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Author Allah Nawaz

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CD206+ M2-Like Macrophages Are Essential for Successful Implantation.

Yosuke Ono, Osamu Yoshino, Takehiro Hiraoka, Erina Sato, Yamato Fukui, Akemi Ushijima, Allah Nawaz, Yasushi Hirota, Shinichiro Wada, Kazuyuki Tobe, Akitoshi Nakashima, Yutaka Osuga, Shigeru Saito,

Macrophages (MΦs) play important roles in implantation. Depletion of CD11b+ pan-MΦs in CD11b-diphtheria-toxin-receptor (DTR) mice is reported to cause implantation failure due to decreased progesterone production in the corpus luteum. However, of the M1 and M2, the type of MΦs that is important for implantation is unknown. In this study, ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:557184]

Cited: 0 times

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Bofutsushosan improves gut barrier function with a bloom of Akkermansia muciniphila and improves glucose metabolism in mice with diet-induced obesity.

Shiho Fujisaka, Isao Usui, Allah Nawaz, Yoshiko Igarashi, Keisuke Okabe, Yukihiro Furusawa, Shiro Watanabe, Seiji Yamamoto, Masakiyo Sasahara, Yoshiyuki Watanabe, Yoshinori Nagai, Kunimasa Yagi, Takashi Nakagawa, Kazuyuki Tobe,

Obesity and insulin resistance are associated with dysbiosis of the gut microbiota and impaired intestinal barrier function. Herein, we report that Bofutsushosan (BFT), a Japanese herbal medicine, Kampo, which has been clinically used for constipation in Asian countries, ameliorates glucose metabolism in mice with diet-induced obesity. A 16S rRNA sequence ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5544]

Cited: 2 times

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Development of herbal formulation of medicinal plants and determination of its antihyperuricemic potential in vitro and in vivo rat's model.

Muhammad Bilal, Saeed Ahmad, Tayyeba Rehman, Waheed Mumtaz Abbasi, Aymen Owais Ghauri, Muhammad Adeel Arshad, Sultan Ayaz, Allah Nawaz,

Hyperuricemia is a common metabolic disorder and several herbal formulations are being used for its treatment. The study aimed to develop herbal formulation (Urinil B) and find its hypouricemic effects in vitro and in vivo. Urinil B was prepared by taking Trachyspermum ammi, Piper nigrum and Berberis vulgaris equally. In ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(2):641-649]

Cited: 2 times

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Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway.

Yasuhiro Nishida, Allah Nawaz, Tomonobu Kado, Akiko Takikawa, Yoshiko Igarashi, Yasuhiro Onogi, Tsutomu Wada, Toshiyasu Sasaoka, Seiji Yamamoto, Masakiyo Sasahara, Johji Imura, Kumpei Tokuyama, Isao Usui, Takashi Nakagawa, Shiho Fujisaka, Yagi Kunimasa, Kazuyuki Tobe,

BACKGROUND:Skeletal muscle is mainly responsible for insulin-stimulated glucose disposal. Dysfunction in skeletal muscle metabolism especially during obesity contributes to the insulin resistance. Astaxanthin (AX), a natural antioxidant, has been shown to ameliorate hepatic insulin resistance in obese mice. However, its effects in skeletal muscle are poorly understood. The current study ... Read more >>

J Cachexia Sarcopenia Muscle (Journal of cachexia, sarcopenia and muscle)
[2020, 11(1):241-258]

Cited: 6 times

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Linkage of CD8+ T cell exhaustion with high-fat diet-induced tumourigenesis.

Tomonobu Kado, Allah Nawaz, Akiko Takikawa, Isao Usui, Kazuyuki Tobe,

Obesity increases the risk of cancer. Increased levels of hormones (such as oestrogen, insulin, insulin-like growth factor, and leptin), free fatty acid-induced production of reactive oxygen species, an altered intestinal microbiome and chronic inflammation are known to be associated with an increased cancer risk in obese subjects. However, the mechanism ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):12284]

Cited: 1 time

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M2-like macrophages serve as a niche for adipocyte progenitors in adipose tissue.

Allah Nawaz, Kazuyuki Tobe,

Adipose tissue (AT) is composed not only of adipocytes, but also of macrophages, endothelial cells and preadipocytes. Macrophages are an important component of AT, and are involved in tissue homeostasis, tissue repair and fibrosis. AT-resident macrophages are categorized into two subtypes, the M1-like and M2-like macrophages. M2-like macrophages are reported ... Read more >>

J Diabetes Investig (Journal of diabetes investigation)
[2019, 10(6):1394-1400]

Cited: 3 times

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Macrophage-specific hypoxia-inducible factor-1α deletion suppresses the development of liver tumors in high-fat diet-fed obese and diabetic mice.

