Full Text Journal Articles by
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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

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Clinical Research: From Case Reports to International Multicenter Clinical Trials.

Simon Finfer, Deborah Cook, Flavia R Machado, Anders Perner,

Crit Care Med (Critical care medicine)
[2021, 49(11):1866-1882]

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

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Interactions in clinical trials: Protocol and statistical analysis plan for an explorative study of four randomized ICU trials on use of pantoprazole, oxygenation targets, haloperidol and intravenous fluids.

Olav L Schjørring, Theis Lange, Mette Krag, Nina Christine Andersen-Ranberg, Tine S Meyhoff, Søren Marker, Thomas L Klitgaard, Stine Estrup, Morten Hylander Møller, Bodil S Rasmussen, Lone M Poulsen, Anders Perner,

<h4>Background</h4>Intensive care unit (ICU) patients receive numerous interventions, but knowledge about potential interactions between these interventions is limited. Co-enrolment in randomized clinical trials represents a unique opportunity to investigate any such interactions. We aim to assess interactions in four randomized clinical trials with overlap in inclusion periods and patient populations.<h4>Methods</h4>This ... Read more >>

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2021, :]

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Using machine learning for predicting intensive care unit resource use during the COVID-19 pandemic in Denmark.

Stephan Sloth Lorenzen, Mads Nielsen, Espen Jimenez-Solem, Tonny Studsgaard Petersen, Anders Perner, Hans-Christian Thorsen-Meyer, Christian Igel, Martin Sillesen,

The COVID-19 pandemic has put massive strains on hospitals, and tools to guide hospital planners in resource allocation during the ebbs and flows of the pandemic are urgently needed. We investigate whether machine learning (ML) can be used for predictions of intensive care requirements a fixed number of days into ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):18959]

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A descriptive study of the surge response and outcomes of ICU patients with COVID-19 during first wave in Nordic countries.

Michelle S Chew, Salla Kattainen, Nicolai Haase, Eirik A Buanes, Linda B Kristinsdottir, Kristin Hofsø, Jon Henrik Laake, Reidar Kvåle, Johanna Hästbacka, Matti Reinikainen, Stepani Bendel, Tero Varpula, Sten Walther, Anders Perner, Hans K Flaatten, Martin I Sigurdsson,

<h4>Background</h4>We sought to provide a description of surge response strategies and characteristics, clinical management and outcomes of patients with severe COVID-19 in the intensive care unit (ICU) during the first wave of the pandemic in Denmark, Finland, Iceland, Norway and Sweden.<h4>Methods</h4>Representatives from the national ICU registries for each of the ... Read more >>

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2021, :]

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Oxygenation targets in ICU patients with COVID-19: A post hoc subgroup analysis of the HOT-ICU trial.

Bodil S Rasmussen, Thomas L Klitgaard, Anders Perner, Björn A Brand, Thomas Hildebrandt, Martin Siegemund, Alexa Hollinger, Søren R Aagaard, Morten H Bestle, Klaus V Marcussen, Anne C Brøchner, Christoffer G Sølling, Lone M Poulsen, Jon H Laake, Tayyba N Aslam, Minna Bäcklund, Marjatta Okkonen, Matthew Morgan, Mike Sharman, Theis Lange, Jørn Wetterslev, Olav L Schjørring,

<h4>Background</h4>Supplemental oxygen is the key intervention for severe and critical COVID-19 patients. With the unstable supplies of oxygen in many countries, it is important to define the lowest safe dosage.<h4>Methods</h4>In spring 2020, 110 COVID-19 patients were enrolled as part of the Handling Oxygenation Targets in the ICU trial (HOT-ICU). Patients ... Read more >>

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2021, :]

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Patient and public involvement in contemporary large intensive care trials: Protocol for a meta-epidemiological study.

