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Clinical utilization of bacteriophages: a new perspective to combat the antimicrobial resistance in Brazil.

Willames M B S Martins, Mark A Toleman, Ana C Gales,

Due to the emergence of multi-drug resistant bacteria, and the evident limitation in therapeutic options, alternatives to combat bacterial infections have been sought. One of these is phage therapy, which is the use of bacterial viruses to kill pathogenic bacteria responsible for the infection. These viruses called bacteriophages are very ... Read more >>

Braz J Infect Dis (The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases)
[2020, :]

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Joint report of SBI (Brazilian Society of Infectious Diseases), FEBRASGO (Brazilian Federation of Gynecology and Obstetrics Associations), SBU (Brazilian Society of Urology) and SBPC/ML (Brazilian Society of Clinical Pathology/Laboratory Medicine): recommendations for the clinical management of lower urinary tract infections in pregnant and non-pregnant women.

Patricia de Rossi, Sergio Cimerman, José Carlos Truzzi, Clóvis Arns da Cunha, Rosiane Mattar, Marinês Dalla Valle Martino, Maurício Hachul, Adagmar Andriolo, José Ananias Vasconcelos Neto, João Antônio Pereira-Correia, Antonia M O Machado, Ana Cristina Gales,

Urinary tract infection (UTI) is a common condition in women. There is an increased concern on reduction of bacterial susceptibility resulting from wrongly prescribing antimicrobials. This paper summarizes the recommendations of four Brazilian medical societies (SBI - Brazilian Society of Infectious Diseases, FEBRASGO - Brazilian Federation of Gynecology and Obstetrics ... Read more >>

Braz J Infect Dis (The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases)
[2020, :]

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A Klebsiella pneumoniae strain co-harbouring mcr-1 and mcr-3 from a human in Thailand.

Yang Yu, Diego O Andrey, Run-Shi Yang, Kirsty Sands, Uttapoln Tansawai, Mei Li, Edward Portal, Ana C Gales, Pannika R Niumsup, Jian Sun, Xiaoping Liao, Ya-Hong Liu, Timothy R Walsh,

J. Antimicrob. Chemother. (The Journal of antimicrobial chemotherapy)
[2020, :]

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Healthcare-associated carbapenem-resistant OXA-72-producing Acinetobacter baumannii of the clonal complex CC79 colonizing migratory and captive aquatic birds in a Brazilian Zoo.

Ana Clara Narciso, Willames M B S Martins, Luiz G P Almeida, Rodrigo Cayô, Stéfanie Vanessa Santos, Patrícia Locosque Ramos, Nilton Lincopan, Ana Tereza R Vasconcelos, Ana Cristina Gales,

Carbapenem resistance in Acinetobacter baumannii is a public health issue globally, mainly due to the production of carbapenem hydrolyzing class D β-lactamases (CHDLs). In Brazil, OXA-23 and OXA-143 CHDLs have been prevalent in A. baumannii from clinical settings, with some OXA-23 reports in the environmental samples, whereas OXA-72 has begun ... Read more >>

Sci. Total Environ. (The Science of the total environment)
[2020, 726:138232]

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In vitro synergy of ceftolozane/tazobactam in combination with fosfomycin or aztreonam against MDR Pseudomonas aeruginosa.

Gabriel T Cuba, Gerlan Rocha-Santos, Rodrigo Cayô, Ana Paula Streling, Carolina S Nodari, Ana C Gales, Antonio C C Pignatari, David P Nicolau, Carlos R V Kiffer,

Carbapenem-resistant Pseudomonas aeruginosa (CR-PSA) imposes great limitations on empirical therapeutic choices, which are further complicated by metallo-β-lactamase production. This study evaluated in vitro antimicrobial synergy of ceftolozane/tazobactam in combination with aztreonam and fosfomycin against MDR PSA. MICs were determined by broth microdilution and gradient strips. The effect of ceftolozane/tazobactam+aztreonam and ... Read more >>

J. Antimicrob. Chemother. (The Journal of antimicrobial chemotherapy)
[2020, :]

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Exposure to sub-inhibitory ciprofloxacin and nitrofurantoin concentrations increases recA gene expression in uropathogenic Escherichia coli: The role of RecA protein as a drug target.

