Full Text Journal Articles by
Author Alyssa Lebel

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From One Pain to Many: The Emergence of Overlapping Pains in Children and Adolescents.

Deirdre E Logan, Carolina Donado, Karen Kaczynski, Alyssa Lebel, Neil Schechter,

<h4>Objectives</h4>The objective of this study was to compare children and adolescents with overlapping chronic pains (OCP) to those with single chronic pains (SCP) among youth presenting in specialized clinical settings, in an effort to identify potential risk factors for developing overlapping pains.<h4>Methods</h4>A total of 1235 youth ages 8 to 18 ... Read more >>

Clin J Pain (The Clinical journal of pain)
[2021, 37(6):404-412]

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Left to themselves: Time to target chronic pain in childhood rare diseases.

Christine B Sieberg, Alyssa Lebel, Erin Silliman, Scott Holmes, David Borsook, Igor Elman,

<h4>Background</h4>Chronic pain is prevalent among patients with rare diseases (RDs). However, little is understood about how biopsychosocial mechanisms may be integrated in the unique set of clinical features and therapeutic challenges inherent in their pain conditions.<h4>Methods</h4>This review presents examples of major categories of RDs with particular pain conditions. In addition, ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2021, 126:276-288]

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Pediatric Episodic Migraine with Aura: A Unique Entity?

Hannah F J Shapiro, Alyssa Lebel,

Migraine headache is a common cause of pain and disability in children and adolescents and is a major contributor to frequently missed school days and limitations in activities. Of children and adolescents with migraine headache, approximately one-third have migraine with aura (MA). MA is often considered to be similar to ... Read more >>

Children (Basel) (Children (Basel, Switzerland))
[2021, 8(3):]

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Altered Brain Network Connectivity Underlies Persistent Post-Traumatic Headache following Mild Traumatic Brain Injury in Youth.

Jordan Lemme, Scott Holmes, Diana Sibai, Joud Mari, Laura E Simons, Rami Burstein, David Zurakowski, Alyssa Lebel, Michael O'Brien, Jaymin Upadhyay, David Borsook,

Post-traumatic headaches (PTHs) are associated with mild traumatic brain injuries (mTBI) and may predict the persistence of concussion symptoms. Altered brain networks implicated in brain injury and the affective components of headache-related pain may underlie the resolution of PTH. This is a hypothesis-generating investigation to evaluate the extent to which ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, 38(12):1632-1641]

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Pain stickiness in pediatric complex regional pain syndrome: A role for the nucleus accumbens.

Andrew M Youssef, Ke Peng, Pearl Kijoo Kim, Alyssa Lebel, Navil F Sethna, Corey Kronman, David Zurakowski, David Borsook, Laura E Simons,

Some individuals with chronic pain experience improvement in their pain with treatment, whereas others do not. The neurobiological reason is unclear, but an understanding of brain structure and functional patterns may provide insights into pain's responsivity to treatment. In this investigation, we used magnetic resonance imaging (MRI) techniques to determine ... Read more >>

Neurobiol Pain (Neurobiology of pain (Cambridge, Mass.))
[2021, 9:100062]

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Pain Stickiness in Complex Regional Pain Syndrome: A role for the Nucleus Accumbens

Andrew Youssef, Ke Peng, Pearl Kijoo Kim, Alyssa Lebel, Navil Sethna, Corey Kronman, David Zurakowski, David Borsook, Laura Simons,

Some individuals with chronic pain experience improvement in their pain with treatment, whereas others do not. The neurobiological reason is unclear, but an understanding of brain structure and functional patterns may provide insights into pain’s responsivity to treatment. In this investigation, we used magnetic resonance imaging (MRI) techniques to determine ... Read more >>

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Parenting, self-regulation, and treatment adherence in pediatric chronic headache: A self-determination theory perspective.

