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Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study.

Alex Iranzo, Graham Fairfoul, Anutra Chumbala Na Ayudhaya, Monica Serradell, Ellen Gelpi, Isabel Vilaseca, Raquel Sanchez-Valle, Carles Gaig, Joan Santamaria, Eduard Tolosa, Renata L Riha, Alison J E Green,

<h4>Background</h4>Isolated rapid-eye-movement (REM) sleep behaviour disorder (IRBD) can be part of the prodromal stage of the α-synucleinopathies Parkinson's disease and dementia with Lewy bodies. Real-time quaking-induced conversion (RT-QuIC) analysis of CSF has high sensitivity and specificity for the detection of misfolded α-synuclein in patients with Parkinson's disease and dementia with ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):203-212]

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Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease.

Peter Hermann, Brian Appleby, Jean-Philippe Brandel, Byron Caughey, Steven Collins, Michael D Geschwind, Alison Green, Stephane Haïk, Gabor G Kovacs, Anna Ladogana, Franc Llorens, Simon Mead, Noriyuki Nishida, Suvankar Pal, Piero Parchi, Maurizio Pocchiari, Katsuya Satoh, Gianluigi Zanusso, Inga Zerr,

Sporadic Creutzfeldt-Jakob disease is a fatal neurodegenerative disease caused by misfolded prion proteins (PrP<sup>Sc</sup>). Effective therapeutics are currently not available and accurate diagnosis can be challenging. Clinical diagnostic criteria use a combination of characteristic neuropsychiatric symptoms, CSF proteins 14-3-3, MRI, and EEG. Supportive biomarkers, such as high CSF total tau, ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):235-246]

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Regional Differences in Neuroinflammation-Associated Gene Expression in the Brain of Sporadic Creutzfeldt-Jakob Disease Patients.

Aušrinė Areškevičiūtė, Thomas Litman, Helle Broholm, Linea C Melchior, Pia R Nielsen, Alison Green, Jens O Eriksen, Colin Smith, Eva L Lund,

Neuroinflammation is an essential part of neurodegeneration. Yet, the current understanding of neuroinflammation-associated molecular events in distinct brain regions of prion disease patients is insufficient to lay the ground for effective treatment strategies targeting this complex neuropathological process. To address this problem, we analyzed the expression of 800 neuroinflammation-associated genes ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 22(1):]

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RT-QuIC-based detection of alpha-synuclein seeding activity in brains of dementia with Lewy Body patients and of a transgenic mouse model of synucleinopathy.

Jung-Youn Han, Hyung-Sup Jang, Alison J E Green, Young Pyo Choi,

RT-QuIC is a shaking-based cyclic amplification technique originally developed in the prion field to detect minute amounts of scrapie prion protein (PrP<sup>Sc</sup>). In this study, we applied the RT-QuIC assay to investigate a-synuclein (a-syn) seeding activity in brains of Dementia with Lewy Body (DLB) patients and in brains of G2-3 ... Read more >>

Prion (Prion)
[2020, 14(1):88-94]

Cited: 1 time

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Ring trial of 2nd generation RT-QuIC diagnostic tests for sporadic CJD.

Christina D Orrú, Bradley R Groveman, Aaron Foutz, Matilde Bongianni, Franco Cardone, Neil McKenzie, Audrey Culeux, Anna Poleggi, Katarina Grznarova, Daniela Perra, Michele Fiorini, Xiaoqin Liu, Anna Ladogana, Marco Sbriccoli, Andrew G Hughson, Stéphane Haïk, Alison J Green, Michael D Geschwind, Maurizio Pocchiari, Jiri G Safar, Gianluigi Zanusso, Byron Caughey,

<h4>Objective</h4>Real-time quaking-induced conversion (RT-QuIC) assays detect prion-seeding activity in a variety of human biospecimens, including cerebrospinal fluid and olfactory mucosa swabs. The assay has shown high diagnostic accuracy in patients with prion disorders. Recently, advances in these tests have led to markedly improved diagnostic sensitivity and reduced assay times. Accordingly, ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2020, 7(11):2262-2271]

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Application of telehealth for comprehensive Creutzfeldt-Jakob disease surveillance in the United Kingdom.

