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Publisher Correction: A mass spectrometry-based proteome map of drug action in lung cancer cell lines.

Benjamin Ruprecht, Julie Di Bernardo, Zhao Wang, Xuan Mo, Oleg Ursu, Matthew Christopher, Rafael B Fernandez, Li Zheng, Brian D Dill, Huijun Wang, Yuting Xu, Andy Liaw, Jonathan D Mortison, Nirodhini Siriwardana, Brian Andresen, Meir Glick, James R Tata, Victoria Kutilek, Ivan Cornella-Taracido, An Chi,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, 16(10):1149]

Cited: 0 times

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A mass spectrometry-based proteome map of drug action in lung cancer cell lines.

Benjamin Ruprecht, Julie Di Bernardo, Zhao Wang, Xuan Mo, Oleg Ursu, Matthew Christopher, Rafael B Fernandez, Li Zheng, Brian D Dill, Huijun Wang, Yuting Xu, Andy Liaw, Jonathan D Mortison, Nirodhini Siriwardana, Brian Andresen, Meir Glick, James R Tata, Victoria Kutilek, Ivan Cornella-Taracido, An Chi,

Mass spectrometry-based discovery proteomics is an essential tool for the proximal readout of cellular drug action. Here, we apply a robust proteomic workflow to rapidly profile the proteomes of five lung cancer cell lines in response to more than 50 drugs. Integration of millions of quantitative protein-drug associations substantially improved ... Read more >>

Nat. Chem. Biol. (Nature chemical biology)
[2020, 16(10):1111-1119]

Cited: 0 times

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Cancer-Associated Fibroblasts Promote Immunosuppression by Inducing ROS-Generating Monocytic MDSCs in Lung Squamous Cell Carcinoma.

Handan Xiang, Carlo P Ramil, Josephine Hai, Chunsheng Zhang, Huijun Wang, Amanda A Watkins, Roshi Afshar, Peter Georgiev, Marc A Sze, Xuelei S Song, Patrick J Curran, Mangeng Cheng, J Richard Miller, Dongyu Sun, Andrey Loboda, Yanlin Jia, Lily Y Moy, An Chi, Philip E Brandish,

Cancer-associated fibroblasts (CAF) represent a functionally heterogeneous population of activated fibroblasts that constitutes a major component of tumor stroma. Although CAFs have been shown to promote tumor growth and mediate resistance to chemotherapy, the mechanisms by which they may contribute to immune suppression within the tumor microenvironment (TME) in lung ... Read more >>

Cancer Immunol Res (Cancer immunology research)
[2020, 8(4):436-450]

Cited: 1 time

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A reevaluation of the spleen tyrosine kinase (SYK) activation mechanism.

My S Mansueto, Abigail Reens, Larissa Rakhilina, An Chi, Bo-Sheng Pan, J Richard Miller,

Spleen tyrosine kinase (SYK) is a signaling node in many immune pathways and comprises two tandem Src homology (SH) 2 domains, an SH2-kinase linker, and a C-terminal tyrosine kinase domain. Two prevalent models of SYK activation exist. The "OR-gate" model contends that SYK can be fully activated by phosphorylation or ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2019, 294(19):7658-7668]

Cited: 1 time

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Comparison of the Rat and Human Dorsal Root Ganglion Proteome.

Adam G Schwaid, Alicja Krasowka-Zoladek, An Chi, Ivan Cornella-Taracido,

Dorsal root ganglion (DRG) are a key tissue in the nervous system that have a role in neurological disease, particularly pain. Despite the importance of this tissue, the proteome of DRG is poorly understood, and it is unknown whether the proteome varies between organisms or different DRG along the spine. ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):13469]

Cited: 1 time

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Genomic atlas of the human plasma proteome.

Benjamin B Sun, Joseph C Maranville, James E Peters, David Stacey, James R Staley, James Blackshaw, Stephen Burgess, Tao Jiang, Ellie Paige, Praveen Surendran, Clare Oliver-Williams, Mihir A Kamat, Bram P Prins, Sheri K Wilcox, Erik S Zimmerman, An Chi, Narinder Bansal, Sarah L Spain, Angela M Wood, Nicholas W Morrell, John R Bradley, Nebojsa Janjic, David J Roberts, Willem H Ouwehand, John A Todd, Nicole Soranzo, Karsten Suhre, Dirk S Paul, Caroline S Fox, Robert M Plenge, John Danesh, Heiko Runz, Adam S Butterworth,

Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control inter-individual variation in plasma protein levels are not well understood. Here we characterize the genetic architecture of the human plasma proteome in healthy blood donors from the INTERVAL ... Read more >>

Nature (Nature)
[2018, 558(7708):73-79]

Cited: 108 times

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Highly potent visnagin derivatives inhibit Cyp1 and prevent doxorubicin cardiotoxicity.

