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Author Alkistis Skalkidou

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Association of Attention-Deficit/Hyperactivity Disorder With Teenage Birth Among Women and Girls in Sweden.

Charlotte Skoglund, Helena Kopp Kallner, Alkistis Skalkidou, Anna-Karin Wikström, Cecilia Lundin, Susanne Hesselman, Anna Wikman, Inger Sundström Poromaa,

Importance:Attention-deficit/hyperactivity disorder (ADHD) is associated with a plethora of adverse health outcomes throughout life. While Swedish specialized youth clinics have carefully and successfully targeted risk of unplanned pregnancies in adolescents, important risk groups, such as women and girls with ADHD, might not be identified or appropriately assisted by these interventions. ... Read more >>

JAMA Netw Open (JAMA network open)
[2019, 2(10):e1912463]

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Comparison of major depression diagnostic classification probability using the SCID, CIDI, and MINI diagnostic interviews among women in pregnancy or postpartum: An individual participant data meta-analysis.

Brooke Levis, Dean McMillan, Ying Sun, Chen He, Danielle B Rice, Ankur Krishnan, Yin Wu, Marleine Azar, Tatiana A Sanchez, Matthew J Chiovitti, Parash Mani Bhandari, Dipika Neupane, Nazanin Saadat, Kira E Riehm, Mahrukh Imran, Jill T Boruff, Pim Cuijpers, Simon Gilbody, John P A Ioannidis, Lorie A Kloda, Scott B Patten, Ian Shrier, Roy C Ziegelstein, Liane Comeau, Nicholas D Mitchell, Marcello Tonelli, Simone N Vigod, Franca Aceti, Rubén Alvarado, Cosme Alvarado-Esquivel, Muideen O Bakare, Jacqueline Barnes, Cheryl Tatano Beck, Carola Bindt, Philip M Boyce, Adomas Bunevicius, Tiago Castro E Couto, Linda H Chaudron, Humberto Correa, Felipe Pinheiro de Figueiredo, Valsamma Eapen, Michelle Fernandes, Barbara Figueiredo, Jane R W Fisher, Lluïsa Garcia-Esteve, Lisa Giardinelli, Nadine Helle, Louise M Howard, Dina Sami Khalifa, Jane Kohlhoff, Laima Kusminskas, Zoltán Kozinszky, Lorenzo Lelli, Angeliki A Leonardou, Beth A Lewis, Michael Maes, Valentina Meuti, Sandra Nakić Radoš, Purificación Navarro García, Daisuke Nishi, Daniel Okitundu Luwa E-Andjafono, Emma Robertson-Blackmore, Tamsen J Rochat, Heather J Rowe, Bonnie W M Siu, Alkistis Skalkidou, Alan Stein, Robert C Stewart, Kuan-Pin Su, Inger Sundström-Poromaa, Meri Tadinac, S Darius Tandon, Iva Tendais, Pavaani Thiagayson, Annamária Töreki, Anna Torres-Giménez, Thach D Tran, Kylee Trevillion, Katherine Turner, Johann M Vega-Dienstmaier, Karen Wynter, Kimberly A Yonkers, Andrea Benedetti, Brett D Thombs,

OBJECTIVES:A previous individual participant data meta-analysis (IPDMA) identified differences in major depression classification rates between different diagnostic interviews, controlling for depressive symptoms on the basis of the Patient Health Questionnaire-9. We aimed to determine whether similar results would be seen in a different population, using studies that administered the Edinburgh ... Read more >>

Int J Methods Psychiatr Res (International journal of methods in psychiatric research)
[2019, :e1803]

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Investigating the association between neuroticism and adverse obstetric and neonatal outcomes.

