Full Text Journal Articles by
Author Amanda Willig

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Brief Report: Differences in Types of Myocardial Infarctions Among People Aging With HIV.

Heidi M Crane, Robin M Nance, Bridget M Whitney, Susan R Heckbert, Matthew Budoff, Kevin High, Alan Landay, Matthew Feinstein, Richard D Moore, William Christopher Mathews, Katerina Christopoulos, Michael S Saag, Amanda Willig, Joseph J Eron, Mari M Kitahata, Joseph A C Delaney, ,

<h4>Background</h4>Type 1 myocardial infarctions (T1MIs) result from atherosclerotic plaque instability, rupture, and/or erosion. Type 2 MIs (T2MIs) are secondary to causes such as sepsis and cocaine-induced vasospasm resulting in an oxygen demand-supply mismatch and are associated with higher mortality than T1MIs. T2MIs account for a higher proportion of MIs among ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):208-212]

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Genetic architecture of cardiometabolic risks in people living with HIV.

Haoxiang Chang, Anshuman Sewda, Carla Marquez-Luna, Sierra R White, Bridget M Whitney, Jessica Williams-Nguyen, Robin M Nance, Won Jun Lee, Mari M Kitahata, Michael S Saag, Amanda Willig, Joseph J Eron, W Christopher Mathews, Peter W Hunt, Richard D Moore, Allison Webel, Kenneth H Mayer, Joseph A Delaney, Paul K Crane, Heidi M Crane, Ke Hao, Inga Peter,

<h4>Background</h4>Advances in antiretroviral therapies have greatly improved the survival of people living with human immunodeficiency virus (HIV) infection (PLWH); yet, PLWH have a higher risk of cardiovascular disease than those without HIV. While numerous genetic loci have been linked to cardiometabolic risk in the general population, genetic predictors of the ... Read more >>

BMC Med (BMC medicine)
[2020, 18(1):288]

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Patient-Centered Outcomes and Key Study Procedure Finalization in the Pilot Feasibility Gout Randomized Trial: Comparative Feasibility Study in GOUt, CHerry Extract Versus Diet Modification (Mini-GOUCH).

Jasvinder A Singh, Amanda L Willig, Betty Darnell, Candace Green, Sarah Morgan, Rick Weiss, Kenneth G Saag, Gary Cutter, Gerald McGwin,

<h4>Objective</h4>The aim of this study was to report patient-centered outcomes and finalization of key study procedures from a 9-month pilot internet randomized controlled trial of cherry extract versus diet modification.<h4>Methods</h4>We randomized 84 people with physician-confirmed gout in an internet study to cherry extract (n = 41) or dietitian-assisted diet modification ... Read more >>

J Clin Rheumatol (Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases)
[2020, 26(5):181-191]

Cited: 1 time

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Assessment of an adolescent-girl-focused nutritional educational intervention within a girls' empowerment programme: a cluster randomised evaluation in Zambia.

Paul C Hewett, Amanda L Willig, Jean Digitale, Erica Soler-Hampejsek, Jere R Behrman, Karen Austrian,

<h4>Objective</h4>Adolescent girls are at risk for both macro- and micronutrient deficiencies affecting growth, maternal and child health. This study assessed the impact of an adolescent-girl-tailored nutritional education curriculum on nutritional outcomes, including knowledge, dietary behaviour, anthropometry and anaemia.<h4>Design</h4>A cluster-randomised evaluation was conducted with two study arms: girls in mentor-led weekly ... Read more >>

Public Health Nutr (Public health nutrition)
[2020, :1-14]

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A Randomized Internet-Based Pilot Feasibility and Planning Study of Cherry Extract and Diet Modification in Gout.

