teeter, Kenichi Tanaka, Samuel M Galvagno, Daniel L Herr, Thomas M Scalea, Michael A Mazzeffi,

<h4>Background</h4>Coronavirus disease-2019 (COVID-19) is associated with hypercoagulability and increased thrombotic risk in critically ill patients. To our knowledge, no studies have evaluated whether aspirin use is associated with reduced risk of mechanical ventilation, intensive care unit (ICU) admission, and in-hospital mortality.<h4>Methods</h4>A retrospective, observational cohort study of adult patients admitted with ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 132(4):930-941]

Cited: 93 times

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SARS-CoV-2 infection of the oral cavity and saliva.

Ni Huang, Paola Pérez, Takafumi Kato, Yu Mikami, Kenichi Okuda, Rodney C Gilmore, Cecilia Domínguez Conde, Billel Gasmi, Sydney Stein, Margaret Beach, Eileen Pelayo, Jose O Maldonado, Bernard A Lafont, Shyh-Ing Jang, Nadia Nasir, Ricardo J Padilla, Valerie A Murrah, Robert Maile, William Lovell, Shannon M Wallet, Natalie M Bowman, Suzanne L Meinig, Matthew C Wolfgang, Saibyasachi N Choudhury, Mark Novotny, Brian D Aevermann, Richard H Scheuermann, Gabrielle Cannon, Carlton W Anderson, Rhianna E Lee, Julie T Marchesan, Mandy Bush, Marcelo Freire, Adam J Kimple, Daniel L Herr, Joseph Rabin, Alison Grazioli, Sanchita Das, Benjamin N French, Thomas Pranzatelli, John A Chiorini, David E Kleiner, Stefania Pittaluga, Stephen M Hewitt, Peter D Burbelo, Daniel Chertow, , , Karen Frank, Janice Lee, Richard C Boucher, Sarah A Teichmann, Blake M Warner, Kevin M Byrd,

Despite signs of infection-including taste loss, dry mouth and mucosal lesions such as ulcerations, enanthema and macules-the involvement of the oral cavity in coronavirus disease 2019 (COVID-19) is poorly understood. To address this, we generated and analyzed two single-cell RNA sequencing datasets of the human minor salivary glands and gingiva ... Read more >>

Nat Med (Nature medicine)
[2021, 27(5):892-903]

Cited: 56 times

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Seven-Year Follow-Up of an Online Critical Care Curriculum.

Ali Tabatabai, John C Greenwood, James H Lantry, Andrea R Levine, Nirav G Shah, William C Chiu, Nicholas A Morris, Jonathan H Chow, Samuel A Tisherman, Michael T McCurdy,

<b>Background:</b> In July of 2013, the University of Maryland launched MarylandCCProject.com. This free-access educational website delivers asynchronous high-quality multidisciplinary critical care education targeted at critical care trainees. The lectures, presented in real time on-site, are recorded and available on the website or as a podcast on iTunes or Android. Thus, ... Read more >>

ATS Sch (ATS scholar)
[2021, 2(2):224-235]

Cited: 0 times

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A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19.

, Jens D Lundgren, Birgit Grund, Christina E Barkauskas, Thomas L Holland, Robert L Gottlieb, Uriel Sandkovsky, Samuel M Brown, Kirk U Knowlton, Wesley H Self, D Clark Files, Mamta K Jain, Thomas Benfield, Michael E Bowdish, Bradley G Leshnower, Jason V Baker, Jens-Ulrik Jensen, Edward M Gardner, Adit A Ginde, Estelle S Harris, Isik S Johansen, Norman Markowitz, Michael A Matthay, Lars Østergaard, Christina C Chang, Victoria J Davey, Anna Goodman, Elizabeth S Higgs, Daniel D Murray, Thomas A Murray, Roger Paredes, Mahesh K B Parmar, Andrew N Phillips, Cavan Reilly, Shweta Sharma, Robin L Dewar, Marc Teitelbaum, Deborah Wentworth, Huyen Cao, Paul Klekotka, Abdel G Babiker, Annetine C Gelijns, Virginia L Kan, Mark N Polizzotto, B Taylor Thompson, H Clifford Lane, James D Neaton,

<h4>Background</h4>LY-CoV555, a neutralizing monoclonal antibody, has been associated with a decrease in viral load and the frequency of hospitalizations or emergency department visits among outpatients with coronavirus disease 2019 (Covid-19). Data are needed on the effect of this antibody in patients who are hospitalized with Covid-19.<h4>Methods</h4>In this platform trial of ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 384(10):905-914]

Cited: 76 times

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Impact of Sex and Metabolic Comorbidities on COVID-19 Mortality Risk Across Age Groups: 66,646 Inpatients Across 613 U.S. Hospitals.

Katherine E Goodman, Laurence S Magder, Jonathan D Baghdadi, Lisa Pineles, Andrea R Levine, Eli N Perencevich, Anthony D Harris,

<h4>Background</h4>The relationship between common patient characteristics, such as sex and metabolic comorbidities, and mortality from COVID-19 remains incompletely understood. Emerging evidence suggests that metabolic risk factors may also vary by age. This study aimed to determine the association between common patient characteristics and mortality across age-groups among COVID-19 inpatients.<h4>Methods</h4>We performed ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

Cited: 21 times

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Real-Time Remote Tele-Mentored Echocardiography: A Systematic Review.

