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Author Ana Berceanu

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Ponatinib-based therapy in adults with relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia: results of the real-life OPAL study.

Suzanne Tavitian, Madalina Uzunov, Emilie Bérard, Didier Bouscary, Xavier Thomas, Emmanuel Raffoux, Thibaut Leguay, Maria Pilar Gallego Hernanz, Ana Berceanu, Stéphane Leprêtre, Yosr Hicheri, Patrice Chevallier, Sarah Bertoli, Véronique Lhéritier, Hervé Dombret, Françoise Huguet,

The OPAL study is a French multicenter observational retrospective analysis of adults with relapsed/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia treated in a real-life setting by ponatinib. Twenty-nine patients were included since 2012. Median age was 55  years. The initial dose of ponatinib, combined to chemotherapy in half of the patients, ... Read more >>

Leuk. Lymphoma (Leukemia & lymphoma)
[2020, :1-7]

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Arsenic Trioxide Treatment during Pregnancy for Acute Promyelocytic Leukemia in a 22-Year-Old Woman.

Claire Cochet, Marion Simonet, Julie Cattin, Jean-Patrick Metz, Ana Berceanu, Eric Deconinck, Etienne Daguindau, Françoise Schillinger, Pierre Fenaux, Nicolas Mottet, Yohan Desbrosses,

Acute leukemia during pregnancy is rare (1 for 100000 pregnancies). The association of arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) is known as the best therapy in standard-risk acute promyelocytic leukemia (APL). We describe the first case of a pregnancy with ATRA and ATO reported in the literature. In ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:3686584]

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Positive quantitative PCR detecting Fusarium solani in a case of mixed invasive fungal disease due to Mucorales and Fusarium solani.

Anne-Pauline Bellanger, Steffi Rocchi, Ana Berceanu, Emeline Scherer, Fabrice Larosa, Laurence Millon,

We present a case of invasive fungal co-infection in a young patient treated for an acute myeloid leukemia and having undergone a twice-haploid matched unrelated donor hematopoietic stem cell transplantation (HSCT) with two different donors. A mucormycosis diagnosis was made shortly after the patient's admission using imagery and specific Mucorales ... Read more >>

Bone Marrow Transplant. (Bone marrow transplantation)
[2020, 55(5):873-876]

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Letermovir for Secondary Prophylaxis of Cytomegalovirus Infection and Disease after Allogeneic Hematopoietic Cell Transplantation: Results from the French Compassionate Program.

Christine Robin, Anne Thiebaut, Sophie Alain, Flore Sicre de Fontbrune, Ana Berceanu, Maud D'Aveni, Patrice Ceballos, Rabah Redjoul, Stéphanie Nguyen-Quoc, Nathalie Bénard, Golriz Pahlavan-Grumel, Catherine Cordonnier,

Letermovir potently inhibits the cytomegalovirus (CMV)-terminase complex. Letermovir primary prophylaxis given for the first 3 months after allogeneic hematopoietic cell transplantation (HCT) has been shown to reduce clinically significant CMV infection and is well tolerated. Until now, only case reports or small retrospective series have been published on the use ... Read more >>

Biol. Blood Marrow Transplant. (Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation)
[2020, 26(5):978-984]

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Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients.

Anne-Pauline Bellanger, Ana Berceanu, Emeline Scherer, Yohan Desbrosses, Etienne Daguindau, Steffi Rocchi, Laurence Millon,

We present 2 fatal cases of invasive fungal disease with isavuconazole treatment failure in immunocompromised patients: one with a TR34-L98H azole-resistant Aspergillus fumigatus isolate and the other a Rhizomucor-A. fumigatus co-infection. Such patients probably require surveillance by galactomannan antigen detection and quantitative PCRs for A. fumigatus and Mucorales fungi. ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2019, 25(9):1778-1779]

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Outcomes of Salvage Haploidentical Transplant with Post-Transplant Cyclophosphamide for Rescuing Graft Failure Patients: a Report on Behalf of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy.

Pedro H Prata, Matthieu Resche-Rigon, Didier Blaise, Gérard Socié, Pierre-Simon Rohrlich, Noel Milpied, Pascal Turlure, Stephanie Nguyen, Anne Sirvent, Claude-Eric Bulabois, Ana Berceanu, Amandine Charbonnier, Patrice Chevallier, Jacques-Olivier Bay, Benedicte Neven, Charlotte Jubert, Mohamad Mohty, Marie-Thérèse Rubio, Régis Peffault de Latour,

Prognosis of patients with graft failure is dismal, and retransplantation is the sole option for long-term survival. To address the interest of haploidentical transplantation as a salvage option in this context, we analyzed data from 24 patients with graft failure or loss retransplanted with a haploidentical donor who received post-transplant ... Read more >>

Biol. Blood Marrow Transplant. (Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation)
[2019, 25(9):1798-1802]

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Altered thymic CD4+ T-cell recovery after allogeneic hematopoietic stem cell transplantation is critical for nocardiosis.

