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Author Alison J E Green

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Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study.

Alex Iranzo, Graham Fairfoul, Anutra Chumbala Na Ayudhaya, Monica Serradell, Ellen Gelpi, Isabel Vilaseca, Raquel Sanchez-Valle, Carles Gaig, Joan Santamaria, Eduard Tolosa, Renata L Riha, Alison J E Green,

<h4>Background</h4>Isolated rapid-eye-movement (REM) sleep behaviour disorder (IRBD) can be part of the prodromal stage of the α-synucleinopathies Parkinson's disease and dementia with Lewy bodies. Real-time quaking-induced conversion (RT-QuIC) analysis of CSF has high sensitivity and specificity for the detection of misfolded α-synuclein in patients with Parkinson's disease and dementia with ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):203-212]

Cited: 0 times

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RT-QuIC-based detection of alpha-synuclein seeding activity in brains of dementia with Lewy Body patients and of a transgenic mouse model of synucleinopathy.

Jung-Youn Han, Hyung-Sup Jang, Alison J E Green, Young Pyo Choi,

RT-QuIC is a shaking-based cyclic amplification technique originally developed in the prion field to detect minute amounts of scrapie prion protein (PrP<sup>Sc</sup>). In this study, we applied the RT-QuIC assay to investigate a-synuclein (a-syn) seeding activity in brains of Dementia with Lewy Body (DLB) patients and in brains of G2-3 ... Read more >>

Prion (Prion)
[2020, 14(1):88-94]

Cited: 1 time

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Epitope mapping of the protease resistant products of RT-QuIC does not allow the discrimination of sCJD subtypes.

Gabriele Piconi, Alexander H Peden, Marcelo A Barria, Alison J E Green,

Sporadic Creutzfeldt-Jakob disease (sCJD) is a transmissible, rapidly progressive and fatal neurodegenerative disease. The transmissible agent linked to sCJD is composed of the misfolded form of the host-encoded prion protein. The combination of histopathological and biochemical analyses has allowed the identification and sub-classification of six sCJD subtypes. This classification depends ... Read more >>

PLoS One (PloS one)
[2019, 14(6):e0218509]

Cited: 1 time

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α-Synuclein real-time quaking-induced conversion in the cerebrospinal fluid of uncertain cases of parkinsonism.

Anouke van Rumund, Alison J E Green, Graham Fairfoul, Rianne A J Esselink, Bastiaan R Bloem, Marcel M Verbeek,

A reliable biomarker is needed for accurate and early differentiation between Parkinson disease and the various forms of atypical parkinsonism. We used a novel real-time quaking-induced conversion (RT-QuIC) assay to detect α-synuclein (α-syn) aggregates in cerebrospinal fluid (CSF) of 118 patients with parkinsonism of uncertain clinical etiology and 52 controls. ... Read more >>

Ann Neurol (Annals of neurology)
[2019, 85(5):777-781]

Cited: 12 times

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RT-QuIC: a new test for sporadic CJD.

Alison J E Green,

The diagnosis of sporadic Creutzfeldt-Jakob disease (CJD) can be difficult, but the real-time quaking-induced conversion (RT-QuIC) assays have made a considerable impact on its clinical diagnosis. This technique exploits the ability of the misfolded pathological form of prion protein (PrP<sup>Sc</sup>) found in cerebrospinal fluid (CSF) to induce conversion of normal ... Read more >>

Pract Neurol (Practical neurology)
[2019, 19(1):49-55]

Cited: 13 times

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Diagnosis of Methionine/Valine Variant Creutzfeldt-Jakob Disease by Protein Misfolding Cyclic Amplification.

Daisy Bougard, Maxime Bélondrade, Charly Mayran, Lilian Bruyère-Ostells, Sylvain Lehmann, Chantal Fournier-Wirth, Richard S Knight, Robert G Will, Alison J E Green,

A patient with a heterozygous variant of Creutzfeldt-Jakob disease (CJD) with a methionine/valine genotype at codon 129 of the prion protein gene was recently reported. Using an ultrasensitive and specific protein misfolding cyclic amplification-based assay for detecting variant CJD prions in cerebrospinal fluid, we discriminated this heterozygous case of variant ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2018, 24(7):1364-1366]

Cited: 6 times

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Prion protein amplification techniques.

Alison J E Green, Gianluigi Zanusso,

Protein amplification techniques exploit the ability of PrP<sup>TSE</sup> to induce a conformational change in prion protein (PrP) in a continuous fashion, so that the small amount of PrP<sup>TSE</sup> found in tissues and biologic fluids in prion diseases can be amplified to a point where they are detectable by conventional laboratory ... Read more >>

Handb Clin Neurol (Handbook of clinical neurology)
[2018, 153:357-370]

Cited: 5 times

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Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies.

Graham Fairfoul, Lynne I McGuire, Suvankar Pal, James W Ironside, Juliane Neumann, Sharon Christie, Catherine Joachim, Margaret Esiri, Samuel G Evetts, Michal Rolinski, Fahd Baig, Claudio Ruffmann, Richard Wade-Martins, Michele T M Hu, Laura Parkkinen, Alison J E Green,

We have developed a novel real-time quaking-induced conversion RT-QuIC-based assay to detect alpha-synuclein aggregation in brain and cerebrospinal fluid from dementia with Lewy bodies and Parkinson's disease patients. This assay can detect alpha-synuclein aggregation in Dementia with Lewy bodies and Parkinson's disease cerebrospinal fluid with sensitivities of 92% and 95%, ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2016, 3(10):812-818]

Cited: 91 times

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A Naturally Occurring Bovine Tauopathy Is Geographically Widespread in the UK.