Alexis Salerno, Diane Kuhn, Rayan El Sibai, Andrea R Levine, Michael T McCurdy,

<i>Background and Objectives</i>: Real-time remote tele-mentored echocardiography (RTMUS echo) involves the transmission of clinical ultrasound (CU) cardiac images with direct feedback from a CU expert at a different location. In this review, we summarize the current uses of RTMUS to diagnose and manage cardiovascular dysfunction and discuss expanded and future ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2020, 56(12):]

Cited: 0 times

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Effects of Oral Sodium Nitrite on Blood Pressure, Insulin Sensitivity, and Intima-Media Arterial Thickening in Adults With Hypertension and Metabolic Syndrome.

Kara S Hughan, Andrea Levine, Nicole Helbling, Steven Anthony, James P DeLany, Maja Stefanovic-Racic, Bret H Goodpaster, Mark T Gladwin,

The nitrate-nitrite-NO pathway regulates NO synthase-independent vasodilation and NO signaling. Ingestion of inorganic nitrite has vasodilatory and blood pressure-lowering effects. Preclinical studies in rodent models suggest there may be a benefit of nitrite in lowering serum triglyceride levels and improving the metabolic syndrome. In a phase 2 study, we evaluated ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2020, 76(3):866-874]

Cited: 3 times

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Initiation of a survey of healthcare worker distress and moral injury at the onset of the COVID-19 surge.

Stella E Hines, Katherine H Chin, Andrea R Levine, Emerson M Wickwire,

Am J Ind Med (American journal of industrial medicine)
[2020, 63(9):830-833]

Cited: 6 times

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A Simple But Often Ignored Formula to Improve Critical Care: "Telemedicine + Ultrasound = Tele-Ultrasound".

Andrea R Levine, Avelino C Verceles, Michael T McCurdy,

Crit Care Med (Critical care medicine)
[2020, 48(6):e540]

Cited: 2 times

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Argument for Personalized Vasopressors in Septic Shock.

Andrea R Levine, Jonathan H Chow, Michael T McCurdy,

Crit Care Med (Critical care medicine)
[2020, 48(5):e439]

Cited: 0 times

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Tele-Ultrasound in Resource-Limited Settings: A Systematic Review.

Noel Britton, Michael A Miller, Sami Safadi, Ariel Siegel, Andrea R Levine, Michael T McCurdy,

Background: Telemedicine, or healthcare delivery from a distance, has evolved over the past 50 years and helped alter health care delivery to patients around the globe. Its integration into numerous domains has permitted high quality care that transcends obstacles of geographic distance, lack of access to health care providers, and ... Read more >>

Front Public Health (Frontiers in public health)
[2019, 7:244]

Cited: 21 times

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AMP Kinase Activation Attenuates Cardiac Remodeling in Pulmonary Hypertension due to Heart Failure with Preserved Ejection Fraction; Lung Epithelial Progenitor Cells in Alveolar Regeneration; and Drug Discovery and Novel Therapies for Lung Cancer.

Andrea R Levine, William Bain, Joseph S Bednash, Mark T Gladwin, Bryan J McVerry,

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2019, 60(2):244-247]

Cited: 0 times

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Brief training increases nurses' comfort using tele-ultrasound: A feasibility study.

Taylor M Douglas, Andrea R Levine, Peter P Olivieri, Michael T McCurdy, Alfred Papali, Marc T Zubrow, Karen M Rodick, Julie M Hurley, Avelino C Verceles,

<h4>Background</h4>Nurses and other non-physician providers have demonstrated proficiency at obtaining images in the tele-ultrasound system. However, use of this skill requires comfort with the procedure and willingness to incorporate it into practice.<h4>Objectives</h4>To assess 1) level of comfort of non-physician providers performing tele-ultrasound before and after brief training and 2) feasibility ... Read more >>

Intensive Crit Care Nurs (Intensive & critical care nursing)
[2019, 51:45-49]

Cited: 1 time

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Pulmonary vascular disease in the setting of heart failure with preserved ejection fraction.

Andrea R Levine, Marc A Simon, Mark T Gladwin,

Heart failure with preserved ejection fraction (HFpEF) is defined as clinical features of heart failure, ideally with biomarker evidence such as elevated plasma natriuretic peptide levels, in the setting of an ejection fraction (EF) greater than 50% and imaging evidence of diastolic left ventricular dysfunction [1,2]. In the absence of ... Read more >>

Trends Cardiovasc Med (Trends in cardiovascular medicine)
[2019, 29(4):207-217]

Cited: 8 times

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Emerging therapeutics in pulmonary hypertension.