Akiko Takikawa, Isao Usui, Shiho Fujisaka, Koichi Tsuneyama, Keisuke Okabe, Takashi Nakagawa, Allah Nawaz, Tomonobu Kado, Teruo Jojima, Yoshimasa Aso, Yoshihiro Hayakawa, Kunikimi Yagi, Kazuyuki Tobe,

AIMS/INTRODUCTION:Chronic inflammation of the liver is often observed with obesity or type 2 diabetes. In these pathological conditions, the immunological cells, such as macrophages, play important roles in the development or growth of liver cancer. Recently, it was reported that hypoxia-inducible factor-1α (HIF-1α) is a key molecule for the acquisition of ... Read more >>

J Diabetes Investig (Journal of diabetes investigation)
[2019, 10(6):1411-1418]

Cited: 0 times

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Partial depletion of CD206-positive M2-like macrophages induces proliferation of beige progenitors and enhances browning after cold stimulation.

Yoshiko Igarashi, Allah Nawaz, Tomonobu Kado, Muhammad Bilal, Takahide Kuwano, Seiji Yamamoto, Masakiyo Sasahara, Xu Jiuxiang, Akiko Inujima, Keiichi Koizumi, Johji Imura, Naotoshi Shibahara, Isao Usui, Shiho Fujisaka, Kazuyuki Tobe,

Beige adipocytes are an inducible form of thermogenic adipocytes that become interspersed within white adipose tissue (WAT) depots in response to cold exposure. Previous studies have shown that type 2 cytokines and M2 macrophages induce cold-induced browning in inguinal WAT (ingWAT) by producing catecholamines. Exactly how the conditional and partial ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):14567]

Cited: 6 times

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Publisher Correction: Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice.

Allah Nawaz, Arshad Mehmood, Yukiko Kanatani, Tomonobu Kado, Yoshiko Igarashi, Akiko Takikawa, Seiji Yamamoto, Keisuke Okabe, Takashi Nakagawa, Kunimasa Yagi, Shiho Fujisaka, Kazuyuki Tobe,

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):14597]

Cited: 0 times

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CD11c+ M1-like macrophages (MΦs) but not CD206+ M2-like MΦ are involved in folliculogenesis in mice ovary.

Yosuke Ono, Miwako Nagai, Osamu Yoshino, Kaori Koga, Allah Nawaz, Hideki Hatta, Hirofumi Nishizono, Gentaro Izumi, Akitoshi Nakashima, Johji Imura, Kazuyuki Tobe, Tomoyuki Fujii, Yutaka Osuga, Shigeru Saito,

Macrophages (MΦs) are involved in folliculogenesis and ovulation. However, it is unknown which type of MΦ, M1 or M2, plays a more essential role in the ovary. CD206 or CD11c diphtheria toxin receptor transgenic (DTR) mice, which enable depletion of CD206+ M2 MΦs and CD11c+ MΦ or CD11c+ Dendritic cells ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):8171]

Cited: 6 times

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Effects of medicinal plants on Alzheimer's disease and memory deficits.

Muhammad Akram, Allah Nawaz,

Alzheimer's disease is an age-related neurodegenerative disorder characterized by memory deficits. Various studies have been carried out to find therapeutic approaches for Alzheimer's disease. However, the proper treatment option is still not available. There is no cure for Alzheimer's disease, but symptomatic treatment may improve the memory and other dementia ... Read more >>

(Neural regeneration research)
[2017, 12(4):660-670]

Cited: 8 times

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Laparoscopic Sleeve Gastrectomy - A Prospective Follow Up Of 30 Patients.

Asad Ali Toor, Muhammad Waris Farooka, Mahmood Ayyaz, Zeeshan Razzaq, Awais Amjad Malik, Allah Nawaz, Asif Mahmood, Henry Paul Redmond,

BACKGROUND:Morbid obesity has become a surgically treatable problem. Laparoscopic sleeve gastrectomy is becoming a popular choice both for surgeons and patients due to effectiveness and low complication rates. METHODS:It was a prospective case series spanning over 6 years. Patient enrolment started from January 2009 and data collection completed in January ... Read more >>

J Ayub Med Coll Abbottabad (Journal of Ayub Medical College, Abbottabad : JAMC)
[2017, 29(1):45-49]

Cited: 0 times

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HIF-1α in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance.

