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Advances in subcutaneous injections: PRECISE II: a study of safety and subject preference for an innovative needle-free injection system.

E Lynne Kelley, Richard H Smith, Gillian Corcoran, Sandra Nygren, Mary V Jacoski, Andrea Fernandes,

Needle-free injection is a desirable goal for many reasons, including reducing pain, anxiety, and eliminating safety risks associated with needle-stick injuries. However, development of a safe, reliable needle-free device optimized for at-home use has been met with many challenges. Portal Instruments Inc. has been developing needle-free medication delivery using a ... Read more >>

Drug Deliv (Drug delivery)
[2021, 28(1):1915-1922]

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Serum Biomarkers Predict Symptom Duration in Long Term COVID-19 Across a Diverse Population

Xiaolin Jia, Shu Cao, Alexandra Lee, Sayantani Sindher, Neera Ahuja, Maja Artandi, Linda Barman, Catherine Blish, Andra Blomkalns, Iris Chang, William Collins, Mackenzie Cox, Manisha Desai, Hena Din, Evan Do, Andrea Fernandes, Linda Geng, Yael Rosenberg-Hasson, Holden Maecker, Megan Mahoney, Monali Manohar, Ruth O’Hara, Stanford COVID-19 Biobank Study Group, Natasha Purington, Katharina Röltgen, Angela Rogers, Theo Snow, Daniel Solis, Laura Vaughan, Monica Vel, Michelle Verghese, Yingjie Weng, Rajan Puri, Samuel Yang, Scott Boyd, Benjamin Pinsky, Sharon Chinthrajah, Kari Nadeau,

Background: Prolonged symptoms after SARS-CoV-2 infection are well-documented. However, which factors influence development of long-term symptoms, how symptoms vary across ethnic groups, and whether long-term symptoms correlate with serologic biomarkers remain elusive. <br><br>Methods: Adult inpatient and outpatient SARS-CoV-2 RT-PCR positive patients were recruited at Stanford from March 2020 to February ... Read more >>

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A New Target Organ of Leishmania (Viannia) braziliensis Chronic Infection: The Intestine.

Amanda Gubert Alves Dos Santos, Maria Gabriela Lima da Silva, Erick Lincoln Carneiro, Lainy Leiny de Lima, Andrea Claudia Bekner Silva Fernandes, Thaís Gomes Verzignassi Silveira, Debora de Mello Gonçales Sant'Ana, Gessilda de Alcantara Nogueira-Melo,

<i>Leishmania (Viannia) braziliensis</i> is one of the main causes of cutaneous leishmaniasis in the Americas. This species presents genetic polymorphism that can cause destructive lesions in oral, nasal, and oropharyngeal tracts. In a previous study, the parasite caused several histopathological changes to hamster ileums. Our study evaluates immune response components, ... Read more >>

Front Cell Infect Microbiol (Frontiers in cellular and infection microbiology)
[2021, 11:687499]

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Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19.

Aaron J Wilk, Madeline J Lee, Bei Wei, Benjamin Parks, Ruoxi Pi, Giovanny J Martínez-Colón, Thanmayi Ranganath, Nancy Q Zhao, Shalina Taylor, Winston Becker, , David Jimenez-Morales, Andra L Blomkalns, Ruth O'Hara, Euan A Ashley, Kari C Nadeau, Samuel Yang, Susan Holmes, Marlene Rabinovitch, Angela J Rogers, William J Greenleaf, Catherine A Blish,

Our understanding of protective versus pathological immune responses to SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of patients at the extremes of the disease severity spectrum. Here, we performed multi-omic single-cell immune profiling of 64 COVID-19 patients across the full range of disease ... Read more >>

J Exp Med (The Journal of experimental medicine)
[2021, 218(8):]

Cited: 3 times

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A family with partially penetrant multicentric carpotarsal osteolysis due to gonadal mosaicism: First reported case.