Neil Watson, Hatice Kurudzhu, Alison Green, David Summers, Colin Smith, Suvankar Pal,

Creutzfeldt-Jakob disease (CJD) is a fatal human prion disease. Surveillance systems operate globally with the goals of accurate in-life case ascertainment, appropriate public health interventions to minimise secondary transmission, and monitoring trends in disease epidemiology. The UK experienced the highest incidence of variant CJD (vCJD) in the world following widespread ... Read more >>

J Neurol Sci (Journal of the neurological sciences)
[2021, 420:117221]

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Diagnosing and providing initial management for patients with Gestational Diabetes: What is the General Practitioner's experience?

Alison Green, Leonie Callaway, H David McIntyre, Ben Mitchell,

AIM:This study explores the General Practice (GP) experience of Gestational Diabetes Mellitus (GDM). Much has been written about patient perspectives, yet little is known about the GP perspective at initial diagnosis and management. GDM is increasingly managed in the secondary and tertiary sector, the confidence of GPs and their role ... Read more >>

Diabetes Res Clin Pract (Diabetes research and clinical practice)
[2020, 166:108290]

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Meeting fisheries, ecosystem function, and biodiversity goals in a human-dominated world.

Joshua E Cinner, Jessica Zamborain-Mason, Georgina G Gurney, Nicholas A J Graham, M Aaron MacNeil, Andrew S Hoey, Camilo Mora, Sébastien Villéger, Eva Maire, Tim R McClanahan, Joseph M Maina, John N Kittinger, Christina C Hicks, Stephanie D'agata, Cindy Huchery, Michele L Barnes, David A Feary, Ivor D Williams, Michel Kulbicki, Laurent Vigliola, Laurent Wantiez, Graham J Edgar, Rick D Stuart-Smith, Stuart A Sandin, Alison L Green, Maria Beger, Alan M Friedlander, Shaun K Wilson, Eran Brokovich, Andrew J Brooks, Juan J Cruz-Motta, David J Booth, Pascale Chabanet, Mark Tupper, Sebastian C A Ferse, U Rashid Sumaila, Marah J Hardt, David Mouillot,

The worldwide decline of coral reefs necessitates targeting management solutions that can sustain reefs and the livelihoods of the people who depend on them. However, little is known about the context in which different reef management tools can help to achieve multiple social and ecological goals. Because of nonlinearities in ... Read more >>

Science (Science (New York, N.Y.))
[2020, 368(6488):307-311]

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Diagnostic value of surrogate CSF biomarkers for Creutzfeldt-Jakob disease in the era of RT-QuIC.

Samir Abu-Rumeileh, Simone Baiardi, Barbara Polischi, Angela Mammana, Alessia Franceschini, Alison Green, Sabina Capellari, Piero Parchi,

Prion real-time quaking-induced conversion (RT-QuIC) is emerging as the most potent assay for the in vivo diagnosis of Creutzfeldt-Jakob disease (CJD), but its full application, especially as a screening test, is limited by suboptimal substrate availability, reagent costs, and incomplete assay standardization. Therefore, the search for the most informative cerebrospinal ... Read more >>

J Neurol (Journal of neurology)
[2019, 266(12):3136-3143]

Cited: 4 times

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Epitope mapping of the protease resistant products of RT-QuIC does not allow the discrimination of sCJD subtypes.

Gabriele Piconi, Alexander H Peden, Marcelo A Barria, Alison J E Green,

Sporadic Creutzfeldt-Jakob disease (sCJD) is a transmissible, rapidly progressive and fatal neurodegenerative disease. The transmissible agent linked to sCJD is composed of the misfolded form of the host-encoded prion protein. The combination of histopathological and biochemical analyses has allowed the identification and sub-classification of six sCJD subtypes. This classification depends ... Read more >>

PLoS One (PloS one)
[2019, 14(6):e0218509]

Cited: 1 time

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α-synuclein RT-QuIC in cerebrospinal fluid of LRRK2-linked Parkinson's disease.

