Full Text Journal Articles by
Author Amelia Moore

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A Short Dynamic Scan Method of Measuring Bone Metabolic Flux Using [18F]NaF PET.

Tanuj Puri, Musib M Siddique, Michelle L Frost, Amelia E B Moore, Glen M Blake,

[<sup>18</sup>F]NaF PET measurements of bone metabolic flux (K<sub>i</sub>) are conventionally obtained with 60-min dynamic scans analysed using the Hawkins model. However, long scan times make this method expensive and uncomfortable for subjects. Therefore, we evaluated and compared measurements of K<sub>i</sub> with shorter scan times analysed with fixed values of the ... Read more >>

Tomography (Tomography (Ann Arbor, Mich.))
[2021, 7(4):623-635]

Cited: 0 times

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Comparison of ordered-subset expectation maximization and filtered back projection reconstruction based on quantitative outcome from dynamic [18F]NaF PET images.

James M Wong, Tanuj Puri, Muhammad Musib Siddique, Michelle L Frost, Amelia E B Moore, Glen M Blake, Ignac Fogelman,

[18F]NaF PET imaging is a useful tool for measuring regional bone metabolism. However, due to tracer in urine, [18F]NaF PET images of the hip reconstructed using filtered back projection (FBP) frequently show streaking artifacts in slices through the bladder leading to noisy time-activity curves unsuitable for quantification. This study compares ... Read more >>

Nucl Med Commun (Nuclear medicine communications)
[2021, 42(6):699-706]

Cited: 0 times

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Serum vitamin K1 (phylloquinone) is associated with fracture risk and hip strength in post-menopausal osteoporosis: A cross-sectional study.

Amelia E Moore, EunJi Kim, Dwight Dulnoan, A Louise Dolan, Kieran Voong, Imtiaz Ahmad, Renata Gorska, Dominic J Harrington, Geeta Hampson,

<h4>Purpose</h4>Vitamin K may play a potential role in bone metabolism, although further evidence is needed. The mechanisms behind its skeletal effects and optimum intake for maintaining bone health remain poorly defined. To elucidate these two issues, we investigated the association between circulating vitamin K<sub>1</sub> (phylloquinone) concentrations with fracture risk, bone ... Read more >>

Bone (Bone)
[2020, 141:115630]

Cited: 2 times

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Evaluation of aortic 18F-NaF tracer uptake using PET/CT as a predictor of aortic calcification in postmenopausal women: A longitudinal study.

Marina Cecelja, Amelia Moore, Ignac Fogelman, Michelle L Frost, Glen M Blake, Phil Chowienczyk,

<h4>Introduction</h4>Aortic calcification as detected by computed tomography is associated with arterial stiffening and is an important predictor of cardiovascular morbidity and mortality. Uptake of <sup>18</sup>F-sodium fluoride (<sup>18</sup>F-NaF) in the aortic wall reflects metabolically active areas of calcification. The aim of this study was to determine if <sup>18</sup>F-NaF uptake in the ... Read more >>

JRSM Cardiovasc Dis (JRSM cardiovascular disease)
[2019, 8:2048004019848870]

Cited: 3 times

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The influence of CT and dual-energy X-ray absorptiometry (DXA) bone density on quantitative [18F] sodium fluoride PET.

Inderbir S Jassel, Musib Siddique, Michelle L Frost, Amelia E B Moore, Tanuj Puri, Glen M Blake,

<h4>Background</h4>[<sup>18</sup>F] sodium fluoride PET/CT provides quantitative measures of bone metabolic activity expressed by the parameters standardised uptake value (SUV) and bone plasma clearance (<i>K</i> <sub>i</sub>) that correlate with measurements of bone formation rate obtained by bone biopsy with double tetracycline labelling. Both SUV and <i>K</i> <sub>i</sub> relate to the tracer ... Read more >>

Quant Imaging Med Surg (Quantitative imaging in medicine and surgery)
[2019, 9(2):201-209]

Cited: 2 times

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Site specific measurements of bone formation using [18F] sodium fluoride PET/CT.

Glen M Blake, Tanuj Puri, Musib Siddique, Michelle L Frost, Amelia E B Moore, Ignac Fogelman,

Dynamic positron emission tomography (PET) imaging with fluorine-18 labelled sodium fluoride ([18F]NaF) allows the quantitative assessment of regional bone formation by measuring the plasma clearance of fluoride to bone at any site in the skeleton. Today, hybrid PET and computed tomography (CT) dual-modality systems (PET/CT) are widely available, and [18F]NaF ... Read more >>

Quant Imaging Med Surg (Quantitative imaging in medicine and surgery)
[2018, 8(1):47-59]

Cited: 12 times

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Relevance of Bisphosphonate Therapy in Osteoporosis and Cancer--No Cause for Alarm in Dentistry.

