Full Text Journal Articles by
Author Alkistis Skalkidou

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Adherence to Swedish national pregnancy dating guidelines and management of discrepancies between pregnancy dating methods: a survey study.

Merit Kullinger, Michaela Granfors, Helle Kieler, Alkistis Skalkidou,

BACKGROUND:Swedish national guidelines for pregnancy dating were published in 2010. Follow-up is needed to assess adherence and to identify whether any clinical topics are not covered in the guidelines. METHODS:All units in Sweden that performed ultrasound-based pregnancy dating were asked to complete a web-based questionnaire comprising multiple-response questions and commentary ... Read more >>

Reprod Health (Reproductive health)
[2019, 16(1):95]

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Epidural Analgesia During Childbirth and Postpartum Depressive Symptoms: A Population-Based Longitudinal Cohort Study.

Patricia Eckerdal, Natasa Kollia, Linnea Karlsson, Agneta Skoog-Svanberg, Anna-Karin Wikström, Ulf Högberg, Alkistis Skalkidou,

BACKGROUND:Severe pain has been linked to depression, which raises the question of whether epidural analgesia (EDA) during childbirth is associated with a reduced risk of postpartum depression (PPD). This association has been explored previously, but the studies were restricted by small sample sizes and the inability to control for relevant ... Read more >>

Anesth. Analg. (Anesthesia and analgesia)
[2019, :]

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Maternal body mass index moderates antenatal depression effects on infant birthweight.

Heidrun Petursdottir Maack, Alkistis Skalkidou, Anna Sjöholm, Karin Eurenius-Orre, Ajlana Mulic-Lutvica, Anna-Karin Wikström, Inger Sundström Poromaa,

Obesity and depression are two common medical problems that pregnant women present with in antenatal care. Overweight and obesity at the beginning of the pregnancy, and excessive weight gain during pregnancy, are independent explanatory variables for fetal birthweight and independent risk factors for giving birth to a large for gestational ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):6213]

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Experiences of sexual violence among women seeking services at a family planning unit in Sweden.

Mariella Öberg, Alkistis Skalkidou, Gun Heimer,

Background: Experiences of sexual violence among women can lead to ill health and increase the risk of lifetime co-occurrence of violence. Identifying risk factors and victims facilitates development of effective programmes for treatment and prevention of additional violence. The primary aim of this study was to assess the prevalence and ... Read more >>

Ups. J. Med. Sci. (Upsala journal of medical sciences)
[2019, 124(2):135-139]

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Characteristics of women with different perinatal depression trajectories.

Anna Wikman, Cathrine Axfors, Stavros I Iliadis, John Cox, Emma Fransson, Alkistis Skalkidou,

Maternal perinatal depression (PND), a common mental disorder with a prevalence of over 10%, is associated with long-term health risks for both mothers and offspring. This study aimed at describing characteristics related to background and lifestyle, pregnancy, delivery, and postpartum of different PND trajectories defined according to the onset of ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2019, :]

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Surgical menopause in association with cognitive function and risk of dementia: A systematic review and meta-analysis.

Marios K Georgakis, Theano Beskou-Kontou, Ioannis Theodoridis, Alkistis Skalkidou, Eleni Th Petridou,

INTRODUCTION:Experimental and epidemiological studies suggest female sex hormones to have long-lasting neuroprotective and anti-ageing properties. Surgically-induced menopause leads to a premature cessation of exposure to female sex hormones and could thus impact late-life cognitive function. Yet, evidence remains controversial. METHODS:We systematically reviewed literature for articles investigating the association of surgical ... Read more >>

Psychoneuroendocrinology (Psychoneuroendocrinology)
[2019, 106:9-19]

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Parental age and the risk of childhood acute myeloid leukemia: results from the Childhood Leukemia International Consortium.

