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Author Ana M Puga

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Effectiveness of Community-Based Interventions Programs in Childhood Obesity Prevention in a Spanish Population According to Different Socioeconomic School Settings.

Ana M Puga, Alejandra Carretero-Krug, Ana M Montero-Bravo, Gregorio Varela-Moreiras, Teresa Partearroyo,

Overweight and obesity amongst childhood are currently global health issues. However, this is the best stage of life to prevent diseases and to promote healthy habits. In our study, we evaluate the effectiveness of the THAO Salud Infantil, a community-based intervention program, by means of a cross-sectional study carried out ... Read more >>

Nutrients (Nutrients)
[2020, 12(9):]

Cited: 0 times

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Association between Hydration Status and Body Composition in Healthy Adolescents from Spain.

Ana Isabel Laja García, Carmen Moráis-Moreno, Mª de Lourdes Samaniego-Vaesken, Ana M Puga, Gregorio Varela-Moreiras, Teresa Partearroyo,

At present, obesity and overweight are major public health concerns. Their classical determinants do not sufficiently explain the current situation and it is urgent to investigate other possible causes. In recent years, it has been suggested that water intake could have important implications for weight management. Thus, the aim of ... Read more >>

Nutrients (Nutrients)
[2019, 11(11):]

Cited: 0 times

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Influence of Water Intake and Balance on Body Composition in Healthy Young Adults from Spain.

Ana Isabel Laja García, Carmen Moráis-Moreno, Mª de Lourdes Samaniego-Vaesken, Ana M Puga, Teresa Partearroyo, Gregorio Varela-Moreiras,

The increasing prevalence of overweight and obesity has become an epidemic public health problem worldwide. In the last years, several investigations have suggested that water intake and retention could have important implications for both weight management and body composition. However, there is a lack of information about this issue globally, ... Read more >>

Nutrients (Nutrients)
[2019, 11(8):]

Cited: 1 time

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Effects of Drugs and Excipients on Hydration Status.

Ana M Puga, Sara Lopez-Oliva, Carmen Trives, Teresa Partearroyo, Gregorio Varela-Moreiras,

Despite being the most essential nutrient, water is commonly forgotten in the fields of pharmacy and nutrition. Hydration status is determined by water balance (the difference between water input and output). Hypohydration or negative water balance is affected by numerous factors, either internal (i.e., a lack of thirst sensation) or ... Read more >>

Nutrients (Nutrients)
[2019, 11(3):]

Cited: 3 times

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Interplay between Nutrition and Hearing Loss: State of Art.

Ana M Puga, María A Pajares, Gregorio Varela-Moreiras, Teresa Partearroyo,

Hearing loss has been recently ranked as the fifth leading cause of years lived with disability, ahead of many other chronic diseases such as diabetes, dementia, or chronic obstructive pulmonary disease. Moreover, according to the World Health Organization, moderate-to-profound hearing loss affects about 466 million people worldwide. Its incidence varies ... Read more >>

Nutrients (Nutrients)
[2018, 11(1):]

Cited: 2 times

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Additive manufacturing of scaffolds with dexamethasone controlled release for enhanced bone regeneration.

Pedro F Costa, Ana M Puga, Luis Díaz-Gomez, Angel Concheiro, Dirk H Busch, Carmen Alvarez-Lorenzo,

The adoption of additive manufacturing in tissue engineering and regenerative medicine (TERM) strategies greatly relies on the development of novel 3D printable materials with advanced properties. In this work we have developed a material for bone TERM applications with tunable bioerosion rate and dexamethasone release profile which can be further ... Read more >>

Int J Pharm (International journal of pharmaceutics)
[2015, 496(2):541-550]

Cited: 10 times

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Antiretroviral treatment initiation does not differentially alter neurocognitive functioning over time in youth with behaviorally acquired HIV.

Sharon L Nichols, James Bethel, Bill G Kapogiannis, Tiandong Li, Steven P Woods, E Doyle Patton, Weijia Ren, Sarah E Thornton, Hanna O Major-Wilson, Ana M Puga, John W Sleasman, Bret J Rudy, Craig M Wilson, Patricia A Garvie, ,

Although youth living with behaviorally acquired HIV (YLWH) are at risk for cognitive impairments, the relationship of impairments to HIV and potential to improve with antiretroviral therapy (ART) are unclear. This prospective observational study was designed to examine the impact of initiation and timing of ART on neurocognitive functioning in ... Read more >>

J Neurovirol (Journal of neurovirology)
[2016, 22(2):218-230]

Cited: 1 time

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Long-term safety and efficacy of atazanavir-based therapy in HIV-infected infants, children and adolescents: the Pediatric AIDS Clinical Trials Group Protocol 1020A.

