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Author Alla Guekht

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A WHO resolution on epilepsy and other neurological disorders.

Andrea Sylvia Winkler, Matilde Leonardi, Benedict Daniel Michael, Foad Abd-Allah, William Carroll, Alla Guekht, ,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):171-172]

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Complementary and alternative medicine in epilepsy: A global survey of physicians' opinions.

Ali A Asadi-Pooya, Francesco Brigo, Simona Lattanzi, Ioannis Karakis, Marjan Asadollahi, Eugen Trinka, Lobna Talaat El Ghoneimy, Chrisma Pretorius, Guilca Contreras, Anilu Daza-Restrepo, Kette Valente, Luciana D'Alessio, Saule T Turuspekova, Ghaieb Aljandeel, Samson Khachatryan, Abdulaziz Ashkanani, Torbjörn Tomson, Mansur Kutlubaev, Alla Guekht, Taoufik Alsaadi, Yamile Calle-Lopez, Boulenouar Mesraoua, Loreto Ríos-Pohl, Abdullah Al-Asmi, Vicente Villanueva, Stanley C Igwe, Najib Kissani, Asel Jusupova,

<h4>Purpose</h4>To investigate the opinions of physicians on the use of complementary and alternative medicine (CAM) in patients with epilepsy (PWE) worldwide.<h4>Methods</h4>Online survey addressed to neurologists and psychiatrists from different countries.<h4>Results</h4>Totally, 1112 physicians from 25 countries (different world region: Europe, North America, South America, Middle-East, Africa, Former Soviet Union Republics) participated; ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2021, 117:107835]

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Risk factors for long-term consequences of COVID-19 in hospitalised adults in Moscow using the ISARIC Global follow-up protocol: StopCOVID cohort study

Daniel Munblit, Polina Bobkova, Ekaterina Spiridonova, Anastasia Shikhaleva, Aysylu Gamirova, Oleg Blyuss, Nikita Nekliudov, Polina Bugaeva, Margarita Andreeva, Audrey DunnGalvin, Pasquale Comberiati, Christian Apfelbacher, Jon Genuneit, Sergey Avdeev, Valentina Kapustina, Alla Guekht, Victor Fomin, Andrey Svistunov, Peter Timashev, Thomas Drake, Sarah Wulf Hanson, Laura Merson, Peter Horby, Louise Sigfrid, Janet Scott, Malcolm Semple, John Warner, Theo Vos, Piero Olliaro, Petr Glybochko, Denis Butnaru, ,

<h4>ABSTRACT</h4> <h4>Background</h4> The long-term sequalae of COVID-19 remain poorly characterised. In this study, we aimed to assess long-standing symptoms (LS) (symptoms lasting from the time of discharge) in previously hospitalised patients with COVID-19 and assess associated risk factors. <h4>Methods</h4> This is a longitudinal cohort study of adults (≥18 years of ... Read more >>

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SLC6A3 (DAT1) as a novel candidate biomarker gene for suicidal behavior: a pilot study

Ekaterina Rafikova, Maria Shadrina, Peter Slominsky, Alla Guekht, Aleksei Ryskov, Dmitry Shibalev, Vasiliy Vasilyev,

<h4>Objective: </h4> This study aims to estimate the contribution of 11 polymorphisms in the genes SLC6A4 (5HTT), HTR1A, HTR2A, HTR1B, SLC6A3 (DAT1), DRD4, DRD2, COMT and BDNF to suicidal behavior and severity of symptoms of depression and anxiety in Russian population. <h4>Methods: </h4> The study was performed on 100 patients ... Read more >>

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Validation of the Russian version of neurological disorders depression inventory for epilepsy (NDDI-E).

