Full Text Journal Articles by
Author Amanda Ruiz

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The Trypanosoma brucei subpellicular microtubule array is organized into functionally discrete subdomains defined by microtubule associated proteins

Amy Sinclair, Christine Huynh, Thomas Sladewski, Jenna Zuromski, Amanda Ruiz, Christopher de Graffenried,

Abstract Microtubules are inherently dynamic cytoskeletal polymers whose length and activity can be altered to perform essential functions in eukaryotic cells, such as providing tracks for intracellular trafficking and forming the mitotic spindle. Microtubules can be bundled to create more stable structures that collectively propagate force, such as in the ... Read more >>

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Cost of closure: Comparing success and spending of fat graft myringoplasties with and without hyaluronic acid.

Margaret Tashjian, Amanda Ruiz, Jordyn Dinwiddie, Chris Greenlee, Todd Wine,

INTRODUCTION:Myringoplasties are common pediatric procedures used to surgically close a perforated tympanic membrane. While a wide variety of graft materials are available to surgeons, the cost effectiveness of these different techniques is not well studied. OBJECTIVES:To compare the cost effectiveness of the fat graft myringoplasty (FGM) with the hyaluronic acid ... Read more >>

Int. J. Pediatr. Otorhinolaryngol. (International journal of pediatric otorhinolaryngology)
[2020, 135:110104]

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Targeting dual signalling pathways in concert with immune checkpoints for the treatment of pancreatic cancer.

Erik S Knudsen, Vishnu Kumarasamy, Sejin Chung, Amanda Ruiz, Paris Vail, Stephanie Tzetzo, Jin Wu, Ram Nambiar, Jared Sivinski, Shailender S Chauhan, Mukund Seshadri, Scott I Abrams, Jianmin Wang, Agnieszka K Witkiewicz,

OBJECTIVE:This study exploits the intersection between molecular-targeted therapies and immune-checkpoint inhibition to define new means to treat pancreatic cancer. DESIGN:Patient-derived cell lines and xenograft models were used to define the response to CDK4/6 and MEK inhibition in the tumour compartment. Impacts relative to immunotherapy were performed using subcutaneous and orthotopic ... Read more >>

Gut (Gut)
[2020, :]

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Targeting dual signaling pathways in concert with immune checkpoints for the treatment of pancreatic cancer

Erik Knudsen, Vishnu Kumarasamy, Sejin Chung, Paris Vail, Stephanie Tzetzo, Amanda Ruiz, Mukund Seshadri, Scott Abrams, Jianmin Wang, Agnieszka Witkiewicz,

ABSTRACT Pancreatic cancer harbors a poor prognosis due to the lack of effective systemic therapies. Here we interrogated means to target key effector pathways down-stream from KRAS. We found that combination treatment with MEK and CDK4/6 inhibitors was effective across a broad range of PDX models in delaying tumor progression. ... Read more >>

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Modeling Tumor Evolutionary Dynamics to Predict Clinical Outcomes for Patients with Metastatic Colorectal Cancer: A Retrospective Analysis.

Jiawei Zhou, Yutong Liu, Yubo Zhang, Quefeng Li, Yanguang Cao,

Over 50% of colorectal cancer patients develop resistance after a transient response to therapy. Understanding tumor resistance from an evolutionary perspective leads to better predictions of treatment outcomes. The objectives of this study were to develop a computational framework to analyze tumor longitudinal measurements and recapitulate the individual evolutionary dynamics ... Read more >>

Cancer Res (Cancer research)
[2020, 80(3):591-601]

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Chemotherapy impacts on the cellular response to CDK4/6 inhibition: distinct mechanisms of interaction and efficacy in models of pancreatic cancer.

Vishnu Kumarasamy, Amanda Ruiz, Ram Nambiar, Agnieszka K Witkiewicz, Erik S Knudsen,

Pancreatic ductal adenocarcinoma (PDAC) is a therapy recalcitrant disease characterized by the aberrations in multiple genes that drive pathogenesis and limit therapeutic response. While CDK4/6 represents a downstream target of both KRAS mutation and loss of the CDKN2A tumor suppressor in PDAC, clinical and preclinical studies indicate that pharmacological CDK4/6 ... Read more >>

Oncogene (Oncogene)
[2020, 39(9):1831-1845]

Cited: 4 times

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Does Tonsillectomy Increase Obesity Risk in Children with Down Syndrome?

Amanda G Ruiz, Dexiang Gao, David G Ingram, Francis Hickey, Matthew A Haemer, Norman R Friedman,

OBJECTIVES:To examine weight changes relative to surgical success in children with Down syndrome and obstructive sleep apnea (OSA). STUDY DESIGN:Retrospective chart review of children with Down syndrome undergoing tonsillectomy from 2005 to 2016 for OSA at a tertiary care children's hospital. Only patients with pre-and postoperative polysomnogram within 6 months of ... Read more >>

J Pediatr (The Journal of pediatrics)
[2019, 211:179-184.e1]

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Pediatric Obstructive Sleep-Disordered Breathing: Updated Polysomnography Practice Patterns.

