Full Text Journal Articles by
Author Alp Usubutun

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Recurrent mucinous neoplasm arising in cesarean scar: A case report and review of literature.

Fatma Gundogdu, Nazlı Orhan, Nejat Ozgul, Alp Usubutun,

Ovarian mucinous tumors are one of the common epithelial tumors in the ovary, but their recurrence is extremely rare. In a 37-year-old female patient who had had five operations in 7 years due to recurrent mucinous neoplasms, a mass extending to the umbilicus was recently detected during a routine examination. With ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, :]

Cited: 0 times

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Relationship of lymph node status with survival and recurrence among women with endometrial cancer.

Osman Cagin Buldukoglu, Alev Turker, Alp Usubutun, Mehmet Coskun Salman,

<h4>Objective</h4>To explore the relationship of lymph node ratio (LNR) and other lymph node parameters with disease-free (DFS) and overall (OS) survival among women with endometrial cancer.<h4>Methods</h4>Retrospective analysis of data of women diagnosed with endometrial cancer at Hacettepe University Hospitals, Ankara, Turkey, between 2003 and 2013. Women who had their surgical ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2020, 151(2):267-271]

Cited: 4 times

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The evaluation of laparotomy results in breast cancer patients with gynecological pathologies.

Nihal Şahin Uysal, Gökhan Boyraz, Alp Usubütün, Zafer S Tuncer,

<h4>Aim</h4>The aim of the study was to evaluate the results of the laparotomies due to gynecological pathologies in breast cancer patients and to assess the distribution of gynecological pathologies and the clinical and laboratory findings contributing to the diagnosis.<h4>Methods</h4>This study was conducted between years 2002 and 2011 at Hacettepe University ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2020, 46(10):2126-2133]

Cited: 0 times

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Clinical and histopathological comparative study of two equine-derived bone graft: a human study.

Selen Adiloglu, Calal Bahadir Giray, Ibrahim Kulac, Alp Usubutun, Alper Aktas,

<h4>Objective</h4>To compare the performance of collagenated bone graft substances with different collagen ratios after sinus floor augmentation.<h4>Methods</h4>The cross-sectional study was conducted at Hacettepe University, Ankara, Turkey, from September 2011 to September 2013. Sinus floor augmentation was done with two different equinederived xenografts in patients before dental implant application. Of the ... Read more >>

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2019, 69(11):1617-1622]

Cited: 0 times

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Hyperprolactinaemia associated with giant uterine myoma, description of a case and review of literature.

Suleyman Nahit Sendur, Fatih Aktoz, Alp Usubutun, Zafer Selcuk Tuncer, Tomris Erbas,

J Obstet Gynaecol (Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology)
[2019, 39(7):1034-1036]

Cited: 2 times

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Imaging in secondary tumors of the ovary.

Ali Devrim Karaosmanoglu, Mehmet Ruhi Onur, Mehmet Coskun Salman, Alp Usubutun, Musturay Karcaaltincaba, Mustafa Nasuh Ozmen, Deniz Akata,

Metastatic involvement of the ovaries is not rare. The most common tumor types metastasizing to the ovaries, from non-gynecological organs, are breast, colorectal, gastric, and appendix tumors. Lymphogenous, hematogenous, and transcoelomic pathways have all been proposed among potential pathways. Early diagnosis and treatment have an important potential to improve the ... Read more >>

Abdom Radiol (NY) (Abdominal radiology (New York))
[2019, 44(4):1493-1505]

Cited: 1 time

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How to Handle Lymphadenectomy Specimens to Identify Metastasis More Accurately in Gynecologic Pathology.

Gunsu Kimyon Comert, Nazmiye Dincer, Alp Usubutun,

<h4>Aim</h4>To identify the value of processing multiple sections to detect metastasis in lymph nodes (LNs) dissected during gynecologic cancer surgery, and to evaluate the sizes of metastatic LNs in each region to compare with the largest one.<h4>Materials and methods</h4>This retrospective study included 362 patients who had gynecologic cancer with at ... Read more >>

Int J Surg Pathol (International journal of surgical pathology)
[2019, 27(3):244-250]

Cited: 0 times

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Recurrence rate of odontogenic keratocyst treated by enucleation and peripheral ostectomy: Retrospective case series with up to 12 years of follow-up.