Anu Närhi, Andrea Fernandes, Sanna Toiviainen-Salo, Jessica Harris, Aideen McInerney-Leo, Syndia Lazarus, Kristiina Avela, Emma L Duncan,

Multicentric carpotarsal osteolysis (MCTO) is an autosomal dominant condition characterized by carpal-tarsal abnormalities; over half of affected individuals also develop renal disease. MCTO is caused by mutations of MAFB; however, there is no clear phenotype-genotype correlation. We describe the first reported family of variable MCTO phenotype due to mosaicism: the ... Read more >>

Am J Med Genet A (American journal of medical genetics. Part A)
[2021, 185(8):2477-2481]

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Aristolochia Herbs and Iatrogenic Disease: The Case of Portland's Powders.

Tristan Tomlinson, Andrea Fernandes, Arthur P Grollman,

<i>Aristolochia</i> herbals have a 2500-year history of medicinal use. We focused this article on Portland's Powders, an 18<sup>th</sup>-century British gout medicine containing <i>Aristolochia</i> herbs. The powders constitute an 18<sup>th</sup>-century iteration of an herbal remedy, which was used, with variations, since at least the fifth century BCE. The use of Portland's ... Read more >>

Yale J Biol Med (The Yale journal of biology and medicine)
[2020, 93(2):355-363]

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British Gynaecological Cancer Society recommendations and guidance on patient-initiated follow-up (PIFU).

Claire Newton, Andy Nordin, Philip Rolland, Thomas Ind, Peter Larsen-Disney, Pierre Martin-Hirsch, Kinter Beaver, Helen Bolton, Richard Peevor, Andrea Fernandes, Fiona Kew, Partha Sengupta, Tracie Miles, Lynn Buckley, Helen Manderville, Ketan Gajjar, Jo Morrison, Jonathan Ledermann, Jonathan Frost, Alexandra Lawrence, Sudha Sundar, Christina Fotopoulou,

The National Cancer Survivorship Initiative through the National Health Service (NHS) improvement in the UK started the implementation of stratified pathways of patient-initiated follow-up (PIFU) across various tumor types. Now the initiative is continued through the Living With and Beyond Cancer program by NHS England. Evidence from non-randomized studies and ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(5):695-700]

Cited: 1 time

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PCR primers designed for new world Leishmania: A systematic review.

Carolina Cella Conter, Camila Alves Mota, Barbara Andreo Dos Santos, Laís de Souza Braga, Mariana de Souza Terron, Taísa Rocha Navasconi, Andrea Claudia Bekner Silva Fernandes, Izabel Galhardo Demarchi, Kárin Rosi Reinhold de Castro, Sandra Mara Alessi Aristides, Maria Valdrinez Campana Lonardoni, Jorge Juarez Vieira Teixeira, Thaís Gomes Verzignassi Silveira,

Studies of the primers that were designed to detect New World Leishmania were systematically reviewed to report the characteristics of each target, detection limit, specificity of the primers designed and diagnostic sensibility. The papers identified in the databases PubMed and Web of Science involved 50 studies. Minicircle is the most ... Read more >>

Exp Parasitol (Experimental parasitology)
[2019, 207:107773]

Cited: 2 times

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Comparative Study of the Use of HPA Lanolin and Breast Milk for Treating Pain Associated with Nipple Trauma.

Corintio Mariani Neto, Rosemeire Sartori de Albuquerque, Sonia Cristina de Souza, Renata Oliveira Giesta, Andrea Penha Spinola Fernandes, Bárbara Mondin,

<h4>Objective</h4> To compare two different treatments-the use of highly purified anhydrous (HPA) lanolin and expressed breast milk-for women with pain and nipple trauma during the breastfeeding process.<h4>Method</h4> A total of 180 puerperal women were randomly assigned to 2 groups: one was treated with HPA lanolin and the other with their own expressed ... Read more >>

Rev Bras Ginecol Obstet (Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia)
[2018, 40(11):664-672]

Cited: 0 times

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Identifying Suicide Ideation and Suicidal Attempts in a Psychiatric Clinical Research Database using Natural Language Processing.

Andrea C Fernandes, Rina Dutta, Sumithra Velupillai, Jyoti Sanyal, Robert Stewart, David Chandran,

Research into suicide prevention has been hampered by methodological limitations such as low sample size and recall bias. Recently, Natural Language Processing (NLP) strategies have been used with Electronic Health Records to increase information extraction from free text notes as well as structured fields concerning suicidality and this allows access ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):7426]

Cited: 25 times

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Demographic and clinical factors associated with different antidepressant treatments: a retrospective cohort study design in a UK psychiatric healthcare setting.