Norman R Friedman, Amanda G Ruiz, Dexiang Gao, Alexandria Jensen, Ron B Mitchell,

OBJECTIVE:To assess the current practice patterns of pediatric otolaryngologists in managing obstructive sleep-disordered breathing 6 years following the 2011 publication of the clinical practice guideline "Polysomnography for Sleep-Disordered Breathing prior to Tonsillectomy in Children." STUDY DESIGN:Cross-sectional survey. SETTING:American Society of Pediatric Otolaryngology (ASPO) members. SUBJECTS AND METHODS:An electronic survey to ... Read more >>

Otolaryngol Head Neck Surg (Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery)
[2019, 161(3):529-535]

Cited: 0 times

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Demonstrating the benefits of a multidisciplinary aerodigestive program.

Amanda G Ruiz, Jay M Bhatt, Emily M DeBoer, Joel Friedlander, Norah Janosy, Melissa Brooks Peterson, Todd Wine, Robin Deterding, Jeremy D Prager,

OBJECTIVES/HYPOTHESIS:The Aerodigestive Program (the Aero Program) at Children's Hospital Colorado is a multidisciplinary program focused on airway, digestive, and lung disorders in complex children, involving collaboration between gastroenterology, pulmonology, anesthesiology, and otolaryngology in clinic and operating room. These programs have proliferated as institutions focus on providing greater care coordination and ... Read more >>

Laryngoscope (The Laryngoscope)
[2020, 130(2):521-525]

Cited: 1 time

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Cell cycle plasticity driven by MTOR signaling: integral resistance to CDK4/6 inhibition in patient-derived models of pancreatic cancer.

Erik S Knudsen, Vishnu Kumarasamy, Amanda Ruiz, Jared Sivinski, Sejin Chung, Adam Grant, Paris Vail, Shailender S Chauhan, Tun Jie, Taylor S Riall, Agnieszka K Witkiewicz,

Pancreatic ductal adenocarcinoma (PDAC), like many KRAS-driven tumors, preferentially loses CDKN2A that encodes an endogenous CDK4/6 inhibitor to bypass the RB-mediated cell cycle suppression. Analysis of a panel of patient-derived cell lines and matched xenografts indicated that many pancreatic cancers have intrinsic resistance to CDK4/6 inhibition that is not due ... Read more >>

Oncogene (Oncogene)
[2019, 38(18):3355-3370]

Cited: 5 times

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FUT2 Variants Confer Susceptibility to Familial Otitis Media.

Regie Lyn P Santos-Cortez, Charlotte M Chiong, Daniel N Frank, Allen F Ryan, Arnaud P J Giese, Tori Bootpetch Roberts, Kathleen A Daly, Matthew J Steritz, Wasyl Szeremeta, Melquiadesa Pedro, Harold Pine, Talitha Karisse L Yarza, Melissa A Scholes, Erasmo Gonzalo D V Llanes, Saira Yousaf, Norman Friedman, Ma Leah C Tantoco, Todd M Wine, Patrick John Labra, Jeanne Benoit, Amanda G Ruiz, Rhodieleen Anne R de la Cruz, Christopher Greenlee, Ayesha Yousaf, Jonathan Cardwell, Rachelle Marie A Nonato, Dylan Ray, Kimberly Mae C Ong, Edward So, Charles E Robertson, Jordyn Dinwiddie, Sheryl Mae Lagrana-Villagracia, , Samuel P Gubbels, Rehan S Shaikh, Stephen P Cass, Elisabet Einarsdottir, Nanette R Lee, David A Schwartz, Teresa Luisa I Gloria-Cruz, Michael J Bamshad, Ivana V Yang, Juha Kere, Generoso T Abes, Jeremy D Prager, Saima Riazuddin, Abner L Chan, Patricia J Yoon, Deborah A Nickerson, Eva Maria Cutiongco-de la Paz, Sven-Olrik Streubel, Maria Rina T Reyes-Quintos, Herman A Jenkins, Petri Mattila, Kenny H Chan, Karen L Mohlke, Suzanne M Leal, Lena Hafrén, Tasnee Chonmaitree, Michele M Sale, Zubair M Ahmed,

Non-secretor status due to homozygosity for the common FUT2 variant c.461G>A (p.Trp154∗) is associated with either risk for autoimmune diseases or protection against viral diarrhea and HIV. We determined the role of FUT2 in otitis media susceptibility by obtaining DNA samples from 609 multi-ethnic families and simplex case subjects with ... Read more >>

Am J Hum Genet (American journal of human genetics)
[2018, 103(5):679-690]

Cited: 11 times

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Evaluating the yield of gastrointestinal testing in pediatric patients in aerodigestive clinic.

