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The Design, Implementation, and Acceptability of a Telehealth Comprehensive Recovery Service for People With Complex Psychosis Living in NYC During the COVID-19 Crisis.

David A Lynch, Alice Medalia, Alice Saperstein,

Introduction:The COVID-19 crisis and subsequent stay-at-home orders have produced unprecedented challenges to the dissemination of recovery oriented behavioral health services (RS) that support the treatment of those with complex psychosis (CP).This population has typically been managed with in-person pharmacotherapy and/or RS, with the goals of relieving symptoms, improving life satisfaction ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:581149]

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Effectiveness of cognitive remediation in the ultra-high risk state for psychosis.

Louise B Glenthøj, Lise S Mariegaard, Birgitte Fagerlund, Jens R M Jepsen, Tina D Kristensen, Christina Wenneberg, Kristine Krakauer, Alice Medalia, David L Roberts, Carsten Hjorthøj, Merete Nordentoft,

(World psychiatry : official journal of the World Psychiatric Association (WPA))
[2020, 19(3):401-402]

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A randomized controlled trial of cognitive remediation and long-acting injectable risperidone after a first episode of schizophrenia: improving cognition and work/school functioning.

Keith H Nuechterlein, Joseph Ventura, Kenneth L Subotnik, Denise Gretchen-Doorly, Luana R Turner, Laurie R Casaus, John Luo, Michael L Boucher, Jacqueline N Hayata, Morris D Bell, Alice Medalia,

BACKGROUND:Cognitive deficits at the first episode of schizophrenia are predictive of functional outcome. Interventions that improve cognitive functioning early in schizophrenia are critical if we hope to prevent or limit long-term disability in this disorder. METHODS:We completed a 12-month randomized controlled trial of cognitive remediation and of long-acting injectable (LAI) ... Read more >>

Psychol Med (Psychological medicine)
[2020, :1-10]

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Cognitive remediation plus standard treatment versus standard treatment alone for individuals at ultra-high risk of developing psychosis: Results of the FOCUS randomised clinical trial.

Louise B Glenthøj, Lise S Mariegaard, Birgitte Fagerlund, Jens R M Jepsen, Tina D Kristensen, Christina Wenneberg, Kristine Krakauer, Alice Medalia, David L Roberts, Carsten Hjorthøj, Merete Nordentoft,

BACKGROUND:Individuals at ultra-high risk (UHR) for psychosis have significant cognitive deficits that can impede functional recovery. Applying cognitive remediation (CR) before the onset of frank psychosis may improve the cognitive and functional prognosis of UHR individuals, however, little is known about the feasibility and efficacy of CR for this population. ... Read more >>

Schizophr Res (Schizophrenia research)
[2020, :]

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Telehealth Conversion of Serious Mental Illness Recovery Services During the COVID-19 Crisis.

Alice Medalia, David A Lynch, Tiffany Herlands,

Psychiatr Serv (Psychiatric services (Washington, D.C.))
[2020, 71(8):872]

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T46. THE EFFECT OF COMPREHENSIVE COGNITIVE REMEDIATION IN INDIVIDUALS AT ULTRA-HIGH RISK FOR PSYCHOSIS: A SINGLE-BLIND, RANDOMISED, CLINICAL TRIAL (FOCUS).

Louise Birkedal Glenthoej, Mariegaard Lise, Birgitte Fagerlund, Jens Richardt Jepsen, Tina Dam Kristensen, Christina Wenneberg, Kristine Krakauer, Alice Medalia, David Roberts, Carsten Hjorthøj, Merete Nordentoft,

AbstractBackgroundIndividuals at ultra-high risk (UHR) for psychosis display significant cognitive deficits that constitute a barrier to functional recovery. Applying cognitive remediation (CR) before the onset of manifest psychosis may improve cognition and the clinical and functional prognosis of UHR individuals.MethodsThis randomised, clinical trial randomly assigned 146 UHR individuals aged 18–40 ... Read more >>

(Schizophrenia bulletin)
[2020, 46(Suppl 1):S249-S249]

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Addressing cognitive health in coordinated specialty care for early psychosis: Real-world perspectives.