Alicia Garrido, Graham Fairfoul, Eduardo S Tolosa, Maria José Martí, Alison Green, ,

<h4>Background</h4>Leucine-rich kinase 2 (LRRK2)-linked Parkinson's disease (PD) is clinically indistinguishable from idiopathic PD (IPD). A pleiotropic neuropathology has been recognized but the majority of studies in LRRK2 p.G2019S patients reveal Lewy-type synucleinopathy as its principal histological substrate. To date no in vivo biomarkers of synucleinopathy have been found in LRRK2 mutation ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2019, 6(6):1024-1032]

Cited: 7 times

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Poster Group Abstracts

Roberts Alysha, Raju Kavita, Sebastian Haupt Thomas, Dow Todd, Smyth Mike, Toguri J Thomas, Bihun Rosalind, Mountjoy Margo, Costa Andrew, Campbell Graham, Fong Emily, Wong Alex, Kemble Tibetha, Chan Stephanie, Dias Nathasha, Leslie Amanda, McCann Maggie, McFadyen Kristen, Spohn Olivia, Vogt Janet, Isaacs Barry, Loh Alvin, Leung Fok-Han, Dick Jeremy, Pinder Karen, Kitching George T., Zhong Adrina, Mak Orianna, Ley Marissa, Javadian Farnaz, Davidson Alexandra, Shah Rajiv, Shah Anita, Shirreff Lindsay, Shore Eliane, Nguyen David-Dan, de Meulemeester Julie, Niburski Kacper, Best Gordon, Demir Koray, Mitchell Eric, Riggs James, Barnfield Rebecca, Nault Trystan, Tipnis Rajas, Benedict Leshawn, Si Kevin, Leung Fok-Han, Haupt Thomas, Dow Todd, Smyth Mike, Roberts Alysha, Raju Kavita, Toguri Tom, MacLeod Anna, Sapa Alex, Niazi Ahtsham, Matava Clyde, Zhou Tina (Shijie), Dupuis Lucie, Cytrynbaum Cheryl, Mendoza-Londono Roberto, Brickman Arielle, Wu Vincent, Zevin Boris, Bowden* Sylvie, Khan* Shawn, Sorouri Kimia, Searle Stephanie, Carr Lauren, Simpson Jory, Rafiq Farina, Haroon Babar, Zhang Zhubo, Ding Avrilynn, Winthrop Andrea, Katsoulas Eleni, Lidster Natalie, VanDeCappelle Caitlin, Sharma Saroo, Wilson Samuel, Karol Dalia, Elliott Christopher G., Chen Kuan-chin Jean, Pasricha Sachin, Keri Zsuzsanna, Holden Matthew, Ungi Tamas, Fichtinger Gabor, Sandhu Vijay, Hawa Raed, Garcia Carla, Waddell Andrea, Glanz Sophie, McDonald Rachel, Kachaniwsky Lisa, Kolker Sabrina, Yang Pearl, Fleming Karen, Ménard-Cholette Vincent, Richard Élizabeth, Thériault Julie, Wang Emily, Battaglia Frank, Langlois Emilie, Market Marisa, Shin John, Seabrook Christine, Brandys Tim, Cormier Alexander, Brennan Erin, Mah Evan, Deck Megan, Yu Julie, Lyster Kish, Kawchuk Joann, Brownbridge Brian, Turnquist Alison, Terrett Luke, Thoma Brent, Battaglia Frank, Merlano Maria, Sayed Céline, McConnell Meghan, Ramnanan Christopher, Rastogi Nikhil, Battaglia Frank, McConnell Meghan, Ramnanan Christopher, Rastogi Nikhil, Merlano Maria, Sayed Celine, Elfassy Michael, Duncan Laura, Green Alison, Tzanetos Katina, Nyhof-Young Joyce, Fong-Leboeuf Alexis, Simin Irina, Le Andy, Andrews Debra, Henriksen Cynthia, Jobin Vincent, Fugère Louise, Jung Flora, Wiley Mike, Howard Frazer, Sequeira Nicholas, Nyhof-Young Joyce, Mavin Sarah, Adams-Carpino Gayle, Kindrat April, Baranova Katherina, Torti Jacqueline, Goldszmidt Mark, Thejoe Maichael, Krekoski Carrie, Newton Christie, Sequeira Nicholas, MacMillan Tom, Wu Robert, Cavalcanti Rodrigo, Maleki Mona, Huang Kelly, McEwen Heather, Regehr Glenn, Simin Irina, Naidu Dhiren, Hillier Tracey, Rida Tul-Zahra, Muldoon Laura, Chomienne* Marie-Hélène, Toupin-April* Karine, Thabet Chloe, Doherty Megan, Fras Tatiana, McKague Meredith, Taylor-Gjevre Regina, Prystajecky Michael, Trinder Krista, Liu Fangyi, Qin Yang, Javeed Imaan, Nyhof-Young Joyce, Tia Vivian, Yu Richard, Cameron John, Russelo Dylan, Kim Danny, Bell Alison, Gibson Michelle, Mahjoub Yasamin, Wan Miranda, DeCock Marie, Lewis Melanie, Conn Richard, Kearney Orla, Shields Michael, Tully Mary, Dornan Tim, Khan Shawn, Kirubarajan* Abirami, Shamsheri* Tahmina, Mehta Sangeeta, Nepton-Riverin Mélissa, Lavoie Genevieve, Courtois Émilie, Ouellet- Dufour Pascale, Lam Kaitlyn, Shachar Ben, Leung Fok-Han, Rojas Gualdron David, Nyhof-Young Joyce, Samuels Hannah, Rojas Luengas Vanessa, Zereshkian Arman, Veinot Paula, Bowry Ashna, Law Marcus, Duggal Aashna, Jeffery Thomas, Joanne Rodger Dr., Von Hauff Patrick, Tracey Hillier Dr., Dehmoobad Sharifabadi Anahita, Doja Asif, Clarkin Chantalle, Rajaram Akshay, Patel Nimesh, Hickey Zachary, Newbigging Joseph, Wolfrom Brent, Evans Emily, Doherty Megan, Weng Aselin, Tran Brian, Luong Victoria, Shields Chris, Petrie Allison, Neumann Katerina, Grock Andy, Bhalerao Anuja, Chan Teresa, Thoma Brent, Trueger Seth, Tang Natasha, Mylopoulus Maria, Sockalingam Sanjeev, Perron Janaya E., Coffey Michael J., Lovell-Simons Andrew, Li Zheyu, Takeda Seiya, Dominguez Luis, Ooi Chee Y., Ng Maxwell, Malyala Rohit, Chen He Tian, Kuo Katherine, Ball Alexander K., Rathbone Michel P., Wainman Bruce,