Richard M Rutstein, Pearl Samson, Terry Fenton, Courtney V Fletcher, Jennifer J Kiser, Lynne M Mofenson, Elizabeth Smith, Bobbie Graham, Marina Mathew, Grace Aldrovani, ,

<h4>Background</h4>Atazanavir (ATV) is an attractive option for the treatment of Pediatric HIV infection, based on once-daily dosing and the availability of a formulation appropriate for younger children. Pediatric AIDS Clinical Trials Group 1020A was a phase I/II open label study of ATV (with/without ritonavir [RTV] boosting)-based treatment of HIV-infected children; ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2015, 34(2):162-167]

Cited: 7 times

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Effect of cytomegalovirus co-infection on normalization of selected T-cell subsets in children with perinatally acquired HIV infection treated with combination antiretroviral therapy.

Suad Kapetanovic, Lisa Aaron, Grace Montepiedra, Patricia Anthony, Kasalyn Thuvamontolrat, Savita Pahwa, Sandra Burchett, Adriana Weinberg, Andrea Kovacs, ,

<h4>Background</h4>We examined the effect of cytomegalovirus (CMV) co-infection and viremia on reconstitution of selected CD4+ and CD8+ T-cell subsets in perinatally HIV-infected (PHIV+) children ≥ 1-year old who participated in a partially randomized, open-label, 96-week combination antiretroviral therapy (cART)-algorithm study.<h4>Methods</h4>Participants were categorized as CMV-naïve, CMV-positive (CMV+) viremic, and CMV+ aviremic, ... Read more >>

PLoS One (PloS one)
[2015, 10(3):e0120474]

Cited: 3 times

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Osteogenic poly(ε-caprolactone)/poloxamine homogeneous blends prepared by supercritical foaming.

Maria B C de Matos, Ana M Puga, Carmen Alvarez-Lorenzo, Angel Concheiro, Mara E M Braga, Hermínio C de Sousa,

Homogeneous poly(ε-caprolactone) (PCL) and poloxamines (PLXs) porous blends were prepared using a supercritical carbon dioxide-assisted foaming/mixing (SFM) approach aiming to obtain cytocompatible implantable materials presenting tunable morphologies, bioerosion rates, bioactive molecules release and osteogenic features. Pure PCL, pure PLXs (T908 and T1107 varieties) and three distinct PCL:PLX 75:25, 50:50, 25:75% ... Read more >>

Int J Pharm (International journal of pharmaceutics)
[2015, 479(1):11-22]

Cited: 0 times

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Predictors of resolution and persistence of renal laboratory abnormalities in pediatric HIV infection.

Charles D Mitchell, Miriam C Chernoff, George R Seage, Murli U Purswani, Hans M L Spiegel, Gaston Zilleruelo, Carolyn Abitbol, Barbara Heckman, Christopher B Ponce, James M Oleske, ,

<h4>Background</h4>Among human immunodeficiency virus (HIV)-infected youth, the role of renal disease (RD) and its management has become increasingly important as these children/adolescents mature into young adults. The identification of predictors of abnormal renal laboratory events (RLE) may be helpful in the management of their HIV infection and its associated renal ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2015, 30(1):153-165]

Cited: 3 times

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Materials with fungi-bioinspired surface for efficient binding and fungi-sensitive release of antifungal agents.

Tania Segura, Ana M Puga, Guillermina Burillo, José Llovo, Gilles Brackman, Tom Coenye, Angel Concheiro, Carmen Alvarez-Lorenzo,

Materials with fungi-bioinspired surface have been designed to host ergosterol-binding polyene antibiotics and to release them via a competitive mechanism only when fungi are present in the medium. Silicone rubber (SR) surfaces were endowed with selective loading and fungi-triggered release of polyene antifungal agents by means of a two-step functionalization ... Read more >>

Biomacromolecules (Biomacromolecules)
[2014, 15(5):1860-1870]

Cited: 8 times

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Pectin-coated chitosan microgels crosslinked on superhydrophobic surfaces for 5-fluorouracil encapsulation

Ana M Puga, Ana Catarina Lima, Angel Concheiro, Carmen Alvarez-Lorenzo, Joao F. Mano,

5-Fluorouracil (5-FU)-loaded chitosan microgels for oral and topical chemotherapy were prepared applying a superhydrophobic surface-based encapsulation technology. Drug-loaded chitosan dispersions were cross-linked and then coated with drug-free chitosan or pectin layers at the solid-air interface in a highly efficient and environment-friendly way. The size of the microgels (with diameters of ... Read more >>

(Carbohydrate polymers.)
[2013, 98(1):331-340]

Cited: 11 times

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Pectin-coated chitosan microgels crosslinked on superhydrophobic surfaces for 5-fluorouracil encapsulation.

