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Outcomes of cesarean delivery in obstetric patients with SARS-CoV-2 infection.

Allison Lankford, Jeffrey Berger, Ivy Benjenk, Amanda Jackson, Homa Ahmadzia, Michael Mazzeffi,

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, :]

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Specialist palliative and end-of-life care for patients with cancer and SARS-CoV-2 infection: a European perspective.

Gehan Soosaipillai, Anjui Wu, Gino M Dettorre, Nikolaos Diamantis, John Chester, Charlotte Moss, Juan Aguilar-Company, Mark Bower, Christopher Ct Sng, Ramon Salazar, Joan Brunet, Eleanor Jones, Ricard Mesia, Amanda Jackson, Uma Mukherjee, Ailsa Sita-Lumsden, Elia Seguí, Diego Ottaviani, Anna Carbó, Sarah Benafif, Rachel Würstlein, Carme Carmona, Neha Chopra, Claudia Andrea Cruz, Judith Swallow, Nadia Saoudi, Eudald Felip, Myria Galazi, Isabel Garcia-Fructuoso, Alvin J X Lee, Thomas Newsom-Davis, Yien Ning Sophia Wong, Anna Sureda, Clara Maluquer, Isabel Ruiz-Camps, Alba Cabirta, Aleix Prat, Angela Loizidou, Alessandra Gennari, Daniela Ferrante, Josep Tabernero, Beth Russell, Mieke Van Hemelrijck, Saoirse Dolly, Nicholas J Hulbert-Williams, David J Pinato,

<h4>Background</h4>Specialist palliative care team (SPCT) involvement has been shown to improve symptom control and end-of-life care for patients with cancer, but little is known as to how these have been impacted by the COVID-19 pandemic. Here, we report SPCT involvement during the first wave of the pandemic and compare outcomes ... Read more >>

Ther Adv Med Oncol (Therapeutic advances in medical oncology)
[2021, 13:17588359211042224]

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Plasma Pharmacokinetics of High-Dose Oral versus Intravenous Rifampicin in Patients with Tuberculous Meningitis: a Randomized Controlled Trial.

Sean Wasserman, Angharad Davis, Cari Stek, Maxwell Chirehwa, Stephani Botha, Remy Daroowala, Marise Bremer, Mpumi Maxebengula, Sonya Koekemoer, Rene Goliath, Amanda Jackson, Thomas Crede, Jonathan Naude, Patryk Szymanski, Yakoob Vallie, Muhammed S Moosa, Lubbe Wiesner, John Black, Graeme Meintjes, Gary Maartens, Robert J Wilkinson,

Higher doses of intravenous rifampicin may improve outcomes in tuberculous meningitis but are impractical in high-burden settings. We hypothesized that plasma rifampicin exposures would be similar between oral dosing of 35 mg/kg of body weight and intravenous dosing of 20 mg/kg, which has been proposed for efficacy trials in tuberculous meningitis. We ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2021, 65(8):e0014021]

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Virologic efficacy of tenofovir, lamivudine and dolutegravir as second-line antiretroviral therapy in adults failing a tenofovir-based first-line regimen.

Claire M Keene, Rulan Griesel, Ying Zhao, Zimasa Gcwabe, Kaneez Sayed, Andrew Hill, Tali Cassidy, Olina Ngwenya, Amanda Jackson, Gert van Zyl, Charlotte Schutz, Rene Goliath, Tracy Flowers, Eric Goemaere, Lubbe Wiesner, Bryony Simmons, Gary Maartens, Graeme Meintjes,

<h4>Objective</h4>Recycling tenofovir and lamivudine/emtricitabine (XTC) with dolutegravir would provide a more tolerable, affordable, and scalable second-line regimen than dolutegravir with an optimized nucleoside reverse transcriptase inhibitor (NRTI) backbone. We evaluated efficacy of tenofovir/lamivudine/dolutegravir (TLD) in patients failing first-line tenofovir/XTC/efavirenz or nevirapine.<h4>Design</h4>Single arm, prospective, interventional study.<h4>Setting</h4>Two primary care clinics in Khayelitsha, ... Read more >>

AIDS (AIDS (London, England))
[2021, 35(9):1423-1432]

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Study protocol for a phase 2A trial of the safety and tolerability of increased dose rifampicin and adjunctive linezolid, with or without aspirin, for HIV-associated tuberculous meningitis [LASER-TBM].