Background/Purpose: Medical students face numerous stressors during their pre-clinical years, including developing confidence in their skills, knowledge and deciding which specialty to pursue. For those interested in specialties with limited integration into the traditional pre-clinical curriculum, or students who still have a broad range of interests at the end of ... Read more >>

Can Med Educ J (Canadian medical education journal)
[2019, 10(2):e257-e293]

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Comparative study of cerebrospinal fluid α-synuclein seeding aggregation assays for diagnosis of Parkinson's disease.

Un Jung Kang, Amelia K Boehme, Graham Fairfoul, Mohammad Shahnawaz, Thong Chi Ma, Samantha J Hutten, Alison Green, Claudio Soto,

<h4>Background</h4>PD diagnosis is based primarily on clinical criteria and can be inaccurate. Biological markers, such as α-synuclein aggregation, that reflect ongoing pathogenic processes may increase diagnosis accuracy and allow disease progression monitoring. Though α-synuclein aggregation assays have been published, reproducibility, standardization, and validation are key challenges for their development as ... Read more >>

Mov Disord (Movement disorders : official journal of the Movement Disorder Society)
[2019, 34(4):536-544]

Cited: 13 times

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Concerns of young protesters are justified.

Gregor Hagedorn, Peter Kalmus, Michael Mann, Sara Vicca, Joke Van den Berge, Jean-Pascal van Ypersele, Dominique Bourg, Jan Rotmans, Roope Kaaronen, Stefan Rahmstorf, Helga Kromp-Kolb, Gottfried Kirchengast, Reto Knutti, Sonia I Seneviratne, Philippe Thalmann, Raven Cretney, Alison Green, Kevin Anderson, Martin Hedberg, Douglas Nilsson, Amita Kuttner, Katharine Hayhoe,

Science (Science (New York, N.Y.))
[2019, 364(6436):139-140]

Cited: 3 times

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α-Synuclein real-time quaking-induced conversion in the cerebrospinal fluid of uncertain cases of parkinsonism.