Jasvinder A Singh, Candace Green, Sarah Morgan, Amanda L Willig, Betty Darnell, Kenneth G Saag, Rick Weiss, Gary Cutter, Gerald McGwin,

OBJECTIVE:The aim of this study was to conduct a 9-month pilot Internet randomized controlled trial (RCT) of cherry extract and diet modification in gout to assess the feasibility of an Internet study and obtain effect estimates. METHODS:After providing online informed consent in response to Internet advertisements and social media or ... Read more >>

J Clin Rheumatol (Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases)
[2020, 26(4):147-156]

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The PROSPER-HIV Study: A Research Protocol to Examine Relationships Among Physical Activity, Diet Intake, and Symptoms in Adults Living With HIV.

Allison R Webel, Dustin Long, Benigno Rodriguez, Christine Horvat Davey, Thomas W Buford, Heidi M Crane, Kenneth Mayer, Michael S Saag, Amanda L Willig,

J Assoc Nurses AIDS Care (The Journal of the Association of Nurses in AIDS Care : JANAC)
[2020, 31(3):346-352]

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Cognitive Effects of a Ketogenic Diet on Neurocognitive Impairment in Adults Aging With HIV: A Pilot Study.

Shannon A Morrison, Pariya L Fazeli, Barbara Gower, Amanda L Willig, Jarred Younger, N Markie Sneed, David E Vance,

We assessed a ketogenic diet (KD) intervention protocol and the cognitive effects of KD in older adults with HIV-associated neurocognitive impairment. Adults older than 50 years and living with HIV and mild-to-moderate neurocognitive impairment were randomized to either a KD or a patient-choice diet for 12 weeks followed by a ... Read more >>

J Assoc Nurses AIDS Care (The Journal of the Association of Nurses in AIDS Care : JANAC)
[2020, 31(3):312-324]

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Weight gain among treatment-naïve persons with HIV starting integrase inhibitors compared to non-nucleoside reverse transcriptase inhibitors or protease inhibitors in a large observational cohort in the United States and Canada.

Kassem Bourgi, Cathy A Jenkins, Peter F Rebeiro, Frank Palella, Richard D Moore, Keri N Altoff, John Gill, Charles S Rabkin, Stephen J Gange, Michael A Horberg, Joseph Margolick, Jun Li, Cherise Wong, Amanda Willig, Viviane D Lima, Heidi Crane, Jennifer Thorne, Michael Silverberg, Gregory Kirk, William C Mathews, Timothy R Sterling, Jordan Lake, John R Koethe, ,

INTRODUCTION:Weight gain following antiretroviral therapy (ART) initiation is common, potentially predisposing some persons with HIV (PWH) to cardio-metabolic disease. We assessed relationships between ART drug class and weight change among treatment-naïve PWH initiating ART in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). METHODS:Adult, treatment-naïve PWH in ... Read more >>

J Int AIDS Soc (Journal of the International AIDS Society)
[2020, 23(4):e25484]

Cited: 5 times

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Obesity Affects the Association of Bioelectrical Impedance Phase Angle With Mortality in People Living With HIV.

Viola Cogliandro, Donna Yester, Andrew O Westfall, James L Raper, Michael S Saag, German Henostroza, E Turner Overton, Amanda L Willig,

Bioelectrical impedance analysis phase angle (BIA-PA) is a valid indicator of mortality risk in people living with HIV; however, it is not known whether BIA-PA is valid for people living with HIV who are overweight or obese. We assessed whether BIA-PA differentially predicted mortality by body mass index category in ... Read more >>

J Assoc Nurses AIDS Care (The Journal of the Association of Nurses in AIDS Care : JANAC)
[2020, 31(1):51-59]

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Physical activity trends and metabolic health outcomes in people living with HIV in the US, 2008-2015.

Amanda L Willig, Allison R Webel, Andrew O Westfall, Emily B Levitan, Heidi M Crane, Thomas W Buford, Greer A Burkholder, James H Willig, Aaron J Blashill, Richard D Moore, W Christopher Mathews, Anne Zinski, Josh Muhammad, Elvin H Geng, Sonia Napravnik, Joseph J Eron, Benigno Rodriguez, Marcas M Bamman, E Turner Overton,

Despite its potential to improve metabolic health outcomes, longitudinal physical activity (PA) patterns and their association with cardiometabolic disease among people living with HIV (PLWH) have not been well characterized. We investigated this relationship among PLWH in the Centers for AIDS Research Network of Integrated Clinical Systems with at least ... Read more >>

Prog Cardiovasc Dis (Progress in cardiovascular diseases)
[2020, 63(2):170-177]

Cited: 1 time

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Turning Chutes into Ladders for Women Faculty: A Review and Roadmap for Equity in Academia.