Amelia Elizabeth Moore, Tara Renton, Talli Taylor, Shina Popat, Mukundil Kris Jasani,

This report provides important background information on osteoporosis (OP) and bone complications of cancer for the dental team, and discusses why bisphosphonate (BP) therapy is vital for patients with the two conditions. It also addresses several questions, including in particular: 'Is withholding BP therapy the best way to prevent osteonecrosis ... Read more >>

Dent Update (Dental update)
[2016, 43(3):235-6, 239-40, 242]

Cited: 0 times

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Sea snake harvest in the gulf of Thailand.

Nguyen Van Cao, Nguyen Thien Tao, Amelia Moore, Alfred Montoya, Arne Redsted Rasmussen, Kenneth Broad, Harold K Voris, Zoltan Takacs,

Conservation of sea snakes is virtually nonexistent in Asia, and its role in human-snake interactions in terms of catch, trade, and snakebites as an occupational hazard is mostly unexplored. We collected data on sea snake landings from the Gulf of Thailand, a hotspot for sea snake harvest by squid fishers ... Read more >>

Conserv Biol (Conservation biology : the journal of the Society for Conservation Biology)
[2014, 28(6):1677-1687]

Cited: 5 times

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Imaging of site specific bone turnover in osteoporosis using positron emission tomography.

Glen M Blake, Musib Siddique, Michelle L Frost, Amelia E B Moore, Ignac Fogelman,

The functional imaging technique of dynamic fluorine-18 labeled sodium fluoride positron emission tomography ((18)F-NaF PET) allows the quantitative assessment of regional bone formation by measuring the plasma clearance of fluoride to bone at any site in the skeleton. (18)F-NaF PET provides a novel and noninvasive method of studying site-specific bone ... Read more >>

Curr Osteoporos Rep (Current osteoporosis reports)
[2014, 12(4):475-485]

Cited: 19 times

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Sea Snake Harvest in the Gulf of Thailand

NGUYEN CAO, NGUYEN THIEN TAO, AMELIA MOORE, ALFRED MONTOYA, ARNE REDSTED RASMUSSEN, KENNETH BROAD, HAROLD K VORIS, ZOLTAN TAKACS,

Conservation of sea snakes is virtually nonexistent in Asia, and its role in human–snake interactions in terms of catch, trade, and snakebites as an occupational hazard is mostly unexplored. We collected data on sea snake landings from the Gulf of Thailand, a hotspot for sea snake harvest by squid fishers ... Read more >>

Conserv Biol (Conservation biology : the journal of the Society for Conservation Biology)
[2014, 28(6):1677-1687]

Cited: 0 times

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Correcting (18)F-fluoride PET static scan measurements of skeletal plasma clearance for tracer efflux from bone.

Musib Siddique, Michelle L Frost, Amelia E B Moore, Ignac Fogelman, Glen M Blake,

<h4>Objective</h4>The aim of the study was to examine whether (18)F-fluoride PET ((18)F-PET) static scan measurements of bone plasma clearance (Ki) can be corrected for tracer efflux from bone from the time of injection.<h4>Materials and methods</h4>The efflux of tracer from bone mineral to plasma was described by a first-order rate constant ... Read more >>

Nucl Med Commun (Nuclear medicine communications)
[2014, 35(3):303-310]

Cited: 7 times

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¹⁸F-fluoride PET as a noninvasive imaging biomarker for determining treatment efficacy of bone active agents at the hip: a prospective, randomized, controlled clinical study.

Michelle L Frost, Amelia E Moore, Musib Siddique, Glen M Blake, Didier Laurent, Babul Borah, Ursula Schramm, Marie-Anne Valentin, Theodore C Pellas, Paul K Marsden, Paul J Schleyer, Ignac Fogelman,

The functional imaging technique of ¹⁸F-fluoride positron emission tomography (¹⁸F-PET) allows the noninvasive quantitative assessment of regional bone formation at any skeletal site, including the spine and hip. The aim of this study was to determine if ¹⁸F-PET can be used as an early biomarker of treatment efficacy at the ... Read more >>

J Bone Miner Res (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research)
[2013, 28(6):1337-1347]

Cited: 18 times

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(18)F-fluoride positron emission tomography measurements of regional bone formation in hemodialysis patients with suspected adynamic bone disease.