Cathrine Axfors, Patricia Eckerdal, Helena Volgsten, Anna-Karin Wikström, Lisa Ekselius, Mia Ramklint, Inger Sundström Poromaa, Alkistis Skalkidou,

Neuroticism is not only associated with affective disorders but also with certain somatic health problems. However, studies assessing whether neuroticism is associated with adverse obstetric or neonatal outcomes are scarce. This observational study comprises first-time mothers (n = 1969) with singleton pregnancies from several cohorts based in Uppsala, Sweden. To assess neuroticism-related ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):15470]

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Cohort profile: the Biology, Affect, Stress, Imaging and Cognition (BASIC) study on perinatal depression in a population-based Swedish cohort.

Cathrine Axfors, Emma Bränn, Hanna E Henriksson, Charlotte Hellgren, Theodora Kunovac Kallak, Emma Fransson, Susanne Lager, Stavros I Iliadis, Sara Sylvén, Fotios C Papadopoulos, Lisa Ekselius, Inger Sundström-Poromaa, Alkistis Skalkidou,

PURPOSE:With the population-based, prospective Biology, Affect, Stress, Imaging and Cognition (BASIC) cohort, we aim to investigate the biopsychosocial aetiological processes involved in perinatal depression (PND) and to pinpoint its predictors in order to improve early detection. PARTICIPANTS:From September 2009 to November 2018, the BASIC study at Uppsala University Hospital, Sweden, ... Read more >>

BMJ Open (BMJ open)
[2019, 9(10):e031514]

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Blood plasma metabolic profiling of pregnant women with antenatal depressive symptoms.

Hanna E Henriksson, Christina Malavaki, Emma Bränn, Vasilis Drainas, Susanne Lager, Stavros I Iliadis, Fotios C Papadopoulos, Inger Sundström Poromaa, George P Chrousos, Maria I Klapa, Alkistis Skalkidou,

Antenatal depression affects ~9-19% of pregnant women and can exert persistent adverse effects on both mother and child. There is a need for a deeper understanding of antenatal depression mechanisms and the development of tools for reliable diagnosis and early identification of women at high risk. As the use of ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2019, 9(1):204]

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Investigating the effect of lifestyle risk factors upon number of aspirated and mature oocytes in in vitro fertilization cycles: Interaction with antral follicle count.

Lana Salih Joelsson, Evangelia Elenis, Kjell Wanggren, Anna Berglund, Anastasia N Iliadou, Carolyn E Cesta, Sunni L Mumford, Richard White, Tanja Tydén, Alkistis Skalkidou,

INTRODUCTION:There is evidence demonstrating that certain lifestyle factors have a detrimental effect on fertility. Since such factors often coexist, possible synergistic effects merit further investigation. Thus we aimed to examine the cumulative impact of lifestyle factors on in vitro fertilization (IVF) early reproductive treatment outcomes and their interaction with measures ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0221015]

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Adherence to Swedish national pregnancy dating guidelines and management of discrepancies between pregnancy dating methods: a survey study.

Merit Kullinger, Michaela Granfors, Helle Kieler, Alkistis Skalkidou,

BACKGROUND:Swedish national guidelines for pregnancy dating were published in 2010. Follow-up is needed to assess adherence and to identify whether any clinical topics are not covered in the guidelines. METHODS:All units in Sweden that performed ultrasound-based pregnancy dating were asked to complete a web-based questionnaire comprising multiple-response questions and commentary ... Read more >>

Reprod Health (Reproductive health)
[2019, 16(1):95]

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Epidural Analgesia During Childbirth and Postpartum Depressive Symptoms: A Population-Based Longitudinal Cohort Study.

Patricia Eckerdal, Natasa Kollia, Linnea Karlsson, Agneta Skoog-Svanberg, Anna-Karin Wikström, Ulf Högberg, Alkistis Skalkidou,

BACKGROUND:Severe pain has been linked to depression, which raises the question of whether epidural analgesia (EDA) during childbirth is associated with a reduced risk of postpartum depression (PPD). This association has been explored previously, but the studies were restricted by small sample sizes and the inability to control for relevant ... Read more >>

Anesth. Analg. (Anesthesia and analgesia)
[2019, :]

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Maternal body mass index moderates antenatal depression effects on infant birthweight.