Paraskevi Panagopoulou, Alkistis Skalkidou, Erin Marcotte, Friederike Erdmann, Xiaomei Ma, Julia E Heck, Anssi Auvinen, Beth A Mueller, Logan G Spector, Eve Roman, Catherine Metayer, Corrado Magnani, Maria S Pombo-de-Oliveira, Michael E Scheurer, Ana-Maria Mora, John D Dockerty, Johnni Hansen, Alice Y Kang, Rong Wang, David R Doody, Eleanor Kane, Joachim Schüz, Christos Christodoulakis, Evangelia Ntzani, Eleni Th Petridou, , ,

BACKGROUND:Parental age has been associated with several childhood cancers, albeit the evidence is still inconsistent. AIM:To examine the associations of parental age at birth with acute myeloid leukemia (AML) among children aged 0-14 years using individual-level data from the Childhood Leukemia International Consortium (CLIC) and non-CLIC studies. MATERIAL/METHODS:We analyzed data of ... Read more >>

Cancer Epidemiol (Cancer epidemiology)
[2019, 59:158-165]

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Stress-related genetic polymorphisms in association with peripartum depression symptoms and stress hormones: A longitudinal population-based study.

Alkistis Skalkidou, Inger Sundström Poromaa, Stavros I Iliadis, Anja C Huizink, Charlotte Hellgren, Eva Freyhult, Erika Comasco,

Individual differences in the response of the stress system to hormonal changes during pregnancy and the postpartum period render some women susceptible to developing depression. The present study sought to investigate peripartum depression and stress hormones in relation to stress-related genotypes. The Edinburgh Postnatal Depression Scale was used to assess ... Read more >>

Psychoneuroendocrinology (Psychoneuroendocrinology)
[2019, 103:296-305]

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Hypothalamic-pituitary-adrenal axis responsiveness, startle response, and sensorimotor gating in late pregnancy.

Julia Breedh, Erika Comasco, Charlotte Hellgren, Fotios C Papadopoulos, Alkistis Skalkidou, Inger Sundström Poromaa,

During pregnancy, the hypothalamic-pituitary-adrenal (HPA) axis, the main regulator of the stress response, undergoes dramatic changes. The acoustic startle response (ASR) and the prepulse inhibition (PPI) of the startle response are neurophysiological research tools and objective measures of an individual's response to an emotional context or stressor. The ASR and ... Read more >>

Psychoneuroendocrinology (Psychoneuroendocrinology)
[2019, 106:1-8]

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Neighborhood deprivation and adverse perinatal outcomes in Sweden: A population-based register study.

Susanne Hesselman, Anna-Karin Wikström, Alkistis Skalkidou, Inger Sundström-Poromaa, Anna Wikman,

INTRODUCTION:Neighborhood deprivation has been associated with adverse perinatal outcomes but it is unclear to what extent maternal and social risk factors explain the association and how a stressful environment per se contributes. MATERIAL AND METHODS:A population-based register study including 218 030 deliveries in Sweden between January 2013 and July 2017 was ... Read more >>

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2019, :]

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Inflammatory and anti-inflammatory markers in plasma: from late pregnancy to early postpartum.

Emma Bränn, Åsa Edvinsson, Anna Rostedt Punga, Inger Sundström-Poromaa, Alkistis Skalkidou,

During pregnancy, the woman's body undergoes tremendous changes in immune system adaptation. The immunological shifts that occur in pregnancy can partially be explained by alterations in hormonal levels. Furthermore, during pregnancy, many autoimmune diseases go into remission, only to flare again in the early postpartum period. Given these important changes ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):1863]

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Antenatal depressive symptoms and early initiation of breastfeeding in association with exclusive breastfeeding six weeks postpartum: a longitudinal population-based study.

Karin Cato, Sara M Sylvén, Marios K Georgakis, Natasa Kollia, Christine Rubertsson, Alkistis Skalkidou,

BACKGROUND:Depressive symptoms negatively impact on breastfeeding duration, whereas early breastfeeding initiation after birth enhances the chances for a longer breastfeeding period. Our aim was to investigate the interplay between depressive symptoms during pregnancy and late initiation of the first breastfeeding session and their effect on exclusive breastfeeding at six weeks ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2019, 19(1):49]

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Neuroticism is associated with higher antenatal care utilization in obstetric low-risk women.

Cathrine Axfors, Charlotte Hellgren, Helena Volgsten, Agneta Skoog Svanberg, Lisa Ekselius, Anna-Karin Wikström, Mia Ramklint, Alkistis Skalkidou, Inger Sundström-Poromaa,

INTRODUCTION:Elevated neuroticism is associated with higher health care utilization in the general population. This study aimed to investigate the association between neuroticism and the use of publicly financed antenatal care in obstetric low-risk women, taking predisposing and need factors for health care utilization into consideration. MATERIAL AND METHODS:Participants comprised 1052 ... Read more >>

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2019, 98(4):470-478]

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Women with prolonged nausea in pregnancy have increased risk for depressive symptoms postpartum.