Ana M Puga, Ana Catarina Lima, Joao F Mano, Angel Concheiro, Carmen Alvarez-Lorenzo,

5-Fluorouracil (5-FU)-loaded chitosan microgels for oral and topical chemotherapy were prepared applying a superhydrophobic surface-based encapsulation technology. Drug-loaded chitosan dispersions were cross-linked and then coated with drug-free chitosan or pectin layers at the solid-air interface in a highly efficient and environment-friendly way. The size of the microgels (with diameters of ... Read more >>

Carbohydr Polym (Carbohydrate polymers)
[2013, 98(1):331-340]

Cited: 8 times

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End-group rearrangements in poly(propylene sulfide) matrix-assisted laser desorption/ionization time-of-flight analysis. Experimental evidence and possible mechanisms.

Enrique Lallana, Tiziana Ferreri, Sabrina C Carroccio, Ana M Puga, Nicola Tirelli,

<h4>Rationale</h4>Polysulfides [poly(1,2-alkylene sulfides)] are oxidation-responsive polymers that are finding application in drug release and biomaterials. The precise knowledge of their macromolecular characteristics is of the essence in view of their application to biological systems.<h4>Methods</h4>Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) with and without silver trifluoroacetate was used to characterize ... Read more >>

Rapid Commun Mass Spectrom (Rapid communications in mass spectrometry : RCM)
[2012, 26(18):2158-2164]

Cited: 0 times

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The impact of HAART on cardiomyopathy among children and adolescents perinatally infected with HIV-1.

Kunjal Patel, Russell B Van Dyke, Murray A Mittleman, Steven D Colan, James M Oleske, George R Seage, ,

<h4>Objective</h4>Previous studies of cardiomyopathy among children perinatally infected with HIV were conducted before the routine use of HAART. Nucleoside analogs [nucleoside reverse transcriptase inhibitors (NRTIs)], the backbone of HAART, have been associated with mitochondrial toxicity, which can lead to cardiomyopathy. We evaluated the association of HAART and specific NRTIs associated ... Read more >>

AIDS (AIDS (London, England))
[2012, 26(16):2027-2037]

Cited: 16 times

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Hot melt poly-ε-caprolactone/poloxamine implantable matrices for sustained delivery of ciprofloxacin.

Ana M Puga, Ana Rey-Rico, Beatriz Magariños, Carmen Alvarez-Lorenzo, Angel Concheiro,

It has been suggested that prevention and treatment of osteomyelitis could be achieved through local drug delivery using implantable devices, which provide therapeutic levels at the infection site with minimum side-effects. Physical blends of polycaprolactone (PCL) and poloxamine (Tetronic®) were prepared by applying a solvent-free hot melting approach to obtain ... Read more >>

Acta Biomater (Acta biomaterialia)
[2012, 8(4):1507-1518]

Cited: 14 times

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Sex-based outcomes of darunavir-ritonavir therapy: a single-group trial.

Judith Currier, Dawn Averitt Bridge, Debbie Hagins, Carmen D Zorrilla, Judith Feinberg, Robert Ryan, Ron Falcon, Alan Tennenberg, Joseph Mrus, Kathleen Squires, ,

<h4>Background</h4>Women account for an increasing proportion of patients with HIV-1 but remain underrepresented in antiretroviral clinical trials.<h4>Objective</h4>To evaluate sex-based differences in efficacy and adverse events in treatment-experienced, HIV-positive women and men receiving darunavir-ritonavir therapy over 48 weeks.<h4>Design</h4>Multicenter, open-label, phase 3b study designed to enroll a high proportion of women, with ... Read more >>

Ann Intern Med (Annals of internal medicine)
[2010, 153(6):349-357]

Cited: 52 times

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Phase I/II, open-label trial of safety and immunogenicity of meningococcal (groups A, C, Y, and W-135) polysaccharide diphtheria toxoid conjugate vaccine in human immunodeficiency virus-infected adolescents.

George K Siberry, Paige L Williams, Jorge Lujan-Zilbermann, Meredith G Warshaw, Stephen A Spector, Michael D Decker, Barbara E Heckman, Emily F Demske, Jennifer S Read, Patrick Jean-Philippe, William Kabat, Sharon Nachman, ,

<h4>Background</h4>Quadrivalent meningococcal polysaccharide conjugate vaccine (MCV4) is routinely recommended for healthy youth in the United States, but there are no data about its use in HIV-infected people.<h4>Methods</h4>P1065 is a Phase I/II trial of MCV4 safety and immunogenicity in HIV-infected children and youth performed at 27 US sites of the IMPAACT ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2010, 29(5):391-396]

Cited: 23 times

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Impact of HAART and CNS-penetrating antiretroviral regimens on HIV encephalopathy among perinatally infected children and adolescents.

