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Author Amit Prasad

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Immunoinformatics driven construction of multi-epitope vaccine candidate against Ascaris lumbricoides using its entire immunogenic epitopes.

Rimanpreet Kaur, Naina Arora, Suraj Singh Rawat, Anand Kumar Keshri, Neha Singh, Sumit Kumar Show, Pramod Kumar, Amit Mishra, Amit Prasad,

<h4>Objective</h4><i>Ascaris lumbricoides</i> infects 80 million people per year, causing malnutrition, stunted growth of children etc., but there is no vaccine available against it. We aimed to design a multimeric-subunit vaccine using comprehensive immunoinformatic approach.<h4>Research design and methods</h4>The T and B cell epitopes were shortlisted on antigenicity, allergenicity, and toxicity from ... Read more >>

Expert Rev Vaccines (Expert review of vaccines)
[2021, :1-13]

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Vaccine for a neglected tropical disease Taenia solium cysticercosis: fight for eradication against all odds.

Rimanpreet Kaur, Naina Arora, Suraj S Rawat, Anand Kumar Keshri, Shubha Rani Sharma, Amit Mishra, Gagandeep Singh, Amit Prasad,

<h4>Introduction</h4><i>Taenia solium</i> infection is among the 17 most neglected tropical diseases identified by World Health Organization and to be eradicated by 2030. This parasite infects the central nervous system (Neurocysticercosis [NCC]) and intestine [Taeniasis]). NCC is the most frequent cause of acquired epilepsy in endemic regions and Taeniasis is responsible ... Read more >>

Expert Rev Vaccines (Expert review of vaccines)
[2021, :1-12]

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Proteome Linked Biochemical Targets: Can Repair Defective Cellular Physiological Mechanisms?

Ankur Rakesh Dubey, Amit Prasad, Krishna Mohan Poluri, Amit Kumar, Awanish Kumar, Amit Mishra,

Major cause of proteopathies is the accumulation of unwanted mutant and aberrant proteins. We know that imperfect ageing is one of chief risk factor for most neurodegenerative diseases. Neurodegenerative diseases are characterized by mutant misfolded protein aggregates developing neural stress and debilitating several neuronal processes. Reducing the levels of these ... Read more >>

Cell Physiol Biochem (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology)
[2021, 55(S2):49-70]

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Complex Inclusion Bodies and Defective Proteome Hubs in Neurodegenerative Disease: New Clues, New Challenges.

Arun Upadhyay, Naveen Sundaria, Rohan Dhiman, Vijay Kumar Prajapati, Amit Prasad, Amit Mishra,

A healthy physiological environment of cells represents the dynamic homeostasis of crowded molecules. A subset of cellular proteome forms protein quality control (PQC) machinery to maintain an uninterrupted synthesis of new polypeptides and targeted elimination of old or defective proteins. The process of PQC may get overwhelmed under specific genetic ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421989582]

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A Model for a Standardized and Sustainable Pediatric Anesthesia-Intensive Care Unit Hand-Off Process.

Priti G Dalal, Theodore J Cios, Theodore K M DeMartini, Amit A Prasad, Meghan C Whitley, Joseph B Clark, Leon Lin, Dennis J Mujsce, Robert E Cilley,

<h4>Background and objectives</h4>The hand-off process between pediatric anesthesia and intensive care unit (ICU) teams involves the exchange of patient health information and plays a major role in reducing errors and increasing staff satisfaction. Our objectives were to (1) standardize the hand-off process in children's ICUs, and (2) evaluate the provider ... Read more >>

Children (Basel) (Children (Basel, Switzerland))
[2020, 7(9):]

Cited: 1 time

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Taenia solium proteins: a beautiful kaleidoscope of pro and anti-inflammatory antigens.

Naina Arora, Amit Prasad,

<b>Background:</b> Neurocysticercosis (NCC) is an acquired infection of central nervous system associated with epileptic seizures. The parasite 'Taenia solium' causes this disease and has a complex life cycle and molts into various stages that influence the host-parasite interaction. The disease has a long asymptomatic phase with viable cyst and degeneration ... Read more >>

Expert Rev Proteomics (Expert review of proteomics)
[2020, 17(7-8):609-622]

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Standardization improves postoperative patient handoff experience for junior clinicians.

