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Author Ali Hajiran

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Geospatial Cellular Distribution of Cancer-Associated Fibroblasts Significantly Impacts Clinical Outcomes in Metastatic Clear Cell Renal Cell Carcinoma

Nicholas Chakiryan, Gregory Kimmel, Youngchul Kim, Joseph Johnson, Noel Clark, Ali Hajiran, Andrew Chang, Ahmet Aydin, Logan Zemp, Esther Katende, Jad Chahoud, Meghan Ferrall-Fairbanks, Philippe Spiess, Natasha Francis, Michelle Fournier, Jasreman Dhillon, Jong Park, Liang Wang, James Mule, Philipp Altrock, Brandon Manley,

Cancer-associated fibroblasts (CAF) are highly prevalent cells in the tumor microenvironment in clear cell renal cell carcinoma (ccRCC). CAFs exhibit a pro-tumor effect in vitro and have been implicated in tumor cell proliferation, metastasis, and treatment resistance. Our objective is to analyze the geospatial distribution of CAFs with proliferating and ... Read more >>

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Correlating Immune Cell Infiltration Patterns with Recurrent Somatic Mutations in Advanced Clear Cell Renal Cell Carcinoma.

Nicholas H Chakiryan, Ali Hajiran, Youngchul Kim, Ahmet M Aydin, Logan Zemp, Esther Katende, Jonathan Nguyen, Wenyi Fan, Chia-Ho Cheng, Neale Lopez-Blanco, Jad Chahoud, Philippe E Spiess, Michelle Fournier, Jasreman Dhillon, Liang Wang, Carlos Moran-Segura, James Mulé, Dongliang Du, Sean J Yoder, Anders Berglund, Jamie K Teer, Brandon J Manley,

<h4>Background</h4>Clear cell renal cell carcinoma (ccRCC) tumors have low frequencies of genetic alterations compared with other malignancies, but very high levels of immune cell infiltration and favorable response rates to immunotherapy. Currently, the interplay between specific ccRCC somatic mutations and immune infiltration pattern is unclear.<h4>Objective</h4>To analyze the associations between common ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Pathologic Downstaging and Survival Outcomes Associated with Neoadjuvant Chemotherapy for Variant Histology Muscle Invasive Bladder Cancer.

Nicholas H Chakiryan, Da David Jiang, Kyle A Gillis, Elizabeth Green, Ali Hajiran, Lee Hugar, Logan Zemp, Jingsong Zhang, Rohit Jain, Jad Chahoud, Michael Poch, Brandon J Manley, Roger Li, Wade Sexton, Scott M Gilbert,

<h4>Purpose</h4>Patients with muscle invasive bladder cancer (MIBC) of variant histology have a poor prognosis. It is unclear if neoadjuvant chemotherapy prior to radical cystectomy is associated with pathologic downstaging or improved overall survival (OS) for patients with variant histology. Our objective was to assess for associations between receipt of neoadjuvant ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001855]

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Real-World Survival Outcomes Associated With First-Line Immunotherapy, Targeted Therapy, and Combination Therapy for Metastatic Clear Cell Renal Cell Carcinoma.

Nicholas H Chakiryan, Da David Jiang, Kyle A Gillis, Elizabeth Green, Ali Hajiran, Lee Hugar, Logan Zemp, Jingsong Zhang, Rohit K Jain, Jad Chahoud, Philippe E Spiess, Wade Sexton, Scott M Gilbert, Brandon J Manley,

<h4>Importance</h4>Clinical trials have shown an overall survival (OS) benefit associated with first-line immunotherapy (IT) and combination targeted therapy (TT) and IT regimens compared with TT among patients with metastatic clear cell renal cell carcinoma (RCC). Generalizability of these findings in a real-world cohort outside of a clinical trial setting is ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(5):e2111329]

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Spatial clustering of CD68+ tumor associated macrophages with tumor cells is associated with worse overall survival in metastatic clear cell renal cell carcinoma.

Nicholas H Chakiryan, Gregory J Kimmel, Youngchul Kim, Ali Hajiran, Ahmet M Aydin, Logan Zemp, Esther Katende, Jonathan Nguyen, Neale Lopez-Blanco, Jad Chahoud, Philippe E Spiess, Michelle Fournier, Jasreman Dhillon, Liang Wang, Carlos Moran-Segura, Asmaa El-Kenawi, James Mulé, Philipp M Altrock, Brandon J Manley,

Immune infiltration is typically quantified using cellular density, not accounting for cellular clustering. Tumor-associated macrophages (TAM) activate oncogenic signaling through paracrine interactions with tumor cells, which may be better reflected by local cellular clustering than global density metrics. Using multiplex immunohistochemistry and digital pathologic analysis we quantified cellular density and ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0245415]

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Retroperitoneal Lymph Node Dissection Versus Surveillance for Adult Early Stage Pure Testicular Teratoma: A Nationwide Analysis.

Ali Hajiran, Mounsif Azizi, Ahmet M Aydin, Nicholas H Chakiryan, Charles C Peyton, David C Boulware, Brandon J Manley, Scott M Gilbert, Wade J Sexton,

<h4>Purpose</h4>Following radical orchiectomy, surveillance and primary retroperitoneal lymph node dissection (RPLND) are acceptable options for the management of early stage pure testicular teratoma in adult patients; however, there is no uniform consensus. The aim of this study was to investigate survival outcomes of adults with early stage pure testicular teratoma ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2021, 28(7):3648-3655]

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The Factors Affecting Expansion of Reactive Tumor Infiltrating Lymphocytes (TIL) From Bladder Cancer and Potential Therapeutic Applications.