Anouke van Rumund, Alison J E Green, Graham Fairfoul, Rianne A J Esselink, Bastiaan R Bloem, Marcel M Verbeek,

A reliable biomarker is needed for accurate and early differentiation between Parkinson disease and the various forms of atypical parkinsonism. We used a novel real-time quaking-induced conversion (RT-QuIC) assay to detect α-synuclein (α-syn) aggregates in cerebrospinal fluid (CSF) of 118 patients with parkinsonism of uncertain clinical etiology and 52 controls. ... Read more >>

Ann Neurol (Annals of neurology)
[2019, 85(5):777-781]

Cited: 12 times

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Renewed assessment of the risk of emergent advanced cell therapies to transmit neuroproteinopathies.

Paul A De Sousa, Diane Ritchie, Alison Green, Siddharthan Chandran, Richard Knight, Mark W Head,

The inadvertent transmission of long incubating, untreatable and fatal neurodegenerative prionopathies, notably iatrogenic Creutzfeldt-Jakob disease, following transplantation of cadaver-derived corneas, pituitary growth, hormones and dura mater, constitutes a historical precedent which has underpinned the application of precautionary principles to modern day advanced cell therapies. To date these have been reflected ... Read more >>

Acta Neuropathol (Acta neuropathologica)
[2019, 137(3):363-377]

Cited: 0 times

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TDP-43 as a potential biomarker for amyotrophic lateral sclerosis: a systematic review and meta-analysis.

Vivek Majumder, Jenna M Gregory, Marcelo A Barria, Alison Green, Suvankar Pal,

<h4>Background</h4>Frontotemporal dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are incurable, progressive and fatal neurodegenerative diseases with patients variably affected clinically by motor, behavior, and cognitive deficits. The accumulation of an RNA-binding protein, TDP-43, is the most significant pathological finding in approximately 95% of ALS cases and 50% of FTD cases, ... Read more >>

BMC Neurol (BMC neurology)
[2018, 18(1):90]

Cited: 11 times

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RT-QuIC: a new test for sporadic CJD.

Alison J E Green,

The diagnosis of sporadic Creutzfeldt-Jakob disease (CJD) can be difficult, but the real-time quaking-induced conversion (RT-QuIC) assays have made a considerable impact on its clinical diagnosis. This technique exploits the ability of the misfolded pathological form of prion protein (PrP<sup>Sc</sup>) found in cerebrospinal fluid (CSF) to induce conversion of normal ... Read more >>

Pract Neurol (Practical neurology)
[2019, 19(1):49-55]

Cited: 13 times

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Diagnosis of Methionine/Valine Variant Creutzfeldt-Jakob Disease by Protein Misfolding Cyclic Amplification.

Daisy Bougard, Maxime Bélondrade, Charly Mayran, Lilian Bruyère-Ostells, Sylvain Lehmann, Chantal Fournier-Wirth, Richard S Knight, Robert G Will, Alison J E Green,

A patient with a heterozygous variant of Creutzfeldt-Jakob disease (CJD) with a methionine/valine genotype at codon 129 of the prion protein gene was recently reported. Using an ultrasensitive and specific protein misfolding cyclic amplification-based assay for detecting variant CJD prions in cerebrospinal fluid, we discriminated this heterozygous case of variant ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2018, 24(7):1364-1366]

Cited: 6 times

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Sporadic Creutzfeldt-Jakob Disease in a Woman Married Into a Gerstmann-Sträussler-Scheinker Family: An Investigation of Prions Transmission via Microchimerism.