Alice M Saperstein, Alice Medalia, Iruma Bello, Lisa B Dixon,

AIM:Addressing cognitive health during the early phase of psychosis has the potential to enhance recovery outcomes, yet methods to assess and treat cognitive problems are not a systematic part of Coordinated Specialty Care (CSC) in the United States. We sought to understand how CSC providers perceive cognitive health and gauge ... Read more >>

Early Interv Psychiatry (Early intervention in psychiatry)
[2020, :]

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Plasticity of DNA methylation, functional brain connectivity and efficiency in cognitive remediation for schizophrenia.

New Fei Ho, Jordon Xin Jie Tng, Mingyuan Wang, Guoyang Chen, Vigneshwaran Subbaraju, Suhailah Shukor, Desiree Si Xian Ng, Bhing-Leet Tan, Shu Juan Puang, Sok-Hong Kho, Rachel Wan En Siew, Gwen Li Sin, Pui Wai Eu, Juan Zhou, Judy Chia Ghee Sng, Kang Sim, Alice Medalia,

Cognitive remediation (CR) is predicated on principles of neuroplasticity, but the actual molecular and neurocircuitry changes underlying cognitive change in individuals with impaired neuroplastic processes is poorly understood. The present study examined epigenetic-neurocircuitry-behavioral outcome measures in schizophrenia, before and after participating in a CR program that targeted higher-order cognitive functions. ... Read more >>

J Psychiatr Res (Journal of psychiatric research)
[2020, 126:122-133]

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How does awareness of cognitive impairment impact motivation and treatment outcomes during cognitive remediation for schizophrenia?

Alice M Saperstein, David A Lynch, Min Qian, Alice Medalia,

BACKGROUND:There is concern that awareness of cognitive deficit among people with schizophrenia receiving Cognitive Remediation (CR) might undermine motivation, engagement, and CR outcomes. We therefore examined the relationship of subjective awareness of cognitive deficit to aspects of motivation and cognitive learning during an efficacious CR program. METHODS:Individuals with schizophrenia/schizoaffective disorder ... Read more >>

Schizophr. Res. (Schizophrenia research)
[2020, 218:70-75]

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The Design, Implementation, and Acceptability of a Telehealth Comprehensive Recovery Service for People With Complex Psychosis Living in NYC During the COVID-19 Crisis

David A. Lynch, Alice Medalia, Alice Saperstein,

Introduction The COVID-19 crisis and subsequent stay-at-home orders have produced unprecedented challenges to the dissemination of recovery oriented behavioral health services (RS) that support the treatment of those with complex psychosis (CP).This population has typically been managed with in-person pharmacotherapy and/or RS, with the goals of relieving symptoms, improving life ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:]

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The cognitive training version of the MUSIC® model of motivation inventory: A follow-up validity study.

Alice M Saperstein, Brett D Jones, Marie C Hansen, Alice Medalia,

Further validation of the MUSIC® Model of Motivation Inventory (MMI) for use in Cognitive Remediation (CR) for schizophrenia is needed. The MMI was compared to the Intrinsic Motivation Inventory - Schizophrenia Research and Perceived Competency Scale following early treatment exposure in a CR clinical trial. MMI Usefulness, Success, and Interest ... Read more >>

Schizophr. Res. (Schizophrenia research)
[2020, 216:516-519]

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Cognitive remediation for schizophrenia: An expert working group white paper on core techniques.

Christopher R Bowie, Morris D Bell, Joanna M Fiszdon, Jason K Johannesen, Jean-Pierre Lindenmayer, Susan R McGurk, Alice A Medalia, Rafael Penadés, Alice M Saperstein, Elizabeth W Twamley, Torill Ueland, Til Wykes,

Cognitive remediation is now widely recognized as an effective treatment for cognitive deficits in schizophrenia. Its effects are meaningful, durable, and related to improvements in everyday functional outcomes. As with many therapies, the evolution of cognitive remediation has resulted in treatment programs that use a variety of specific techniques, yet ... Read more >>

Schizophr. Res. (Schizophrenia research)
[2020, 215:49-53]

Cited: 2 times

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Bimodal distribution of tone-matching deficits indicates discrete pathophysiological entities within the syndrome of schizophrenia.