Angharad G Davis, Sean Wasserman, Mpumi Maxebengula, Cari Stek, Marise Bremer, Remy Daroowala, Saalikha Aziz, Rene Goliath, Stephani Stegmann, Sonya Koekemoer, Amanda Jackson, Louise Lai Sai, Yakub Kadernani, Thandi Sihoyiya, C Jason Liang, Lori Dodd, Paolo Denti, Thomas Crede, Jonathan Naude, Patryk Szymanski, Yakoob Vallie, Ismail Banderker, Shiraz Moosa, Peter Raubenheimer, Rachel P J Lai, John Joska, Sam Nightingale, Anna Dreyer, Gerda Wahl, Curtis Offiah, Isak Vorster, Sally Candy, Frances Robertson, Ernesta Meintjes, Gary Maartens, John Black, Graeme Meintjes, Robert J Wilkinson,

<b>Background:</b> Tuberculous meningitis (TBM) is the most lethal form of tuberculosis with a mortality of ~50% in those co-infected with HIV-1. Current antibiotic regimens are based on those known to be effective in pulmonary TB and do not account for the differing ability of the drugs to penetrate the central ... Read more >>

Wellcome Open Res (Wellcome open research)
[2021, 6:136]

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Study protocol for a phase 2A trial of the safety and tolerability of increased dose rifampicin and adjunctive linezolid, with or without aspirin, for HIV-associated tuberculous meningitis [LASER-TBM]

Angharad Davis, Sean Wasserman, Mpumi Maxebengula, Cari Stek, Marise Bremer, Remy Daroowala, Saalikha Aziz, Rene Goliath, Stephani Stegmann, Sonya Koekemoer, Amanda Jackson, Louise Lai Sai, Yakub Kadernani, Thandi Sihoyiya, C.Jason Liang, Lori Dodd, Paolo Denti, Thomas Crede, Jonathan Naude, Patryk Szymanski, Yakoob Vallie, Ismail Banderker, Shiraz Moosa, Peter Raubenheimer, Rachel P.J. Lai, John Joska, Sam Nightingale, Anna Dreyer, Gerda Wahl, Curtis Offiah, Isak Vorster, Sally Candy, Frances Robertson, Ernesta Meintjes, Gary Maartens, John Black, Graeme Meintjes, Robert Wilkinson,

<ns3:p> <h4>Background: </h4> Tuberculous meningitis (TBM) is the most lethal form of tuberculosis with a mortality of ~50% in those co-infected with HIV-1. Current antibiotic regimens are based on those known to be effective in pulmonary TB and do not account for the differing ability of the drugs to penetrate ... Read more >>

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Whole blood-based measurement of SARS-CoV-2-specific T cell responses reveals asymptomatic infection and vaccine efficacy in healthy subjects and patients with solid organ cancers

Martin Scurr, Wioleta Zelek, George Lippiatt, Michelle Somerville, Stephanie Burnell, Lorenzo Capitani, Kate Davies, Helen Lawton, Thomas Tozer, Tara Rees, Kerry Roberts, Mererid Evans, Amanda Jackson, Charlotte Young, Lucy Fairclough, Mark Wills, Andrew Westwell, Paul Morgan, Awen Gallimore, Andrew Godkin,

Accurate assessment of SARS-CoV-2 immunity in the population is critical to evaluating vaccine efficacy and devising public health policies. Whilst the exact nature of effective immunity remains incompletely defined, SARS-CoV-2-specific T cell responses are a critical feature of the immune response that will likely form a key correlate of protection ... Read more >>

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A case of placenta previa with increta with a history of pelvic radiation.