Michelle L Frost, Juliet E Compston, David Goldsmith, Amelia E Moore, Glen M Blake, Musib Siddique, Linda Skingle, Ignac Fogelman,

(18)F-fluoride positron emission tomography ((18)F-PET) allows the assessment of regional bone formation and could have a role in the diagnosis of adynamic bone disease (ABD) in patients with chronic kidney disease (CKD). The purpose of this study was to examine bone formation at multiple sites of the skeleton in hemodialysis ... Read more >>

Calcif Tissue Int (Calcified tissue international)
[2013, 93(5):436-447]

Cited: 12 times

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Quantitative PET Imaging Using (18)F Sodium Fluoride in the Assessment of Metabolic Bone Diseases and the Monitoring of Their Response to Therapy.

Glen M Blake, Musib Siddique, Michelle L Frost, Amelia E B Moore, Ignac Fogelman,

Studies of bone remodeling using bone biopsy and biochemical markers of bone turnover measured in serum and urine are important for investigating how new treatments for osteoporosis affect bone metabolism. Positron emission tomography with (18)F sodium fluoride ((18)F NaF PET) for studying bone metabolism complements these conventional methods. Unlike biochemical ... Read more >>

PET Clin (PET clinics)
[2012, 7(3):275-291]

Cited: 9 times

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Comparison of six quantitative methods for the measurement of bone turnover at the hip and lumbar spine using 18F-fluoride PET-CT.

Tanuj Puri, Glen M Blake, Michelle L Frost, Musib Siddique, Amelia E B Moore, Paul K Marsden, Gary J R Cook, Ignac Fogelman, Kathleen M Curran,

<h4>Aim</h4>The aim of this study was to evaluate the relationship between different quantification methods used for the measurement of bone plasma clearance (K(i)) using F-PET at the hip and lumbar spine.<h4>Methods</h4>Twelve healthy postmenopausal women aged 52-71 years were recruited. Each participant underwent 60-min dynamic F-PET scans at the lumbar spine ... Read more >>

Nucl Med Commun (Nuclear medicine communications)
[2012, 33(6):597-606]

Cited: 8 times

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A semipopulation input function for quantifying static and dynamic 18F-fluoride PET scans.

Glen Mervyn Blake, Musib Siddique, Tanuj Puri, Michelle Lorraine Frost, Amelia Elizabeth Moore, Gary James R Cook, Ignac Fogelman,

<h4>Purpose</h4>We describe a semipopulation input function for evaluating bone plasma clearance from static and dynamic (18)F-fluoride PET scans.<h4>Methods</h4>The semipopulation input function was derived by fitting an exponential curve to venous plasma measurements obtained 30-60 min after injection and adding a population residual curve representing the bolus peak scaled for injected ... Read more >>

Nucl Med Commun (Nuclear medicine communications)
[2012, 33(8):881-888]

Cited: 14 times

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Estimation of regional bone metabolism from whole-body 18F-fluoride PET static images.

Musib Siddique, Glen M Blake, Michelle L Frost, Amelia E B Moore, Tanuj Puri, Paul K Marsden, Ignac Fogelman,

<h4>Purpose</h4>We evaluate a new quantitative method of acquiring and analysing (18)F positron emission tomography (PET) studies that enables regional bone plasma clearance (K ( i )) to be estimated from static scans acquired at multiple sites in the skeleton following a single injection of tracer.<h4>Methods</h4>Dynamic lumbar spine (18)F PET data ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2012, 39(2):337-343]

Cited: 20 times

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Semiautomatic region-of-interest validation at the femur in (18)F-fluoride PET/CT.

Tanuj Puri, Glen M Blake, Kathleen M Curran, Hamish Carr, Amelia E B Moore, Niall Colgan, Martin J O'Connell, Paul K Marsden, Ignac Fogelman, Michelle L Frost,

<h4>Unlabelled</h4>The assessment of regional skeletal metabolism using (18)F-fluoride PET ((18)F-PET) requires segmentation of the tissue region of interest (ROI). The aim of this study was to validate a novel approach to define multiple ROIs at the proximal femur similar to those used in dual x-ray absorptiometry. Regions were first drawn ... Read more >>

J Nucl Med Technol (Journal of nuclear medicine technology)
[2012, 40(3):168-174]

Cited: 1 time

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The assessment of regional skeletal metabolism: studies of osteoporosis treatments using quantitative radionuclide imaging.