Heidrun Petursdottir Maack, Alkistis Skalkidou, Anna Sjöholm, Karin Eurenius-Orre, Ajlana Mulic-Lutvica, Anna-Karin Wikström, Inger Sundström Poromaa,

Obesity and depression are two common medical problems that pregnant women present with in antenatal care. Overweight and obesity at the beginning of the pregnancy, and excessive weight gain during pregnancy, are independent explanatory variables for fetal birthweight and independent risk factors for giving birth to a large for gestational ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):6213]

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Experiences of sexual violence among women seeking services at a family planning unit in Sweden.

Mariella Öberg, Alkistis Skalkidou, Gun Heimer,

Background: Experiences of sexual violence among women can lead to ill health and increase the risk of lifetime co-occurrence of violence. Identifying risk factors and victims facilitates development of effective programmes for treatment and prevention of additional violence. The primary aim of this study was to assess the prevalence and ... Read more >>

Ups. J. Med. Sci. (Upsala journal of medical sciences)
[2019, 124(2):135-139]

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Characteristics of women with different perinatal depression trajectories.

Anna Wikman, Cathrine Axfors, Stavros I Iliadis, John Cox, Emma Fransson, Alkistis Skalkidou,

Maternal perinatal depression (PND), a common mental disorder with a prevalence of over 10%, is associated with long-term health risks for both mothers and offspring. This study aimed at describing characteristics related to background and lifestyle, pregnancy, delivery, and postpartum of different PND trajectories defined according to the onset of ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2019, :]

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Parental age and the risk of childhood acute myeloid leukemia: results from the Childhood Leukemia International Consortium.

Paraskevi Panagopoulou, Alkistis Skalkidou, Erin Marcotte, Friederike Erdmann, Xiaomei Ma, Julia E Heck, Anssi Auvinen, Beth A Mueller, Logan G Spector, Eve Roman, Catherine Metayer, Corrado Magnani, Maria S Pombo-de-Oliveira, Michael E Scheurer, Ana-Maria Mora, John D Dockerty, Johnni Hansen, Alice Y Kang, Rong Wang, David R Doody, Eleanor Kane, Joachim Schüz, Christos Christodoulakis, Evangelia Ntzani, Eleni Th Petridou, , ,

BACKGROUND:Parental age has been associated with several childhood cancers, albeit the evidence is still inconsistent. AIM:To examine the associations of parental age at birth with acute myeloid leukemia (AML) among children aged 0-14 years using individual-level data from the Childhood Leukemia International Consortium (CLIC) and non-CLIC studies. MATERIAL/METHODS:We analyzed data of ... Read more >>

Cancer Epidemiol (Cancer epidemiology)
[2019, 59:158-165]

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Stress-related genetic polymorphisms in association with peripartum depression symptoms and stress hormones: A longitudinal population-based study.

Alkistis Skalkidou, Inger Sundström Poromaa, Stavros I Iliadis, Anja C Huizink, Charlotte Hellgren, Eva Freyhult, Erika Comasco,

Individual differences in the response of the stress system to hormonal changes during pregnancy and the postpartum period render some women susceptible to developing depression. The present study sought to investigate peripartum depression and stress hormones in relation to stress-related genotypes. The Edinburgh Postnatal Depression Scale was used to assess ... Read more >>

Psychoneuroendocrinology (Psychoneuroendocrinology)
[2019, 103:296-305]

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Surgical menopause in association with cognitive function and risk of dementia: A systematic review and meta-analysis.

Marios K Georgakis, Theano Beskou-Kontou, Ioannis Theodoridis, Alkistis Skalkidou, Eleni Th Petridou,

INTRODUCTION:Experimental and epidemiological studies suggest female sex hormones to have long-lasting neuroprotective and anti-ageing properties. Surgically-induced menopause leads to a premature cessation of exposure to female sex hormones and could thus impact late-life cognitive function. Yet, evidence remains controversial. METHODS:We systematically reviewed literature for articles investigating the association of surgical ... Read more >>

Psychoneuroendocrinology (Psychoneuroendocrinology)
[2019, 106:9-19]

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Neighborhood deprivation and adverse perinatal outcomes in Sweden: A population-based register study.