Amit Prasad, Theodore J Cios, Whitney Staub-Juergens, Carol Dziedzina, Srikantha Rao, Kai Singbartl,

<h4>Objectives</h4>Effective communication among health care providers is critically important for patient safety. Handoff of patient care from the operating room (OR) to the intensive care unit (ICU) is particularly prone to errors. The process is more complicated in an academic environment in which junior clinicians are being trained. Standardization of, ... Read more >>

Am J Manag Care (The American journal of managed care)
[2020, 26(6):e184-e190]

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Evaluation of Taenia solium cyst fluid-based enzyme linked immunoelectro transfer blot for Neurocysticercosis diagnosis in urban and highly endemic rural population of North India.

Naina Arora, Rimanpreet Kaur, Suraj Singh Rawat, Ankur Kumar, Aloukick Kumar Singh, Shweta Tripathi, Amit Mishra, Gagandeep Singh, Amit Prasad,

<h4>Background</h4>Neurocysticercosis (NCC) is infection by cestode Taenia solium/pork tapeworm. Sero-diagnosis of NCC is still a challenge. Radiological imaging (CT/MRI) are cost intensive, requires technical expertise and resource intensive. Hence, its availability is restricted in endemic zone. Existing Enzyme electro immune transfer blot (EITB) antigens are difficult to make and is ... Read more >>

Clin Chim Acta (Clinica chimica acta; international journal of clinical chemistry)
[2020, 508:16-21]

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Unveiling Taenia solium kinome profile and its potential for new therapeutic targets.

Naina Arora, Anand Raj, Farhan Anjum, Rimanpreet Kaur, Suraj Singh Rawat, Rajiv Kumar, Shweta Tripathi, Gagandeep Singh, Amit Prasad,

<b>Background</b>: Helminth infections cause widespread morbidity and are a significant global disease burden. One among them is Neurocysticercosis, a central nervous system infection caused by the larvae <i>Taenia solium</i>, leading to epilepsy. Helminths are strong immune modulators and can survive for a long time in adverse host environments. Kinases are ... Read more >>

Expert Rev Proteomics (Expert review of proteomics)
[2020, 17(1):85-94]

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Development of multi-epitope chimeric vaccine against Taenia solium by exploring its proteome: an in silico approach.

Rimanpreet Kaur, Naina Arora, Majeed Abdulwahid Jamakhani, Shelvia Malik, Pramod Kumar, Farhan Anjum, Shweta Tripathi, Amit Mishra, Amit Prasad,

<b>Objective</b>: <i>Taenia solium</i> is a neglected tropical disease; larvae of this parasite infect central nervous system i.e. Neurocysticercosis, and adults mature and survive into intestine i.e. Taeniasis. Globally more than 50 million people are at the risk of infection. This is one of the main etiological agents for onset of new early epilepsy in developing countries. ... Read more >>

Expert Rev Vaccines (Expert review of vaccines)
[2020, 19(1):105-114]

Cited: 3 times

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Ubiquitin ligase LRSAM1 suppresses neurodegenerative diseases linked aberrant proteins induced cell death.

Ribhav Mishra, Ayeman Amanullah, Arun Upadhyay, Rohan Dhiman, Ankur Rakesh Dubey, Sarika Singh, Amit Prasad, Amit Mishra,

Accumulation of aberrant misfolded proteins is a major hallmark of several neurodegenerative diseases. Intracellular accumulations of such abnormal proteins are selectively cleared by the ubiquitin-proteasome system (UPS). But how the failure of misfolded protein degradation cause proteinopathies is still an unanswered question?. Previous studies have suggested that few selective quality ... Read more >>

Int J Biochem Cell Biol (The international journal of biochemistry & cell biology)
[2020, 120:105697]

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Early prediction of transition to durable mechanical circulatory support in patients undergoing peripheral veno-arterial extracorporeal membrane oxygenation for critical cardiogenic shock.