Alessandra Caruso, Wendy Grolnick, Jonathan Rabner, Alyssa Lebel,

This study examined parenting factors associated with children's self-regulation and physician-rated treatment adherence using a self-determination theory framework in pediatric chronic headache. Participants were 58 children and adolescents (aged 10-17 years), who underwent initial and follow-up multidisciplinary evaluation at a headache clinic, and their mothers. Regression analyses showed that higher maternal ... Read more >>

J Health Psychol (Journal of health psychology)
[2021, 26(10):1637-1650]

Cited: 1 time

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The Impact of Sleep on Disability and School Functioning: Results From a Tertiary Pediatric Headache Center.

Michelle A Clementi, Yu-Hsing Chang, Rupa Gambhir, Alyssa Lebel, Deirdre E Logan,

Pediatric headache patients often experience significant sleep disturbance, which may be a risk factor for poor physical, academic, and emotional functioning, including increased anxiety/fear. The current retrospective cohort study of a clinical sample of youth with persistent headache aimed to examine the impact of sleep on functional outcomes and to ... Read more >>

J Child Neurol (Journal of child neurology)
[2020, 35(3):221-227]

Cited: 1 time

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Pediatric Headache and Sleep Disturbance: A Comparison of Diagnostic Groups - A Response.

Karen Kaczynski, Jonathan Rabner, Mikayla Farrell, Victoria Karian, Cindy Chang, Alyssa Lebel,

Headache (Headache)
[2019, 59(8):1387-1388]

Cited: 0 times

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Shifting brain circuits in pain chronicity.

Andrew M Youssef, Monica Azqueta-Gavaldon, Katie E Silva, Nadia Barakat, Natalia Lopez, Farah Mahmud, Alyssa Lebel, Navil F Sethna, David Zurakowski, Laura E Simons, Eduard Kraft, David Borsook,

The evaluation of brain changes to a specific pain condition in pediatric and adult patients allows for insights into potential mechanisms of pain chronicity and possibly long-term brain changes. Here we focused on the primary somatosensory system (SS) involved in pain processing, namely the ventroposterolateral thalamus (VPL) and the primary ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2019, 40(15):4381-4396]

Cited: 2 times

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Migraine in the Young Brain: Adolescents vs. Young Adults.

Elisabeth Colon, Allison Ludwick, Sophie L Wilcox, Andrew M Youssef, Amy Danehy, Damien A Fair, Alyssa A Lebel, Rami Burstein, Lino Becerra, David Borsook,

Migraine is a disease that peaks in late adolescence and early adulthood. The aim of this study was to evaluate age-related brain changes in resting state functional connectivity (rs-FC) in migraineurs vs. age-sex matched healthy controls at two developmental stages: adolescence vs. young adulthood. The effect of the disease was ... Read more >>

Front Hum Neurosci (Frontiers in human neuroscience)
[2019, 13:87]

Cited: 4 times

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Predictors of Primary Intracranial Hypertension in Children Using a Newly Suggested Opening Pressure Cutoff of 280 mm H2O.

Atima C Delaney, Aynslee Velarde, Marvin B Harper, Alyssa Lebel, Assaf Landschaft, Michael Monuteaux, Gena Heidary, Amir A Kimia,

OBJECTIVES:We assessed the clinical characteristics of primary intracranial hypertension (PIH) in children using a newly recommended threshold for cerebrospinal fluid opening pressure (280 mm H2O). METHOD:Cross-sectional study of patients age ≤21 years who had a lumbar puncture done for evaluation of PIH. Patients were excluded if lumbar puncture was done ... Read more >>

Pediatr Neurol (Pediatric neurology)
[2019, 91:27-33]

Cited: 0 times

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Design and Reporting Characteristics of Clinical Trials of Select Chronic and Recurrent Pediatric Pain Conditions: An Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks Systematic Review.