Mikhail Zinchuk, Georgii Kustov, Evgenii Pashnin, Anna Gersamia, Flora Rider, Alexander Yakovlev, Alla Guekht,

<h4>Objective</h4>To translate and validate the English version of the Neurologic Depression Disorders Inventory in Epilepsy (NDDI-E) into the Russian language as an instrument for rapid detection of major depressive episodes (MDE) for patients with epilepsy (PWE) from Russian Federation.<h4>Methods</h4>One hundred and 75 consecutive PWE were included in the study. All ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 113:107549]

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Non-Suicidal Self-Injury in Russian Patients with Suicidal Ideation.

Mikhail Zinchuk, Massimiliano Beghi, Ettore Beghi, Elisa Bianchi, Alla Avedisova, Alexander Yakovlev, Alla Guekht,

<h4>Background</h4>Nonsuicidal self-injury (NSSI) is recognized as a public health concern for its association with unfavorable outcomes, including suicidal behavior. The aim of this study is to identify factors associated with NSSI among patients with nonpsychotic mental disorders (NPMD) and suicidal ideation in Russia.<h4>Methods</h4>A retrospective cohort study was conducted in the ... Read more >>

Arch Suicide Res (Archives of suicide research : official journal of the International Academy for Suicide Research)
[2020, :1-25]

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How to understand and address the cultural aspects and consequences of diagnosis of epilepsy, including stigma.

Patricia Braga, Hassan Hosny, Angelina Kakooza-Mwesige, Flora Rider, Manjari Tripathi, Alla Guekht,

Epilepsy is one of the most prevalent serious neurological diseases. It is unique, being the only severe and disabling neurological disease that is fully treatable in the majority of cases, but on the other hand, associated with stigma, prejudice and discriminatory practices, which negatively impact people's everyday life in important ... Read more >>

Epileptic Disord (Epileptic disorders : international epilepsy journal with videotape)
[2020, 22(5):531-547]

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A Translational Study on Acute Traumatic Brain Injury: High Incidence of Epileptiform Activity on Human and Rat Electrocorticograms and Histological Correlates in Rats.

Ilia G Komoltsev, Mikhail V Sinkin, Aleksandra A Volkova, Elizaveta A Smirnova, Margarita R Novikova, Olga O Kordonskaya, Alexander E Talypov, Alla B Guekht, Vladimir V Krylov, Natalia V Gulyaeva,

<h4>Background</h4>In humans, early pathological activity on invasive electrocorticograms (ECoGs) and its putative association with pathomorphology in the early period of traumatic brain injury (TBI) remains obscure.<h4>Methods</h4>We assessed pathological activity on scalp electroencephalograms (EEGs) and ECoGs in patients with acute TBI, early electrophysiological changes after lateral fluid percussion brain injury (FPI), ... Read more >>

Brain Sci (Brain sciences)
[2020, 10(9):]

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Testing blood and CSF in people with epilepsy: a practical guide.

Fiona Sutton, Diana Barca, Ilia Komoltsev, Dana Craiu, Alla Guekht, Tim von Oertzen, Hannah R Cock,

Laboratory investigations, whilst not essential to the diagnosis of seizures or of epilepsy, can be fundamental to determining the cause and guiding management. Over 50% of first seizures have an acute symptomatic cause, including a range of metabolic, toxic or infectious cause. The same triggers can precipitate status epilepticus, either ... Read more >>

Epileptic Disord (Epileptic disorders : international epilepsy journal with videotape)
[2020, 22(4):381-398]

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A European questionnaire survey on epilepsy monitoring units' current practice for postoperative psychogenic nonepileptic seizures' detection.