C Karaca, K-A Dere, N Er, A Aktas, E Tosun, O-T Koseoglu, A Usubutun,

<h4>Background</h4>Odontogenic keratocysts have been reported with high recurrence rates in the literature so various treatment modalities from simple enucleation to resection have been performed to achieve the cure. The purpose of this retrospective study was to investigate the recurrence rate of odontogenic keratocysts (OKCs) treated by enucleation and peripheral ostectomy.<h4>Material ... Read more >>

Med Oral Patol Oral Cir Bucal (Medicina oral, patologia oral y cirugia bucal)
[2018, 23(4):e443-e448]

Cited: 3 times

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Differential expression of leukemia inhibitory factor and insulin like growth factor-1 between normal pregnancies, partial hydatidiform moles and complete hydatidiform moles.

Ozge Senem Yucel Cicek, Emine Rumeysa Hekimoglu, Mert Turgal, Pergin Atilla, Ayse Nur Cakar, Alp Usubutun, Mehmet Sinan Beksac,

<h4>Introduction</h4>Leukemia inhibitory factor (LIF) and insulin like growth factor-1 (IGF-1) are two of the most important growth factors mediating trophoblast actions. We hypothesized that the localization and expression patterns of LIF and IGF-1 in partial and complete hydatidiform moles (HM) compared with normal first trimester placentas may provide an understanding ... Read more >>

Placenta (Placenta)
[2018, 69:64-70]

Cited: 1 time

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Comparison of Mayo and Milwaukee Risk Stratification Models for Predicting Lymph Node Metastasis in Endometrial Cancer.

Gokhan Boyraz, Fatma Oz Atalay, Mehmet Coskun Salman, Alp Usubutun, Anil Erturk, Murat Gultekin, Nejat Ozgul, Kunter Yuce,

OBJECTIVE:The aim of this study was to compare Mayo and Milwaukee risk stratification models for predicting lymphatic dissemination in patients with endometrial cancer (EC). METHODS:A total of 904 patients with EC underwent surgical treatment between 2004 and 2016 at Hacettepe University Hospital, and clinicopathological data of patients were retrieved from ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2018, 28(5):869-874]

Cited: 4 times

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The Clinicopathological Study of 21 Cases With Uterine Smooth Muscle Tumors of Uncertain Malignant Potential: Centralized Review Can Purify the Diagnosis.

Derman Basaran, Alp Usubutun, Mehmet Coskun Salman, Mehmet Ali Narin, Gokhan Boyraz, Osman Turkmen, Gunsu Comert Kimyon, Alper Karalok, Dilek Bulbul, Taner Turan, Nejat Ozgul, Kunter Yuce,

OBJECTIVE:The objective of this study was to investigate the clinicopathological features and factors associated with recurrence in patients with uterine smooth muscle tumor of uncertain malignant potential (STUMP). METHODS:Forty-six cases diagnosed between 2000 and 2014 from 2 tertiary centers underwent blind slide review. Initial diagnosis included smooth muscle tumors with ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2018, 28(2):233-240]

Cited: 4 times

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Endocannabinoids modulate apoptosis in endometriosis and adenomyosis.

Elif Bilgic, Elif Guzel, Sevil Kose, Makbule Cisel Aydin, Eda Karaismailoglu, Irem Akar, Alp Usubutun, Petek Korkusuz,

Adenomyosis that is a form of endometriosis is the growth of ectopic endometrial tissue within the muscular wall of the uterus (myometrium), which may cause dysmenorrhea and infertility. Endocannabinoid mediated apoptotic mechanisms of endometriosis and adenomyosis are not known. We hypothesized that the down regulation of endocannabinoid receptors and/or alteration ... Read more >>

Acta Histochem (Acta histochemica)
[2017, 119(5):523-532]

Cited: 5 times

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Sclerosing Stromal Tumor Mimicking a Pregnancy Luteoma: Case Report of a Diagnostically Challenging Entity Further Complicated by the Presence of Metastatic Signet Ring Cell Carcinoma From the Stomach.