Michelle I Cardel, Emily Dhurandhar, Ceren Yarar-Fisher, Monica Foster, Bertha Hidalgo, Leslie A McClure, Sherry Pagoto, Nathanial Brown, Dori Pekmezi, Noha Sharafeldin, Amanda L Willig, Christine Angelini,

Despite significant progress in recent decades, the recruitment, advancement, and promotion of women in academia remain low. Women represent a large portion of the talent pool in academia, and receive >50% of all PhDs, but this has not yet translated into sustained representation in faculty and leadership positions. Research indicates ... Read more >>

J Womens Health (Larchmt) (Journal of women's health (2002))
[2020, 29(5):721-733]

Cited: 3 times

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LB9. The Effect of Initiating Integrase Inhibitor-based vs. Non-Nucleoside Reverse Transcriptase Inhibitor-based Antiretroviral Therapy on Progression to Diabetes among North American Persons in HIV Care

Peter F Rebeiro, Peter F Rebeiro, Cathy Jenkins, Aihua Bian, Jordan Lake, Jordan Lake, Kassem Bourgi, Kassem Bourgi, Michael A Horberg, Michael A Horberg, Richard Moore, Richard Moore, Keri Altoff, Marina Klein, Joseph J Eron, Joseph J Eron, M John Gill, Mari Kitahata, Sonia Napravnik, Michael Silverberg, Angel M Mayor, Amanda Willig, Amanda Willig, Michelle Floris-Moore, Timothy Sterling, John R Koethe, John R Koethe,

Abstract <h4>Background</h4> Integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) has been implicated in greater weight gain than other regimens among people with HIV, but there is little evidence about its role in serious clinical outcomes proximal to weight gain. We therefore examined the impact of initial ART regimen class/drug ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S996-S997]

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344. HIV and Diabetes in the Era of Antiretroviral Therapy

Gabriel Sabbaj. Spieler, Edgar T Overton, Amanda Willig, Greer A Burkholder, Mohit Varshney, Andrew O Westfall,

Abstract <h4>Background</h4> With advancements in ART, non-AIDS comorbidities are becoming more common among people living with HIV (PWH). In this analysis, we identified PWH followed at a single Ryan White HIV Clinic in Alabama and determined the overall prevalence of diabetes (DM). We then evaluated the cohort for risk factors ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S183-S183]

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Cognitive Reserve Over the Lifespan: Neurocognitive Implications for Aging With HIV.

David E Vance, Loretta Lee, Jose A Muñoz-Moreno, Shannon Morrison, Turner Overton, Amanda Willig, Pariya L Fazeli,

Approximately 59% of adults living with HIV experience HIV-associated neurocognitive disorder, a collection of symptoms and cognitive deficits in various cognitive domains. As the HIV population ages, the prevalence and severity of such cognitive deficits are expected to grow. Understanding how these cognitive deficits manifest is important for nurses and ... Read more >>

J Assoc Nurses AIDS Care (The Journal of the Association of Nurses in AIDS Care : JANAC)
[2019, 30(5):e109-e121]

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Physical Functioning Among Patients Aging With Human Immunodeficiency Virus (HIV) Versus HIV Uninfected: Feasibility of Using the Short Physical Performance Battery in Clinical Care of People Living With HIV Aged 50 or Older.

Heidi M Crane, Michael E Miller, June Pierce, Amanda L Willig, Michael Lloyd Case, Aimee M Wilkin, Sharon Brown, Mary Grace Asirot, Rob J Fredericksen, Michael S Saag, Alan L Landay, Kevin P High,

Background:The Short Physical Performance Battery (SPPB) is a well regarded physical functioning assessment including balance, gait speed, and chair-stand tests. Its use has not been widely assessed in human immunodeficiency virus (HIV) care. We evaluated the feasibility of integrating the SPPB into care of aging people living with HIV (PLWH) ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(3):ofz038]

Cited: 1 time

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Physical Activity Intensity is Associated with Symptom Distress in the CNICS Cohort.