Amanda Baucom, Thomas Herzog, Amanda Jackson, Shaun A Wahab, Caroline Billingsley,

<h4>Background</h4>Prior pelvic radiation increases risks of pregnancy complications that can be life threatening. No documented pregnancy has successfully occurred with pelvic radiation dosing of >45 Gy. This case report describes a successful conception after receiving 54 Gy with subsequent severe pregnancy complications.Case34 yo G4P2012 with a history of pelvic radiation who presented ... Read more >>

Gynecol Oncol Rep (Gynecologic oncology reports)
[2021, 37:100800]

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Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial.

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<h4>Background</h4>Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19.<h4>Methods</h4>This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised ... Read more >>

Lancet (Lancet (London, England))
[2021, 397(10289):2049-2059]

Cited: 27 times

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Communicable and non-communicable co-morbidities and the presentation of COVID-19 in an African setting of high HIV-1 and tuberculosis prevalence

Elsa du Bruyn, Cari Stek, Remi Daroowala, Qonita Said-Hartley, Marvin Hsiao, Rene Goliath, Fatima Abrahams, Amanda Jackson, Sean Wasserman, Brian Allwood, Angharad Davis, Rachel P-J. Lai, Anna Coussens, Katalin Wilkinson, Jantina de Vries, Nicki Tiffin, Maddalena Cerrone, Ntobeko Ntusi, Catherine Riou, Robert Wilkinson, Saalikha Aziz, Nonzwakazi Bangani, John Black, Marise Bremer, Wendy Burgers, Zandile Ciko, Hanif Esmail, Siamon Gordon, Yolande Harley, Francisco Lakay, Fernando-Oneissi Martinez-Estrada, Graeme Meintjes, Marc Mendelson, Tari Papavarnavas, Alize Proust, Sheena Ruzive, Georgia Schafer, Keboile Serole, Claire Whitaker, Kennedy Zvinairo,

<h4>Objectives</h4> To describe the presentation and outcome of SARS-CoV2 infection in an African setting of high non-communicable co-morbidity and also HIV-1 and tuberculosis prevalence. <h4>Design</h4> Case control analysis with cases stratified by HIV-1 and tuberculosis status. <h4>Setting</h4> A single-centre observational case-control study of adults admitted to a South African hospital ... Read more >>

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Efficacy and safety of tisotumab vedotin in previously treated recurrent or metastatic cervical cancer (innovaTV 204/GOG-3023/ENGOT-cx6): a multicentre, open-label, single-arm, phase 2 study.

Robert L Coleman, Domenica Lorusso, Christine Gennigens, Antonio González-Martín, Leslie Randall, David Cibula, Bente Lund, Linn Woelber, Sandro Pignata, Frederic Forget, Andrés Redondo, Signe Diness Vindeløv, Menghui Chen, Jeffrey R Harris, Margaret Smith, Leonardo Viana Nicacio, Melinda S L Teng, Annouschka Laenen, Reshma Rangwala, Luis Manso, Mansoor Mirza, Bradley J Monk, Ignace Vergote, ,

<h4>Background</h4>Few effective second-line treatments exist for women with recurrent or metastatic cervical cancer. Accordingly, we aimed to evaluate the efficacy and safety of tisotumab vedotin, a tissue factor-directed antibody-drug conjugate, in this patient population.<h4>Methods</h4>This multicentre, open-label, single-arm, phase 2 study was done across 35 academic centres, hospitals, and community practices ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2021, 22(5):609-619]

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Aspirin Use Is Associated With Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients With Coronavirus Disease 2019.