Ághata Cardoso da Silva Ribeiro, Willames Marcos Brasileiro da Silva Martins, Adilson Aderito da Silva, Ana Cristina Gales, Daniela Gonçales Galasse Rando, Luciene Andrade da Rocha Minarini,

Sub-inhibitory concentrations (sub-MIC) of antimicrobial agents can lead to genetic changes in bacteria, modulating the expression of genes related to bacterial stress and leading to drug resistance. Herein we describe the impact of sub-MIC of ciprofloxacin and nitrofurantoin on three uropathogenic Escherichia coli strains. Disk-diffusion assays with different antimicrobial agents ... Read more >>

Eur J Pharm Sci (European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences)
[2020, 146:105268]

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In Vitro Susceptibility to Ceftazidime/Avibactam and Comparators in Clinical Isolates of Enterobacterales from Five Latin American Countries.

Tobias Manuel Appel, María Fernanda Mojica, Elsa De La Cadena, Christian José Pallares, Marcela A Radice, Paulo Castañeda-Méndez, Diego A Jaime-Villalón, Ana C Gales, José M Munita, María Virginia Villegas,

Background: High rates of resistance to third-generation cephalosporins and carbapenems in Enterobacterales have been reported in Latin America. Ceftazidime/avibactam (CZA) is the combination of a third-generation cephalosporin and a non-β-lactam β-lactamase inhibitor, which has shown activity against isolates producing class A, C and D β-lactamases. Herein, we evaluated the activity ... Read more >>

Antibiotics (Basel) (Antibiotics (Basel, Switzerland))
[2020, 9(2):]

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An Emerging Clone, KPC-2-Producing Klebsiella pneumoniae ST16, Associated with High Mortality Rates in a CC258 Endemic Setting.

Diego O Andrey, Priscila Dantas, Willames B S Martins, Fabíola Marques de Carvalho, Luiz A Gonzaga, Kirsty Sands, Edward Portal, Julien Sauser, Rodrigo Cayô, Marisa F Nicolas, Ana Tereza R Vasconcelos, Eduardo A Medeiros, Timothy R Walsh, Ana C Gales,

BACKGROUND:Carbapenemase-producing K. pneumoniae have become a global priority, not least in low-middle income countries. Here, we report the emergence and clinical impact of a novel KPC-K. pneumoniae ST16 clone in a Clonal Complex (CC)258 endemic setting. METHODS:In a teaching Brazilian hospital, a retrospective cohort of adult KPC-KP bloodstream infections (BSI) ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2019, :]

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612. Molecular Mechanisms Leading to Ceftolozane–Tazobactam Resistance in Clinical Isolates of Pseudomonas aeruginosa from Five Latin American Countries.

Maria F Mojica, Rafael Rios, Elsa De La Cadena, Adriana Correa, Lorena Diaz, Lina V Millan, Angie K Hernandez, Jinnethe Reyes, Cristhian Hernández-Gómez, Marcela A Radice, Paulo Castañeda-Méndez, Diego A Jaime-Villalón, Ana C Gales, Jose M Munita, Catalina López, Monica Maria Rojas Rojas, Maria Virginia Villegas,

AbstractBackgroundCeftolozane–tazobactam (C/T) is a combination of an antipseudomonal cephalosporin with a known β-lactamase inhibitor, with a potent in vitro activity against P. aeruginosa (Pae), without activity against carbapenemases. Among the mechanisms of resistance to C/T that have emerged, substitutions in the Pseudomonal-derived cephalosporinase (PDC), in AmpR, and in some ESBLs, ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S285-S286]

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Virulence potential of a multidrug-resistant Escherichia coli strain belonging to the emerging clonal group ST101-B1 isolated from bloodstream infection

Ana Carolina de Mello Santos, Rosa Maria Silva, Tiago Barcelos Valiatti, Fernanda Fernandes dos Santos, José Francisco Santos-Neto, Rodrigo Cayô, Ana Paula Streling, Carolina Silva Nodari, Ana Cristina Gales, Milton Yutaka Nishiyama-Junior, Eneas Carvalho, Tânia Aparecida Tardelli Gomes,

Abstract Escherichia coli EC121 is a multidrug-resistant (MDR) strain isolated from bloodstream infection of an inpatient with persistent gastroenteritis and Zone T lymphoma, that died due to septic shock. Despite causing an extraintestinal infection, it harbors few known virulence factors and was assigned into phylogenetic group B1. To evaluate if ... Read more >>

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Gene Composition as a Potential Barrier to Large Recombinations in the Bacterial Pathogen Klebsiella pneumoniae.

