Ana Isabel Laja García, Carmen Moráis-Moreno, Mª de Lourdes Samaniego-Vaesken, Ana M Puga, Gregorio Varela-Moreiras, Teresa Partearroyo,
At present, obesity and overweight are major public health concerns. Their classical determinants do not sufficiently explain the current situation and it is urgent to investigate other possible causes. In recent years, it has been suggested that water intake could have important implications for weight management. Thus, the aim of ... Read more >>
Nutrients (Nutrients)
[2019, 11(11):]
Cited: 0 times
Ana Isabel Laja García, Carmen Moráis-Moreno, Mª de Lourdes Samaniego-Vaesken, Ana M Puga, Teresa Partearroyo, Gregorio Varela-Moreiras,
The increasing prevalence of overweight and obesity has become an epidemic public health problem worldwide. In the last years, several investigations have suggested that water intake and retention could have important implications for both weight management and body composition. However, there is a lack of information about this issue globally, ... Read more >>
Nutrients (Nutrients)
[2019, 11(8):]
Cited: 1 time
Ana M Puga, Sara Lopez-Oliva, Carmen Trives, Teresa Partearroyo, Gregorio Varela-Moreiras,
Despite being the most essential nutrient, water is commonly forgotten in the fields of pharmacy and nutrition. Hydration status is determined by water balance (the difference between water input and output). Hypohydration or negative water balance is affected by numerous factors, either internal (i.e., a lack of thirst sensation) or ... Read more >>
Nutrients (Nutrients)
[2019, 11(3):]
Cited: 1 time
Ana M Puga, María A Pajares, Gregorio Varela-Moreiras, Teresa Partearroyo,
Hearing loss has been recently ranked as the fifth leading cause of years lived with disability, ahead of many other chronic diseases such as diabetes, dementia, or chronic obstructive pulmonary disease. Moreover, according to the World Health Organization, moderate-to-profound hearing loss affects about 466 million people worldwide. Its incidence varies ... Read more >>
Nutrients (Nutrients)
[2018, 11(1):]
Cited: 1 time
Pedro F Costa, Ana M Puga, Luis Díaz-Gomez, Angel Concheiro, Dirk H Busch, Carmen Alvarez-Lorenzo,
The adoption of additive manufacturing in tissue engineering and regenerative medicine (TERM) strategies greatly relies on the development of novel 3D printable materials with advanced properties. In this work we have developed a material for bone TERM applications with tunable bioerosion rate and dexamethasone release profile which can be further ... Read more >>
Int J Pharm (International journal of pharmaceutics)
[2015, 496(2):541-550]
Cited: 6 times
Sharon L Nichols, James Bethel, Bill G Kapogiannis, Tiandong Li, Steven P Woods, E Doyle Patton, Weijia Ren, Sarah E Thornton, Hanna O Major-Wilson, Ana M Puga, John W Sleasman, Bret J Rudy, Craig M Wilson, Patricia A Garvie, ,
Although youth living with behaviorally acquired HIV (YLWH) are at risk for cognitive impairments, the relationship of impairments to HIV and potential to improve with antiretroviral therapy (ART) are unclear. This prospective observational study was designed to examine the impact of initiation and timing of ART on neurocognitive functioning in ... Read more >>
J. Neurovirol. (Journal of neurovirology)
[2016, 22(2):218-230]
Cited: 1 time
Richard M Rutstein, Pearl Samson, Terry Fenton, Courtney V Fletcher, Jennifer J Kiser, Lynne M Mofenson, Elizabeth Smith, Bobbie Graham, Marina Mathew, Grace Aldrovani, ,
BACKGROUND:Atazanavir (ATV) is an attractive option for the treatment of Pediatric HIV infection, based on once-daily dosing and the availability of a formulation appropriate for younger children. Pediatric AIDS Clinical Trials Group 1020A was a phase I/II open label study of ATV (with/without ritonavir [RTV] boosting)-based treatment of HIV-infected children; ... Read more >>
Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2015, 34(2):162-167]
Cited: 7 times
Suad Kapetanovic, Lisa Aaron, Grace Montepiedra, Patricia Anthony, Kasalyn Thuvamontolrat, Savita Pahwa, Sandra Burchett, Adriana Weinberg, Andrea Kovacs, ,
<label>BACKGROUND</label>We examined the effect of cytomegalovirus (CMV) co-infection and viremia on reconstitution of selected CD4+ and CD8+ T-cell subsets in perinatally HIV-infected (PHIV+) children ≥ 1-year old who participated in a partially randomized, open-label, 96-week combination antiretroviral therapy (cART)-algorithm study.<label>METHODS</label>Participants were categorized as CMV-naïve, CMV-positive (CMV+) viremic, and CMV+ aviremic, ... Read more >>
PLoS ONE (PloS one)
[2015, 10(3):e0120474]
Cited: 2 times
Maria B C de Matos, Ana M Puga, Carmen Alvarez-Lorenzo, Angel Concheiro, Mara E M Braga, Hermínio C de Sousa,
Homogeneous poly(ε-caprolactone) (PCL) and poloxamines (PLXs) porous blends were prepared using a supercritical carbon dioxide-assisted foaming/mixing (SFM) approach aiming to obtain cytocompatible implantable materials presenting tunable morphologies, bioerosion rates, bioactive molecules release and osteogenic features. Pure PCL, pure PLXs (T908 and T1107 varieties) and three distinct PCL:PLX 75:25, 50:50, 25:75% ... Read more >>
Int J Pharm (International journal of pharmaceutics)
[2015, 479(1):11-22]
Cited: 0 times
Tania Segura, Ana M Puga, Guillermina Burillo, José Llovo, Gilles Brackman, Tom Coenye, Angel Concheiro, Carmen Alvarez-Lorenzo,
Materials with fungi-bioinspired surface have been designed to host ergosterol-binding polyene antibiotics and to release them via a competitive mechanism only when fungi are present in the medium. Silicone rubber (SR) surfaces were endowed with selective loading and fungi-triggered release of polyene antifungal agents by means of a two-step functionalization ... Read more >>
Biomacromolecules (Biomacromolecules)
[2014, 15(5):1860-1870]
Cited: 7 times
Charles D Mitchell, Miriam C Chernoff, George R Seage, Murli U Purswani, Hans M L Spiegel, Gaston Zilleruelo, Carolyn Abitbol, Barbara Heckman, Christopher B Ponce, James M Oleske, ,
<label>BACKGROUND</label>Among human immunodeficiency virus (HIV)-infected youth, the role of renal disease (RD) and its management has become increasingly important as these children/adolescents mature into young adults. The identification of predictors of abnormal renal laboratory events (RLE) may be helpful in the management of their HIV infection and its associated renal ... Read more >>
Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2015, 30(1):153-165]
Cited: 3 times
Ana M Puga, Ana Catarina Lima, Joao F Mano, Angel Concheiro, Carmen Alvarez-Lorenzo,
5-Fluorouracil (5-FU)-loaded chitosan microgels for oral and topical chemotherapy were prepared applying a superhydrophobic surface-based encapsulation technology. Drug-loaded chitosan dispersions were cross-linked and then coated with drug-free chitosan or pectin layers at the solid-air interface in a highly efficient and environment-friendly way. The size of the microgels (with diameters of ... Read more >>
Carbohydr Polym (Carbohydrate polymers)
[2013, 98(1):331-340]
Cited: 9 times
Ana M Puga, Ana Catarina Lima, Angel Concheiro, Carmen Alvarez-Lorenzo, Joao F. Mano,
5-Fluorouracil (5-FU)-loaded chitosan microgels for oral and topical chemotherapy were prepared applying a superhydrophobic surface-based encapsulation technology. Drug-loaded chitosan dispersions were cross-linked and then coated with drug-free chitosan or pectin layers at the solid-air interface in a highly efficient and environment-friendly way. The size of the microgels (with diameters of ... Read more >>
(Carbohydrate Polymers)
[2013, 98(1):331-340]
Cited: 10 times