Emily Barot, Maj-Brit Nørregaard Kjaer, Marie Collet, Elena Crescioli, Bodil Steen Rasmussen, Stine Estrup, Camilla Bekker Mortensen, Gitte Kingo Vesterlund, Praleene Sivapalan, Carl Thomas Anthon, Camilla Rahbek Lysholm Bruun, Lone Musaeus Poulsen, Morten Hylander Møller, Anders Perner, Anders Granholm,

<h4>Background</h4>Patient and public involvement (PPI) in randomized clinical trials (RCTs) has increased in recent years but remains the exception rather than the rule. We aim to assess the frequency and extent of PPI in large, contemporary RCTs conducted in an intensive care setting.<h4>Methods and design</h4>We will conduct a meta-epidemiological study ... Read more >>

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2021, 65(9):1351-1354]

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Higher versus lower fraction of inspired oxygen or targets of arterial oxygenation for adults admitted to the intensive care unit.

Marija Barbateskovic, Olav L Schjørring, Sara Russo Krauss, Janus C Jakobsen, Christian S Meyhoff, Rikke M Dahl, Bodil S Rasmussen, Anders Perner, Jørn Wetterslev,

Emergencias (Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias)
[2021, 33(4):309-311]

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Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxia: an international, randomized, blinded trial

Marie Munch, Sheila Myatra, Bharath Kumar Tirupakuzhi Vijayaraghavan, Sanjith Saseedharan, Thomas Benfield, Rebecka Wahlin, Bodil Rasmussen, Anne Sofie Andreasen, Lone Poulsen, Luca Cioccari, Mohd Khan, Farhad Kapadia, Jigeeshu Divatia, Anne Brøchner, Morten Bestle, Marie Helleberg, Jens Michelsen, Ajay Padmanaban, Neeta Bose, Anders Møller, Kapil Borawake, Klaus Kristiansen, Urvi Shukla, Michelle Chew, Subhal Dixit, Charlotte Ulrik, Pravin Amin, Rajesh Chawla, Christian Wamberg, Mehul Shah, Iben Darfelt, Vibeke Jørgensen, Margit Smitt, Anders Granholm, Maj-Brit Kjær, Morten Møller, Tine Meyhoff, Gitte Vesterlund, Naomi Hammond, Sharon Micallef, Abhinav Bassi, Oommen John, Anubhuti Jha, Maria Cronhjort, Stephan Jakob, Christian Gluud, Theis Lange, Vaijayanti Kadam, Klaus Marcussen, Jacob Hollenberg, Anders Hedman, Henrik Nielsen, Olav Schjørring, Marie Jensen, Jens Leistner, Trine Jonassen, Camilla Kristensen, Esben Clapp, Carl Hjortsø, Thomas Jensen, Liv Halstad, Emilie Bak, Reem Zaabalawi, Matias Metcalf-Clausen, Suhayb Abdi, Emma Hatley, Tobias Aksnes, Emil Gleipner-Andersen, Arif Alarcón, Gabriel Yamin, Adam Heymowski, Anton Berggren, Kirstine la Cour, Sarah Weihe, Alison Pind, Janus Engstrøm, Vivekanand Jha, Balasubramanian Venkatesh, Anders Perner, ,

<h4>IMPORTANCE</h4> Dexamethasone 6 mg daily is recommended for up to 10 days in patients with severe and critical COVID-19, but a higher dose may benefit those with more severe disease. <h4>OBJECTIVE</h4> To assess the effects of dexamethasone 12 mg versus 6 mg daily in patients with COVID-19 and severe hypoxia. ... Read more >>

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Use of crystalloids and colloids in Europe per year from 2010 to 2019: Protocol for an international descriptive study.

Núria M Zellweger, Morten Hylander Møller, Karen Louise Ellekjaer, Andreas Bender Jonsson, Kathrine Bruun Svan, Martin Siegemund, Anders Perner,

<h4>Introduction</h4>Intravenous (IV) fluids are widely used in everyday clinical practice. In the last two decades, several trials and clinical practice guidelines have been published on the use of different types and dosages of IV fluid. This may have led to a change in clinical practice. Thus, we aim to describe ... Read more >>

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2021, :]

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Handling oxygenation targets in ICU patients with COVID-19-Protocol and statistical analysis plan in the HOT-COVID trial.