Xavier Roussel, Etienne Daguindau, Ana Berceanu, Yohan Desbrosses, Philippe Saas, Christophe Ferrand, Estelle Seilles, Fabienne Pouthier, Eric Deconinck, Fabrice Larosa,

PURPOSE OF THE STUDY:Nocardia affects immunocompromised human host exhibiting an altered cell-mediated immunity. Infectious risk after allogeneic hematopoietic cell transplantation (AHCT) is significantly correlated to the recovery status of donor-derived immune system, especially CD4+ T-cells reconstitution and thymopoiesis. The purpose of this paper is to highlight a lack of cell-mediated ... Read more >>

Curr Res Transl Med (Current research in translational medicine)
[2019, 67(4):135-143]

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Evaluation of infectious complications after haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide following reduced-intensity and myeloablative conditioning: a study on behalf of the Francophone Society of Stem Cell Transplantation and Cellular Therapy (SFGM-TC).

Amandine Fayard, Elisabeth Daguenet, Didier Blaise, Patrice Chevallier, Hélène Labussière, Ana Berceanu, Ibrahim Yakoub-Agha, Gérard Socié, Amandine Charbonnier, Felipe Suarez, Anne Huynh, Mélanie Mercier, Claude-Eric Bulabois, Bruno Lioure, Sylvain Chantepie, Yves Beguin, Jean-Henri Bourhis, Jean-Valère Malfuson, Laurence Clément, Régis Peffault de la Tour, Jérôme Cornillon,

Several approaches have been developed to overcome historical barriers associated with poor outcomes in the setting of HLA-haploidentical allogeneic transplantation (HaploSCT). Here, we examine the outcome of patients with various hematological disorders undergoing HaploSCT with high-dose, post-transplantation cyclophosphamide. We performed a retrospective study on 381 patients from 30 centers between ... Read more >>

Bone Marrow Transplant. (Bone marrow transplantation)
[2019, 54(10):1586-1594]

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Quantitative PCR (qPCR) Detection of Mucorales DNA in Bronchoalveolar Lavage Fluid To Diagnose Pulmonary Mucormycosis.

Emeline Scherer, Xavier Iriart, Anne Pauline Bellanger, Damien Dupont, Juliette Guitard, Frederic Gabriel, Sophie Cassaing, Eléna Charpentier, Sarah Guenounou, Murielle Cornet, Françoise Botterel, Steffi Rocchi, Ana Berceanu, Laurence Millon,

Early diagnosis and treatment are essential to improving the outcome of mucormycosis. The aim of this retrospective study was to assess the contribution of quantitative PCR detection of Mucorales DNA in bronchoalveolar lavage fluids for early diagnosis of pulmonary mucormycosis. Bronchoalveolar lavage fluid samples (n = 450) from 374 patients ... Read more >>

J. Clin. Microbiol. (Journal of clinical microbiology)
[2018, 56(8):]

Cited: 6 times

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Local retrospective analysis of galactomannan cut-off values in bronchoalveolar lavage fluids for diagnosis of invasive aspergillosis.

Anne-Pauline Bellanger, Houssein Gbaguidi-Haore, Natacha Tatoyan, Ana Berceanu, Emeline Scherer, Laurence Millon,

Galactomannan antigen (GM) testing has been used for decades to screen immunocompromised patients for invasive aspergillosis (IA). Recent publications suggested that using a higher cut-off value than 0.5 in bronchoalveolar lavage fluid (BALF) could be more discriminant for hematology patients. We retrospectively analyzed the values of GM in BALF over ... Read more >>

Folia Microbiol. (Praha) (Folia microbiologica)
[2018, 63(6):757-761]

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Development of a quantitative PCR detecting Cunninghamella bertholletiae to help in diagnosing this rare and aggressive mucormycosis.

Anne-Pauline Bellanger, Ana Berceanu, Steffi Rocchi, Benoit Valot, Jean Fontan, Adrien Chauchet, Nicolas Belin, Emeline Scherer, Eric Deconinck, Jean-Christophe Navellou, Laurence Millon,

Mucormycosis is an invasive mold infection, frequently fatal in immunocompromised patients. We report the case of a patient with chronic lymphocytic leukemia admitted to the hematology unit for febrile aplasia. Pulmonary lesions suggesting a fungal infection expanded/increased despite a combination of posaconazole and liposomal amphotericin B. The fungal biomarkers performed ... Read more >>

Bone Marrow Transplant. (Bone marrow transplantation)
[2018, 53(9):1180-1183]

Cited: 2 times

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Nationwide survey on the use of eltrombopag in patients with severe aplastic anemia: a report on behalf of the French Reference Center for Aplastic Anemia.