Andrea C Fernandes, David Chandran, Mizanur Khondoker, Michael Dewey, Hitesh Shetty, Rina Dutta, Robert Stewart,

<h4>Objective</h4>To investigate the demographic and clinical factors associated with antidepressant use for depressive disorder in a psychiatric healthcare setting using a retrospective cohort study design.<h4>Setting</h4>Data were extracted from a de-identified data resource sourced from the electronic health records of a London mental health service. Relative risk ratios (RRRs) were obtained ... Read more >>

BMJ Open (BMJ open)
[2018, 8(9):e022170]

Cited: 1 time

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Insights of Leishmania (Viannia) braziliensis infection in golden hamster (Mesocricetus auratus) intestine.

Amanda Gubert Alves Dos Santos, Lainy Leiny de Lima, Camila Alves Mota, Marcelo Biondaro Gois, Andrea Claudia Bekner Silva Fernandes, Thaís Gomes Verzignassi Silveira, Debora de Mello Gonçales Sant'Ana, Gessilda de Alcântara Nogueira de Melo,

AIM:The present study compared and evaluated morphological and quantitative alterations in the ileum of hamsters infected by two L. (V.) braziliensis strains isolated from patients with different lesion aspects and treatment responses. MAIN METHODS:Hamsters were infected in the left hindpaw with a suspension of promastigotes (2 × 107/100 μl) of two different strains ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2018, 106:1624-1632]

Cited: 3 times

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Can risk assessment predict suicide in secondary mental healthcare? Findings from the South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLaM BRC) Case Register.

Javier-David Lopez-Morinigo, Andrea C Fernandes, Hitesh Shetty, Rosa Ayesa-Arriola, Ashraful Bari, Robert Stewart, Rina Dutta,

<h4>Purpose</h4>The predictive value of suicide risk assessment in secondary mental healthcare remains unclear. This study aimed to investigate the extent to which clinical risk assessment ratings can predict suicide among people receiving secondary mental healthcare.<h4>Methods</h4>Retrospective inception cohort study (n = 13,758) from the South London and Maudsley NHS Foundation Trust (SLaM) (London, ... Read more >>

Soc Psychiatry Psychiatr Epidemiol (Social psychiatry and psychiatric epidemiology)
[2018, 53(11):1161-1171]

Cited: 2 times

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Clinical and immunological profiles of anaemia in children and adolescents with Plasmodium vivax malaria in the Pará state, Brazilian Amazon.

Ana Maria Revoredo da Silva Ventura, Andrea Aparecida Moraes Fernandes, Graziela Maria Zanini, Lilian Rose Pratt-Riccio, Carina Guilhon Sequeira, Carlos Rodrigo Souza do Monte, Arnaldo Jorge Martins-Filho, Ricardo Luiz Dantas Machado, Rosana Maria Feio Libonati, José Maria de Souza, Cláudio Tadeu Daniel-Ribeiro,

Children and adolescents are at great risk for developing iron deficiency anaemia worldwide. In the tropical areas, malaria and intestinal parasites may also play an important role in anaemia pathogenesis. This study aimed at evaluating clinical and immunological aspects of anaemia in children and adolescents with Plasmodium vivax malaria, in ... Read more >>

Acta Trop (Acta tropica)
[2018, 181:122-131]

Cited: 2 times

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AMERICAN CUTANEOUS LEISHMANIASIS WITH UNUSUAL CLINICAL PRESENTATION AND RESPONSE TO TREATMENT.

Andrea Claudia Bekner Silva Fernandes, Raíssa Bocchi Pedroso, Eneide Aparecida Sabaini Venazzi, Paulo Donizeti Zanzarini, Sandra Mara Alessi Aristides, Maria Valdrinez Campana Lonardoni, Thaís Gomes Verzignassi Silveira,

The clinical manifestations and prognosis of cutaneous leishmaniasis (CL) can be influenced by the immune response of the patient and the species of the parasite. A case of atypical clinical presentation of CL, with development of non-characteristic lesions, poor response to therapy, and a long time to resolution is reported. ... Read more >>

Rev Inst Med Trop Sao Paulo (Revista do Instituto de Medicina Tropical de Sao Paulo)
[2016, 58:20]

Cited: 1 time

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Detection of Suicidality in Adolescents with Autism Spectrum Disorders: Developing a Natural Language Processing Approach for Use in Electronic Health Records.