Emily M DeBoer, Sarah Kinder, Alison Duggar, Jeremy D Prager, Jason Soden, Robin R Deterding, Amanda G Ruiz, Emily L Jensen, Jason Weinman, Todd Wine, John E Fortunato, Joel A Friedlander,

OBJECTIVE:To improve understanding of the interrelatedness of airway and esophageal diagnoses by evaluating the yield of procedural and radiographic testing of the gastrointestinal tract in children with airway conditions by their referring diagnoses in a pediatric aerodigestive clinic. METHODS:A retrospective chart review of all 325 patients seen in the aerodigestive ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2018, 53(11):1517-1524]

Cited: 1 time

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Dornase Alfa Ototoxic Effects in Animals and Efficacy in the Treatment of Clogged Tympanostomy Tubes in Children: A Preclinical Study and a Randomized Clinical Trial.

Kenny H Chan, Gregory C Allen, Peggy E Kelley, Sven-Olrik Streubel, Norman R Friedman, Patricia Yoon, Dexiang Gao, Amanda G Ruiz, Timothy T K Jung,

Importance:Many treatments for clogged tympanostomy tubes (TTs) have been proposed, but none have met scientific rigor for safety and efficacy, including the popular empirical use of ototopical antibiotic drops. Dornase alfa, a recombinant molecule with the unique property of cleaving DNA, may be ideal in treating clogged TTs because both ... Read more >>

JAMA Otolaryngol Head Neck Surg (JAMA otolaryngology-- head & neck surgery)
[2018, 144(9):776-780]

Cited: 0 times

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SNAP-tagged nanobodies enable reversible optical control of a G protein-coupled receptor via a remotely tethered photoswitchable ligand

Helen Farrants, Amanda Acosta Ruiz, Vanessa Gutzeit, Dirk Trauner, Kai Johnsson, Joshua Levitz, Johannes Broichhagen,

Abstract G protein-coupled receptors (GPCRs) mediate the transduction of extracellular signals into complex intracellular responses. Despite their ubiquitous roles in physiological processes and as drug targets for a wide range of disorders, the precise mechanisms of GPCR function at the molecular, cellular, and systems levels remain partially understood. In order ... Read more >>

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Accuracy of Parental Perception of Nighttime Breathing in Children with Down Syndrome.

Norman R Friedman, Amanda G Ruiz, Dexiang Gao, David G Ingram,

Objective In 2011, the American Academy of Pediatrics published a guideline for children with Down syndrome (DS), recommending a polysomnogram (PSG) by age 4 years regardless of symptoms. Their rationale was based on 2 publications with small cohorts, where at least 50% of the children had no obstructive sleep apnea ... Read more >>

Otolaryngol Head Neck Surg (Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery)
[2018, 158(2):364-367]

Cited: 4 times

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Success of Tonsillectomy for Obstructive Sleep Apnea in Children With Down Syndrome.

David G Ingram, Amanda G Ruiz, Dexiang Gao, Norman R Friedman,

Obstructive sleep apnea (OSA) is common in children with Down syndrome (DS) and associated with significant morbidity. In the current study we examined polysomnographic outcomes of children with DS who underwent tonsillectomy.A retrospective chart review of children with DS who underwent a tonsillectomy between 2009-2015 was performed. All children had ... Read more >>

J Clin Sleep Med (Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine)
[2017, 13(8):975-980]

Cited: 5 times

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Composite analysis of immunological and metabolic markers defines novel subtypes of triple negative breast cancer.

Thomas A Adams, Paris J Vail, Amanda Ruiz, Mehri Mollaee, Peter A McCue, Erik S Knudsen, Agnieszka K Witkiewicz,

Cancer biology is influenced by the tumor microenvironment, which impacts disease prognosis and therapeutic interventions. The inter-relationship of tumor-infiltrating lymphocytes, immune response regulators, and a glycolytic tumor environment was evaluated in a cohort of 183 largely consecutive patients with triple negative breast cancer diagnosis. High levels of tumor-infiltrating lymphocytes were ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2018, 31(2):288-298]

Cited: 8 times

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The current state of pediatric drug-induced sleep endoscopy.

Norman R Friedman, Sanjay R Parikh, Stacey L Ishman, Amanda G Ruiz, Hamdy El-Hakim, Seckin O Ulualp, Christopher T Wootten, Peter J Koltai, Dylan K Chan,

The purpose of this investigation was to assess current drug-induced sleep endoscopy (DISE) practice patterns at centers that have published on the technique, to identify areas of agreement, and to identify areas of disagreement that may represent opportunities for improvement and standardization.Multi-institutional survey.A survey was designed in two phases to ... Read more >>

Laryngoscope (The Laryngoscope)
[2017, 127(1):266-272]

Cited: 8 times

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A Pediatric Grading Scale for Lingual Tonsil Hypertrophy.