Jorge Lujan-Zilbermann, Meredith G Warshaw, Paige L Williams, Stephen A Spector, Michael D Decker, Mark J Abzug, Barb Heckman, Adam Manzella, Bill Kabat, Patrick Jean-Philippe, Sharon Nachman, George K Siberry, ,
<label>OBJECTIVE</label>To compare the immunogenicity of 1 vs 2 doses of meningococcal polysaccharide conjugate vaccine (MCV4) in youth infected with human immunodeficiency virus (HIV).<label>STUDY DESIGN</label>P1065 was a phase I/II immunogenicity and safety trial of MCV4 in 324 youth infected with HIV performed at 27 sites of the International Maternal Pediatric Adolescent ... Read more >>
J. Pediatr. (The Journal of pediatrics)
[2012, 161(4):676-81.e2]
Cited: 14 times
Enrique Lallana, Tiziana Ferreri, Sabrina C Carroccio, Ana M Puga, Nicola Tirelli,
RATIONALE: Polysulfides [poly(1,2-alkylene sulfides)] are oxidation-responsive polymers that are finding application in drug release and biomaterials. The precise knowledge of their macromolecular characteristics is of the essence in view of their application to biological systems. METHODS: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) with and without silver trifluoroacetate was ... Read more >>
Rapid Commun. Mass Spectrom. (Rapid communications in mass spectrometry : RCM)
[2012, 26(18):2158-2164]
Cited: 0 times
Kunjal Patel, Russell B Van Dyke, Murray A Mittleman, Steven D Colan, James M Oleske, George R Seage, ,
<label>OBJECTIVE</label>Previous studies of cardiomyopathy among children perinatally infected with HIV were conducted before the routine use of HAART. Nucleoside analogs [nucleoside reverse transcriptase inhibitors (NRTIs)], the backbone of HAART, have been associated with mitochondrial toxicity, which can lead to cardiomyopathy. We evaluated the association of HAART and specific NRTIs associated ... Read more >>
AIDS (AIDS (London, England))
[2012, 26(16):2027-2037]
Cited: 16 times
Ana M Puga, Ana Rey-Rico, Beatriz Magariños, Carmen Alvarez-Lorenzo, Angel Concheiro,
It has been suggested that prevention and treatment of osteomyelitis could be achieved through local drug delivery using implantable devices, which provide therapeutic levels at the infection site with minimum side-effects. Physical blends of polycaprolactone (PCL) and poloxamine (Tetronic®) were prepared by applying a solvent-free hot melting approach to obtain ... Read more >>
Acta Biomater (Acta biomaterialia)
[2012, 8(4):1507-1518]
Cited: 13 times
George K Siberry, Paige L Williams, Jorge Lujan-Zilbermann, Meredith G Warshaw, Stephen A Spector, Michael D Decker, Barbara E Heckman, Emily F Demske, Jennifer S Read, Patrick Jean-Philippe, William Kabat, Sharon Nachman, ,
Quadrivalent meningococcal polysaccharide conjugate vaccine (MCV4) is routinely recommended for healthy youth in the United States, but there are no data about its use in HIV-infected people.P1065 is a Phase I/II trial of MCV4 safety and immunogenicity in HIV-infected children and youth performed at 27 US sites of the IMPAACT ... Read more >>
Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2010, 29(5):391-396]
Cited: 22 times
Elizabeth G Livingston, Yanling Huo, Kunjal Patel, Susan B Brogly, Ruth Tuomala, Gwendolyn B Scott, Arlene Bardeguez, Alice Stek, Jennifer S Read, ,
OBJECTIVE:To estimate risk of infant respiratory morbidity associated with cesarean delivery before labor and ruptured membranes among HIV-1-infected women. METHODS:In a prospective cohort study of HIV-1-infected women and their infants, mode of delivery was determined by clinicians at the participating sites. For this analysis, "elective cesarean delivery" was defined as ... Read more >>
Obstet Gynecol (Obstetrics and gynecology)
[2010, 116(2 Pt 1):335-343]
Cited: 5 times
Judith Currier, Dawn Averitt Bridge, Debbie Hagins, Carmen D Zorrilla, Judith Feinberg, Robert Ryan, Ron Falcon, Alan Tennenberg, Joseph Mrus, Kathleen Squires, ,
