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Author An Wen Chan

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Selective outcome reporting across psychopharmacotherapy randomized controlled trials.

Michelle Lancee, Marleen Schuring, Joeri K Tijdink, An-Wen Chan, Christiaan H Vinkers, Jurjen J Luykx,

<h4>Objective</h4>Selective reporting impairs the valid interpretation of trials and leads to bias with regards to the clinical evidence. We aimed to examine factors associated with selective reporting in psychopharmacotherapy trials and thus enable solutions to prevent such selective reporting in the future.<h4>Methods</h4>We retrieved all registry records of trials investigating medication ... Read more >>

Int J Methods Psychiatr Res (International journal of methods in psychiatric research)
[2021, :e1900]

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Reliability of Trial Information Across Registries for Trials With Multiple Registrations: A Systematic Review.

Benjamin Speich, Viktoria L Gloy, Katharina Klatte, Dmitry Gryaznov, Ala Taji Heravi, Nilabh Ghosh, Ioana R Marian, Hopin Lee, Anita Mansouri, Szimonetta Lohner, Ramon Saccilotto, Edris Nury, An-Wen Chan, Anette Blümle, Ayodele Odutayo, Sally Hopewell, Matthias Briel, ,

<h4>Importance</h4>Clinical trial registries are important for gaining an overview of ongoing research efforts and for deterring and identifying publication bias and selective outcome reporting. The reliability of the information in trial registries is uncertain.<h4>Objective</h4>To assess the reliability of information across registries for trials with multiple registrations.<h4>Evidence review</h4>For this systematic review, ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(11):e2128898]

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Outcomes of skin cancers in pediatric solid organ transplant patients: A systematic review.

Muskaan Sachdeva, Irene Lara-Corrales, Elena Pope, An-Wen Chan, Rulan S Parekh, Abhijat Kitchlu, Cathryn Sibbald,

<h4>Background</h4>The most frequently reported malignancies after solid organ transplant are cutaneous, but data on the risk in pediatric populations varies across studies.<h4>Objectives</h4>To perform a systematic review including reported features and outcomes of skin cancers in pediatric solid organ transplant recipients.<h4>Methods</h4>EMBASE and MEDLINE were systematically searched (Prospero CRD42020201659).<h4>Results</h4>The review summarizes data ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2021, :e14146]

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Incidence and mortality rates of keratinocyte carcinoma from 1998-2017: a population-based study of sex differences in Ontario, Canada.

Evan Tang, Kinwah Fung, An-Wen Chan,

<h4>Background</h4>Keratinocyte carcinoma is the most common malignant disease, but it is not captured in major registries. We aimed to describe differences by sex in the incidence and mortality rates of keratinocyte carcinoma in Ontario, Canada.<h4>Methods</h4>We conducted a population-based retrospective study of adults residing in Ontario between Jan. 1, 1998, and ... Read more >>

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2021, 193(39):E1516-E1524]

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Guidelines for cellular and molecular pathology content in clinical trial protocols: the SPIRIT-Path extension.

Timothy J Kendall, Max Robinson, Daniel J Brierley, Shujing Jane Lim, Daniel J O'Connor, Abeer M Shaaban, Ian Lewis, An-Wen Chan, David J Harrison, ,

The 2013 SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) Statement provides evidence-based recommendations for the minimum content to be included in a clinical trial protocol. Assessment of biospecimens is often required for trial eligibility or as part of an outcome evaluation, and precision molecular approaches are increasingly used in ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2021, 22(10):e435-e445]

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A study protocol for the development of a SPIRIT extension for trials conducted using cohorts and routinely collected data (SPIRIT-ROUTINE)

Megan McCarthy, Linda O'Keeffe, Paula Williamson, Matthew Sydes, Amanda Farrin, Fiona Lugg-Widger, Gwyneth Davies, Kerry Avery, An-Wen Chan, Linda Kwakkenbos, Brett Thombs, Alan Watkins, Lars Hemkens, Chris Gale, Merrick Zwarenstein, Sinead Langan, Lehana Thabane, Edmund Juszczak, David Moher, Patricia Kearney,

Background:  Protocols are an essential document for conducting randomised controlled trials (RCTs). However, the completeness of the information provided is often inadequate. To help improve the content of trial protocols, an international group of stakeholders published the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) Initiative in 2013. Presently, there is ... Read more >>

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Gender disparity between authors in leading medical journals during the COVID-19 pandemic: a cross-sectional review.