Meral Uner, Alp Usubutun,

Sclerosing stromal tumors of the ovary are very rare. We report the case of a 29-year-old pregnant woman who presented with a history of preterm labor and gestational hypertension. A huge mass measuring 30 cm in greatest dimension was recognized on the right ovary during cesarean section. Signet ring cell ... Read more >>

Int J Surg Pathol (International journal of surgical pathology)
[2017, 25(8):739-744]

Cited: 0 times

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HPV types and E6/E7 mRNA expression in cervical samples from Turkish women with abnormal cytology in Ankara, Turkey.

İpek Tüney, Aylin Altay, Koray Ergünay, Sevgen Çelik Önder, Alp Usubütün, Mehmet Coşkun Salman, Gülendam Bozdayi, Erdem Karabulut, Osman Selim Badur, Kunter Yüce, Ahmet Pinar,

<h4>Background/aim</h4>Human papillomaviruses have been established as a risk factor for invasive carcinoma of the uterine cervix. HPV E6/E7 oncogene expression has recently emerged as a promising biomarker to determine the risk for progression to high-grade cervical lesions. The aim of this study was to evaluate HPV mRNA and DNA detection ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2017, 47(1):194-200]

Cited: 1 time

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Diagnostic and Treatment Reproducibility of Cervical Intraepithelial Neoplasia / Squamous Intraepithelial Lesion and Factors Affecting the Diagnosis.

Arzu Sağlam, Alp Usubütün, Anıl Dolgun, George L Mutter, M Coşkun Salman, Olcay Kurtulan, Aytekin Akyol, Eylem Akar Özkan, Sema Baykara, Dilek Bülbül, Zerrin Calay, Funda Eren, Derya Gümürdülü, Nihan Haberal, Şennur Ilvan, Şeyda Karaveli, Meral Koyuncuoğlu, Bahar Müezzinoğlu, Kamil Hakan Müftüoğlu, Özlem Özen, Necmettin Özdemir, Elif Peştereli, Çağnur Ulukuş, Osman Zekioğlu,

<h4>Objective</h4>Inter-observer differences in the diagnosis of HPV related cervical lesions are problematic and response of gynecologists to these diagnostic entities is non-standardized. This study evaluated the diagnostic reproducibility of "cervical intraepithelial neoplasia" (CIN) and "squamous intraepithelial lesion" (SIL) diagnoses.<h4>Material and method</h4>19 pathologists evaluated 66 cases once using H&E slides and ... Read more >>

Turk Patoloji Derg (Turk patoloji dergisi)
[2017, 1(1):177-191]

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What does the Data of 354,725 Patients from Turkey Tell Us About Cervical Smear Epithelial Cell Abnormalities? - The Epithelial Cell Abnormality Rate is Increasing - Quality Control Studies and Corrective Activity are Musts.

İlknur Çetinaslan Türkmen, Alp Usubütün, Aslı Çakir, Özlem Aydin, Filiz Aka Bolat, Metin Akbulut, Serdar Altinay, Sema Arici, Figen Aslan, Müzeyyen Astarci, Emine Kılıç Bağir, Yılmaz Baş, Nuray Başsüllü, Betül Çelik, Handan Çetiner, Bengü Çobanoğlu, Abdullah Aydin, Hale Demir, Hayriye Tatlı Doğan, Kamile Gülçin Eken, Selma Şengiz Erhan, Gülgün Erdoğan, Kıvılcım Eren Erdoğan, Funda Eren, Şafak Ersöz, Pınar Firat, İclal Gürses, Nihan Haberal, Dudu Solakoğlu Kahraman, Gülçin Harman Kamali, Yasemin Yuyucu Karabulut, Mehmet Kefeli, Meral Koyuncuoğlu, R Doğan Köseoğlu, Bahar Müezzinoğlu, Binnur Onal, Sevgen Önder, Zuhal Özcan, Elife Kimiloğlu, Hatice Özer, F Cavide Sönmez, Sevinç Şahin, Nurhan Şahin, Tülin Yalta,

<h4>Objective</h4>There is no other screening program close to the success rate of PAP test. Cervical cytology constitutes a large workload so that quality control in cervical cytology is important for the quality assurance of pathology laboratories.<h4>Material and method</h4>In this study, we collected the cervical cytology results from all over Turkey ... Read more >>

Turk Patoloji Derg (Turk patoloji dergisi)
[2017, 33(2):134-143]

Cited: 1 time

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Wilms' tumor 1 protein expression in endometrial adenocarcinoma and endometrial intra-epithelial neoplasia.