Glen M Blake, Michelle L Frost, Amelia E B Moore, Musib Siddique, Ignac Fogelman,

Studies of bone remodeling using bone biopsy and biochemical markers of bone turnover play an important role in research studies to investigate the effect of new osteoporosis treatments on bone quality. Quantitative radionuclide imaging using either positron emission tomography with fluorine-18 sodium fluoride or gamma camera studies with technetium-99m methylene ... Read more >>

J Clin Densitom (Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry)
[2011, 14(3):263-271]

Cited: 3 times

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Validation of image-derived arterial input functions at the femoral artery using 18F-fluoride positron emission tomography.

Tanuj Puri, Glen M Blake, Michelle L Frost, Amelia E B Moore, Musib Siddique, Gary J R Cook, Paul K Marsden, Ignac Fogelman, Kathleen M Curran,

<h4>Introduction</h4>The use of image-derived arterial input functions (IDAIF) for the dynamic quantification of bone metabolism using 18F-fluoride positron emission tomography 18F-PET is an attractive alternative to direct arterial blood sampling.<h4>Purposes</h4>(a) To validate a method for obtaining the IDAIF by imaging the femoral artery against a method for deriving the IDAIF ... Read more >>

Nucl Med Commun (Nuclear medicine communications)
[2011, 32(9):808-817]

Cited: 11 times

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Changes observed in radionuclide bone scans during and after teriparatide treatment for osteoporosis.

Amelia E B Moore, Glen M Blake, Kathleen A Taylor, Valerie A Ruff, Asad E Rana, Xiaohai Wan, Ignac Fogelman,

<h4>Purpose</h4>Visual changes on radionuclide bone scans have been reported with teriparatide treatment. To assess this, serial studies were evaluated and quantified in ten postmenopausal women with osteoporosis treated with teriparatide (20 μg/day subcutaneous) who had (99m)Tc-methylene diphosphonate (MDP) bone scans (baseline, 3 and 18 months, then after 6 months off ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2012, 39(2):326-336]

Cited: 9 times

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The precision and sensitivity of (18)F-fluoride PET for measuring regional bone metabolism: a comparison of quantification methods.

Musib Siddique, Michelle L Frost, Glen M Blake, Amelia E B Moore, Yosra Al-Beyatti, Paul K Marsden, Paul J Schleyer, Ignac Fogelman,

<h4>Unlabelled</h4>The planning of research studies requires an understanding of the minimum number of subjects required. The aim of this study was to evaluate different methods of analyzing (18)F-fluoride PET ((18)F(-) PET) dynamic spine scans to find the approach that requires the smallest sample size to detect a statistically significant response ... Read more >>

J Nucl Med (Journal of nuclear medicine : official publication, Society of Nuclear Medicine)
[2011, 52(11):1748-1755]

Cited: 18 times

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Differential effects of teriparatide on regional bone formation using (18)F-fluoride positron emission tomography.

Michelle L Frost, Musib Siddique, Glen M Blake, Amelia E B Moore, Paul J Schleyer, Joel T Dunn, Edward J Somer, Paul K Marsden, Richard Eastell, Ignac Fogelman,

Teriparatide increases skeletal mass, bone turnover markers, and bone strength, but local effects on bone tissue may vary between skeletal sites. We used positron emission tomography (PET) to study (18)F-fluoride plasma clearance (K(i)) at the spine and standardized uptake values (SUVs) at the spine, pelvis, total hip, and femoral shaft ... Read more >>

J Bone Miner Res (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research)
[2011, 26(5):1002-1011]

Cited: 36 times

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Radionuclide studies of bone metabolism: do bone uptake and bone plasma clearance provide equivalent measurements of bone turnover?

Glen M Blake, Musib Siddique, Michelle L Frost, Amelia E B Moore, Ignac Fogelman,

Quantitative radionuclide imaging using (18)F-fluoride positron emission tomography (18F-PET) or (99m)Tc-methylene diphosphonate ((99m)Tc-MDP) bone scans provides a novel tool for studying regional and whole skeleton bone turnover that complements the information provided by biochemical markers. Radionuclide bone scans can be quantified by measuring either tracer uptake or, if blood sampling ... Read more >>

Bone (Bone)
[2011, 49(3):537-542]

Cited: 15 times

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Quantitative studies of bone using (99m)Tc-methylene diphosphonate skeletal plasma clearance.

Glen M Blake, Amelia E B Moore, Ignac Fogelman,

Quantitative bone scan imaging has a useful role in research for examining the pathophysiology of metabolic bone diseases and the response of patients to treatment. The advantage of nuclear medicine imaging as a way of measuring the rate of bone remodeling is that either the whole skeleton or discrete regions ... Read more >>

Semin Nucl Med (Seminars in nuclear medicine)
[2009, 39(6):369-379]

Cited: 11 times

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