Vaidehi Misra, Frozan Safi, Kathryn A Brewerton, Wei Wu, Robin Mason, An-Wen Chan, Paula A Rochon, Iliana C Lega, Husam Abdel-Qadir,

<h4>Objectives</h4>Evaluate gender differences in authorship of COVID-19 articles in high-impact medical journals compared with other topics.<h4>Design</h4>Cross-sectional review.<h4>Data sources</h4>Medline database.<h4>Eligibility criteria</h4>Articles published from 1 January to 31 December 2020 in the seven leading general medical journals by impact factor. Article types included primary research, reviews, editorials and commentaries.<h4>Data extraction</h4>Key data elements ... Read more >>

BMJ Open (BMJ open)
[2021, 11(7):e051224]

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SPIRIT-PRO Extension explanation and elaboration: guidelines for inclusion of patient-reported outcomes in protocols of clinical trials.

Melanie Calvert, Madeleine King, Rebecca Mercieca-Bebber, Olalekan Aiyegbusi, Derek Kyte, Anita Slade, An-Wen Chan, E Basch, Jill Bell, Antonia Bennett, Vishal Bhatnagar, Jane Blazeby, Andrew Bottomley, Julia Brown, Michael Brundage, Lisa Campbell, Joseph C Cappelleri, Heather Draper, Amylou C Dueck, Carolyn Ells, Lori Frank, Robert M Golub, Ingolf Griebsch, Kirstie Haywood, Amanda Hunn, Bellinda King-Kallimanis, Laura Martin, Sandra Mitchell, Thomas Morel, Linda Nelson, Josephine Norquist, Daniel O'Connor, Michael Palmer, Donald Patrick, Gary Price, Antoine Regnault, Ameeta Retzer, Dennis Revicki, Jane Scott, Richard Stephens, Grace Turner, Antonia Valakas, Galina Velikova, Maria von Hildebrand, Anita Walker, Lari Wenzel,

Patient-reported outcomes (PROs) are used in clinical trials to provide valuable evidence on the impact of disease and treatment on patients' symptoms, function and quality of life. High-quality PRO data from trials can inform shared decision-making, regulatory and economic analyses and health policy. Recent evidence suggests the PRO content of ... Read more >>

BMJ Open (BMJ open)
[2021, 11(6):e045105]

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Guidelines for Reporting Trial Protocols and Completed Trials Modified Due to the COVID-19 Pandemic and Other Extenuating Circumstances: The CONSERVE 2021 Statement.

Aaron M Orkin, Peter J Gill, Davina Ghersi, Lisa Campbell, Jeremy Sugarman, Richard Emsley, Philippe Gabriel Steg, Charles Weijer, John Simes, Tanja Rombey, Hywel C Williams, Janet Wittes, David Moher, Dawn P Richards, Yvette Kasamon, Kenneth Getz, Sally Hopewell, Kay Dickersin, Taixiang Wu, Ana Patricia Ayala, Kenneth F Schulz, Sabine Calleja, Isabelle Boutron, Joseph S Ross, Robert M Golub, Karim M Khan, Cindy Mulrow, Nandi Siegfried, Joerg Heber, Naomi Lee, Pamela Reed Kearney, Rhoda K Wanyenze, Asbjørn Hróbjartsson, Rebecca Williams, Nita Bhandari, Peter Jüni, An-Wen Chan, ,

<h4>Importance</h4>Extenuating circumstances can trigger unplanned changes to randomized trials and introduce methodological, ethical, feasibility, and analytical challenges that can potentially compromise the validity of findings. Numerous randomized trials have required changes in response to the COVID-19 pandemic, but guidance for reporting such modifications is incomplete.<h4>Objective</h4>As a joint extension for the ... Read more >>

JAMA (JAMA)
[2021, 326(3):257-265]

Cited: 1 time

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The authors reply to: "Antihypertensives and skin cancer" and "Association between thiazide diuretics and skin cancer: still nebulous".

Aaron M Drucker, An-Wen Chan,

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2021, 193(25):E964]

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Acute graft-versus-host disease after double lung transplantation.