Aarti Asnani, Baohui Zheng, Yan Liu, You Wang, Howard H Chen, Anita Vohra, An Chi, Ivan Cornella-Taracido, Huijun Wang, Douglas G Johns, David E Sosnovik, Randall T Peterson,

Anthracyclines such as doxorubicin are highly effective chemotherapy agents used to treat many common malignancies. However, their use is limited by cardiotoxicity. We previously identified visnagin as protecting against doxorubicin toxicity in cardiac but not tumor cells. In this study, we sought to develop more potent visnagin analogs in order ... Read more >>

JCI Insight (JCI insight)
[2018, 3(1):]

Cited: 4 times

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Consequences of natural perturbations in the human plasma proteome

Benjamin Sun, Joseph Maranville, James Peters, David Stacey, James Staley, James Blackshaw, Stephen Burgess, Tao Jiang, Ellie Paige, Praveen Surendran, Clare Oliver-Williams, Mihir Kamat, Bram Prins, Sheri Wilcox, Erik Zimmerman, An Chi, Narinder Bansal, Sarah Spain, Angela Wood, Nicholas Morrell, John Bradley, Nebojsa Janjic, David Roberts, Willem Ouwehand, John Todd, Nicole Soranzo, Karsten Suhre, Dirk Paul, Caroline Fox, Robert Plenge, John Danesh, Heiko Runz, Adam Butterworth,

Abstract Proteins are the primary functional units of biology and the direct targets of most drugs, yet there is limited knowledge of the genetic factors determining inter-individual variation in protein levels. Here we reveal the genetic architecture of the human plasma proteome, testing 10.6 million DNA variants against levels of ... Read more >>

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Cited: 6 times

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Erratum to: Aryl hydrocarbon receptor signaling modifies Toll-like receptor-regulated responses in human dendritic cells.

Sarah Kado, W L William Chang, Aimy Nguyen Chi, Monika Wolny, David M Shepherd, Christoph F A Vogel,

Arch Toxicol (Archives of toxicology)
[2017, 91(7):2713]

Cited: 0 times

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Mitochondrial complex I deficiency leads to the retardation of early embryonic development in Ndufs4 knockout mice.

Mei Wang, Ya-Ping Huang, Han Wu, Ke Song, Cong Wan, A-Ni Chi, Ya-Mei Xiao, Xiao-Yang Zhao,

BACKGROUND:The NDUFS4 gene encodes an 18-kD subunit of mitochondria complex I, and mutations in this gene lead to the development of a severe neurodegenerative disease called Leigh syndrome (LS) in humans. To investigate the disease phenotypes and molecular mechanisms of Leigh syndrome, the Ndufs4 knockout (KO) mouse has been widely ... Read more >>

(PeerJ)
[2017, 5:e3339]

Cited: 2 times

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Aryl hydrocarbon receptor signaling modifies Toll-like receptor-regulated responses in human dendritic cells.

Sarah Kado, W L William Chang, Aimy Nguyen Chi, Monika Wolny, David M Shepherd, Christoph F A Vogel,

Currently, it is not well understood how ligands of the aryl hydrocarbon receptor (AhR) modify inflammatory responses triggered by Toll-like receptor (TLR) agonists in human dendritic cells (DCs). Here, we show that AhR ligands 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the tryptophan derivatives 6-formylindolo[3,2-b] carbazole (FICZ), kynurenine (kyn), and the natural dietary compound indole-3-carbinol ... Read more >>

Arch Toxicol (Archives of toxicology)
[2017, 91(5):2209-2221]

Cited: 9 times

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Effect of cryopreservation on delineation of immune cell subpopulations in tumor specimens as determinated by multiparametric single cell mass cytometry analysis.

Elma Kadić, Raymond J Moniz, Ying Huo, An Chi, Ilona Kariv,

Comprehensive understanding of cellular immune subsets involved in regulation of tumor progression is central to the development of cancer immunotherapies. Single cell immunophenotyping has historically been accomplished by flow cytometry (FC) analysis, enabling the analysis of up to 18 markers. Recent advancements in mass cytometry (MC) have facilitated detection of ... Read more >>

BMC Immunol. (BMC immunology)
[2017, 18(1):6]

Cited: 9 times

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Empowering self-care ability - a follow-up study of clinical-based perimenopausal women personal health counselling.

Chi An, Yen-Yen Yu, Bee-Chin Chou, Li-Yun Szu, Lee-Ing Tsao,

This study aimed to evaluate the longitudinal effects of a personal counselling intervention for perimenopausal women in northern Taiwan.Women face a variety of physical changes during menopause. Counselling intervention could enrich individual health education for menopausal women.Quasi-experimental design.The study used one-on-one personal health counselling with a 'menopausal health passport' for ... Read more >>

J Clin Nurs (Journal of clinical nursing)
[2016, 25(19-20):2979-2988]

Cited: 0 times

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Phosphoproteomics in drug discovery.