Francesco Comandatore, Davide Sassera, Sion C Bayliss, Erika Scaltriti, Stefano Gaiarsa, Xiaoli Cao, Ana C Gales, Ryoichi Saito, Stefano Pongolini, Sylvain Brisse, Edward J Feil, Claudio Bandi,

Klebsiella pneumoniae (Kp) is one of the most important nosocomial pathogens worldwide, able to cause multiorgan infections and hospital outbreaks. One of the most widely disseminated lineage of Kp is the clonal group 258 (CG258), which includes the highly resistant "high-risk" sequence types ST258 and ST11. Genomic investigations revealed that ... Read more >>

Genome Biol Evol (Genome biology and evolution)
[2019, 11(11):3240-3251]

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Performance of distinct phenotypic methods for carbapenemase detection: The influence of culture media.

Jhonatha Rodrigo Cordeiro-Moura, Lorena Cristina Corrêa Fehlberg, Carolina Silva Nodari, Adriana Pereira de Matos, Vinicius de Oliveira Alves, Rodrigo Cayô, Ana Cristina Gales,

We evaluated the performance of five phenotypic tests [Modified Hodge Test (MHT); combined-disk test (CDT) using phenylboronic acid, EDTA, and cloxacillin; CarbaNP and CarbAcinetoNP; Blue-Carba, Carbapenembac™ and Carbapenembac Metallo™] for carbapenemase detection in Gram-negative bacilli (GNB). A total of 73 carbapenemase producers and 27 non-carbapenemase producers were tested. All GNB ... Read more >>

Diagn. Microbiol. Infect. Dis. (Diagnostic microbiology and infectious disease)
[2020, 96(1):114912]

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Genetic Characterization of Plasmid-Borne bla OXA-58 in Distinct Acinetobacter Species.

Adriana P Matos, Rodrigo Cayô, Luiz G P Almeida, Ana Paula Streling, Carolina S Nodari, Willames M B S Martins, Ana Clara Narciso, Rosa M Silva, Ana T R Vasconcelos, Ana C Gales,

We characterize by whole-plasmid-sequence (WPS) two-plasmid-borne bla OXA-58 obtained from Acinetobacter seifertii (Asp-1069) and A. baumannii (Acb-45063) clinical strains recovered 17 years apart from distinct Brazilian regions. Multilocus sequence type (MLST) analysis showed that the Asp-1069 and Acb-45063 strains belong to ST551 and ST15/CC15, respectively. WPS analysis demonstrated that bla OXA-58 ... Read more >>

mSphere (mSphere)
[2019, 4(5):]

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Top 10 evidence-based recommendations from the Brazilian Society of Infectious Diseases for the Choosing Wisely Project.

Alessandro C Pasqualotto, Camila S Almeida, Dimas A Kliemann, Guilherme B Barcellos, Flávio Queiroz-Telles, Edson Abdala, Mariangela Resende, Filipe P Batista, José E Vidal, Jaime Rocha, Sonia M Raboni, Sergio Cimerman, Ana C Gales,

The Choosing Wisely Initiative aims to collect statements from medical societies all over the world on medical interventions that result in no benefit to patients, with the potential to cause harm. In this article we present the views of the Diagnostic Laboratory Group at the Brazilian Society of Infectious Diseases ... Read more >>

Braz J Infect Dis (The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases)
[2019, 23(5):331-335]

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Ceftazidime-Avibactam as Salvage Therapy for Infections Caused by Enterobacteriales Coresistant to Carbapenems and Polymyxins.