Jonathan H Chow, Ashish K Khanna, Shravan Kethireddy, David Yamane, Andrea Levine, Amanda M Jackson, Michael T McCurdy, Ali Tabatabai, Gagan Kumar, Paul Park, Ivy Benjenk, Jay Menaker, Nayab Ahmed, Evan Glidewell, Elizabeth Presutto, Shannon Cain, Naeha Haridasa, Wesley Field, Jacob G Fowler, Duy Trinh, Kathleen N Johnson, Aman Kaur, Amanda Lee, Kyle Sebastian, Allison Ulrich, Salvador Peña, Ross Carpenter, Shruti Sudhakar, Pushpinder Uppal, Benjamin T Fedeles, Aaron Sachs, Layth Dahbour, William Teeter, Kenichi Tanaka, Samuel M Galvagno, Daniel L Herr, Thomas M Scalea, Michael A Mazzeffi,

<h4>Background</h4>Coronavirus disease-2019 (COVID-19) is associated with hypercoagulability and increased thrombotic risk in critically ill patients. To our knowledge, no studies have evaluated whether aspirin use is associated with reduced risk of mechanical ventilation, intensive care unit (ICU) admission, and in-hospital mortality.<h4>Methods</h4>A retrospective, observational cohort study of adult patients admitted with ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 132(4):930-941]

Cited: 66 times

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Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

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<h4>Background</h4>In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation.<h4>Methods</h4>This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those ... Read more >>

Lancet (Lancet (London, England))
[2021, 397(10285):1637-1645]

Cited: 107 times

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TBDBT: A TB DataBase Template for collection of harmonized TB clinical research data in REDCap, facilitating data standardisation for inter-study comparison and meta-analyses.

Taryn Allie, Amanda Jackson, Jon Ambler, Katherine Johnston, Elsa Du Bruyn, Charlotte Schultz, Linda Boloko, Sean Wasserman, Angharad Davis, Graeme Meintjes, Robert J Wilkinson, Nicki Tiffin,

Clinical tuberculosis research, both within research groups and across research ecosystems, is often undertaken in isolation using bespoke data collection platforms and applying differing data conventions. This failure to harmonise clinical phenotype data or apply standardised data collection and storage standards in turn limits the opportunity to undertake meta-analyses using ... Read more >>

PLoS One (PloS one)
[2021, 16(3):e0249165]

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The role of blinded independent radiologic review in ovarian cancer clinical trials: Discerning the value.

Amy Loreen, Clarissa Polen-De, Bradley J Monk, Amanda L Jackson, Caroline C Billingsley, Thomas J Herzog,

Gynecol Oncol (Gynecologic oncology)
[2021, 161(2):491-495]

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Clinical Outcomes of Pregnant and Postpartum Extracorporeal Membrane Oxygenation Patients.

Allison S Lankford, Jonathan H Chow, Amanda M Jackson, Marianne Wallis, Samuel M Galvagno, Andrew M Malinow, Ozhan M Turan, Jay A Menaker, Sarah D Crimmins, Raymond Rector, David Kaczorowski, Bartley Griffith, Zachary Kon, Daniel Herr, Michael A Mazzeffi,

<h4>Background</h4>The use of extracorporeal membrane oxygenation (ECMO) as a rescue therapy for cardiopulmonary failure is expanding in critical care medicine. In this case series, we describe the clinical outcomes of 21 consecutive pregnant or postpartum patients that required venovenous (VV) or venoarterial (VA) ECMO. Our objective was to characterize maternal ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 132(3):777-787]

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AntiRetroviral Therapy In Second-line: investigating Tenofovir-lamivudine-dolutegravir (ARTIST): protocol for a randomised controlled trial

Ying Zhao, Claire Keene, Rulan Griesel, Kaneez Sayed, Zimasa Gcwabe, Amanda Jackson, Olina Ngwenya, Charlotte Schutz, Rene Goliath, Tali Cassidy, Eric Goemaere, Andrew Hill, Gary Maartens, Graeme Meintjes,

Background: Dolutegravir has superior efficacy and tolerability than lopinavir-ritonavir in second-line antiretroviral therapy after failure of a first-line non-nucleoside reverse transcriptase inhibitors-based regimen, when dolutegravir is accompanied by at least one fully active nucleoside reverse transcriptase inhibitor (NRTI). Resistance testing to select NRTIs is not feasible in low- and middle-income ... Read more >>

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Systemic pro-inflammatory response identifies patients with cancer with adverse outcomes from SARS-CoV-2 infection: the OnCovid Inflammatory Score.