Melody K Morris, An Chi, Ioannis N Melas, Leonidas G Alexopoulos,

Several important aspects of the drug discovery process, including target identification, mechanism of action determination and biomarker identification as well as drug repositioning, require complete understanding of the effects of drugs on protein phosphorylation in relevant biological systems. Novel high-throughput phosphoproteomic technologies can be employed to measure these phosphorylation events. ... Read more >>

Drug Discov. Today (Drug discovery today)
[2014, 19(4):425-432]

Cited: 14 times

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Identification of direct target engagement biomarkers for kinase-targeted therapeutics.

Cloud P Paweletz, Jannik N Andersen, Roy Pollock, Kumiko Nagashima, Mansuo L Hayashi, Shangshuan U Yu, Hongbo Guo, Ekaterina V Bobkova, Zangwei Xu, Alan Northrup, Peter Blume-Jensen, Ronald C Hendrickson, An Chi,

Pharmacodynamic (PD) biomarkers are an increasingly valuable tool for decision-making and prioritization of lead compounds during preclinical and clinical studies as they link drug-target inhibition in cells with biological activity. They are of particular importance for novel, first-in-class mechanisms, where the ability of a targeted therapeutic to impact disease outcome ... Read more >>

PLoS ONE (PloS one)
[2011, 6(10):e26459]

Cited: 14 times

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Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor.

Kumiko Nagashima, Stuart D Shumway, Sriram Sathyanarayanan, Albert H Chen, Brian Dolinski, Youyuan Xu, Heike Keilhack, Thi Nguyen, Maciej Wiznerowicz, Lixia Li, Bart A Lutterbach, An Chi, Cloud Paweletz, Timothy Allison, Youwei Yan, Sanjeev K Munshi, Anke Klippel, Manfred Kraus, Ekaterina V Bobkova, Sujal Deshmukh, Zangwei Xu, Uwe Mueller, Alexander A Szewczak, Bo-Sheng Pan, Victoria Richon, Roy Pollock, Peter Blume-Jensen, Alan Northrup, Jannik N Andersen,

Phosphoinositide-dependent kinase 1 (PDK1) is a critical activator of multiple prosurvival and oncogenic protein kinases and has garnered considerable interest as an oncology drug target. Despite progress characterizing PDK1 as a therapeutic target, pharmacological support is lacking due to the prevalence of nonspecific inhibitors. Here, we benchmark literature and newly ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2011, 286(8):6433-6448]

Cited: 28 times

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Dietary β-glucan regulates the levels of inflammatory factors, inflammatory cytokines, and immunoglobulins in interleukin-10 knockout mice.

Michael B Ye, Jong Phil Bak, Chi Sun An, Hai Lan Jin, Jong Moon Kim, Hyuk Jung Kweon, Dong Kug Choi, Pyo Jam Park, Young Jun Kim, Beong Ou Lim,

β-Glucan is known to have anti-inflammatory properties, and several studies have demonstrated the beneficial effects of dietary β-glucan on inflammatory bowel disease (IBD). However, it is unknown how β-glucan mediates its protective effects on IBD. Therefore, we used a well-established mouse model for IBD, interleukin (IL)-10(-/-) mice, to explore the ... Read more >>

J Med Food (Journal of medicinal food)
[2011, 14(5):468-474]

Cited: 3 times

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Sleep disturbance experiences among perimenopausal women in Taiwan.

Hsiu-Chin Hsu, Ning-Hung Chen, Hei-Jen Jou, Chi An, Lee-Ing Tsao,

AIM: To generate a descriptive theory framework regarding the experiences of sleep disturbances among perimenopausal women in Taiwan. BACKGROUND: Although studies show that some perimenopausal women are troubled by sleep problems, little information was found about the subjective experiences of sleep disturbances among these women. Research is required to explore ... Read more >>

J Clin Nurs (Journal of clinical nursing)
[2009, 18(15):2116-2124]

Cited: 8 times

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Pathway-based identification of biomarkers for targeted therapeutics: personalized oncology with PI3K pathway inhibitors.

Jannik N Andersen, Sriram Sathyanarayanan, Alessandra Di Bacco, An Chi, Theresa Zhang, Albert H Chen, Brian Dolinski, Manfred Kraus, Brian Roberts, William Arthur, Rich A Klinghoffer, Diana Gargano, Lixia Li, Igor Feldman, Bethany Lynch, John Rush, Ronald C Hendrickson, Peter Blume-Jensen, Cloud P Paweletz,

Although we have made great progress in understanding the complex genetic alterations that underlie human cancer, it has proven difficult to identify which molecularly targeted therapeutics will benefit which patients. Drug-specific modulation of oncogenic signaling pathways in specific patient subpopulations can predict responsiveness to targeted therapy. Here, we report a ... Read more >>

Sci Transl Med (Science translational medicine)
[2010, 2(43):43ra55]

Cited: 75 times

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MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.