Akiko Takikawa, Arshad Mahmood, Allah Nawaz, Tomonobu Kado, Keisuke Okabe, Seiji Yamamoto, Aminuddin Aminuddin, Satoko Senda, Koichi Tsuneyama, Masashi Ikutani, Yasuharu Watanabe, Yoshiko Igarashi, Yoshinori Nagai, Kiyoshi Takatsu, Keiichi Koizumi, Johji Imura, Nobuhito Goda, Masakiyo Sasahara, Michihiro Matsumoto, Kumiko Saeki, Takashi Nakagawa, Shiho Fujisaka, Isao Usui, Kazuyuki Tobe,

Adipose tissue hypoxia is an important feature of pathological adipose tissue expansion. Hypoxia-inducible factor-1α (HIF-1α) in adipocytes reportedly induces oxidative stress and fibrosis, rather than neoangiogenesis via vascular endothelial growth factor (VEGF)-A. We previously reported that macrophages in crown-like structures (CLSs) are both hypoxic and inflammatory. In the current study, ... Read more >>

Diabetes (Diabetes)
[2016, 65(12):3649-3659]

Cited: 25 times

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Review: Comprehensive review on treatment of HIV.

Muhammad Daniyal, Muhammad Akram, Abdul Hamid, Allah Nawaz, Khan Usmanghani, Saeed Ahmed, Leena Hameed,

HIV or AIDS is a major threat for humanity in the world especially in developing countries. The causative factor of the syndrome is HIV, which infects and destroys one of the cellular components of the immune system, the T cells, causing deficiency in the immunological surveillance and ultimately leading to ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2016, 29(4):1331-1338]

Cited: 3 times

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M2 macrophages in metabolism.

Shiho Fujisaka, Isao Usui, Allah Nawaz, Akiko Takikawa, Tomonobu Kado, Yoshiko Igarashi, Kazuyuki Tobe,

Adipose tissue not only functions as the major energy-storing tissue, but also functions as an endocrine organ that regulates systemic metabolism by releasing various hormones called adipokines. Macrophages play a critical role in maintaining adipocyte health in a lean state and in remodeling during the progression of obesity. Large numbers ... Read more >>

(Diabetology international)
[2016, 7(4):342-351]

Cited: 3 times

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Ways to manage hepatitis C without cirrhosis: Treatment by comparison of coded eastern medicine hepcinal with interferon alpha 2b and ribavirin.

Allah Nawaz, Halima Nazar, Khan Usmanghani, Zeeshan Ahmed Sheikh, Muhammad Amjad Chishti, Irshad Ahmad,

Hepatitis C virus (HCV) infection is a serious and significant global health problem in the Pakistan and elsewhere. In majority of cases HCV infection remains asymptomatic but in advance cases it may progress to fibrosis of liver, shrinkage of liver cells or failure of liver. The hepatitis C may progress ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2016, 29(3):919-927]

Cited: 2 times

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The effects of new polyherbal Unani formulation AJMAL06 on serum creatinine level in chronic renal failure.

Muhammad Shakil Ahmad Siddiqui, Aftab Saeed, Allah Nawaz, Safila Naveed, Khan Usmanghani,

This study was conducted to evaluate the efficacy of Unani Ajmal06, an herbal formulation for management of chronic renal failure (CRF). The therapeutic evaluations of three different formulations such as Itrifal Kashneezi, Jawarsih Zarooni Sada medicines were conducted on number 35 CRF patients clinically diagnosed cases of chronic kidney failure. ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2016, 29(2 Suppl):657-661]

Cited: 2 times

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Surgical Site Infection in Diabetic and Non-Diabetic Patients Undergoing Laparoscopic Cholecystectomy.

Usman Ismat, Ahsan Khan, Allah Nawaz, Rashid Mansoor, Awais Amjad Malik, Falak Sher, Mahmood Ayyaz,

To compare the frequency of surgical site infections in patients with type II diabetes undergoing laparoscopic cholecystectomy as compared with non-diabetic patients.Cohort study.Surgical Unit 2, Services Hospital, Lahore, from May to October 2012.Patients were divided into two groups of 60 each, undergoing laparoscopic cholecystectomy. Group A comprised non-diabetic patients and ... Read more >>

J Coll Physicians Surg Pak (Journal of the College of Physicians and Surgeons--Pakistan : JCPSP)
[2016, 26(2):100-102]

Cited: 0 times

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Comparative clinical efficacy and safety of coded herbal medicine Dermovix in the management of patients with atopic dermatitis versus allopathic medicine.