Marina R Connolly, Jenna Y Chaudari, Ximeng Yang, Nam Ward, Rachel A Kitt, Rachel S Herrmann, Elliot J Krane, Alyssa A LeBel, Shannon M Smith, Gary A Walco, Steven J Weisman, Dennis C Turk, Robert H Dworkin, Jennifer S Gewandter,

Fewer randomized clinical trials (RCTs) are conducted for chronic or recurrent pain in pediatric populations compared with adult populations; thus, data to support treatment efficacy in children are limited. This article evaluates the design features and reporting practices of RCTs for chronic and recurrent pain that are likely unique to, ... Read more >>

J Pain (The journal of pain)
[2019, 20(4):394-404]

Cited: 1 time

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Differences in Pediatric Headache Prescription Patterns by Diagnosis.

Jonathan Rabner, Allison Ludwick, Alyssa LeBel,

<h4>Background</h4>Few studies have reported prescription patterns for headache medication.<h4>Objective</h4>The aim was to present the rates of specific medication prescribed to pediatric patients diagnosed with migraine, tension-type headache (TTH), and new daily persistent headache (NDPH), as well as differences in those prescription patterns by diagnosis, age, and gender.<h4>Patients and methods</h4>A query ... Read more >>

Paediatr Drugs (Paediatric drugs)
[2018, 20(3):273-284]

Cited: 1 time

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Rapid Screening of Risk in Pediatric Headache: Application of the Pediatric Pain Screening Tool.

Lauren C Heathcote, Jonathan Rabner, Alyssa Lebel, Jessica M Hernandez, Laura E Simons,

<h4>Objective</h4>The current study examined the application of a screening tool to identify biopsychosocial risk factors and derive prognostic risk groups in children and adolescents with headache pain.<h4>Methods</h4>Youth (n = 242, 8-17 years, 75.6% female) presenting for evaluation at a tertiary pediatric headache clinic completed the nine-item Pediatric Pain Screening Tool (PPST) ... Read more >>

J Pediatr Psychol (Journal of pediatric psychology)
[2018, 43(3):243-251]

Cited: 6 times

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Pediatric Headache and Sleep Disturbance: A Comparison of Diagnostic Groups.

Jonathan Rabner, Karen J Kaczynski, Laura E Simons, Alyssa LeBel,

OBJECTIVE:To examine whether sleep disturbance differs by headache diagnosis in a pediatric sample, and whether this effect remains when other factors affecting sleep are included. BACKGROUND:Primary headache disorders can be severe and disabling, impacting a child's functioning and quality of life. Many children and adolescents with chronic headaches also experience ... Read more >>

Headache (Headache)
[2018, 58(2):217-228]

Cited: 7 times

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Age- and sex-related differences in the presentation of paediatric migraine: A retrospective cohort study.

Sophie Louise Wilcox, Allison Marra Ludwick, Alyssa Lebel, David Borsook,

Introduction Although migraine is a common headache complaint in children and adolescents there remains a significant gap in understanding the unique aspects of the disease in these age groups and their evolution with development. The aim of this retrospective cohort study was to identify migraine features that are influenced by ... Read more >>

Cephalalgia (Cephalalgia : an international journal of headache)
[2018, 38(6):1107-1118]

Cited: 4 times

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The Sleep Hygiene Inventory for Pediatrics: Development and Validation of a New Measure of Sleep in a Sample of Children and Adolescents With Chronic Headache.

Jonathan Rabner, Karen J Kaczynski, Laura E Simons, Alyssa A Lebel,

Sleep plays a pivotal role in children and adolescents with headache. Although several sleep measures exist, no developed measures target the sleep issues common in pediatric patients with headache. The Sleep Hygiene Inventory for Pediatrics (SHIP) was developed for clinical purposes to fulfill this need. The aim of this study ... Read more >>

J Child Neurol (Journal of child neurology)
[2017, 32(13):1040-1046]

Cited: 3 times

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In child and adult migraineurs the somatosensory cortex stands out … again: An arterial spin labeling investigation.