Matthew K Hensley, Andrea Levine, Mark T Gladwin, Yen-Chun Lai,

Pulmonary hypertension (PH) is a progressive and often fatal illness presenting with nonspecific symptoms of dyspnea, lower extremity edema, and exercise intolerance. Pathologically, endothelial dysfunction leads to abnormal intimal and smooth muscle proliferation along with reduced apoptosis, resulting in increased pulmonary vascular resistance and elevated pulmonary pressures. PH is subdivided ... Read more >>

Am J Physiol Lung Cell Mol Physiol (American journal of physiology. Lung cellular and molecular physiology)
[2018, 314(5):L769-L781]

Cited: 9 times

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Remote tele-mentored ultrasound for non-physician learners using FaceTime: A feasibility study in a low-income country.

Thomas E Robertson, Andrea R Levine, Avelino C Verceles, Jessica A Buchner, James H Lantry, Alfred Papali, Marc T Zubrow, L Nathalie Colas, Marc E Augustin, Michael T McCurdy, ,

<h4>Purpose</h4>Ultrasound (US) is a burgeoning diagnostic tool and is often the only available imaging modality in low- and middle-income countries (LMICs). However, bedside providers often lack training to acquire or interpret US images. We conducted a study to determine if a remote tele-intensivist could mentor geographically removed LMIC providers to ... Read more >>

J Crit Care (Journal of critical care)
[2017, 40:145-148]

Cited: 10 times

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Tele-Medicine and Point-of-Care Ultrasound: A New Paradigm for Resource-Constrained Settings.

Andrea R Levine, Thomas E Robertson, Alfred Papali, Avelino C Verceles, Michael T McCurdy,

Chest (Chest)
[2016, 149(6):1580-1581]

Cited: 2 times

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Ultrasound images transmitted via FaceTime are non-inferior to images on the ultrasound machine.

Andrea R Levine, Jessica A Buchner, Avelino C Verceles, Marc T Zubrow, Haney A Mallemat, Alfred Papali, Michael T McCurdy,

<h4>Purpose</h4>Remote telementored ultrasound (RTMUS) systems can deliver ultrasound (US) expertise to regions lacking highly trained bedside ultrasonographers and US interpreters. To date, no studies have evaluated the quality and clinical utility of US images transmitted using commercially available RTMUS systems.<h4>Methods</h4>This prospective pilot evaluated the quality of US images (right internal ... Read more >>

J Crit Care (Journal of critical care)
[2016, 33:51-55]

Cited: 10 times

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Tele-intensivists can instruct non-physicians to acquire high-quality ultrasound images.

Andrea R Levine, Michael T McCurdy, Marc T Zubrow, Alfred Papali, Haney A Mallemat, Avelino C Verceles,

<h4>Purpose</h4>Intensive care unit telemedicine (tele-ICU) uses audiovisual systems to remotely monitor and manage patients. Intensive care unit ultrasound can augment an otherwise limited bedside evaluation. To date, no studies have utilized tele-ICU technology to assess the quality and clinical use of real-time ultrasound images. We assessed whether tele-intensivists can instruct ... Read more >>

J Crit Care (Journal of critical care)
[2015, 30(5):871-875]

Cited: 15 times

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Implicit memory in Korsakoff's syndrome: a review of procedural learning and priming studies.

Scott M Hayes, Catherine B Fortier, Andrea Levine, William P Milberg, Regina McGlinchey,

Korsakoff's syndrome (KS) is characterized by dense anterograde amnesia resulting from damage to the diencephalon region, typically resulting from chronic alcohol abuse and thiamine deficiency. This review assesses the integrity of the implicit memory system in KS, focusing on studies of procedural learning and priming. KS patients are impaired on ... Read more >>

Neuropsychol Rev (Neuropsychology review)
[2012, 22(2):132-153]

Cited: 15 times

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Crack cocaine, disease progression, and mortality in a multicenter cohort of HIV-1 positive women.

Judith A Cook, Jane K Burke-Miller, Mardge H Cohen, Robert L Cook, David Vlahov, Tracey E Wilson, Elizabeth T Golub, Rebecca M Schwartz, Andrea A Howard, Claudia Ponath, Michael W Plankey, Alexandra M Levine, Dennis D Grey,

<h4>Background</h4>Longitudinal associations between patterns of crack cocaine use and progression of HIV-1 disease are poorly understood, especially among women. This study explores relationships between crack use and HIV-1 disease outcomes in a multicenter cohort of infected women.<h4>Methods</h4>Subjects were 1686 HIV-seropositive women enrolled at six US research centers in the Women's ... Read more >>

AIDS (AIDS (London, England))
[2008, 22(11):1355-1363]

Cited: 135 times

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Adenovirus-mediated expression of TIMP-1 and TIMP-2 in bone inhibits osteolytic degradation by human prostate cancer.

Xiyun Deng, Guangchun He, Andrea Levine, Ya Cao, Chad Mullins,

Matrix metalloproteinases (MMPs) are proteolytic enzymes that play critical roles in the pathogenesis of human cancers. Clinical trials using synthetic small molecule MMP inhibitors have been carried out but with little success. Tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors that block the extracellular matrix-degrading activity of MMPs. Here, we ... Read more >>

Int J Cancer (International journal of cancer)
[2008, 122(1):209-218]

Cited: 21 times

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