Clément Dondé, Antigona Martínez, Joshua T Kantrowitz, Gail Silipo, Elisa C Dias, Gaurav H Patel, Juan Sanchez-Peña, Cheryl M Corcoran, Alice Medalia, Alice Saperstein, Blair Vail, Daniel C Javitt,

To date, no measures are available that permit differentiation of discrete, clinically distinct subtypes of schizophrenia (SZ) with potential differential underlying pathophysiologies. Over recent years, there has been increasing recognition that SZ is heterogeneously associated with deficits in early auditory processing (EAP), as demonstrated using clinically applicable tasks such as ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2019, 9(1):221]

Cited: 3 times

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39.1 BASELINE EARLY AUDITORY PROCESSING AS A TAILORING VARIABLE TO PERSONALIZE COGNITIVE REMEDIATION FOR SCHIZOPHRENIA.

Alice Medalia, Alice Saperstein, Min Qian, Daniel Javitt,

AbstractBackgroundSchizophrenia is associated with cognitive deficits that negatively impact essential areas of daily functioning. Evidence of learning-dependent plasticity in the distributed neural systems that underlie perception and cognition has opened up a burgeoning field of research in cognitive remediation (CR). While the aggregate literature on CR for schizophrenia indicates moderate ... Read more >>

(Schizophrenia bulletin)
[2019, 45(Suppl 2):S151-S151]

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39. THE ROLE OF EARLY SENSORY PROCESSING IN THE SYMPTOMS, BEHAVIOR AND TREATMENT OF SCHIZOPHRENIA.

Alice Medalia,

AbstractStudies of schizophrenia have traditionally focused on deficits in higher-order cognitive processes such as memory and executive function, but there is an increasing realization that deficits can also be found at the level of early sensory processing. These deficits are associated with cognitive, emotional, and functional ability in schizophrenia, and ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2019, 45(Suppl 2):S150-S151]

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Impact of baseline early auditory processing on response to cognitive remediation for schizophrenia.

Alice Medalia, Alice M Saperstein, Min Qian, Daniel C Javitt,

BACKGROUND:Early auditory processing (EAP) has increasingly become a focus of efforts to identify biomarkers of treatment response in schizophrenia. EAP deficits lead to poor functional outcome via impaired cognition, and treatments that target EAP may drive downstream cognitive improvements. Assessment of baseline need provides an opportunity for cognitive remediation (CR) ... Read more >>

Schizophr Res (Schizophrenia research)
[2019, 208:397-405]

Cited: 4 times

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Expert Consensus on Screening and Assessment of Cognition in Psychiatry.

Roger S McIntyre, Nicole Anderson, Bernhard T Baune, Elisa Brietzke, Katherine Burdick, Phillipe Fossati, Philip Gorwood, Catherine Harmer, John Harrison, Philip Harvey, Rodrigo B Mansur, Alice Medalia, Kamilla Miskowiak, Tanya Ramey, Carola Rong, Joshua D Rosenblat, Allan Young, Stephen M Stahl,

During the past two decades, it has been amply documented that neuropsychiatric disorders (NPDs) disproportionately account for burden of illness attributable to chronic non-communicable medical disorders globally. It is also likely that human capital costs attributable to NPDs will disproportionately increase as a consequence of population aging and beneficial risk ... Read more >>

CNS Spectr (CNS spectrums)
[2019, 24(1):154-162]

Cited: 2 times

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Validation of the MUSIC Model of Motivation Inventory for use with cognitive training for schizophrenia spectrum disorders: A multinational study.

Marie C Hansen, Brett D Jones, Shaun M Eack, Louise Birkedal Glenthøj, Satoru Ikezawa, Tatsuro Iwane, Sean A Kidd, Martin Lepage, Jean-Pierre Lindenmayer, Isidora Ljuri, Keiko Maida, Yasuhiro Matsuda, Kazuyuki Nakagome, Merete Nordentoft, Veronica Ozog, Danielle Penney, Alice M Saperstein, Atsuko Sunaga, Sophia Vinogradov, Gursharan Virdee, Jessica A Wojtalik, Alice Medalia,

AIM:Low motivation is a core symptom of schizophrenia which significantly impacts successful engagement in and benefit from psychosocial treatments. Therefore, it is important for clinicians to design psychosocial treatments to effectively motivate and engage patients during the treatment. The MUSIC® Model of Academic Motivation Inventory (MMI) is an 18-item instrument ... Read more >>

Schizophr Res (Schizophrenia research)
[2019, 206:142-148]

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Cognitive therapies for psychosis: Advances and challenges.

