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Author Anand Patwardhan


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aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis.

Olivia Molinar-Inglis, Cierra A Birch, Dequina Nicholas, Lennis Orduña-Castillo, Metztli Cisneros-Aguirre, Anand Patwardhan, Buxin Chen, Neil J Grimsey, Luisa J Coronel, Huilan Lin, Patrick K Gomez Menzies, Mark A Lawson, Hemal H Patel, JoAnn Trejo,

Endothelial dysfunction is associated with vascular disease and results in disruption of endothelial barrier function and increased sensitivity to apoptosis. Currently, there are limited treatments for improving endothelial dysfunction. Activated protein C (aPC), a promising therapeutic, signals via protease-activated receptor-1 (PAR1) and mediates several cytoprotective responses, including endothelial barrier stabilization ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(49):e2106623118]

Cited: 0 times

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Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH.

Marcus Y Chin, Anand R Patwardhan, Kean-Hooi Ang, Austin L Wang, Carolina Alquezar, Mackenzie Welch, Phi T Nguyen, Michael Grabe, Anna V Molofsky, Michelle R Arkin, Aimee W Kao,

Lysosomes are important sites for macromolecular degradation, defined by an acidic lumenal pH of ∼4.5. To better understand lysosomal pH, we designed a novel, genetically encoded, fluorescent protein (FP)-based pH biosensor called Fluorescence Indicator REporting pH in Lysosomes (FIRE-pHLy). This biosensor was targeted to lysosomes with lysosomal-associated membrane protein 1 ... Read more >>

ACS Sens (ACS sensors)
[2021, 6(6):2168-2180]

Cited: 4 times

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