Johnny Downs, Sumithra Velupillai, Gkotsis George, Rachel Holden, Maxim Kikoler, Harry Dean, Andrea Fernandes, Rina Dutta,

Over 15% of young people with autism spectrum disorders (ASD) will contemplate or attempt suicide during adolescence. Yet, there is limited evidence concerning risk factors for suicidality in childhood ASD. Electronic health records (EHRs) can be used to create retrospective clinical cohort data for large samples of children with ASD. ... Read more >>

AMIA Annu Symp Proc (AMIA ... Annual Symposium proceedings. AMIA Symposium)
[2017, 2017:641-649]

Cited: 6 times

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Risk assessment and suicide by patients with schizophrenia in secondary mental healthcare: a case-control study.

Javier-David Lopez-Morinigo, Rosa Ayesa-Arriola, Beatriz Torres-Romano, Andrea C Fernandes, Hitesh Shetty, Matthew Broadbent, Maria-Encarnacion Dominguez-Ballesteros, Robert Stewart, Anthony S David, Rina Dutta,

<h4>Objectives</h4>To investigate the role of risk assessment in predicting suicide in patients with schizophrenia spectrum disorders (SSDs) receiving secondary mental healthcare. We postulated that risk assessment plays a limited role in predicting suicide in these patients.<h4>Design</h4>Retrospective case-control study.<h4>Setting</h4>Anonymised electronic mental health record data from the South London and Maudsley National ... Read more >>

BMJ Open (BMJ open)
[2016, 6(9):e011929]

Cited: 6 times

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In vitro characterization of Leishmania (Viannia) braziliensis isolates from patients with different responses to Glucantime(®) treatment from Northwest Paraná, Brazil.

Andrea Claudia Bekner Silva Fernandes, Raíssa Bocchi Pedroso, Tatiane França Perles de Mello, Lucélia Donatti, Eneide Aparecida Sabaini Venazzi, Izabel Galhardo Demarchi, Sandra Mara Alessi Aristides, Maria Valdrinez Campana Lonardoni, Thaís Gomes Verzignassi Silveira,

Leishmaniasis is a group of diseases that presents various clinical manifestations. Many studies have shown that the parasite plays an important role in the clinical manifestations and prognosis of this disease. The cutaneous and mucosal forms of American tegumentary leishmaniasis (ATL) are associated with Leishmania (Viannia) braziliensis, which exhibits intraspecific ... Read more >>

Exp Parasitol (Experimental parasitology)
[2016, 167:83-93]

Cited: 3 times

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Cohort profile of the South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLaM BRC) Case Register: current status and recent enhancement of an Electronic Mental Health Record-derived data resource.

Gayan Perera, Matthew Broadbent, Felicity Callard, Chin-Kuo Chang, Johnny Downs, Rina Dutta, Andrea Fernandes, Richard D Hayes, Max Henderson, Richard Jackson, Amelia Jewell, Giouliana Kadra, Ryan Little, Megan Pritchard, Hitesh Shetty, Alex Tulloch, Robert Stewart,

<h4>Purpose</h4>The South London and Maudsley National Health Service (NHS) Foundation Trust Biomedical Research Centre (SLaM BRC) Case Register and its Clinical Record Interactive Search (CRIS) application were developed in 2008, generating a research repository of real-time, anonymised, structured and open-text data derived from the electronic health record system used by ... Read more >>

BMJ Open (BMJ open)
[2016, 6(3):e008721]

Cited: 137 times

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Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid.