Allison R Webel, Amanda L Willig, Wei Liu, Abdus Sattar, Stephen Boswell, Heidi M Crane, Peter Hunt, Mari Kitahata, W Christopher Matthews, Michael S Saag, Michael M Lederman, Benigno Rodriguez,

Symptom distress remains a challenging aspect of living with HIV. Physical activity is a promising symptom management strategy, but its effect on symptom distress has not been examined in a large, longitudinal HIV-infected cohort. We hypothesized that higher physical activity intensity would be associated with reduced symptom distress. We included ... Read more >>

AIDS Behav (AIDS and behavior)
[2019, 23(3):627-635]

Cited: 1 time

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A Randomized Internet-Based Pilot Feasibility and Planning Study of Cherry Extract and Diet Modification in Gout.

Jasvinder A Singh, Candace Green, Sarah Morgan, Amanda L Willig, Betty Darnell, Kenneth G Saag, Rick Weiss, Gary Cutter, Gerald McGwin,

OBJECTIVE:The aim of this study was to conduct a 9-month pilot Internet randomized controlled trial (RCT) of cherry extract and diet modification in gout to assess the feasibility of an Internet study and obtain effect estimates. METHODS:After providing online informed consent in response to Internet advertisements and social media or ... Read more >>

J Clin Rheumatol (Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases)
[2019, :]

Cited: 1 time

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The ketogenic diet as a non-pharmacological treatment for HIV-associated neurocognitive disorder: A descriptive analysis.

Shannon A Morrison, Pariya L Fazeli, Barbara Gower, Jarred Younger, Amanda Willig, N Markie Sneed, David E Vance,

Mitochondrial dysfunction is associated with abnormal glucose metabolism, inflammation and greater oxidative stress in the brain, each of which may contribute uniquely and perhaps synergistically to HIV-Associated Neurocognitive Disorders (HAND) risk. The ketogenic (i.e., low carbohydrate) diet provides the brain with a highly efficient mitochondrial fuel and is associated with ... Read more >>

J Psychiatry Behav Sci (Journal of psychiatry and behavioral science)
[2018, 3:]

Cited: 0 times

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Practice Paper of the Academy of Nutrition and Dietetics: Nutrition Intervention and Human Immunodeficiency Virus Infection.

Amanda Willig, Lauri Wright, Theresa A Galvin,

Nutrition is an integral component of medical care for people living with human immunodeficiency virus (HIV)/autoimmune deficiency syndrome (AIDS) (PLWHA). The Academy of Nutrition and Dietetics supports integration of medical nutrition therapy into routine care for this population. Fewer PLWHA experience wasting and undernutrition, while the prevalence of obesity and ... Read more >>

J Acad Nutr Diet (Journal of the Academy of Nutrition and Dietetics)
[2018, 118(3):486-498]

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Racial disparities in the prevalence and control of hypertension among a cohort of HIV-infected patients in the southeastern United States.

Greer A Burkholder, Ashutosh R Tamhane, Monika M Safford, Paul M Muntner, Amanda L Willig, James H Willig, James L Raper, Michael S Saag, Michael J Mugavero,

<h4>Background</h4>African Americans are disproportionately affected by both HIV and hypertension. Failure to modify risk factors for cardiovascular disease and chronic kidney disease such as hypertension among HIV-infected patients may attenuate the benefits conferred by combination antiretroviral therapy. In the general population, African Americans with hypertension are less likely to have ... Read more >>

PLoS One (PloS one)
[2018, 13(3):e0194940]

Cited: 2 times

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Vitamin D Supplementation Does Not Affect Metabolic Changes Seen With ART Initiation.