Nicole Kim, Nadia Kashetsky, Yuliya Velykoredko, Michelle Murray, Lianne Singer, Zaid Saeed Kamil, Danny Ghazarian, An-Wen Chan,

JAAD Case Rep (JAAD case reports)
[2021, 13:62-64]

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Raising the Bar for Randomized Trials Involving Artificial Intelligence: The SPIRIT-Artificial Intelligence and CONSORT-Artificial Intelligence Guidelines.

Matthew Taylor, Xiaoxuan Liu, Alastair Denniston, Andre Esteva, Justin Ko, Roxana Daneshjou, An-Wen Chan, ,

Artificial intelligence (AI)-based applications have the potential to improve the quality and efficiency of patient care in dermatology. Unique challenges in the development and validation of these technologies may limit their generalizability and real-world applicability. Before the widespread adoption of AI interventions, randomized trials should be conducted to evaluate their ... Read more >>

J Invest Dermatol (The Journal of investigative dermatology)
[2021, 141(9):2109-2111]

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Association between antihypertensive medications and risk of skin cancer in people older than 65 years: a population-based study.

Aaron M Drucker, Loes Hollestein, Yingbo Na, Martin A Weinstock, Wen-Qing Li, Husam Abdel-Qadir, An-Wen Chan,

<h4>Background</h4>The risk of skin cancer associated with antihypertensive medication use is unclear, although thiazides have been implicated in regulatory safety warnings. We aimed to assess whether use of thiazides and other antihypertensives is associated with increased rates of keratinocyte carcinoma and melanoma.<h4>Methods</h4>We conducted a population-based inception cohort study using linked ... Read more >>

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2021, 193(15):E508-E516]

Cited: 5 times

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Restructuring Skin Cancer Care in Ontario: A Provincial Plan.

John Milkovich, Tim Hanna, Carolyn Nessim, Teresa M Petrella, Louis Weatherhead, An-Wen Chan, Jonathan C Irish, Christian Murray, Grace Bannerman, Claire Holloway, Katharina Forster, Laura Pazzano, Frances C Wright, The Ontario Skin Cancer Advisory Committee,

There is a global rise in skin cancer incidence, resulting in an increase in patient care needs and healthcare costs. To optimize health care planning, costs, and patient care, Ontario Health developed a provincial skin cancer plan to streamline the quality of care. We conducted a systematic review and a ... Read more >>

Curr Oncol (Current oncology (Toronto, Ont.))
[2021, 28(2):1183-1196]

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Reporting of methodological studies in health research: a protocol for the development of the MethodologIcal STudy reportIng Checklist (MISTIC).

Daeria O Lawson, Livia Puljak, Dawid Pieper, Stefan Schandelmaier, Gary S Collins, Romina Brignardello-Petersen, David Moher, Peter Tugwell, Vivian A Welch, Zainab Samaan, Brett D Thombs, Anders K Nørskov, Janus C Jakobsen, David B Allison, Evan Mayo-Wilson, Taryn Young, An-Wen Chan, Matthias Briel, Gordon H Guyatt, Lehana Thabane, Lawrence Mbuagbaw,

<h4>Introduction</h4>Methodological studies (ie, studies that evaluate the design, conduct, analysis or reporting of other studies in health research) address various facets of health research including, for instance, data collection techniques, differences in approaches to analyses, reporting quality, adherence to guidelines or publication bias. As a result, methodological studies can help ... Read more >>

BMJ Open (BMJ open)
[2020, 10(12):e040478]

Cited: 1 time

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Accuracy of Algorithms to Identify People with Atopic Dermatitis in Ontario Routinely Collected Health Databases.

Mohamed Abdalla, Branson Chen, Robin Santiago, Jacqueline Young, Lihi Eder, An-Wen Chan, Elena Pope, Karen Tu, Liisa Jaakkimainen, Aaron M Drucker,

J Invest Dermatol (The Journal of investigative dermatology)
[2021, 141(7):1840-1843]

Cited: 0 times

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Reporting guidelines for clinical trials of artificial intelligence interventions: the SPIRIT-AI and CONSORT-AI guidelines.

Hussein Ibrahim, Xiaoxuan Liu, Samantha Cruz Rivera, David Moher, An-Wen Chan, Matthew R Sydes, Melanie J Calvert, Alastair K Denniston,

<h4>Background</h4>The application of artificial intelligence (AI) in healthcare is an area of immense interest. The high profile of 'AI in health' means that there are unusually strong drivers to accelerate the introduction and implementation of innovative AI interventions, which may not be supported by the available evidence, and for which ... Read more >>

Trials (Trials)
[2021, 22(1):11]

Cited: 1 time

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Prospective reporting of statistical analysis plans for randomised controlled trials.