Sofia Markoula, Andreas Liampas, Guido Rubboli, John Duncan, Demetrios N Velis, Andreas Schulze-Bonhage, Alla Guekht, Karen Bartholomeyczik, Jane de Tisi, Adrien Gras, Morten Ingvar Lossius, Flavio Villani, Anke Maren Staack, Annette Hospes, Johannes C Baaijen, Elisabeth C W van Straaten, Hanneke E Ronner, Sara Casciato, Alfredo D'Aniello, Addolorata Mascia, Susana Ferrao Santos, Carla Bentes, Ángel Aledo-Serrano, Antonio Gil-Nagel, Petia Dimova, Hrvoje Hećimović, Çiğdem Özkara, Kristina Malmgren, Savvas Papacostas, Anna Kelemen, Markus Reuber, Eugen Trinka, Philippe Ryvlin,

<h4>Background</h4>In cases undergoing epilepsy surgery, postoperative psychogenic nonepileptic seizures (PNES) may be underdiagnosed complicating the assessment of postsurgical seizures' outcome and the clinical management. We conducted a survey to investigate the current practices in the European epilepsy monitoring units (EMUs) and the data that EMUs could provide to retrospectively detect ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 112:107355]

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The epidemiology of amyotrophic lateral sclerosis in Moscow (Russia).

Lev Brylev, Anastasia Ataulina, Vera Fominykh, Vadim Parshikov, Anna Vorobyeva, Elena Istomina, Rafiz Shikhirimov, Alexandr Salikov, Mariya Zakharova, Alla Guekht, Ettore Beghi,

Objectives: To estimate the incidence of amyotrophic lateral sclerosis (ALS) in Moscow by investigating multiple sources of cases. Incidence rates from previous Russian studies ranged from 0.3 to 0.7 per 100,000/year. Methods: A retrospective study of the incidence of ALS was performed in the South district of Moscow (population, 1,760,000, ... Read more >>

Amyotroph Lateral Scler Frontotemporal Degener (Amyotrophic lateral sclerosis & frontotemporal degeneration)
[2020, 21(5-6):410-415]

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Applications of the European Parkinson's Disease Association sponsored Parkinson's Disease Composite Scale (PDCS).

Roberta Balestrino, Carlos Alberto Hurtado-Gonzalez, Fabrizio Stocchi, Fabiana Giada Radicati, K Ray Chaudhuri, Carmen Rodriguez-Blazquez, Pablo Martinez-Martin, ,

This study was addressed to determine the presence of Parkinson disease (PD) manifestations, their distribution according to motor subtypes, and the relationships with health-related quality of life (QoL) using the recently validated European Parkinson's Disease Association sponsored Parkinson's Disease Composite Scale (PDCS). Frequency of symptoms was determined by the scores ... Read more >>

NPJ Parkinsons Dis (NPJ Parkinson's disease)
[2019, 5:26]

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Prevalence of valproate prescriptions in women of childbearing age in certain regions of Russia.

Karel Kostev, Galina Osina, Flora Rider, Alla Guekht,

AIM:The goal of this retrospective study was to analyze the proportion of women with epilepsy who had received valproate (VPA) prescriptions in certain regions of Russia in 2018. METHODS:This retrospective cross-sectional study was based on the IQVIA Russia longitudinal prescriptions (LRx) database and included all individuals with a documented epilepsy ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2019, 101(Pt A):106584]

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Extensive validation study of the Parkinson's Disease Composite Scale.

P Martinez-Martin, F G Radicati, C Rodriguez Blazquez, J Wetmore, N Kovacs, K Ray Chaudhuri, F Stocchi, ,

<h4>Background and purpose</h4>A composite instrument able to rapidly and reliably assess the most relevant motor and non-motor afflictions suffered by Parkinson's disease (PD) patients in a real world clinic setting is an unmet need. The recently validated PD Composite Scale (PDCS) was designed to fulfil this gap as a quick, ... Read more >>

Eur J Neurol (European journal of neurology)
[2019, 26(10):1281-1288]

Cited: 1 time

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Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source.