Frederik Mølgaard Nielsen, Thomas Lass Klitgaard, Elena Crescioli, Søren Rosborg Aagaard, Anne Sofie Andreasen, Lone Musaeus Poulsen, Martin Siegemund, Anne Craveiro Brøchner, Morten H Bestle, Susanne Andi Iversen, Björn A Brand, Jon Henrik Laake, Thorbjørn Grøfte, Thomas Hildebrandt, Theis Lange, Anders Perner, Olav Lilleholt Schjørring, Bodil Steen Rasmussen,

<h4>Background</h4>Coronavirus disease (COVID-19) primarily affects the lungs and lower airways and may present as hypoxaemic respiratory failure requiring admission to an intensive care unit (ICU) for supportive treatment. Here, supplemental oxygen remains essential for COVID-19 patient management, but the optimal dosage is not defined. We hypothesize that targeting an arterial ... Read more >>

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2021, :]

Cited: 1 time

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Use of hydroxyethyl starch in sepsis research: A systematic review with meta-analysis.

Jes R Johansen, Anders Perner, Julie H Brodtkorb, Morten H Møller,

<h4>Background</h4>After being used for more than a decade the use of hydroxyethyl starch (HES) 130/0.38-0.45 in clinical practice was discouraged because of serious adverse events including bleeding, acute kidney injury and death. But could these adverse effects have been discovered sooner? By comparing the summary effect estimates of the adverse ... Read more >>

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2021, :]

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Randomized clinical trials of patients with acute myocardial infarction-related cardiogenic shock: a systematic review of used cardiogenic shock definitions and outcomes.

Jakob Josiassen, Martin Frydland, Christian Hassager, Jacob Eifer Møller, Anders Perner, Johannes Grand,

<h4>Background</h4>Cardiogenic shock (CS) is a critical complication to acute myocardial infarction (AMI), with short-term mortality rates exceeding 40%. However, no international consensus of a CS definition exists. This may compromise interstudy comparability.<h4>Aims</h4>The aim of the current study was to review differences and similarities of CS enrolment criteria in AMI-related CS ... Read more >>

Kardiol Pol (Kardiologia polska)
[2021, 79(9):1003-1015]

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Effect of immunoglobulin G on cytokine response in necrotising soft-tissue infection: A post hoc analysis.

Morten Hedetoft, Martin B Madsen, Anders Perner, Peter Garred, Ole Hyldegaard,

<h4>Background</h4>A marked inflammatory response in necrotising soft-tissue infection (NSTI) may contribute to the severe clinical course. Intravenous polyspecific immunoglobulin G (IVIG) is used by some as adjuvant treatment for NSTI, but in the randomised INSTINCT trial, no effect of IVIG in NSTI patients was seen on physical quality of life. ... Read more >>

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2021, 65(9):1293-1299]

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COVID-19 versus influenza A/B supeRInfectionS in the IntenSive care unit (CRISIS): Protocol for a Danish nationwide cohort study.

Vibe S Mikkelsen, Marie Helleberg, Nicolai Haase, Morten H Møller, Anders Granholm, Merete Storgaard, Andreas B Jonsson, Kristian Schønning, Nanna Reiter, Sigurður Þór Sigurðsson, Marianne Voldstedlund, Steffen Christensen, Anders Perner,

<h4>Background</h4>Superinfection following viral infection is a known complication, which may lead to longer hospitalisation and worse outcome. Empirical antibiotic therapy may prevent bacterial superinfections, but may also lead to overuse, adverse effects and development of resistant pathogens. Knowledge about the incidence of superinfections in intensive care unit (ICU) patients with ... Read more >>

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2021, 65(9):1345-1350]

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Patient-important outcomes other than mortality in recent ICU trials: Protocol for a scoping review.