Amit Prasad, Christoph E Brehm, Michael Goldenberg, Ali Ghodsizad, Michael M Koerner, Aly El-Banayosy, Kai Singbartl,

Peripheral veno-arterial extracorporeal membrane oxygenation (pVA-ECMO) has gained increasing value in the management of patients with critical cardiogenic shock (cCS), allowing time for myocardial recovery. Failure of myocardial recovery has life-altering consequences: transition to durable mechanical circulatory support (dMCS), urgent heart transplantation, or withdrawal of support. Clinical factors controlling myocardial ... Read more >>

Artif Organs (Artificial organs)
[2020, 44(4):402-410]

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First Report of Acute Bilateral Hyphema in a Theileria equi–Infected Kathiawari Horse

Amit Prasad, Binod Kumar, Vineet Kumar,

Theileria equi is a tickborne hemoparasite that can cause severe illness in equids. In this report, we are describing a condition of acute bilateral hyphema in a 4-month-old Kathiawari filly infected with T. equi. The horse showed clinical signs such as fever, lethargy, icterus, tachycardia, tachypnea, and bilateral hyphema. Laboratory ... Read more >>

J Equine Vet Sci (Journal of equine veterinary science.)
[2019, 77:72-74]

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Two-Dimensional Infrared Spectroscopy Reveals Molecular Self-Assembly on the Surface of Silver Nanoparticles.

Anup Ghosh, Amit K Prasad, Lev Chuntonov,

The conformation of molecules, peptides, and proteins, self-assembled into structured monolayers on the surface of metal nanoparticles (NPs), can strongly affect their properties and use in chemical or nanobiomedical applications. Elucidating molecular conformations on the NP surface is highly challenging, and the microscopic details mostly remain elusive. Using polarization-selective third-order ... Read more >>

J Phys Chem Lett (The journal of physical chemistry letters)
[2019, 10(10):2481-2486]

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First Report of Acute Bilateral Hyphema in a Theileria equi-Infected Kathiawari Horse.

Amit Prasad, Vineet Kumar, Binod Kumar,

Theileria equi is a tickborne hemoparasite that can cause severe illness in equids. In this report, we are describing a condition of acute bilateral hyphema in a 4-month-old Kathiawari filly infected with T. equi. The horse showed clinical signs such as fever, lethargy, icterus, tachycardia, tachypnea, and bilateral hyphema. Laboratory diagnosis ... Read more >>

J Equine Vet Sci (Journal of equine veterinary science.)
[2019, 77:72-74]

Cited: 0 times

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Burdens of the Scientific Revolution: Euro/West-Centrism, Black Boxed Machines, and the (Post) Colonial Present.

Amit Prasad,

How is it possible that past technoscientific research in India does not serve as a sluice for circulations of technoscience even within India? Why do technoscientific artifacts and knowledge continue to flow largely through the West? The answer to these and related questions, I argue, lies in the entanglement of ... Read more >>

Technol Cult (Technology and culture)
[2019, 60(4):1059-1082]

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Continuation of atypical antipsychotic medications in critically ill patients discharged from the hospital: a single-center retrospective analysis.

Kunal Karamchandani, Robert S Schoaps, Anthony Bonavia, Amit Prasad, Ashley Quintili, Erik B Lehman, Zyad J Carr,

<h4>Background</h4>Atypical antipsychotics (AAP) have been associated with reduced duration of delirium in the intensive care setting. However, long-term use of these drugs is associated with significant adverse events, including increased all-cause mortality in the elderly. Inappropriate continuation of AAPs after discharge from the intensive care unit (ICU) is worrisome and ... Read more >>

Ther Adv Drug Saf (Therapeutic advances in drug safety)
[2019, 10:2042098618809933]

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Quantifying conformations of ester vibrational probes with hydrogen-bond-induced Fermi resonances.