Yeliz Atik, Bilge Cetinkaya Demir, Hakan Ozan, Sema Baykara, Alp Usubutun, Fatma Yılmaz Erturk,

<h4>Aim</h4>To investigate the expression of Wilms' tumor 1 (WT1) protein in endometrial adenocarcinoma (EC) and endometrial intra-epithelial neoplasia (EIN).<h4>Methods</h4>WT1 protein expression was determined on immunohistochemistry in 30 EC patients and in 20 EIN patients. WT1 protein expression in proliferative (n = 7), secretory (n = 9) and atrophic endometrium (n ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2016, 42(7):870-875]

Cited: 0 times

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In vitro chemosensitivity in ovarian carcinoma: Comparison of three leading assays.

Burak Tatar, Gökhan Boyraz, İlker Selçuk, Alper K Doğan, Alp Usubütün, Zafer Selçuk Tuncer,

<h4>Objective</h4>An alternative approach to the current therapy of ovarian carcinoma is the individualization of treatment by determining the sensitivity of tumoral tissue to chemotherapeutic agents before the initiation of chemotherapy. The objectives of the study are to determine the efficacy of in vitro chemosensitivity assays in ovarian carcinoma and to ... Read more >>

J Turk Ger Gynecol Assoc (Journal of the Turkish German Gynecological Association)
[2016, 17(1):35-40]

Cited: 3 times

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Serous versus high-grade endometrioid endometrial carcinoma: immunohistochemistry of RFP is not useful for differentiation.

Cigdem Ussakli, Alp Usubutun, Nazmiye Dincer, Anil Dolgun, Diilek Bülbül, Zuhal Isikdogan, Nihan Haberal, Ozlem Ozen, Gaye Guler Tezel,

We evaluated the immunohistochemical expression of ret finger protein (RFP) along with conventional immunohistochemical markers in endometrioid and serous carcinomas of the endometrium. A total of 124 endometrial carcinoma cases (24 grade 1 endometrioid, 60 grade 3 endometrioid, 40 serous) were retrieved from pathology archives. Tissue microarrays were constructed. The ... Read more >>

Pol J Pathol (Polish journal of pathology : official journal of the Polish Society of Pathologists)
[2016, 67(3):221-227]

Cited: 1 time

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HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients.

Xavier Castellsagué, Laia Alemany, Miquel Quer, Gordana Halec, Beatriz Quirós, Sara Tous, Omar Clavero, Llúcia Alòs, Thorsten Biegner, Tomasz Szafarowski, Maria Alejo, Dana Holzinger, Enrique Cadena, Edith Claros, Gillian Hall, Jan Laco, Mario Poljak, Maria Benevolo, Elena Kasamatsu, Hisham Mehanna, Cathy Ndiaye, Núria Guimerà, Belen Lloveras, Xavier León, Juan C Ruiz-Cabezas, Isabel Alvarado-Cabrero, Chang-Suk Kang, Jin-Kyoung Oh, Marcial Garcia-Rojo, Ermina Iljazovic, Oluseyi F Ajayi, Flora Duarte, Ashrafun Nessa, Leopoldo Tinoco, Marco A Duran-Padilla, Edyta C Pirog, Halina Viarheichyk, Hesler Morales, Valérie Costes, Ana Félix, Maria Julieta V Germar, Marisa Mena, Arzu Ruacan, Asha Jain, Ravi Mehrotra, Marc T Goodman, Luis Estuardo Lombardi, Annabelle Ferrera, Sani Malami, Estela I Albanesi, Pablo Dabed, Carla Molina, Rubén López-Revilla, Václav Mandys, Manuel E González, Julio Velasco, Ignacio G Bravo, Wim Quint, Michael Pawlita, Nubia Muñoz, Silvia de Sanjosé, F Xavier Bosch, ,