Thaís Guimarães, Simone A Nouér, Roberta C R Martins, Lauro V Perdigão Neto, Willames M B S Martins, Ana Clara Narciso Barbosa, Adriana L P Ferreira, Silvia F Costa, Ana C Gales,

In this article, we report a case series of patients with infections caused by Enterobacteriales coresistant to carbapenems and polymyxins who were treated with ceftazidime/avibactam (CAZ-AVI) salvage therapy on a compassionate-use protocol. We enrolled 29 adult patients in 3 centers that had an infection due to a resistant microorganism and ... Read more >>

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2019, 63(10):]

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Temporal evolution of antimicrobial resistance among Neisseria gonorrhoeae clinical isolates in the most populated South American Metropolitan Region.

Rafael Affini Martins, Dandara Cassu-Corsi, Carolina Silva Nodari, Rodrigo Cayô, Larissa Natsumeda, Ana Paula Streling, André Mario Doi, Roberto José Carvalho da Silva, Roberta Alessandra Lima Bocalon, Ana Cristina Gales, Antonio Carlos Campos Pignatari,

A total of 124 Neisseria gonorrhoeae isolates recovered during a 12-year period (2003-2015) from outpatients assisted at Centro de Referência e Treinamento DST/AIDS-CRT of São Paulo city, Brazil, were analysed. The following resistance rates were observed: penicillin-59.6%, ciprofloxacin-15.3%, and azithromycin-6.7%. Although reduced susceptibility to these drugs was observed since 2003, ... Read more >>

Mem. Inst. Oswaldo Cruz (Memorias do Instituto Oswaldo Cruz)
[2019, 114:e190079]

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Diversity of metallo-β-lactamase-encoding genes found in distinct species of Acinetobacter isolated from the Brazilian Amazon Region.

Danielle Brasiliense, Rodrigo Cayô, Ana Paula Streling, Carolina S Nodari, Rafael R Barata, Poliana S Lemos, Janaina M Massafra, Yan Correa, Igor Magalhães, Ana C Gales, Roberta Sodré,

BACKGROUND:The multidrug resistance (MDR) phenotype is frequently observed in Acinetobacter baumannii, the most clinically relevant pathogenic species of its genus; recently, other species belonging to the A. calcoaceticus-A. baumannii complex have emerged as important MDR nosocomial pathogens. OBJECTIVES:The present study aimed to verify the occurrence of metallo-β-lactamase genes among distinct ... Read more >>

Mem. Inst. Oswaldo Cruz (Memorias do Instituto Oswaldo Cruz)
[2019, 114:e190020]

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Hexadecane biodegradation of high efficiency by bacterial isolates from Santos Basin sediments.

Vitor B Ferrari, Augusto Cesar, Rodrigo Cayô, Rodrigo B Choueri, Débora N Okamoto, Juliana G Freitas, Mariana Favero, Ana C Gales, Cristina V Niero, Flavia T Saia, Suzan P de Vasconcellos,

The aim of the study was the investigation of bacterial diversity from sediments collected at Santos Estuarine System, regarding to their abilities for hexadecane biotransformation. Hexadecane is a medium-chain linear alkane, considered as a model molecule for hydrocarbon biodegradation studies. It is a component from aliphatic fraction of crude petroleum, ... Read more >>

Mar. Pollut. Bull. (Marine pollution bulletin)
[2019, 142:309-314]

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Geographic and Temporal Patterns of Antimicrobial Resistance in Pseudomonas aeruginosa Over 20 Years From the SENTRY Antimicrobial Surveillance Program, 1997-2016.

Dee Shortridge, Ana C Gales, Jennifer M Streit, Michael D Huband, Athanasios Tsakris, Ronald N Jones,

Background:The SENTRY Antimicrobial Surveillance Program was established in 1997 and encompasses over 750 000 bacterial isolates from ≥400 medical centers worldwide. Among the pathogens tested, Pseudomonas aeruginosa remains a common cause of multidrug-resistant (MDR) bloodstream infections and pneumonia in hospitalized patients. In the present study, we reviewed geographic and temporal ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 1):S63-S68]

Cited: 3 times

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Antimicrobial Susceptibility of Acinetobacter calcoaceticus-Acinetobacter baumannii Complex and Stenotrophomonas maltophilia Clinical Isolates: Results From the SENTRY Antimicrobial Surveillance Program (1997-2016).