Anup Ghosh, Bar Cohn, Amit K Prasad, Lev Chuntonov,

Solvatochromic shifts of local vibrational probes report on the strength of the surrounding electric fields and the probe's hydrogen bonding status. Stretching vibrational mode of the ester carbonyl group is a popular solvatochromic reporter used in the studies of peptides and proteins. Small molecules, used to calibrate the response of ... Read more >>

J Chem Phys (The Journal of chemical physics)
[2018, 149(18):184501]

Cited: 1 time

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Tackling Health Inequalities Using Urban HEART in the Sustainable Development Goals Era.

Amit Prasad, Carme Borrell, Roshanak Mehdipanah, Somnath Chatterji,

J Urban Health (Journal of urban health : bulletin of the New York Academy of Medicine)
[2018, 95(5):610-612]

Cited: 2 times

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Implementation of Urban Health Equity Assessment and Response Tool: a Case of Matsapha, Swaziland.

Kevin Makadzange, Zamahlubi Radebe, Nokuthula Maseko, Voyivoyi Lukhele, Sabelo Masuku, Gciniwe Fakudze, Tigest Ketsela Mengestu, Amit Prasad,

Equity in health implies that ideally everyone could attain their full health potential and that no one should be disadvantaged from achieving this potential because of their social position or other socially determined circumstances. Making cities and human settlements inclusive, safe, resilient and sustainable contributes towards ensuring healthy lives and ... Read more >>

J Urban Health (Journal of urban health : bulletin of the New York Academy of Medicine)
[2018, 95(5):672-681]

Cited: 0 times

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The Urban Health Equity Assessment and Response Tool (HEART)-a Decade of Development and Implementation.

Amit Prasad,

J Urban Health (Journal of urban health : bulletin of the New York Academy of Medicine)
[2018, 95(5):609]

Cited: 3 times

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Recurrence after hospitalization for acute coronary syndrome among HIV-infected and HIV-uninfected individuals.

J L Marcus, L B Hurley, A Prasad, J Zaroff, D B Klein, M A Horberg, A S Go, G N DeLorenze, C P Quesenberry, S Sidney, J C Lo, M J Silverberg,

<h4>Objectives</h4>We evaluated the association of HIV infection and immunodeficiency with acute coronary syndrome (ACS) recurrence, and with all-cause mortality as a secondary outcome, after hospitalization for ACS among HIV-infected and HIV-uninfected individuals.<h4>Methods</h4>We conducted a retrospective cohort study within Kaiser Permanente Northern California of HIV-infected and HIV-uninfected adults discharged after ACS ... Read more >>

HIV Med (HIV medicine)
[2019, 20(1):19-26]

Cited: 2 times

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Measuring the Impact of Environment on the Health of Large Cities.

Christine Stauber, Ellis A Adams, Richard Rothenberg, Dajun Dai, Ruiyan Luo, Scott R Weaver, Amit Prasad, Megumi Kano, John Heath,

The relative significance of indicators and determinants of health is important for local public health workers and planners. Of similar importance is a method for combining and evaluating such markers. We used a recently developed index, the Urban Health Index (UHI), to examine the impact of environmental variables on the ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2018, 15(6):]

Cited: 2 times

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Continuous Erector Spinae Plane Block as an Effective Analgesic Option in Anticoagulated Patients After Left Ventricular Assist Device Implantation: A Case Series.

Sanjib Das Adhikary, Amit Prasad, Behzad Soleimani, Ki Jinn Chin,

J Cardiothorac Vasc Anesth (Journal of cardiothoracic and vascular anesthesia)
[2019, 33(4):1063-1067]

Cited: 8 times

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Communication: Probing the interaction of infrared antenna arrays and molecular films with ultrafast quantum dynamics.

Bar Cohn, Amit K Prasad, Lev Chuntonov,

Narrowband vibrational molecular transitions interacting with the broadband resonance of infrared plasmonic antennas lead to Fano lineshapes observed in linear (FTIR) and third-order (transient absorption and 2DIR) spectroscopic experiments. Both molecular and plasmonic components are inherently dissipative, and the effects associated with their coupling can be observed, in principle, when ... Read more >>

J Chem Phys (The Journal of chemical physics)
[2018, 148(13):131101]

Cited: 1 time

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