Anders Granholm, Benjamin Skov Kaas-Hansen, Maj-Brit Nørregaard Kjaer, Carl Thomas Anthon, Praleene Sivapalan, Olav Lilleholt Schjørring, Lars W Andersen, Ole Mathiesen, Thomas Strøm, Aksel Karl Georg Jensen, Anders Perner, Morten Hylander Møller,

<h4>Background</h4>Randomised clinical trials (RCTs) conducted in intensive care units (ICUs) frequently focus on all-cause mortality, but other patient-important outcomes are increasingly used and recommended. Their use, however, is not straightforward: choices and definitions, operationalisation of death, handling of missing data, choice of effect measures, and statistical analyses for these outcomes ... Read more >>

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2021, 65(7):1002-1007]

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Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia: The COVID STEROID randomised, placebo-controlled trial.

Marie Warrer Munch, Tine Sylvest Meyhoff, Marie Helleberg, Maj-Brit Nørregaard Kjaer, Anders Granholm, Carl Johan Steensen Hjortsø, Thomas Steen Jensen, Morten Hylander Møller, Peter Buhl Hjortrup, Mik Wetterslev, Gitte Kingo Vesterlund, Lene Russell, Vibeke Lind Jørgensen, Klaus Tjelle Kristiansen, Thomas Benfield, Charlotte Suppli Ulrik, Anne Sofie Andreasen, Morten Heiberg Bestle, Lone Musaeus Poulsen, Thomas Hildebrandt, Lene Surland Knudsen, Anders Møller, Christoffer Grant Sølling, Anne Craveiro Brøchner, Bodil Steen Rasmussen, Henrik Nielsen, Steffen Christensen, Thomas Strøm, Maria Cronhjort, Rebecka Rubenson Wahlin, Stephan M Jakob, Luca Cioccari, Balasubramanian Venkatesh, Naomi Hammond, Vivekanand Jha, Sheila Nainan Myatra, Marie Qvist Jensen, Jens Wolfgang Leistner, Vibe Sommer Mikkelsen, Jens S Svenningsen, Signe Bjørn Laursen, Emma Victoria Hatley, Camilla Meno Kristensen, Ali Al-Alak, Esben Clapp, Trine Bak Jonassen, Caroline Løkke Bjerregaard, Niels Christian Haubjerg Østerby, Mette Mindedahl Jespersen, Dalia Abou-Kassem, Mathilde Languille Lassen, Reem Zaabalawi, Mohammed Mahmoud Daoud, Suhayb Abdi, Nick Meier, Kirstine la Cour, Cecilie Bauer Derby, Birka Ravnholt Damlund, Jens Laigaard, Lene Lund Andersen, Johan Mikkelsen, Jeppe Lundholm Stadarfeld Jensen, Anders Hørby Rasmussen, Emil Arnerlöv, Mathilde Lykke, Mikkel Zacharias Bystrup Holst-Hansen, Boris Wied Tøstesen, Janne Schwab, Emilie Kabel Madsen, Christian Gluud, Theis Lange, Anders Perner,

<h4>Background</h4>In the early phase of the pandemic, some guidelines recommended the use of corticosteroids for critically ill patients with COVID-19, whereas others recommended against the use despite lack of firm evidence of either benefit or harm. In the COVID STEROID trial, we aimed to assess the effects of low-dose hydrocortisone ... Read more >>

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2021, :]

Cited: 3 times

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Twenty-four-hour fluid administration in emergency department patients with suspected infection: A multicenter, prospective, observational study.

Marie K Jessen, Lars W Andersen, Marie-Louise H Thomsen, Marie E Jensen, Mathilde E Kirk, Sofie Kildegaard, Poul Petersen, Rajesh Mohey, Anders H Madsen, Anders Perner, Jens Aage Kølsen Petersen, Hans Kirkegaard,

<h4>Background</h4>To describe 24-hour fluid administration in emergency department (ED) patients with suspected infection.<h4>Methods</h4>A prospective, multicenter, observational study conducted in three Danish hospitals, January 20 to March 2, 2020. We included consecutive adult ED patients with suspected infection (drawing of blood culture and/or intravenous antibiotic administration within 6 hours of admission). Oral ... Read more >>

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2021, 65(8):1122-1142]

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The effects of adding quinolones to beta-lactam antibiotics for sepsis.