Susanne Hesselman, Anna-Karin Wikström, Alkistis Skalkidou, Inger Sundström-Poromaa, Anna Wikman,

INTRODUCTION:Neighborhood deprivation has been associated with adverse perinatal outcomes but it is unclear to what extent maternal and social risk factors explain the association and how a stressful environment per se contributes. MATERIAL AND METHODS:A population-based register study including 218 030 deliveries in Sweden between January 2013 and July 2017 was ... Read more >>

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2019, 98(8):1004-1013]

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Hypothalamic-pituitary-adrenal axis responsiveness, startle response, and sensorimotor gating in late pregnancy.

Julia Breedh, Erika Comasco, Charlotte Hellgren, Fotios C Papadopoulos, Alkistis Skalkidou, Inger Sundström Poromaa,

During pregnancy, the hypothalamic-pituitary-adrenal (HPA) axis, the main regulator of the stress response, undergoes dramatic changes. The acoustic startle response (ASR) and the prepulse inhibition (PPI) of the startle response are neurophysiological research tools and objective measures of an individual's response to an emotional context or stressor. The ASR and ... Read more >>

Psychoneuroendocrinology (Psychoneuroendocrinology)
[2019, 106:1-8]

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Inflammatory and anti-inflammatory markers in plasma: from late pregnancy to early postpartum.

Emma Bränn, Åsa Edvinsson, Anna Rostedt Punga, Inger Sundström-Poromaa, Alkistis Skalkidou,

During pregnancy, the woman's body undergoes tremendous changes in immune system adaptation. The immunological shifts that occur in pregnancy can partially be explained by alterations in hormonal levels. Furthermore, during pregnancy, many autoimmune diseases go into remission, only to flare again in the early postpartum period. Given these important changes ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):1863]

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Neuroticism is associated with higher antenatal care utilization in obstetric low-risk women.

Cathrine Axfors, Charlotte Hellgren, Helena Volgsten, Agneta Skoog Svanberg, Lisa Ekselius, Anna-Karin Wikström, Mia Ramklint, Alkistis Skalkidou, Inger Sundström-Poromaa,

INTRODUCTION:Elevated neuroticism is associated with higher health care utilization in the general population. This study aimed to investigate the association between neuroticism and the use of publicly financed antenatal care in obstetric low-risk women, taking predisposing and need factors for health care utilization into consideration. MATERIAL AND METHODS:Participants comprised 1052 ... Read more >>

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2019, 98(4):470-478]

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Antenatal depressive symptoms and early initiation of breastfeeding in association with exclusive breastfeeding six weeks postpartum: a longitudinal population-based study.

Karin Cato, Sara M Sylvén, Marios K Georgakis, Natasa Kollia, Christine Rubertsson, Alkistis Skalkidou,

BACKGROUND:Depressive symptoms negatively impact on breastfeeding duration, whereas early breastfeeding initiation after birth enhances the chances for a longer breastfeeding period. Our aim was to investigate the interplay between depressive symptoms during pregnancy and late initiation of the first breastfeeding session and their effect on exclusive breastfeeding at six weeks ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2019, 19(1):49]

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Women with prolonged nausea in pregnancy have increased risk for depressive symptoms postpartum.

Stavros I Iliadis, Cathrine Axfors, Sara Johansson, Alkistis Skalkidou, Ajlana Mulic-Lutvica,

The aim of this population-based, longitudinal study was to assess the association between nausea and vomiting in pregnancy (NVP) and perinatal depressive symptoms. Pregnant women (N = 4239) undergoing routine ultrasound at gestational week (GW) 17 self-reported on NVP and were divided into those without nausea (G0), early (≤17 GW) nausea without medication ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):15796]

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Inflammatory markers in women with postpartum depressive symptoms.