Norman R Friedman, Jeremy D Prager, Amanda G Ruiz, Eric J Kezirian,

Lingual tonsil hypertrophy (LTH) is a common finding for children with residual obstructive sleep apnea (OSA) following an adenotonsillectomy. Secondary to the significant morbidity associated with OSA, identification and treatment of residual OSA are paramount. A dedicated LTH grading scale for children does not exist. The current adult LTH scale ... Read more >>

Otolaryngol Head Neck Surg (Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery)
[2016, 154(1):171-174]

Cited: 9 times

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Multidisciplinary care of children with repaired esophageal atresia and tracheoesophageal fistula.

Emily M DeBoer, Jeremy D Prager, Amanda G Ruiz, Emily L Jensen, Robin R Deterding, Joel A Friedlander, Jason Soden,

Children with congenital esophageal atresia with tracheoesophageal fistula (TEF) require complex medical and surgical care, but few guidelines exist to guide the long term care of this population. The purpose of this study is to describe the findings and initial management of a comprehensive aerodigestive team in order to understand ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2016, 51(6):576-581]

Cited: 10 times

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Indications, clinical course, and postoperative outcomes of urgent adenotonsillectomy in children.

Conan Liang, Amanda G Ruiz, Emily L Jensen, Norman R Friedman,

Children undergoing urgent adenotonsillectomy have been poorly described in literature.To characterize the clinical course and outcomes of patients who underwent urgent adenotonsillectomy.A 7-year retrospective medical record review of patients undergoing urgent adenotonsillectomy (study group) at a tertiary care pediatric hospital was undertaken. Comparisons were made between the study group and ... Read more >>

JAMA Otolaryngol Head Neck Surg (JAMA otolaryngology-- head & neck surgery)
[2015, 141(3):236-244]

Cited: 2 times

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Friedman tongue position: age distribution and relationship to sleep-disordered breathing.

David G Ingram, Amanda Ruiz, Norman R Friedman,

Friedman tongue position (FTP) may play an important role in the evaluation of children with sleep-related breathing disorders (SRBD), but there are no previous data on FTP distribution by age. The objective of the current study was to determine the distribution of FTP by age and examine the relationship between ... Read more >>

Int. J. Pediatr. Otorhinolaryngol. (International journal of pediatric otorhinolaryngology)
[2015, 79(5):666-670]

Cited: 4 times

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Characteristics of children under 2 years of age undergoing tonsillectomy for upper airway obstruction.

Valérie Côté, Amanda G Ruiz, Jonathan Perkins, Stefan Sillau, Norman R Friedman,

INTRODUCTION:To study characteristics of children less than 2 years who underwent a tonsillectomy for sleep disordered breathing (SDB) or obstructive sleep apnea (OSA) to assess for factors associated with requesting a preoperative polysomnogram (PSG) and to identify predictors of upper airway obstruction in this group. MATERIALS AND METHODS:A retrospective chart ... Read more >>

Int J Pediatr Otorhinolaryngol (International journal of pediatric otorhinolaryngology)
[2015, 79(6):903-908]

Cited: 4 times

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Improving operative flow during pediatric airway evaluation: a quality-improvement initiative.

Jeremy D Prager, Amanda G Ruiz, Kristin Mooney, Dexiang Gao, Judit Szolnoki, Rahul K Shah,

IMPORTANCE: Microlaryngoscopy and bronchoscopy procedures (MLBs) are short-duration, high-acuity procedures that carry risk. Poor case flow and communication exacerbate such potential risk. Efficient operative flow is critical for patient safety and resource expenditure. OBJECTIVES: To identify areas for improvement and evaluate the effectiveness of a multidisciplinary quality-improvement (QI) initiative. DESIGN, ... Read more >>

JAMA Otolaryngol Head Neck Surg (JAMA otolaryngology-- head & neck surgery)
[2015, 141(3):229-235]

Cited: 0 times

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Surgical management of type I and II laryngeal cleft in the pediatric population.

Tendy Chiang, Brook McConnell, Amanda G Ruiz, Emily M DeBoer, Jeremy D Prager,

Laryngeal clefts (LC) are congenital malformations of the upper aerodigestive tract that can cause dysphagia, aspiration, and subsequent pulmonary complications. This investigation assessed the outcomes of multidisciplinary evaluation and surgical management of type I and II LC (LC1-2) at a tertiary children's hospital.A retrospective chart review was used to identify ... Read more >>

Int. J. Pediatr. Otorhinolaryngol. (International journal of pediatric otorhinolaryngology)
[2014, 78(12):2244-2249]

Cited: 8 times

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