Hans-Christoph Diener, Ralph L Sacco, J Donald Easton, Christopher B Granger, Richard A Bernstein, Shinichiro Uchiyama, Jörg Kreuzer, Lisa Cronin, Daniel Cotton, Claudia Grauer, Martina Brueckmann, Marina Chernyatina, Geoffrey Donnan, José M Ferro, Martin Grond, Bernd Kallmünzer, Jerzy Krupinski, Byung-Chul Lee, Robin Lemmens, Jaime Masjuan, Miroslav Odinak, Jeffrey L Saver, Peter D Schellinger, Danilo Toni, Kazunori Toyoda, ,

<h4>Background</h4>Cryptogenic strokes constitute 20 to 30% of ischemic strokes, and most cryptogenic strokes are considered to be embolic and of undetermined source. An earlier randomized trial showed that rivaroxaban is no more effective than aspirin in preventing recurrent stroke after a presumed embolic stroke from an undetermined source. Whether dabigatran ... Read more >>

N Engl J Med (The New England journal of medicine)
[2019, 380(20):1906-1917]

Cited: 29 times

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The provision of epilepsy care across Europe 2017: A 17-year follow-up survey.

Johan Zelano, Judith Klecki, Jakob Christensen, Torbjörn Tomson, Kristina Malmgren, ,

<h4>Objective</h4>To assess the resources available in the provision of epilepsy care across Europe and the developments since the International League Against Epilepsy (ILAE) survey published in 2003 (data collected in 2000).<h4>Methods</h4>An updated online version of the European Epilepsy Services Inventory was distributed to all European chapters of the ILAE (N = 47) ... Read more >>

Epilepsia Open (Epilepsia open)
[2019, 4(1):144-152]

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Acute stress response to a cognitive task in patients with major depressive disorder: potential metabolic and proinflammatory biomarkers.

Tatiana Druzhkova, Ksenia Pochigaeva, Aleksander Yakovlev, Evdokia Kazimirova, Maria Grishkina, Aleksey Chepelev, Alla Guekht, Natalia Gulyaeva,

Responses of the hypothalamic-pituitary-adrenal axis (HPAA), immune system and metabolic pathways are involved in adaptation to stress, while alterations in these responses have been implicated in the development of major depressive disorder (MDD). Multiple laboratory indices are known to react in response to the acute stress, however, no valid biomarkers ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2019, 34(2):621-629]

Cited: 4 times

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Action Plan for Stroke in Europe 2018-2030.

Bo Norrving, Jon Barrick, Antoni Davalos, Martin Dichgans, Charlotte Cordonnier, Alla Guekht, Kursad Kutluk, Robert Mikulik, Joanna Wardlaw, Edo Richard, Darius Nabavi, Carlos Molina, Philip M Bath, Katharina Stibrant Sunnerhagen, Anthony Rudd, Avril Drummond, Anna Planas, Valeria Caso,

Two previous pan-European consensus meetings, the 1995 and 2006 Helsingborg meetings, were convened to review the scientific evidence and the state of current services to identify priorities for research and development and to set targets for the development of stroke care for the decade to follow. Adhering to the same ... Read more >>

Eur Stroke J (European stroke journal)
[2018, 3(4):309-336]

Cited: 21 times

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Advocacy for children with epilepsy: Leveraging the WHA resolution. Advocacy Task Force, Commission of Pediatrics, International League Against Epilepsy.

Jo M Wilmshurst, Alla Guekht, Mary Secco, J Helen Cross, Emilio Perucca, ,

In May 2015 the World Health Assembly (WHA) approved the Resolution on the Global Burden of Epilepsy. This report addresses how the Resolution can be leveraged to improve the care of children with epilepsy worldwide. Children with epilepsy have unique needs and face unique challenges from stigma at all levels ... Read more >>

Epilepsia Open (Epilepsia open)
[2018, 3(2):167-174]

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VaD - An Integrated Framework for Cognitive Rehabilitation.