Bo-Sheng Pan, Grace K Y Chan, Melissa Chenard, An Chi, Lenora J Davis, Sujal V Deshmukh, Jackson B Gibbs, Susana Gil, Gaozhen Hang, Harold Hatch, James P Jewell, Ilona Kariv, Jason D Katz, Kaiko Kunii, Wei Lu, Bart A Lutterbach, Cloud P Paweletz, Xianlu Qu, John F Reilly, Alexander A Szewczak, Qinwen Zeng, Nancy E Kohl, Christopher J Dinsmore,

The receptor tyrosine kinase c-Met is an attractive target for therapeutic blockade in cancer. Here, we describe MK-2461, a novel ATP-competitive multitargeted inhibitor of activated c-Met. MK-2461 inhibited in vitro phosphorylation of a peptide substrate recognized by wild-type or oncogenic c-Met kinases (N1100Y, Y1230C, Y1230H, Y1235D, and M1250T) with IC(50) ... Read more >>

Cancer Res. (Cancer research)
[2010, 70(4):1524-1533]

Cited: 47 times

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Anti-inflammatory effects of Inonotus obliquus in colitis induced by dextran sodium sulfate.

Se Young Choi, Sun Jin Hur, Chi Sun An, Yun Hui Jeon, Young Jun Jeoung, Jong Phil Bak, Beong Ou Lim,

A total of 28 male BALB/c mice (average weight 20.7 +/- 1.6 g) were divided into 4 treatment groups and fed a commercial diet (A), a commercial diet + induced colitis by dextran sodium sulfate (DSS) (B), Inonotus obliquus (IO) administration (C), and IO administration + induced colitis by DSS ... Read more >>

J. Biomed. Biotechnol. (Journal of biomedicine & biotechnology)
[2010, 2010:943516]

Cited: 11 times

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Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1.

Thurl E Harris, Todd A Huffman, An Chi, Jeffrey Shabanowitz, Donald F Hunt, Anil Kumar, John C Lawrence,

Brain, liver, kidney, heart, and skeletal muscle from fatty liver dystrophy (fld/fld) mice, which do not express lipin 1 (lipin), contained much less Mg(2+)-dependent phosphatidic acid phosphatase (PAP) activity than tissues from wild type mice. Lipin harboring the fld(2j) (Gly(84) --> Arg) mutation exhibited relatively little PAP activity. These results ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2007, 282(1):277-286]

Cited: 125 times

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Periplasmic proteins of the extremophile Acidithiobacillus ferrooxidans: a high throughput proteomics analysis.

An Chi, Lissette Valenzuela, Simon Beard, Aaron J Mackey, Jeffrey Shabanowitz, Donald F Hunt, Carlos A Jerez,

Acidithiobacillus ferrooxidans is a chemolithoautotrophic acidophile capable of obtaining energy by oxidizing ferrous iron or sulfur compounds such as metal sulfides. Some of the proteins involved in these oxidations have been described as forming part of the periplasm of this extremophile. The detailed study of the periplasmic components constitutes an ... Read more >>

Mol Cell Proteomics (Molecular & cellular proteomics : MCP)
[2007, 6(12):2239-2251]

Cited: 35 times

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mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin.

Thurl E Harris, An Chi, Jeffrey Shabanowitz, Donald F Hunt, Robert E Rhoads, John C Lawrence,

Insulin stimulates protein synthesis by increasing translation initiation. This response is mediated by mTOR and is believed to result from 4EBP1 phosphorylation, which allows eIF4E to bind eIF4G. Here, we present evidence that mTOR interacts directly with eIF3 and that mTOR controls the association of eIF3 and eIF4G. Activating mTOR ... Read more >>

EMBO J. (The EMBO journal)
[2006, 25(8):1659-1668]

Cited: 64 times

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The longitudinal effects of a perimenopausal health education intervention on the mid-life women in Taiwan.

Lee-Ing Tsao, Mei-Chen Su, Ping-Ju Hsiao, Yueh-Mei Gau, Chi An, Kuan-Chia Lin,

OBJECTIVES: The study purpose was to evaluate the longitudinal effects, after 3 months and 1-year, of a perimenopausal health education intervention for mid-life women in Taiwan. METHODS: This study was conducted at two hospitals and their neighborhood communities (each included three subgroups, traditional Chinese, gynecologic and neighborhood communities), using a ... Read more >>

Maturitas (Maturitas)
[2007, 57(3):296-305]

Cited: 6 times

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