Josh Muhammad, Ellen S Chan, Todd T Brown, Pablo Tebas, Grace A McComsey, Kathleen Melbourne, Royce Hardin, Amanda L Willig, Michael T Yin, Heather Ribaudo, Edgar Turner Overton,

Background:Insulin resistance and lipid changes are common after antiretroviral therapy (ART) initiation. Observational studies suggest that vitamin D supplementation reduces the risk of developing diabetes and improves lipid profiles. Methods:This 48-week prospective, randomized, double-blind, placebo-controlled study evaluated high-dose vitamin D3 (4000 IU daily) plus calcium supplementation (1000 mg calcium carbonate ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2017, 4(4):ofx210]

Cited: 2 times

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Monocyte bioenergetic function is associated with body composition in virologically suppressed HIV-infected women.

Amanda L Willig, Philip A Kramer, Balu K Chacko, Victor M Darley-Usmar, Sonya L Heath, E Turner Overton,

Women living with HIV may present with high levels of body fat that are associated with altered bioenergetic function. Excess body fat may therefore exacerbate the bioenergetic dysfunction observed with HIV infection. To determine if body fat is associated with bioenergetic function in HIV, we conducted a cross-sectional study of ... Read more >>

Redox Biol (Redox biology)
[2017, 12:648-656]

Cited: 3 times

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Associations Between At-Risk Alcohol Use, Substance Use, and Smoking with Lipohypertrophy and Lipoatrophy Among Patients Living with HIV.

Marisela Noorhasan, Daniel R Drozd, Carl Grunfeld, Joseph O Merrill, Greer A Burkholder, Michael J Mugavero, James H Willig, Amanda L Willig, Karen L Cropsey, Kenneth H Mayer, Aaron Blashill, Matthew Mimiaga, Mary E McCaul, Heidi Hutton, Geetanjali Chander, William C Mathews, Sonia Napravnik, Joseph J Eron, Katerina Christopoulos, Rob J Fredericksen, Robin M Nance, Joseph Chris Delaney, Paul K Crane, Michael S Saag, Mari M Kitahata, Heidi M Crane,

<h4>Objective</h4>To examine associations between lipohypertrophy and lipoatrophy and illicit drug use, smoking, and at-risk alcohol use among a large diverse cohort of persons living with HIV (PLWH) in clinical care.<h4>Methods</h4>7,931 PLWH at six sites across the United States completed 21,279 clinical assessments, including lipohypertrophy and lipoatrophy, drug/alcohol use, physical activity ... Read more >>

AIDS Res Hum Retroviruses (AIDS research and human retroviruses)
[2017, 33(6):534-545]

Cited: 1 time

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Metabolic Complications and Glucose Metabolism in HIV Infection: A Review of the Evidence.

Amanda L Willig, Edgar Turner Overton,

HIV infection and antiretroviral therapy (ART) use are associated with perturbations in glucose and lipid metabolism. Increasing incidence of diabetes, cardiovascular disease, and obesity highlights the need for early identification and treatment of metabolic dysfunction. Newer ART regimens are less toxic for cellular function and metabolism but have failed to ... Read more >>

Curr HIV/AIDS Rep (Current HIV/AIDS reports)
[2016, 13(5):289-296]

Cited: 28 times

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Higher Time-Updated Body Mass Index: Association With Improved CD4+ Cell Recovery on HIV Treatment.

John R Koethe, Cathy A Jenkins, Bryan Lau, Bryan E Shepherd, William Wester, Peter F Rebeiro, Michael J Silverberg, Jennifer E Thorne, John Gill, Angel M Mayor, Amanda Willig, Ronald Bosch, Michael A Horberg, Amy C Justice, Timothy R Sterling, Richard D Moore, ,

<h4>Background</h4>Prior studies found overweight or obese HIV-infected individuals had greater early CD4 cell recovery on antiretroviral therapy (ART), but the results have been inconsistent. We assessed the longitudinal relationship between body mass index (BMI) and CD4 cell recovery on ART in a large, multisite cohort to identify potential physiologic links ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2016, 73(2):197-204]

Cited: 17 times

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