Etienne Lengline, Bernard Drenou, Pierre Peterlin, Olivier Tournilhac, Julie Abraham, Ana Berceanu, Brigitte Dupriez, Gaelle Guillerm, Emmanuel Raffoux, Flore Sicre de Fontbrune, Lionel Ades, Marie Balsat, Driss Chaoui, Paul Coppo, Selim Corm, Thierry Leblanc, Natacha Maillard, Louis Terriou, Gerard Socié, Regis Peffault de Latour,

Few therapeutic options are available for patients with aplastic anemia who are ineligible for transplantation or refractory to immunosuppressive therapy. Eltrombopag was recently shown to produce trilineage responses in refractory patients. However, the effects of real-life use of this drug remain unknown. This retrospective study (2012-2016) was conducted by the ... Read more >>

Haematologica (Haematologica)
[2018, 103(2):212-220]

Cited: 7 times

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Effect of Azithromycin on Airflow Decline-Free Survival After Allogeneic Hematopoietic Stem Cell Transplant: The ALLOZITHRO Randomized Clinical Trial.

Anne Bergeron, Sylvie Chevret, Angela Granata, Patrice Chevallier, Laure Vincent, Anne Huynh, Reza Tabrizi, Hélène Labussiere-Wallet, Marc Bernard, Sylvain Chantepie, Jacques-Olivier Bay, Anne Thiebaut-Bertrand, Sylvain Thepot, Nathalie Contentin, Luc-Matthieu Fornecker, Natacha Maillard, Karine Risso, Ana Berceanu, Didier Blaise, Regis Peffault de La Tour, Jason W Chien, Valérie Coiteux, Gérard Socié, ,

Bronchiolitis obliterans syndrome has been associated with increased morbidity and mortality after allogeneic hematopoietic stem cell transplant (HSCT). Previous studies have suggested that azithromycin may reduce the incidence of post-lung transplant bronchiolitis obliterans syndrome.To evaluate if the early administration of azithromycin can improve airflow decline-free survival after allogeneic HSCT.The ALLOZITHRO ... Read more >>

JAMA (JAMA)
[2017, 318(6):557-566]

Cited: 8 times

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Correlation Between Pneumocystis jirovecii Mitochondrial Genotypes and High and Low Fungal Loads Assessed by Single Nucleotide Primer Extension Assay and Quantitative Real-Time PCR.

Alexandre Alanio, Martine Olivi, Odile Cabaret, Françoise Foulet, Anne-Pauline Bellanger, Laurence Millon, Ana Berceanu, Catherine Cordonnier, Jean-Marc Costa, Stéphane Bretagne,

We designed a single nucleotide primer extension (SNaPshot) assay for Pneumocystis jirovecii genotyping, targeting mt85 SNP of the mitochondrial large subunit ribosomal RNA locus, to improve minority allele detection. We then analyzed 133 consecutive bronchoalveolar lavage (BAL) fluids tested positive for P. jirovecii DNA by quantitative real-time PCR, obtained from ... Read more >>

J. Eukaryot. Microbiol. (The Journal of eukaryotic microbiology)
[2015, 62(5):650-656]

Cited: 6 times

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Therapy-related acute myeloid leukemia (t-AML) with poor-risk cytogenetics in two patients with persistent molecular complete remission of acute promyelocytic leukemia.

Mario Ojeda-Uribe, Anne Schneider, Isabelle Luquet, Ana Berceanu, Pascale Cornillet-Lefebvre, Eric Jeandidier, Bruno Lioure, Lionel Ades, Laurent Mauvieux, Chantal Himberlin,

Therapy-related acute myeloid leukemia (t-AML) is a clinical syndrome occurring as a complication after cytotoxic and/or radiation therapy. The incidence of t-AML after acute promyelocytic leukemia (APL), all-transretinoic acid (ATRA), and anthracycline-based therapy is rather low. However, because of the high remission rates and long-term overall survival achieved with current ... Read more >>

Eur. J. Haematol. (European journal of haematology)
[2012, 89(3):267-272]

Cited: 2 times

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Beta-D-glucan detection test: a step toward preemptive therapy for fungal infections in leukemic patients?

Raoul Herbrecht, Ana Berceanu,

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2008, 46(6):886-889]

Cited: 18 times

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Clinical and hematological aspects of chronic myelomonocytic leukemia. Study on 20 cases from a single center from Romania.

R Gologan, Ana Berceanu, Adriana Colita, Valeria Codreanu, Camelia Dobrea, Liana Geoada, Viorica Iacob, Emilia Niculescu-Mizil, Daniela Ostroveanu, Tatiana Puşcariu, Iulia Ursuleac,

Chronic myelomonocytic leukemia (CMML) has long been recognized as a disorder with both myelodysplastic and myeloproliferative characteristics, some patients showing clinical and morphological features resembling myelodysplastic syndrome (MDS) especially refractory anemia with excess of blasts (RAEB) with monocytosis, and others leukocytosis with neutrophilia, monocytosis and splenomegaly resembling myeloproliferative syndrome (MPS). ... Read more >>

Rom J Intern Med (Romanian journal of internal medicine = Revue roumaine de medecine interne)
[2002, 40(1-4):95-102]

Cited: 1 time

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