Steven K Korang, Mathias Maagaard, Joshua B Feinberg, Anders Perner, Christian Gluud, Janus C Jakobsen,

<h4>Background</h4>Sepsis is common, deadly, and a major challenge to treat. Quinolones added to beta-lactam antibiotics are currently recommended as a second-line empiric regimen in sepsis, but the evidence regarding their benefits and harms is unclear.<h4>Objective</h4>To assess the benefits and harms of adding quinolones to standard care for sepsis.<h4>Data sources</h4>We conducted ... Read more >>

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2021, 65(8):1023-1032]

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Prophylactic platelet transfusions in hospitalised patients with thrombocytopenia-Protocol for a systematic review with meta-analysis.

Carl T Anthon, Praleene Sivapalan, Anders Granholm, Frédéric Pène, Kathryn Puxty, Anders Perner, Morten Hylander Møller, Lene Russell,

<h4>Background</h4>Prophylactic platelet transfusions are frequently used to prevent bleeding in hospitalised patients with thrombocytopenia. Recommendations regarding the use of prophylactic platelet transfusions in non-haematological patients are based on extrapolations, observational studies, and expert opinions, and transfusion with platelets has been associated with adverse effects. We aim to assess the overall ... Read more >>

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2021, 65(7):988-994]

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A Multicenter Observational Study Evaluating Outcomes Associated With Antibiotic Combination Versus Monotherapy in Patients With Septic Shock.

Gustav Torisson, Martin Bruun Madsen, Agnes Schmidt Davidsen, Anders Perner, Jeffrey Lipman, Joel Dulhunty, Fredrik Sjövall,

<h4>Objectives</h4>To explore the association between antibiotic combination therapy and in-hospital mortality in patients with septic shock in two tertiary ICUs in different countries.<h4>Design</h4>Retrospective observational study.<h4>Setting</h4>ICUs of two tertiary hospitals, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia, and Rigshospitalet, Copenhagen, Denmark.<h4>Patients</h4>Adult patients with antibiotic treatment greater than or equal to ... Read more >>

Crit Care Explor (Critical care explorations)
[2021, 3(5):e0383]

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New-onset atrial fibrillation in the intensive care unit: Protocol for an international inception cohort study (AFIB-ICU).

Mik Wetterslev, Morten Hylander Møller, Anders Granholm, Nicolai Haase, Christian Hassager, Theis Lange, Johanna Hästbacka, Erika Wilkman, Sheila Nainan Myatra, Jiawei Shen, Youzhong An, Martin Siegemund, Paul J Young, Tayyba N Aslam, Wojciech Szczeklik, Anders Aneman, Yaseen M Arabi, Maria Cronhjort, Frederik Keus, Anders Perner,

<h4>Introduction</h4>New-onset atrial fibrillation (NOAF) is frequently observed in critically ill patients and may be associated with prolonged hospital stay and increased mortality. Considerable variation exists in the reported frequencies of NOAF due to the lack of a standardised definition and detection method. Importantly, there are limited data on NOAF in ... Read more >>

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2021, 65(6):846-851]

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Corticosteroids in COVID-19 and non-COVID-19 ARDS: a systematic review and meta-analysis.

Dipayan Chaudhuri, Kiyoka Sasaki, Aram Karkar, Sameer Sharif, Kimberly Lewis, Manoj J Mammen, Paul Alexander, Zhikang Ye, Luis Enrique Colunga Lozano, Marie Warrer Munch, Anders Perner, Bin Du, Lawrence Mbuagbaw, Waleed Alhazzani, Stephen M Pastores, John Marshall, François Lamontagne, Djillali Annane, Gianfranco Umberto Meduri, Bram Rochwerg,

<h4>Purpose</h4>Corticosteroids are now recommended for patients with severe COVID-19 including those with COVID-related ARDS. This has generated renewed interest regarding whether corticosteroids should be used in non-COVID ARDS as well. The objective of this study was to summarize all RCTs examining the use of corticosteroids in ARDS.<h4>Methods</h4>The protocol of this ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(5):521-537]

Cited: 5 times

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