Emma Bränn, Emma Fransson, Richard A White, Fotios C Papadopoulos, Åsa Edvinsson, Masood Kamali-Moghaddam, Janet L Cunningham, Inger Sundström-Poromaa, Alkistis Skalkidou,

Postpartum depression (PPD) is a devastating disorder affecting not only more than 10% of all women giving birth, but also the baby, the family, and the society. Compiling evidence suggests the involvement of the immune system in the pathophysiology of major depression; yet, the immune response in perinatal depression is ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2018, :]

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Meteorological parameters and air pollen count in association with self-reported peripartum depressive symptoms.

Hanna E Henriksson, Richard A White, Sara M Sylvén, Fotios C Papadopoulos, Alkistis Skalkidou,

BACKGROUND:Meteorological parameters and air pollen count have been associated with affective disorders and suicide. Regarding peripartum depression, the literature is restricted and inconclusive. METHODS:This cross-sectional study included women (pregnant, n = 3843; postpartum, n = 3757) who participated in the BASIC (Biology, Affect, Stress, Imaging, and Cognition) study 2010-2015 and the UPPSAT (Uppsala-Athens) study ... Read more >>

Eur. Psychiatry (European psychiatry : the journal of the Association of European Psychiatrists)
[2018, 54:10-18]

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Advanced parental age as risk factor for childhood acute lymphoblastic leukemia: results from studies of the Childhood Leukemia International Consortium.

Eleni Th Petridou, Marios K Georgakis, Friederike Erdmann, Xiaomei Ma, Julia E Heck, Anssi Auvinen, Beth A Mueller, Logan G Spector, Eve Roman, Catherine Metayer, Corrado Magnani, Maria S Pombo-de-Oliveira, Sameera Ezzat, Michael E Scheurer, Ana Maria Mora, John D Dockerty, Johnni Hansen, Alice Y Kang, Rong Wang, David R Doody, Eleanor Kane, Waffa M Rashed, Nick Dessypris, Joachim Schüz, Claire Infante-Rivard, Alkistis Skalkidou,

Advanced parental age has been associated with adverse health effects in the offspring including childhood (0-14 years) acute lymphoblastic leukemia (ALL), as reported in our meta-analysis of published studies. We aimed to further explore the association using primary data from 16 studies participating in the Childhood Leukemia International Consortium. Data were ... Read more >>

Eur. J. Epidemiol. (European journal of epidemiology)
[2018, 33(10):965-976]

Cited: 1 time

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HRG C633T polymorphism and risk of gestational hypertensive disorders: a pilot study.

Evangelia Elenis, Alkistis Skalkidou, Agneta Skoog-Svanberg, Gunilla Sydsjö, Anneli Stavreus-Evers, Helena Åkerud,

BACKGROUND:Preeclampsia and gestational hypertensive disorders are thought to occur due to endothelial cell dysfunction and abnormal placentation, triggered by angiogenesis-related factors yet undetermined. The aim of this study was to investigate whether a genetic polymorphism (SNP) of Histidine-rich glycoprotein (HRG), HRG C633T SNP, is associated with gestational hypertensive disorders. METHODS:It ... Read more >>

BMC Med. Genet. (BMC medical genetics)
[2018, 19(1):44]

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Discrepancy between pregnancy dating methods affects obstetric and neonatal outcomes: a population-based register cohort study.

Merit Kullinger, Michaela Granfors, Helle Kieler, Alkistis Skalkidou,

To assess associations between discrepancy of pregnancy dating methods and adverse pregnancy, delivery, and neonatal outcomes, odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for discrepancy categories among all singleton births from the Medical Birth Register (1995-2010) with estimated date of delivery (EDD) by last menstrual period (LMP) ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):6936]

Cited: 1 time

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