Gino M Dettorre, Saoirse Dolly, Angela Loizidou, John Chester, Amanda Jackson, Uma Mukherjee, Alberto Zambelli, Juan Aguilar-Company, Mark Bower, Christopher C T Sng, Ramon Salazar, Alexia Bertuzzi, Joan Brunet, Ricard Mesia, Ailsa Sita-Lumsden, Elia Seguí, Federica Biello, Daniele Generali, Salvatore Grisanti, Pavetha Seeva, Gianpiero Rizzo, Michela Libertini, Antonio Maconi, Charlotte Moss, Beth Russell, Nadia Harbeck, Bruno Vincenzi, Rossella Bertulli, Diego Ottaviani, Raquel Liñan, Andrea Marrari, M Carmen Carmona-García, Neha Chopra, Carlo Alberto Tondini, Oriol Mirallas, Valeria Tovazzi, Vittoria Fotia, Claudia Andrea Cruz, Nadia Saoudi-Gonzalez, Eudald Felip, Ariadna Roqué, Alvin J X Lee, Tom Newsom-Davis, David García-Illescas, Roxana Reyes, Yien Ning Sophia Wong, Daniela Ferrante, Lorenza Scotti, Javier Marco-Hernández, Isabel Ruiz-Camps, Andrea Patriarca, Lorenza Rimassa, Lorenzo Chiudinelli, Michela Franchi, Armando Santoro, Aleix Prat, Alessandra Gennari, Mieke Van Hemelrijck, Josep Tabernero, Nikolaos Diamantis, David J Pinato, ,

<h4>Background</h4>Patients with cancer are particularly susceptible to SARS-CoV-2 infection. The systemic inflammatory response is a pathogenic mechanism shared by cancer progression and COVID-19. We investigated systemic inflammation as a driver of severity and mortality from COVID-19, evaluating the prognostic role of commonly used inflammatory indices in SARS-CoV-2-infected patients with cancer ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2021, 9(3):]

Cited: 1 time

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Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

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<h4>Background</h4>Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.<h4>Methods</h4>In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), several possible treatments were ... Read more >>

Lancet (Lancet (London, England))
[2021, 397(10274):605-612]

Cited: 35 times

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Plasma pharmacokinetics of high dose oral versus intravenous rifampicin in patients with tuberculous meningitis: a randomized controlled trial

Sean Wasserman, Angharad Davis, Cari Stek, Maxwell Chirehwa, Stephani Botha, Remy Daroowala, Marise Bremer, Mpumi Maxebengula, Sonya Koekemoer, Rene Goliath, Amanda Jackson, Thomas Crede, Jonathan Naude, Patryk Szymanski, Yakoob Vallie, Muhammed Moosa, Lubbe Wiesner, John Black, Graeme Meintjes, Gary Maartens, Robert Wilkinson,

<h4>ABSTRACT</h4> <h4>Background</h4> Higher doses of intravenous rifampicin may improve outcomes in tuberculous meningitis but is impractical in high burden settings. We hypothesized that plasma rifampicin exposures would be similar between oral 35 mg/kg and intravenous 20 mg/kg, which has been proposed for efficacy trials in tuberculous meningitis. <h4>Materials and methods</h4> ... Read more >>

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Mutated p53 portends improvement in outcomes when bevacizumab is combined with chemotherapy in advanced/recurrent endometrial cancer: An NRG Oncology study.

Kimberly K Leslie, Virginia L Filiaci, Adrianne R Mallen, Kristina W Thiel, Eric J Devor, Katherine Moxley, Debra Richardson, David Mutch, Angeles Alvarez Secord, Krishnansu S Tewari, Megan E McDonald, Cara Mathews, Casey Cosgrove, Summer Dewdney, Yovanni Casablanca, Amanda Jackson, Peter G Rose, XunClare Zhou, Michael McHale, Heather Lankes, Douglas A Levine, Carol Aghajanian,

<h4>Background</h4>Successfully combining targeted agents with chemotherapy is an important future goal for cancer therapy. However, an improvement in patient outcomes requires an enhanced understanding of the tumor biomarkers that predict for drug sensitivity. NRG Oncology/Gynecologic Oncology Group (GOG) Study GOG-86P was one of the first attempts to combine targeted agents ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, 161(1):113-121]