Ana C Gales, Harald Seifert, Deniz Gur, Mariana Castanheira, Ronald N Jones, Helio S Sader,

Background:Acinetobacter calcoaceticus-A. baumannii (Acb) complex and Stenotrophomonas maltophilia represent frequent causes of hospital-acquired infections. We evaluated the frequency and resistance rates of Acb complex and S. maltophilia isolates from medical centers enrolled in the SENTRY Program. Methods:A total of 13 752 Acb complex and 6467 S. maltophilia isolates were forwarded ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 1):S34-S46]

Cited: 7 times

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Reporting elevated vancomycin minimum inhibitory concentration in methicillin-resistant Staphylococcus aureus: consensus by an International Working Group.

Mark Wilcox, Suleiman Al-Obeid, Ana Gales, Roman Kozlov, José A Martínez-Orozco, Flavia Rossi, Sergey Sidorenko, Joseph Blondeau,

Methicillin-resistant Staphylococcus aureus (MRSA) remains an important cause of serious infection, for which vancomycin is often recommended as the first-choice antibiotic treatment. Appropriate vancomycin prescribing requires accurate measurement of minimum inhibitory concentrations (MICs) to avoid treatment failure, and yet determination can be challenging due to methodological difficulties associated with susceptibility ... Read more >>

Future Microbiol (Future microbiology)
[2019, 14:345-352]

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Plazomicin for Infections Caused by Carbapenem-Resistant Enterobacteriaceae.

James A McKinnell, Jamie P Dwyer, George H Talbot, Lynn E Connolly, Ian Friedland, Alex Smith, Adrian M Jubb, Alisa W Serio, Kevin M Krause, George L Daikos, ,

N. Engl. J. Med. (The New England journal of medicine)
[2019, 380(8):791-793]

Cited: 9 times

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A high mortality rate associated with multidrug-resistant Acinetobacter baumannii ST79 and ST25 carrying OXA-23 in a Brazilian intensive care unit.

Kesia Esther da Silva, Wirlaine Glauce Maciel, Julio Croda, Rodrigo Cayô, Ana Carolina Ramos, Romário Oliveira de Sales, Mariana Neri Lucas Kurihara, Nathalie Gaebler Vasconcelos, Ana Cristina Gales, Simone Simionatto,

The global spread of carbapenem-resistant Acinetobacter baumannii (A. baumannii) strains has restricted the therapeutic options available to treat infections due to this pathogen. Understanding the prevalence of such infections and the underlying genetic mechanisms of resistance may help in the implementation of adequate measures to control and prevent acquisition of ... Read more >>

PLoS ONE (PloS one)
[2018, 13(12):e0209367]

Cited: 5 times

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1964. Microbiological Outcomes With Plazomicin (PLZ) vs. Colistin (CST) in Patients With Bloodstream Infections (BSI) Caused by Carbapenem-Resistant Enterobacteriaceae (CRE) in the CARE Study.

Alisa W Serio, Alex Smith, Kevin M Krause, Irene Galani, Ana Cristina Gales, Adrian Jubb, Lynn E Connolly,

AbstractBackgroundPLZ is a next-generation aminoglycoside with structural modifications that protect it from aminoglycoside-modifying enzymes (AMEs) and in vitro activity against multidrug-resistant (MDR) Enterobacteriaceae, including aminoglycoside- and carbapenem-resistant strains. In the CARE study, PLZ was associated with improvement in 28-day all-cause mortality vs. CST in patients with CRE BSI. We report ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S569-S569]

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Characterisation of plasmid-mediated rmtB-1 in Enterobacteriaceae clinical isolates from São Paulo, Brazil.

Dandara Cassu-Corsi, Willames Mbs Martins, Adriana G Nicoletti, Luiz Gp Almeida, Ana Tr Vasconcelos, Ana C Gales,

OBJECTIVES The emergence of 16S rRNA methyltranferases (16 RMTAses) has jeopardised the clinical use of aminoglycosides. RmtB is one of the most frequently reported in Gram-negatives worldwide. In this study, we aimed to estimate the frequency of 16S RMTAses encoding genes in Enterobacteriaceae isolated in a three-month period from a ... Read more >>

Mem. Inst. Oswaldo Cruz (Memorias do Instituto Oswaldo Cruz)
[2018, 113(12):e180392]

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