Martin Jeffrey, Pedro Piccardo, Diane L Ritchie, James W Ironside, Alison J E Green, Gillian McGovern,

Many human neurodegenerative diseases are associated with hyperphosphorylation and widespread intra-neuronal and glial associated aggregation of the microtubule associated protein tau. In contrast, animal tauopathies are not reported with only senescent animals showing inconspicuous tau labelling of fine processes albeit significant tau aggregation may occur in some experimental animal disease. ... Read more >>

PLoS One (PloS one)
[2015, 10(6):e0129499]

Cited: 4 times

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Delirium and cerebrospinal fluid S100B in hip fracture patients: a preliminary study.

Roanna J Hall, Karen J Ferguson, Mary Andrews, Alison J E Green, Tim O White, Ian R Armstrong, Alasdair M J MacLullich,

<h4>Objectives</h4>Delirium is associated with an increased risk of long-term cognitive decline, suggesting the possibility of concurrent central nervous system (CNS) injury. S100B is a putative biomarker of CNS injury and elevated serum levels in delirium have been reported. Here we hypothesize that delirium is associated with raised concentrations of cerebrospinal ... Read more >>

Am J Geriatr Psychiatry (The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry)
[2013, 21(12):1239-1243]

Cited: 13 times

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Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease.

Lynne I McGuire, Alexander H Peden, Christina D Orrú, Jason M Wilham, Nigel E Appleford, Gary Mallinson, Mary Andrews, Mark W Head, Byron Caughey, Robert G Will, Richard S G Knight, Alison J E Green,

<h4>Objective</h4>Current cerebrospinal fluid (CSF) tests for sporadic Creutzfeldt-Jakob disease (sCJD) are based on the detection of surrogate markers of neuronal damage such as CSF 14-3-3, which are not specific for sCJD. A number of prion protein conversion assays have been developed, including real time quaking-induced conversion (RT-QuIC). The objective of ... Read more >>

Ann Neurol (Annals of neurology)
[2012, 72(2):278-285]

Cited: 144 times

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Sensitive and specific detection of sporadic Creutzfeldt-Jakob disease brain prion protein using real-time quaking-induced conversion.

Alexander H Peden, Lynne I McGuire, Nigel E J Appleford, Gary Mallinson, Jason M Wilham, Christina D Orrú, Byron Caughey, James W Ironside, Richard S Knight, Robert G Will, Alison J E Green, Mark W Head,

Real-time quaking-induced conversion (RT-QuIC) is an assay in which disease-associated prion protein (PrP) initiates a rapid conformational transition in recombinant PrP (recPrP), resulting in the formation of amyloid that can be monitored in real time using the dye thioflavin T. It therefore has potential advantages over analogous cell-free PrP conversion ... Read more >>

J Gen Virol (The Journal of general virology)
[2012, 93(Pt 2):438-449]

Cited: 63 times

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Viliuisk encephalomyelitis: intrathecal synthesis of oligoclonal IgG.

Alison J E Green, Tatiana M Sivtseva, Al'bina P Danilova, Vladimir L Osakovsky, Vsevolod A Vladimirtsev, Martin Zeidler, Richard S Knight, Feodor A Platonov, Alexey Shatunov, Vasiliy P Alekseev, Vadim G Krivoshapkin, Colin L Masters, D Carleton Gajdusek, Lev G Goldfarb,

Viliuisk encephalomyelitis (VE) is a neurodegenerative disorder expressed as subacute meningo-encephalitis progressing to a more prolonged pan-encephalitic syndrome with a fatal outcome within 1 to 10 years. Some patients survive to a steady state of global dementia and severe spasticity that may last for over 20 years. Multiple micronecrotic foci ... Read more >>

J Neurol Sci (Journal of the neurological sciences)
[2003, 212(1-2):69-73]

Cited: 8 times

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Role of serum S100B as an early predictor of high intracranial pressure and mortality in brain injury: a pilot study.

Axel Petzold, Alison J E Green, Geoff Keir, Sandra Fairley, N Kitchen, Martin Smith, E J Thompson,

OBJECTIVE:To investigate whether serum S100B is suitable as a sensitive biomarker for early prediction of increased intracranial pressure and mortality rates after brain injury. DESIGN:A prospective, longitudinal study. SETTING:Neurosurgical intensive care unit. PATIENTS:Twenty-one patients with acute brain injury and 13 healthy controls. INTERVENTIONS:None. MEASUREMENTS AND MAIN RESULTS:We assessed Glasgow Coma ... Read more >>

Crit Care Med (Critical care medicine)
[2002, 30(12):2705-2710]

Cited: 58 times

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14-3-3 in the cerebrospinal fluid of patients with variant and sporadic Creutzfeldt-Jakob disease measured using capture assay able to detect low levels of 14-3-3 protein.

Alison J E Green, Sanja Ramljak, Werner E G Müller, Richard S G Knight, Heinz C Schröder,

A protein capture assay was used to measure 14-3-3 (-isoform) in the cerebrospinal fluid (CSF) of patients with either variant or sporadic Creutzfeldt-Jakob disease (CJD). The results were compared with those obtained using Western blotting. Elevated levels of 14-3-3 were found in 58% of variant CJD (vCJD) patients and 82% ... Read more >>

Neurosci Lett (Neuroscience letters)
[2002, 324(1):57-60]

Cited: 14 times

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