<h4>Background</h4>We conducted a large international study to estimate fractions of head and neck cancers (HNCs) attributable to human papillomavirus (HPV-AFs) using six HPV-related biomarkers of viral detection, transcription, and cellular transformation.<h4>Methods</h4>Formalin-fixed, paraffin-embedded cancer tissues of the oral cavity (OC), pharynx, and larynx were collected from pathology archives in 29 countries. ... Read more >>

J Natl Cancer Inst (Journal of the National Cancer Institute)
[2016, 108(6):djv403]

Cited: 218 times

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Intraoperative Ex Vivo High-Resolution Sonography: A Novel Technique for the Assessment of Myometrial Invasion in Endometrial Cancer.

Derman Basaran, Mehmet Coskun Salman, Gokhan Boyraz, Deniz Akata, Mustafa Ozmen, Alp Usubutun, Nejat Ozgul, Kunter Yuce,

OBJECTIVE:This study aims to assess the diagnostic performance of a novel intraoperative ex vivo ultrasonography technique in determining deep myometrial invasion (MI) in patients with apparently low-risk endometrial cancer (EC). METHODS:This prospective study included patients with type I EC who underwent staging laparotomy at Hacettepe University Hospital from December 2011 ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2015, 25(9):1639-1644]

Cited: 1 time

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PREVENTION OF RADIATION-INDUCED RETINOPATHY WITH AMIFOSTINE IN WISTAR ALBINO RATS.

Berna Akkus Yildirim, Eren Çetin, Erkan Topkan, Gokhan Ozyigit, Mustafa Cengiz, Selcuk Surucu, Alp Usubutun, Fadil Akyol,

<h4>Purpose</h4>To evaluate the radioprotective efficacy of amifostine on irradiated mature rat retina.<h4>Methods</h4>A total of 108 Wistar albino rats were categorized into 3 groups, namely, apoptosis (n = 48), acute effects (n = 40), and late changes in retinal cell layers (n = 20). Each group was further subcategorized into 4 ... Read more >>

Retina (Retina (Philadelphia, Pa.))
[2015, 35(7):1458-1464]

Cited: 5 times

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Mucoepidermoid Carcinoma of Uterine Cervix: A Distinct Pathological and Clinical Entity.

Ilker Selcuk, Bulent Ozdal, Mengu Turker, Alp Usubutun, Tayfun Gungor, Mehmet Mutlu Meydanli,

Mucoepidermoid carcinoma of uterine cervix is a rare tumor that has some individual features. Defining risk factors after surgery shape the postoperative treatment modality on cervical cancer patients. Although there is not a well-known strategy for the postoperative follow-up of mucoepidermoid carcinoma, the aggressive behaviour of this tumor makes the ... Read more >>

Case Rep Obstet Gynecol (Case reports in obstetrics and gynecology)
[2015, 2015:491875]

Cited: 1 time

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An Update of Neuroendocrine Tumors of the Female Reproductive System.

Mehmet Kefeli, Alp Usubütün,

Endocrine disease related tumors of female reproductive system mostly seen in ovary. Hormone producing ovarian tumors, ovarian tumor with functioning stroma, tumor related paraneoplastic and paraendocrine syndromes, paraganglioma and neuroendocrine tumors may include in this category. These tumors or its stroma can produce some hormones, which are led to endocrine ... Read more >>

Turk Patoloji Derg (Turk patoloji dergisi)
[2015, 31 Suppl 1:128-144]

Cited: 2 times

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The Role of Frozen-Section in the Surgical Management of Patients with Endometrial Intraepithelial Neoplasia.

Mehmet Coşkun Salman, Derman Başaran, Alp Usubütün, Nejat Özgül, Kunter Yüce,

<h4>Objective</h4>Patients with endometrial intraepithelial neoplasia may have concurrent endometrial cancer if managed surgically or develop cancer in time if managed conservatively. Therefore, intraoperative assessment of the uterus may be helpful if a surgical approach is decided on. Our study aimed to investigate the role of frozen-section examination in patients with ... Read more >>

Turk Patoloji Derg (Turk patoloji dergisi)
[2015, 31(3):181-187]

Cited: 0 times

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