Stavros I Iliadis, Cathrine Axfors, Sara Johansson, Alkistis Skalkidou, Ajlana Mulic-Lutvica,

The aim of this population-based, longitudinal study was to assess the association between nausea and vomiting in pregnancy (NVP) and perinatal depressive symptoms. Pregnant women (N = 4239) undergoing routine ultrasound at gestational week (GW) 17 self-reported on NVP and were divided into those without nausea (G0), early (≤17 GW) nausea without medication ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):15796]

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Inflammatory markers in women with postpartum depressive symptoms.

Emma Bränn, Emma Fransson, Richard A White, Fotios C Papadopoulos, Åsa Edvinsson, Masood Kamali-Moghaddam, Janet L Cunningham, Inger Sundström-Poromaa, Alkistis Skalkidou,

Postpartum depression (PPD) is a devastating disorder affecting not only more than 10% of all women giving birth, but also the baby, the family, and the society. Compiling evidence suggests the involvement of the immune system in the pathophysiology of major depression; yet, the immune response in perinatal depression is ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2018, :]

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Meteorological parameters and air pollen count in association with self-reported peripartum depressive symptoms.

Hanna E Henriksson, Richard A White, Sara M Sylvén, Fotios C Papadopoulos, Alkistis Skalkidou,

BACKGROUND:Meteorological parameters and air pollen count have been associated with affective disorders and suicide. Regarding peripartum depression, the literature is restricted and inconclusive. METHODS:This cross-sectional study included women (pregnant, n = 3843; postpartum, n = 3757) who participated in the BASIC (Biology, Affect, Stress, Imaging, and Cognition) study 2010-2015 and the UPPSAT (Uppsala-Athens) study ... Read more >>

Eur. Psychiatry (European psychiatry : the journal of the Association of European Psychiatrists)
[2018, 54:10-18]

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Advanced parental age as risk factor for childhood acute lymphoblastic leukemia: results from studies of the Childhood Leukemia International Consortium.

Eleni Th Petridou, Marios K Georgakis, Friederike Erdmann, Xiaomei Ma, Julia E Heck, Anssi Auvinen, Beth A Mueller, Logan G Spector, Eve Roman, Catherine Metayer, Corrado Magnani, Maria S Pombo-de-Oliveira, Sameera Ezzat, Michael E Scheurer, Ana Maria Mora, John D Dockerty, Johnni Hansen, Alice Y Kang, Rong Wang, David R Doody, Eleanor Kane, Waffa M Rashed, Nick Dessypris, Joachim Schüz, Claire Infante-Rivard, Alkistis Skalkidou,

Advanced parental age has been associated with adverse health effects in the offspring including childhood (0-14 years) acute lymphoblastic leukemia (ALL), as reported in our meta-analysis of published studies. We aimed to further explore the association using primary data from 16 studies participating in the Childhood Leukemia International Consortium. Data were ... Read more >>

Eur. J. Epidemiol. (European journal of epidemiology)
[2018, 33(10):965-976]

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HRG C633T polymorphism and risk of gestational hypertensive disorders: a pilot study.

Evangelia Elenis, Alkistis Skalkidou, Agneta Skoog-Svanberg, Gunilla Sydsjö, Anneli Stavreus-Evers, Helena Åkerud,

BACKGROUND:Preeclampsia and gestational hypertensive disorders are thought to occur due to endothelial cell dysfunction and abnormal placentation, triggered by angiogenesis-related factors yet undetermined. The aim of this study was to investigate whether a genetic polymorphism (SNP) of Histidine-rich glycoprotein (HRG), HRG C633T SNP, is associated with gestational hypertensive disorders. METHODS:It ... Read more >>

BMC Med. Genet. (BMC medical genetics)
[2018, 19(1):44]

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Discrepancy between pregnancy dating methods affects obstetric and neonatal outcomes: a population-based register cohort study.