Karla Hemming, Anna Kearney, Carrol Gamble, Tianjing Li, Peter Jüni, An-Wen Chan, Matthew R Sydes,

Trials (Trials)
[2020, 21(1):898]

Cited: 1 time

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Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI extension.

Xiaoxuan Liu, Samantha Cruz Rivera, David Moher, Melanie J Calvert, Alastair K Denniston, ,

The CONSORT 2010 statement provides minimum guidelines for reporting randomised trials. Its widespread use has been instrumental in ensuring transparency in the evaluation of new interventions. More recently, there has been a growing recognition that interventions involving artificial intelligence (AI) need to undergo rigorous, prospective evaluation to demonstrate impact on ... Read more >>

Lancet Digit Health (The Lancet. Digital health)
[2020, 2(10):e537-e548]

Cited: 6 times

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Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension.

Samantha Cruz Rivera, Xiaoxuan Liu, An-Wen Chan, Alastair K Denniston, Melanie J Calvert, , , ,

The SPIRIT 2013 statement aims to improve the completeness of clinical trial protocol reporting by providing evidence-based recommendations for the minimum set of items to be addressed. This guidance has been instrumental in promoting transparent evaluation of new interventions. More recently, there has been a growing recognition that interventions involving ... Read more >>

Nat Med (Nature medicine)
[2020, 26(9):1351-1363]

Cited: 27 times

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Cutaneous signs and risk factors for ocular melanoma.

Katherine Ann McDonald, Hatem Krema, An-Wen Chan,

J Am Acad Dermatol (Journal of the American Academy of Dermatology)
[2021, 84(6):1732-1734]

Cited: 0 times

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Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI Extension.

Samantha Cruz Rivera, Xiaoxuan Liu, An-Wen Chan, Alastair K Denniston, Melanie J Calvert, ,

The SPIRIT 2013 (The Standard Protocol Items: Recommendations for Interventional Trials) statement aims to improve the completeness of clinical trial protocol reporting, by providing evidence-based recommendations for the minimum set of items to be addressed. This guidance has been instrumental in promoting transparent evaluation of new interventions. More recently, there ... Read more >>

BMJ (BMJ (Clinical research ed.))
[2020, 370:m3210]

Cited: 13 times

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Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension.

Samantha Cruz Rivera, Xiaoxuan Liu, An-Wen Chan, Alastair K Denniston, Melanie J Calvert, ,

The SPIRIT 2013 statement aims to improve the completeness of clinical trial protocol reporting by providing evidence-based recommendations for the minimum set of items to be addressed. This guidance has been instrumental in promoting transparent evaluation of new interventions. More recently, there has been a growing recognition that interventions involving ... Read more >>

Lancet Digit Health (The Lancet. Digital health)
[2020, 2(10):e549-e560]

Cited: 8 times

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Outcomes of Staged Excision With Circumferential en Face Margin Control for Lentigo Maligna of the Head and Neck.

Annie Liu, Alexis Botkin, Christian Murray, Nowell Solish, Jessica Kitchen, An-Wen Chan,

<h4>Background</h4>Treatment practices vary for lentigo maligna (LM). Staged excision with circumferential margin control (SECMC) has the potential to achieve low recurrence rates.<h4>Objectives</h4>To evaluate the clinical outcomes of SECMC using permanent, paraffin-embedded sections and delayed reconstruction.<h4>Methods</h4>We conducted a retrospective, uncontrolled, observational cohort study involving patients who underwent staged excision for LM ... Read more >>

J Cutan Med Surg (Journal of cutaneous medicine and surgery)
[2021, 25(1):18-24]

Cited: 0 times

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Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI Extension.

Xiaoxuan Liu, Samantha Cruz Rivera, David Moher, Melanie J Calvert, Alastair K Denniston, ,

The CONSORT 2010 (Consolidated Standards of Reporting Trials) statement provides minimum guidelines for reporting randomised trials. Its widespread use has been instrumental in ensuring transparency when evaluating new interventions. More recently, there has been a growing recognition that interventions involving artificial intelligence (AI) need to undergo rigorous, prospective evaluation to ... Read more >>

BMJ (BMJ (Clinical research ed.))
[2020, 370:m3164]

Cited: 11 times

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