Cited: 4 times

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Peptide Ancestry Informative Markers in Uterine Neoplasms from Women of European, African and Asian Ancestry

Nicholas Bateman, Christopher Tarney, Tamara Abulez, Brian Hood, Kelly Conrads, Ming Zhou, Anthony Soltis, Pang-ing Teng, Amanda Jackson, Chunqiao Tian, Clifton Dalgard, Matthew Wilkerson, Michael Kessler, Zachary Goecker, Jeremy Loffredo, Craig Shriver, Hai Hu, Michele Cote, Glendon Parker, James Segars, Ayman Al-Hendy, John Risinger, Kathleen Darcy, Yovanni Casablanca, Larry Maxwell, Thomas Conrads, Timothy O’Connor,

Characterization of ancestry-linked peptide variants in disease-relevant patient tissues represents a foundational step to connect patient ancestry with molecular disease pathogenesis. Nonsynonymous single nucleotide polymorphisms (SNPs) encoding missense substitutions within tryptic peptides exhibiting high allele frequencies in European, African, and East Asian populations, termed peptide ancestry informative markers (pAIMs), were ... Read more >>

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Creation and Evaluation of a Cesarean Section Simulator Training Program for Novice Obstetric Surgeons.

Lisa M Foglia, Allison A Eubanks, Logan C Peterson, Kimberly Hickey, Crystal B Hammons, Lindsey B Borgia, Morgan R Light, Amanda Jackson, Shad Deering,

<h4>Background</h4>We evaluated a novel simulation-based cesarean section training program to teach critical techniques for cesarean section and hemorrhage management.  Methods: This was a prospective educational intervention. After Institutional Review Board approval, we recruited Obstetrics and Gynecology, Family Medicine, and General Surgery residents at three hospitals. All participants received didactic education. Participants ... Read more >>

Cureus (Cureus)
[2020, 12(9):e10324]

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Cervical Stratified Mucin-Producing Intraepithelial Lesion: A Systematic Review of Diagnosis and Management.

Jennifer L Wolf, Caroline C Billingsley, Ady Kendler, Amanda L Jackson,

<h4>Objectives</h4>The aims of the study were to synthesize reported associations of stratified mucin-producing intraepithelial lesion (SMILE) of the cervix with other dysplasia lesions and immunohistochemical (IHC) stains, compare expected patterns of IHC staining to other lesions in the differential diagnosis, and assess follow-up pathology.<h4>Methods</h4>This systematic review includes all case reports ... Read more >>

J Low Genit Tract Dis (Journal of lower genital tract disease)
[2020, 24(3):259-264]

Cited: 1 time

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Adjuvant treatment improves overall survival in women with high-intermediate risk early-stage endometrial cancer with lymphovascular space invasion.

Ji Son, Laura M Chambers, Caitlin Carr, Chad M Michener, Meng Yao, Anna Beavis, Ting-Tai Yen, Rebecca L Stone, Stephanie L Wethington, Amanda N Fader, Wesley C Burkett, Debra L Richardson, Allison S Staley, Susie Ahn, Paola A Gehrig, Diogo Torres, Sean C Dowdy, Mackenzie W Sullivan, Susan C Modesitt, Catherine Watson, Ashley Veade, Jessie Ehrisman, Laura Havrilesky, Angeles Alvarez Secord, Amy Loreen, Kaitlyn Griffin, Amanda Jackson, Akila Viswanathan, Stephanie Ricci,

<h4>Background</h4>Adjuvant therapy in early-stage endometrial cancer has not shown a clear overall survival benefit, and hence, patient selection remains crucial.<h4>Objective</h4>To determine whether women with high-intermediate risk, early-stage endometrial cancer with lymphovascular space invasion particularly benefit from adjuvant treatment in improving oncologic outcomes.<h4>Methods</h4>A multi-center retrospective study was conducted in women with ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(11):1738-1747]

Cited: 0 times

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