Merit Kullinger, Michaela Granfors, Helle Kieler, Alkistis Skalkidou,

To assess associations between discrepancy of pregnancy dating methods and adverse pregnancy, delivery, and neonatal outcomes, odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for discrepancy categories among all singleton births from the Medical Birth Register (1995-2010) with estimated date of delivery (EDD) by last menstrual period (LMP) ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):6936]

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Self-Harm Thoughts Postpartum as a Marker for Long-Term Morbidity.

Stavros I Iliadis, Alkistis Skalkidou, Hanna Ranstrand, Marios K Georgakis, Cathrine Axfors, Fotios C Papadopoulos,

Postpartum depression predisposes to maternal affective and somatic disorders. It is important to identify which women are at an increased risk of subsequent morbidity and would benefit from an intensified follow-up. Self-harm thoughts (SHTs), with or without other depressive symptomatology, might have prognostic value for maternal health beyond the postpartum ... Read more >>

Front Public Health (Frontiers in public health)
[2018, 6:34]

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Systematic misclassification of gestational age by ultrasound biometry: implications for clinical practice and research methodology in the Nordic countries.

Alkistis Skalkidou, Merit Kullinger, Marios K Georgakis, Helle Kieler, Ulrik S Kesmodel,

Historically, pregnancy dating has been based on self-reported information on the first day of the last menstrual period. In the 1970s, ultrasound biometry was introduced as an alternative for pregnancy dating and is now the leading method in Nordic countries. The use of ultrasound led to a reduction of post-term ... Read more >>

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2018, 97(4):440-444]

Cited: 2 times

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A prospective investigation of perceived stress, infertility-related stress, and cortisol levels in women undergoing in vitro fertilization: influence on embryo quality and clinical pregnancy rate.

Carolyn E Cesta, Anna L V Johansson, Julius Hreinsson, Kenny A Rodriguez-Wallberg, Jan I Olofsson, Jan Holte, Håkan Wramsby, Margareta Wramsby, Sven Cnattingius, Alkistis Skalkidou, Anastasia Nyman Iliadou,

INTRODUCTION:Women undergoing fertility treatment experience high levels of stress. However, it remains uncertain if and how stress influences in vitro fertilization (IVF) cycle outcome. This study aimed to investigate whether self-reported perceived and infertility-related stress and cortisol levels were associated with IVF cycle outcomes. MATERIAL AND METHODS:A prospective cohort of ... Read more >>

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2018, 97(3):258-268]

Cited: 2 times

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Delineating the association between mode of delivery and postpartum depression symptoms: a longitudinal study.

Patricia Eckerdal, Marios K Georgakis, Natasa Kollia, Anna-Karin Wikström, Ulf Högberg, Alkistis Skalkidou,

INTRODUCTION:Although a number of perinatal factors have been implicated in the etiology of postpartum depression, the role of mode of delivery remains controversial. Our aim was to explore the association between mode of delivery and postpartum depression, considering the potentially mediating or confounding role of several covariates. MATERIAL AND METHODS:In ... Read more >>

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2018, 97(3):301-311]

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Different patterns of attentional bias in antenatal and postpartum depression.

Åsa Edvinsson, Alkistis Skalkidou, Charlotte Hellgren, Malin Gingnell, Lisa Ekselius, Mimmie Willebrand, Inger Sundström Poromaa,

Background:Biased information processing in attention, memory, and interpretation is proposed to be central cognitive alterations in patients with major depressive disorder, but studies in women with peripartum depression are scarce. Because of the many similarities with depression in nonperipartum states as regards symptom profile and risk factors, we hypothesized that ... Read more >>

Brain Behav (Brain and behavior)
[2017, 7(11):e00844]

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Adult attachment's unique contribution in the prediction of postpartum depressive symptoms, beyond personality traits.

Cathrine Axfors, Sara Sylvén, Mia Ramklint, Alkistis Skalkidou,

Personality traits such as neuroticism can help identify pregnant women at risk of postpartum depressive symptoms (PPDS). However, it is unclear whether attachment style could have an additional contribution to this risk elevation. This study aimed to examine the overlap of adult attachment insecurity and neuroticism/trait anxiety as PPDS predictors, ... Read more >>

J Affect Disord (Journal of affective disorders)
[2017, 222:177-184]

Cited: 1 time

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