Kunjal Patel, Xue Ming, Paige L Williams, Kevin R Robertson, James M Oleske, George R Seage, ,

<h4>Objectives</h4>Prior to antiretroviral treatment, HIV-infected children frequently developed encephalopathy, resulting in debilitating morbidity and mortality. This is the first large study to evaluate the impact of HAART and central nervous system (CNS)-penetrating antiretroviral regimens on the incidence of HIV encephalopathy and survival after diagnosis of HIV encephalopathy among perinatally infected ... Read more >>

AIDS (AIDS (London, England))
[2009, 23(14):1893-1901]

Cited: 77 times

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Randomized controlled trial of feeding a concentrated formula to infants born to women infected by human immunodeficiency virus.

Harland S Winter, James M Oleske, Michael D Hughes, Ross E McKinney, Carol Elgie, Christine Powell, Lynette Purdue, Ana M Puga, Eleanor Jimenez, Gwendolyn B Scott, Maria Leticia Santos Cruz, Jack Moye, ,

<h4>Objective</h4>We tested the hypothesis that concentrated formula (CF) begun within the first 2 weeks of life increases growth in infants born to human immunodeficiency virus (HIV)-infected mothers.<h4>Materials and methods</h4>HIV-exposed infants from the United States, the Bahamas, and Brazil were randomized in a double-blind, controlled trial to receive either a CF ... Read more >>

J Pediatr Gastroenterol Nutr (Journal of pediatric gastroenterology and nutrition)
[2009, 49(2):222-232]

Cited: 3 times

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A phase I-II study of live attenuated varicella-zoster virus vaccine to boost immunity in human immunodeficiency virus-infected children with previous varicella.

Anne A Gershon, Myron J Levin, Adriana Weinberg, Lin-Yee Song, Philip S LaRussa, Sharon P Steinberg, Patterson Bartlett, ,

Herpes zoster, may be severe and recurrent in HIV-infected children. We determined the safety and immunogenicity of live attenuated varicella-zoster virus (VZV) vaccine in 46 HIV-infected children who had experienced varicella. There were no serious adverse events. Two years after vaccination 82% of subjects remained VZV-antibody positive and 60% had ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2009, 28(7):653-655]

Cited: 16 times

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Incidence of noninfectious conditions in perinatally HIV-infected children and adolescents in the HAART era.

Sharon A Nachman, Miriam Chernoff, Philimon Gona, Russell B Van Dyke, Wayne M Dankner, George R Seage, James Oleske, Paige L Williams, ,

<h4>Objective</h4>To estimate highly active antiretroviral therapy (HAART)-era incident rates for the first episode of noninfectious conditions in human immunodeficiency virus (HIV)-infected youth in order to identify HAART-era changes in the natural history of perinatal HIV infection.<h4>Design</h4>Multicenter prospective cohort study.<h4>Setting</h4>More than 80 sites in the United States including Puerto Rico.<h4>Patients</h4>Perinatally HIV-infected ... Read more >>

Arch Pediatr Adolesc Med (Archives of pediatrics & adolescent medicine)
[2009, 163(2):164-171]

Cited: 25 times

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Adherence to antiretrovirals among US women during and after pregnancy.

Arlene D Bardeguez, Jane C Lindsey, Maureen Shannon, Ruth E Tuomala, Susan E Cohn, Elizabeth Smith, Alice Stek, Shelly Buschur, Amanda Cotter, Linda Bettica, Jennifer S Read, ,

BACKGROUND:Antiretrovirals (ARVs) are recommended for maternal health and to reduce HIV-1 mother-to-child transmission, but suboptimal adherence can counteract its benefits. OBJECTIVES:To describe antepartum and postpartum adherence to ARV regimens and factors associated with adherence. METHODS:We assessed adherence rates among subjects enrolled in Pediatric AIDS Clinical Trials Group Protocol 1,025 from ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2008, 48(4):408-417]

Cited: 67 times

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Long-term effects of highly active antiretroviral therapy on CD4+ cell evolution among children and adolescents infected with HIV: 5 years and counting.

Kunjal Patel, Miguel A Hernán, Paige L Williams, John D Seeger, Kenneth McIntosh, Russell B Van Dyke, George R Seage, ,

<h4>Background</h4>Lower percentages of CD4(+) T lymphocytes are associated with adverse clinical outcomes among children and adolescents infected with human immunodeficiency virus (HIV). CD4(+) lymphocyte percentage generally increases with receipt of highly active antiretroviral therapy (HAART), but long-term follow-up is required to assess whether these increases in CD4(+) cell percentage are ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2008, 46(11):1751-1760]

Cited: 60 times

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