Maria Balea, Dafin Muresanu, Anton Alvarez, Volker Homberg, Ovidiu Bajenaru, Alla Guekht, Wolf-Dieter Heiss, Livia Popa, Johannes Vester, Ioana Muresanu, Codruta Birle, Dana Slavoaca,

BACKGROUND & OBJECTIVE:Vascular dementia is the second most common cause of dementia, with clinical features that depend on neural substrates affected by the vascular lesions. Like most neurological disorders, it involves alterations that range from the molecular level to neuronal networks. Such alterations begin as compensatory mechanisms that reshape every ... Read more >>

CNS Neurol Disord Drug Targets (CNS & neurological disorders drug targets)
[2018, 17(1):22-33]

Cited: 2 times

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Transcranial direct current stimulation of 20- and 30-minutes combined with sertraline for the treatment of depression.

Elena L Pavlova, Alexandra A Menshikova, Roman V Semenov, Ekaterina N Bocharnikova, Galina N Gotovtseva, Tatiana A Druzhkova, Anna G Gersamia, Anna A Gudkova, Alla B Guekht,

BACKGROUND:Transcranial direct current stimulation (tDCS) can be an effective treatment for depression, however, the duration of the stimulation session, among other parameters, needs to be optimized. METHODS:69 mild to moderately depressed patients (age 37.6±10.5years, 19 men) were randomized into three groups - 30-, 20-minute or sham tDCS. 10 daily sessions ... Read more >>

Prog Neuropsychopharmacol Biol Psychiatry (Progress in neuro-psychopharmacology & biological psychiatry)
[2018, 82:31-38]

Cited: 5 times

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Ciliary neurotrophic factor in patients with primary open-angle glaucoma and age-related cataract.

Alexander A Shpak, Alla B Guekht, Tatiana A Druzhkova, Ksenia I Kozlova, Natalia V Gulyaeva,

<h4>Purpose</h4>To study the ciliary neurotrophic factor (CNTF) concentration in the aqueous humor (AH), lacrimal fluid (LF), and blood serum (BS) in patients with age-related cataract and primary open-angle glaucoma (POAG).<h4>Methods</h4>CNTF concentrations were studied in 61 patients with age-related cataract, 55 patients with POAG combined with cataract, and 29 healthy controls ... Read more >>

Mol Vis (Molecular vision)
[2017, 23:799-809]

Cited: 7 times

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Safety and efficacy of Cerebrolysin in early post-stroke recovery: a meta-analysis of nine randomized clinical trials.

Natan M Bornstein, Alla Guekht, Johannes Vester, Wolf-Dieter Heiss, Eugene Gusev, Volker Hömberg, Volker W Rahlfs, Ovidiu Bajenaru, Bogdan O Popescu, Dafin Muresanu,

This meta-analysis combines the results of nine ischemic stroke trials, assessing efficacy of Cerebrolysin on global neurological improvement during early post-stroke period. Cerebrolysin is a parenterally administered neuropeptide preparation approved for treatment of stroke. All included studies had a prospective, randomized, double-blind, placebo-controlled design. The patients were treated with 30-50 ml ... Read more >>

Neurol Sci (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2018, 39(4):629-640]

Cited: 9 times

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Brain-Derived Neurotrophic Factor in Patients with Primary Open-Angle Glaucoma and Age-related Cataract.

Alexander A Shpak, Alla B Guekht, Tatiana A Druzhkova, Ksenia I Kozlova, Natalia V Gulyaeva,

<h4>Purpose</h4>To study brain-derived neurotrophic factor (BDNF) content in aqueous humor (AH), lacrimal fluid (LF), and blood serum (BS) in patients with age-related cataract and primary open-angle glaucoma (POAG).<h4>Methods</h4>BDNF was studied in 57 patients with age-related cataract, 55 patients with POAG combined with cataract, and 29 healthy controls (one eye in ... Read more >>

Curr Eye Res (Current eye research)
[2018, 43(2):224-231]

Cited: 6 times

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Letter by Vester et al Regarding Article, "Hope Dies Last-Evidence Again Fails to Support a Neuroprotectant: Cerebrolysin for Acute Ischemic Stroke".

Johannes C Vester, Alla Guekht, Wolf Dieter Heiss,

Stroke (Stroke)
[2017, 48(12):e365]

Cited: 0 times

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