Xavier Castells, Sandra Karanović, Maude Ardin, Karla Tomić, Evanguelos Xylinas, Geoffroy Durand, Stephanie Villar, Nathalie Forey, Florence Le Calvez-Kelm, Catherine Voegele, Krešimir Karlović, Maja Mišić, Damir Dittrich, Igor Dolgalev, James McKay, Shahrokh F Shariat, Viktoria S Sidorenko, Andrea Fernandes, Adriana Heguy, Kathleen G Dickman, Magali Olivier, Arthur P Grollman, Bojan Jelaković, Jiri Zavadil,

<h4>Background</h4>Dietary exposure to cytotoxic and carcinogenic aristolochic acid (AA) causes severe nephropathy typically associated with urologic cancers. Monitoring of AA exposure uses biomarkers such as aristolactam-DNA adducts, detected by mass spectrometry in the kidney cortex, or the somatic A>T transversion pattern characteristic of exposure to AA, as revealed by previous ... Read more >>

Cancer Epidemiol Biomarkers Prev (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology)
[2015, 24(12):1873-1881]

Cited: 8 times

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Suicide completion in secondary mental healthcare: a comparison study between schizophrenia spectrum disorders and all other diagnoses.

Javier-David Lopez-Morinigo, Andrea C Fernandes, Chin-Kuo Chang, Richard D Hayes, Matthew Broadbent, Robert Stewart, Anthony S David, Rina Dutta,

<h4>Background</h4>Suicide completion is a tragic outcome in secondary mental healthcare. However, the extent to which demographic and clinical characteristics, suicide method and service use-related factors vary across psychiatric diagnoses remains poorly understood, particularly regarding differences between 'schizophrenia spectrum disorders (SSD)' and 'all other diagnoses', which may have implications for suicide ... Read more >>

BMC Psychiatry (BMC psychiatry)
[2014, 14:213]

Cited: 10 times

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Development and evaluation of a de-identification procedure for a case register sourced from mental health electronic records.

Andrea C Fernandes, Danielle Cloete, Matthew T M Broadbent, Richard D Hayes, Chin-Kuo Chang, Richard G Jackson, Angus Roberts, Jason Tsang, Murat Soncul, Jennifer Liebscher, Robert Stewart, Felicity Callard,

<h4>Background</h4>Electronic health records (EHRs) provide enormous potential for health research but also present data governance challenges. Ensuring de-identification is a pre-requisite for use of EHR data without prior consent. The South London and Maudsley NHS Trust (SLaM), one of the largest secondary mental healthcare providers in Europe, has developed, from ... Read more >>

BMC Med Inform Decis Mak (BMC medical informatics and decision making)
[2013, 13:71]

Cited: 78 times

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Abuse and other correlates of common mental disorders in youth: a cross-sectional study in Goa, India.

Andrea C Fernandes, Richard D Hayes, Vikram Patel,

<h4>Purpose</h4>There is a paucity of known correlates of common mental disorders (CMDs) among the youth age group in India. This analysis aims to determine risk factors associated with a probable diagnosis of CMD in a youth sample in India.<h4>Methods</h4>This is a secondary analysis of data collected via a door-to-door (community) ... Read more >>

Soc Psychiatry Psychiatr Epidemiol (Social psychiatry and psychiatric epidemiology)
[2013, 48(4):515-523]

Cited: 13 times

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Variation in presentation and presence of DNA adducts and p53 mutations in patients with endemic nephropathy--an environmental form of the aristolochic acid nephropathy.

Sandra Karanović, Ivana Vuković Lela, Bojan Jelaković, Kathleen G Dickman, Anamarija Kovač Peić, Damir Dittrich, Matej Knežević, Vesna Matijević, Andrea S Fernandes, Frederick Miller,

<h4>Background</h4>Endemic nephropathy (EN) and associated urothelial cell cancers (UUC) are an environmental form of aristolochic acid nephropathy where the most probable rout of ingestion of aristolochic acid (AA) was made by bread contaminated with AA, leading to chronic dietary intoxication. Clinical courses of three members of the same family, similarly ... Read more >>

Kidney Blood Press Res (Kidney & blood pressure research)
[2013, 37(1):1-8]

Cited: 6 times

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The role of biomedical engineering in disaster management in resource-limited settings.

Andrea Fernandes, Muhammad H Zaman,

Bull World Health Organ (Bulletin of the World Health Organization)
[2012, 90(8):631-632]

Cited: 3 times

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