Aušrine Areškeviciute, Linea Cecilie Melchior, Helle Broholm, Lars-Henrik Krarup, Suzanne Granhøj Lindquist, Peter Johansen, Neil McKenzie, Alison Green, Jørgen Erik Nielsen, Henning Laursen, Eva Løbner Lund,

This is the first report of presumed sporadic Creutzfeldt-Jakob disease (sCJD) and Gerstmann-Sträussler-Scheinker disease (GSS) with the prion protein gene c.305C>T mutation (p.P102L) occurring in one family. The father and son were affected with GSS and the mother had a rapidly progressive form of CJD. Diagnosis of genetic, variant, and ... Read more >>

J Neuropathol Exp Neurol (Journal of neuropathology and experimental neurology)
[2018, 77(8):673-684]

Cited: 1 time

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Gravity of human impacts mediates coral reef conservation gains.

Joshua E Cinner, Eva Maire, Cindy Huchery, M Aaron MacNeil, Nicholas A J Graham, Camilo Mora, Tim R McClanahan, Michele L Barnes, John N Kittinger, Christina C Hicks, Stephanie D'Agata, Andrew S Hoey, Georgina G Gurney, David A Feary, Ivor D Williams, Michel Kulbicki, Laurent Vigliola, Laurent Wantiez, Graham J Edgar, Rick D Stuart-Smith, Stuart A Sandin, Alison Green, Marah J Hardt, Maria Beger, Alan M Friedlander, Shaun K Wilson, Eran Brokovich, Andrew J Brooks, Juan J Cruz-Motta, David J Booth, Pascale Chabanet, Charlotte Gough, Mark Tupper, Sebastian C A Ferse, U Rashid Sumaila, Shinta Pardede, David Mouillot,

Coral reefs provide ecosystem goods and services for millions of people in the tropics, but reef conditions are declining worldwide. Effective solutions to the crisis facing coral reefs depend in part on understanding the context under which different types of conservation benefits can be maximized. Our global analysis of nearly ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2018, 115(27):E6116-E6125]

Cited: 7 times

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Rapid amplification of prions from variant Creutzfeldt-Jakob disease cerebrospinal fluid.

Marcelo A Barria, Andrew Lee, Alison Je Green, Richard Knight, Mark W Head,

Human prion diseases constitute a group of infectious and invariably fatal neurodegenerative disorders associated with misfolding of the prion protein. Variant Creutzfeldt-Jakob disease (vCJD) is a zoonotic prion disease linked to oral exposure to the infectious agent that causes bovine spongiform encephalopathy (BSE) in cattle. The most recent case of ... Read more >>

J Pathol Clin Res (The journal of pathology. Clinical research)
[2018, 4(2):86-92]

Cited: 4 times

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Prion protein amplification techniques.

Alison J E Green, Gianluigi Zanusso,

Protein amplification techniques exploit the ability of PrP<sup>TSE</sup> to induce a conformational change in prion protein (PrP) in a continuous fashion, so that the small amount of PrP<sup>TSE</sup> found in tissues and biologic fluids in prion diseases can be amplified to a point where they are detectable by conventional laboratory ... Read more >>

Handb Clin Neurol (Handbook of clinical neurology)
[2018, 153:357-370]

Cited: 5 times

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Imaging and CSF analyses effectively distinguish CJD from its mimics.

Peter Rudge, Harpreet Hyare, Alison Green, John Collinge, Simon Mead,

OBJECTIVE:To review clinical and investigation findings in patients referred to a specialist prion clinic who were suspected to have sporadic Creutzfeldt-Jakob disease (sCJD) and yet were found to have an alternative final diagnosis. METHODS:Review the clinical findings and investigations in 214 patients enrolled into the UK National Prion Monitoring Cohort ... Read more >>

J Neurol Neurosurg Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2018, 89(5):461-466]

Cited: 10 times

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High diagnostic value of second generation CSF RT-QuIC across the wide spectrum of CJD prions.

Alessia Franceschini, Simone Baiardi, Andrew G Hughson, Neil McKenzie, Fabio Moda, Marcello Rossi, Sabina Capellari, Alison Green, Giorgio Giaccone, Byron Caughey, Piero Parchi,

An early and accurate in vivo diagnosis of rapidly progressive dementia remains challenging, despite its critical importance for the outcome of treatable forms, and the formulation of prognosis. Real-Time Quaking-Induced Conversion (RT-QuIC) is an in vitro assay that, for the first time, specifically discriminates patients with prion disease. Here, using ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):10655]

Cited: 40 times

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