Andrew M Youssef, Allison Ludwick, Sophie L Wilcox, Alyssa Lebel, Ke Peng, Elisabeth Colon, Amy Danehy, Rami Burstein, Lino Becerra, David Borsook,

Over the past decade, human brain imaging investigations have reported altered regional cerebral blood flow (rCBF) in the interictal phase of migraine. However, there have been conflicting findings across different investigations, making the use of perfusion imaging in migraine pathophysiology more difficult to define. These inconsistencies may reflect technical constraints ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2017, 38(8):4078-4087]

Cited: 11 times

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Autonomic dysfunction in pediatric patients with headache: migraine versus tension-type headache.

Jonathan Rabner, Alessandra Caruso, David Zurakowski, Lori Lazdowsky, Alyssa LeBel,

<h4>Purpose</h4>To examine symptoms indicating central nervous system (CNS) autonomic dysfunction in pediatric patients with migraine and tension-type headache.<h4>Methods</h4>A retrospective chart review assessed six symptoms (i.e. constipation, insomnia, dizziness, blurry vision, abnormal blood pressure, and cold and clammy palms and soles) indicating central nervous system (CNS) autonomic dysfunction in 231 patients, ... Read more >>

Clin Auton Res (Clinical autonomic research : official journal of the Clinical Autonomic Research Society)
[2016, 26(6):455-459]

Cited: 2 times

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Cerebral Proliferative Angiopathy.

Victoria Karian, Jonathan Rabner, Alyssa LeBel,

Pediatr Neurol (Pediatric neurology)
[2017, 66:115-116]

Cited: 0 times

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Parental Attitudes About Placebo Use in Children.

Vanda Faria, Joe Kossowsky, Mike P Petkov, Ted J Kaptchuk, Irving Kirsch, Alyssa Lebel, David Borsook,

<h4>Objective</h4>To assess parental attitudes regarding placebo use in pediatric randomized controlled trials and clinical care.<h4>Study design</h4>Parents with children under age 18 years living in the US completed and submitted an online survey between September and November 2014.<h4>Results</h4>Among all 1300 participants, 1000 (76.9%; 538 mothers and 462 fathers) met the study ... Read more >>

J Pediatr (The Journal of pediatrics)
[2017, 181:272-278.e10]

Cited: 10 times

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"Headache Tools to Stay in School": Assessment, Development, and Implementation of an Educational Guide for School Nurses.

Lori Lazdowsky, Jonathan Rabner, Alessandra Caruso, Karen Kaczynski, Sarah Gottlieb, Elyse Mahoney, Alyssa LeBel,

<h4>Background</h4>Headache is the most common type of pain reported in the pediatric population, and chronic headache is an increasingly prevalent and debilitating pain condition in children and adolescents. With large numbers of students experiencing acute headaches and more students with chronic headache reentering typical school settings, greater availability of tailored ... Read more >>

J Sch Health (The Journal of school health)
[2016, 86(9):645-652]

Cited: 1 time

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Psychosis following traumatic brain injury and cannabis use in late adolescence.

Jonathan Rabner, Sarah Gottlieb, Lori Lazdowsky, Alyssa LeBel,

<h4>Background</h4>Both cannabis and traumatic brain injury (TBI) pose risks on the developing brain, including a potential increased vulnerability for developing psychosis. Recent reports detail an upward trend in both adolescent cannabis use and the concentration of THC, the most potent psychoactive component in cannabis. Similarly, it is estimated that 1.7 ... Read more >>

Am J Addict (The American journal on addictions)
[2016, 25(2):91-93]

Cited: 5 times

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The migraine brain in transition: girls vs boys.

Vanda Faria, Nathalie Erpelding, Alyssa Lebel, Adriana Johnson, Robert Wolff, Damien Fair, Rami Burstein, Lino Becerra, David Borsook,

The prevalence of migraine has an exponential trajectory that is most obvious in young females between puberty and early adulthood. Adult females are affected twice as much as males. During development, hormonal changes may act on predetermined brain circuits, increasing the probability of migraine. However, little is known about the ... Read more >>

Pain (Pain)
[2015, 156(11):2212-2221]

Cited: 25 times

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