Alice Medalia, Aaron T Beck, Paul M Grant,

Schizophr. Res. (Schizophrenia research)
[2019, 203:1-2]

Cited: 1 time

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T206. DOES AGE INFLUENCE RESPONSE TO COGNITIVE REMEDIATION?

Benedetta Seccomandi, Deborah Agbedjro, Morris Bell, Richard Keefe, Matcheri Keshavan, Silvana Galderisi, Alice Medalia, Joanna Fiszdon, Mario Maj, Armida Mucci, Roberto Cavallato, Til Wykes, Matteo Cella,

AbstractBackgroundCognitive deficits are common in people with schizophrenia and have a negative impact on functioning. Cognitive Remediation (CR) is an effective approach to reduce the burden of cognitive difficulties however there are individual differences in therapy response. Previous research suggests that participants age may be a significant moderator of therapy ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2018, 44(Suppl 1):S196-S197]

Cited: 0 times

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Cognitive remediation in large systems of psychiatric care.

Alice Medalia, Alice M Saperstein, Matthew D Erlich, Lloyd I Sederer,

IntroductionWith the increasing enthusiasm to provide cognitive remediation (CR) as an evidence-based practice, questions arise as to what is involved in implementing CR in a large system of care. This article describes the first statewide implementation of CR in the USA, with the goal of documenting the implementation issues that ... Read more >>

CNS Spectr (CNS spectrums)
[2019, 24(1):163-173]

Cited: 1 time

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Cognitive remediation can improve negative symptoms and social functioning in first-episode schizophrenia: A randomized controlled trial.

Joseph Ventura, Kenneth L Subotnik, Denise Gretchen-Doorly, Laurie Casaus, Michael Boucher, Alice Medalia, Morris D Bell, Gerhard S Hellemann, Keith H Nuechterlein,

BACKGROUND:Meta-analyses have reported that the effects of cognitive remediation might go beyond improvement in cognition to include unexpected benefits for schizophrenia patients such as negative symptom reduction and improvements in functioning. In addition, some evidence indicated that these potentially beneficial effects are also present in the initial course of schizophrenia, ... Read more >>

Schizophr Res (Schizophrenia research)
[2019, 203:24-31]

Cited: 3 times

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Cognitive Skills Training for Homeless Transition-Age Youth: Feasibility and Pilot Efficacy of a Community Based Randomized Controlled Trial.

Alice Medalia, Alice M Saperstein, Yanlan Huang, Seonjoo Lee, Elizabeth J Ronan,

Cognitive impairments are common in homeless youth and negatively impact academic and vocational outcomes. We examined the feasibility and efficacy of cognitive interventions provided to 18- to 22-year-old homeless youth living in urban supportive housing. Ninety-one homeless youth were randomized to receive either targeted cognitive training (cognitive remediation) or general ... Read more >>

J Nerv Ment Dis (The Journal of nervous and mental disease)
[2017, 205(11):859-866]

Cited: 1 time

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Informationally administered reward enhances intrinsic motivation in schizophrenia.

Hyeon-Seung Lee, Seon-Kyeong Jang, Ga-Young Lee, Seon-Cheol Park, Alice Medalia, Kee-Hong Choi,

Even when individuals with schizophrenia have an intact ability to enjoy rewarding moments, the means to assist them to translate rewarding experiences into goal-directed behaviors is unclear. The present study sought to determine whether informationally administered rewards enhance intrinsic motivation to foster goal-directed behaviors in individuals with schizophrenia (SZ) and ... Read more >>

Psychiatry Res (Psychiatry research)
[2017, 256:290-297]

Cited: 1 time

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Translating cognitive behavioral interventions from bench to bedside: The feasibility and acceptability of cognitive remediation in research as compared to clinical settings.

Alice Medalia, Matthew D Erlich, Charlotte Soumet-Leman, Alice M Saperstein,

Cognitive remediation (CR) research typically addresses internal validity, and few studies consider CR in a real-world context. This study evaluated the fit between the program conditions and treatment model in research and clinical settings, with the goal of informing future research on the contextual challenges associated with the implementation of ... Read more >>

Schizophr Res (Schizophrenia research)
[2019, 203:49-54]

Cited: 3 times

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