Muhammad Amjad Chishti, Ejaz Mohi-Ud-Din, Khan Usmanghani, Allah Nawaz, Halima Nazar, Irshad Ahmad,

Atopic dermatitis (AD) is defined as a chronic, highly pruritic inflammatory condition of skin. It is estimated that this disease may lead significant morbidity and also adversely affects the quality of life. Atopic dermatitis responds well to home treatment. Proper skin care reduces the need for medicines. Topical creams and ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2015, 28(5):1655-1663]

Cited: 2 times

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Laparoscopic resection of gastro-intestinal stromal tumour.

Usman Ismat Butt, Ahsan Khan, Allah Nawaz, Mahmood Ayyaz, Rashid Mansoor, Awais Amjad Malik, Tehreem Fatima,

Gastro-Intestinal Stromal Tumours are rare tumours, constituting less than 1% of gastrointestinal tumours. They are the most common mesenchymal origin tumours of gastro-intestinal tract. Tyrosine kinase c-kit oncogene mutation is found in all cases. These tumours are sensitive to imatinib. They are usually noted incidentally on endoscopy or present with ... Read more >>

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2015, 65(11):1228-1230]

Cited: 0 times

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Harmonic Scalpel Versus Electrocautery in Axillary Dissection in Carcinoma Breast.

Allah Nawaz, Sadaf Waqar, Ahsan Khan, Rashid Mansoor, Usman Ismat Butt, Mahmood Ayyaz,

To compare the results between harmonics scalpel and electrocautery use in axillary dissection for carcinoma breast.Randomized controlled trial.Department of Surgery, Services Hospital, Lahore, from December 2013 to June 2014.Eighty patients fulfilling the inclusion criteria were selected and equally divided in two groups. Axillary dissection for carcinoma breast was performed by ... Read more >>

J Coll Physicians Surg Pak (Journal of the College of Physicians and Surgeons--Pakistan : JCPSP)
[2015, 25(12):870-873]

Cited: 2 times

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Comparative clinical study on the efficacy of biocor plus compared with simvastatin for the management of hypercholesterolemia.

Zeeshan Sheikh Sheikh, Khan Usmanghani, Halima Nazar, Allah Nawaz, Lala Rukh Jahanzeb, Irshad Ahmad,

Hypercholestriolemia is major risk factor that enhances the incidence of cardiovascular disease and coronary artery disease. The present study was conducted to normalize the lipid profile in the blood by using Biocor Plus for hypercholesterolemia compared with Simvastatin. It was prospective randomized case control study conducted on 70 diagnosed patients ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2015, 28(6 Suppl):2291-2295]

Cited: 2 times

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Laparoscopic cystgastrostomy: A Pakistani perspective.

Awais Amjad Malik, Hafiz Ghulam Isnain, Ahsan Khan, Asad Ali Toor, Allah Nawaz, Rashid Mansoor, Romaisa Shamim, Mahmood Ayyaz,

Laparoscopic Pancreatic Pseudocyst (PP) surgery can be performed via anterior or posterior cystogastrostomy, endoscopy-assisted surgery and cystojejunostomy. We conducted a prospective analysis of our patients undergoing laparoscopic cystogastrostomy to analyse the merits and demerits of the procedure. In a period of 3 years from January 2010 to December 2012 all ... Read more >>

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2015, 65(5):565-568]

Cited: 1 time

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Comparative clinical evaluation on herbal formulation Pepsil, Safoof-e-Katira and Omeprazole in gastro esophageal reflux disease.

Muhammad Umar Toseef, Aftab Saeed, Ejaz Mohi-Ud-Din, Khan Usmanghani, Halima Nazar, Allah Nawaz, Irshad Ahmad, Faheem Ahmed Siddiqui,

This study was conducted to evaluate the role of Unani herbal drugs Pepsil and Safoof-e-katira on the gastro esophageal reflux disease (GERD). This was multicentre randomized case control study conducted at Matab Hakeem Muhammad Noor-ud-din, Burewala; Aziz Muhammad din Medical and Surgical Centre, Burewala and Shifa-ul-mulk Memorial Hospital, Hamdard University ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2015, 28(3):863-870]

Cited: 1 time

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Clinical efficacy of polyherbal formulation Eezpain spray for muscular pain relief.

Allah Nawaz, Zeeshan Ahmed Sheikh, Majid Feroz, Kamran Alam, Halima Nazar, Khan Usmanghani,

The topical herbal formulation Eezpain spray consisting of natural ingredients that have been clinically proved for its analgesic and anti-inflammatory activity. The designed formulation on application knee and wrist joints, back of neck and shoulder, forearms and lower back exhibited significant efficacy. A total of 20 subjects both male and ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2015, 28(1):43-47]

Cited: 2 times

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