Women account for an increasing proportion of patients with HIV-1 but remain underrepresented in antiretroviral clinical trials.To evaluate sex-based differences in efficacy and adverse events in treatment-experienced, HIV-positive women and men receiving darunavir-ritonavir therapy over 48 weeks.Multicenter, open-label, phase 3b study designed to enroll a high proportion of women, with ... Read more >>
Ann. Intern. Med. (Annals of internal medicine)
[2010, 153(6):349-357]
Cited: 49 times
Kunjal Patel, Xue Ming, Paige L Williams, Kevin R Robertson, James M Oleske, George R Seage, ,
<label>OBJECTIVES</label>Prior to antiretroviral treatment, HIV-infected children frequently developed encephalopathy, resulting in debilitating morbidity and mortality. This is the first large study to evaluate the impact of HAART and central nervous system (CNS)-penetrating antiretroviral regimens on the incidence of HIV encephalopathy and survival after diagnosis of HIV encephalopathy among perinatally infected ... Read more >>
AIDS (AIDS (London, England))
[2009, 23(14):1893-1901]
Cited: 75 times
Sharon A Nachman, Miriam Chernoff, Philimon Gona, Russell B Van Dyke, Wayne M Dankner, George R Seage, James Oleske, Paige L Williams, ,
<label>OBJECTIVE</label>To estimate highly active antiretroviral therapy (HAART)-era incident rates for the first episode of noninfectious conditions in human immunodeficiency virus (HIV)-infected youth in order to identify HAART-era changes in the natural history of perinatal HIV infection.<label>DESIGN</label>Multicenter prospective cohort study.<label>SETTING</label>More than 80 sites in the United States including Puerto Rico.<label>PATIENTS</label>Perinatally HIV-infected ... Read more >>
Arch Pediatr Adolesc Med (Archives of pediatrics & adolescent medicine)
[2009, 163(2):164-171]
Cited: 23 times
Harland S Winter, James M Oleske, Michael D Hughes, Ross E McKinney, Carol Elgie, Christine Powell, Lynette Purdue, Ana M Puga, Eleanor Jimenez, Gwendolyn B Scott, Maria Leticia Santos Cruz, Jack Moye, ,
We tested the hypothesis that concentrated formula (CF) begun within the first 2 weeks of life increases growth in infants born to human immunodeficiency virus (HIV)-infected mothers.HIV-exposed infants from the United States, the Bahamas, and Brazil were randomized in a double-blind, controlled trial to receive either a CF (87 kcal/100 ... Read more >>
J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2009, 49(2):222-232]
Cited: 3 times
Anne A Gershon, Myron J Levin, Adriana Weinberg, Lin-Yee Song, Philip S LaRussa, Sharon P Steinberg, Patterson Bartlett, ,
Herpes zoster, may be severe and recurrent in HIV-infected children. We determined the safety and immunogenicity of live attenuated varicella-zoster virus (VZV) vaccine in 46 HIV-infected children who had experienced varicella. There were no serious adverse events. Two years after vaccination 82% of subjects remained VZV-antibody positive and 60% had ... Read more >>
Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2009, 28(7):653-655]
Cited: 16 times
Arlene D Bardeguez, Jane C Lindsey, Maureen Shannon, Ruth E Tuomala, Susan E Cohn, Elizabeth Smith, Alice Stek, Shelly Buschur, Amanda Cotter, Linda Bettica, Jennifer S Read, ,
<label>BACKGROUND</label>Antiretrovirals (ARVs) are recommended for maternal health and to reduce HIV-1 mother-to-child transmission, but suboptimal adherence can counteract its benefits.<label>OBJECTIVES</label>To describe antepartum and postpartum adherence to ARV regimens and factors associated with adherence.<label>METHODS</label>We assessed adherence rates among subjects enrolled in Pediatric AIDS Clinical Trials Group Protocol 1,025 from August 2002 ... Read more >>
J. Acquir. Immune Defic. Syndr. (Journal of acquired immune deficiency syndromes (1999))
[2008, 48(4):408-417]
Cited: 61 times