Ahmet Murat Aydin, Brittany L Bunch, Matthew Beatty, Ali Hajiran, Jasreman Dhillon, Amod A Sarnaik, Shari Pilon-Thomas, Michael A Poch,

Tumor infiltrating lymphocytes (TIL) therapy was shown to provide durable objective response in patients with metastatic melanoma. As a fundamental first step to bring TIL therapy to clinical use, identification of patients whose tumors yield optimal numbers of reactive TIL is indispensable. We have previously shown that expansion of tumor ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:628063]

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Prognostic predictors of lymph node metastasis in penile cancer: a systematic review.

David S Zekan, Ahmad Dahman, Ali J Hajiran, Adam M Luchey, Jad Chahoud, Philippe E Spiess,

<h4>Purpose</h4>Squamous cell carcinoma (SCC) of the penis is a rare disease in developed countries but is associated with significant morbidity and mortality. A crucial prognostic factor is the presence of inguinal lymph node metastases (ILNM) at the time of diagnosis. At least 25% of cases have micrometastases at the time ... Read more >>

Int Braz J Urol (International braz j urol : official journal of the Brazilian Society of Urology)
[2021, 47:]

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Spatial Clustering of CD68+ Tumor Associated Macrophages with Tumor Cells is Associated with Worse Overall Survival in Metastatic Clear Cell Renal Cell Carcinoma

Nicholas Chakiryan, Gregory Kimmel, Youngchul Kim, Ali Hajiran, Ahmet Aydin, Logan Zemp, Esther Katende, Jonathan Nguyen, Neale Lopez-Blanco, Jad Chahoud, Philippe Spiess, Michelle Fournier, Jasreman Dhillon, Liang Wang, Carlos Moran-Segura, Asmaa El-Kenawi, James Mulé, Philipp Altrock, Brandon Manley,

<h4>ABSTRACT</h4> Immune infiltration is typically quantified using cellular density, not accounting for cellular clustering. Tumor-associated macrophages (TAM) activate oncogenic signaling through paracrine interactions with tumor cells, which may be better reflected by local cellular clustering than global density metrics. Using multiplex immunohistochemistry and digital pathologic analysis we quantified cellular density ... Read more >>

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Evaluation of Preoperative Tamsulosin Role in Facilitating Ureteral Orifice Navigation for School-Age Pediatric Ureteroscopy.

Chad Morley, Ali Hajiran, Amr A Elbakry, Hosam S Al-Qudah, Osama Al-Omar,

<h4>Purpose</h4>To address whether preoperative tamsulosin increases the rate of successful ureteral orifice navigation for ureteroscopy (URS) without prestenting in school-age pediatric patients.<h4>Methods</h4>We retrospectively reviewed all pediatric patients who had undergone ureteroscopy (URS) at our institution from 2013 to 2020. Patients were divided into two groups: those who had received tamsulosin ... Read more >>

Res Rep Urol (Research and reports in urology)
[2020, 12:563-568]

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Systemic and intravesical adoptive cell therapy of tumor-reactive T cells can decrease bladder tumor growth in vivo.

Brittany L Bunch, Jennifer Morse, Sarah Asby, Jamie Blauvelt, Ahmet M Aydin, Patrick Innamarato, Ali Hajiran, Matthew Beatty, Michael Poch, Shari Pilon-Thomas,

<h4>Background</h4>The therapeutic armamentarium of bladder cancer has been recently enriched with the introduction of new therapies including immune checkpoint inhibitors, receptor tyrosine kinase inhibitors and antibody drug conjugates, however treatment responses and duration of responses are still less than expected. Adoptive cellular therapy (ACT) using tumor-infiltrating lymphocytes (TILs) has potential ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2020, 8(2):]

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Reply By Authors.

Ali Hajiran, Mounsif Azizi, Ahmet M Aydin, Logan Zemp, Charles C Peyton, Jasreman Dhillon, Samantha Nealon, Richard R Reich, Biwei Cao, Roger Li, Brandon J Manley, Wade J Sexton, Scott M Gilbert,

J Urol (The Journal of urology)
[2021, 205(1):108]

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Topical chemotherapy for penile carcinoma in situ: Contemporary outcomes and reported toxicity.

Ali Hajiran, Logan Zemp, Ahmet M Aydin, Salim K Cheryian, Julio M Pow-Sang, Jad Chahoud, Phillippe E Spiess,

<h4>Purpose</h4>The toxicity of topical chemotherapeutics has been well-characterized in extra-genital squamous cell carcinoma; however, there is limited data regarding the use of topical agents for penile squamous cell carcinoma in situ (CIS). We aim to describe the clinical outcomes and toxicities associated with the use of topical fluorouracil and imiquimod ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(1):72.e1-72.e5]

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The Immune Microenvironment in Penile Cancer and Rationale for Immunotherapy.

Mohamed E Ahmed, Shayan Falasiri, Ali Hajiran, Jad Chahoud, Philippe E Spiess,

Penile cancer is an extremely rare malignancy that accounts for approximately 1% of cancer deaths in the United States every year. While primary penile cancer can be managed surgically, advanced and metastatic forms of the disease require more aggressive management plans with systemic chemotherapy and/or radiotherapy. Despite the meaningful response ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(10):]

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Pathological and Survival Outcomes Associated with Variant Histology Bladder Cancers Managed by Cystectomy with or without Neoadjuvant Chemotherapy.

Ali Hajiran, Mounsif Azizi, Ahmet M Aydin, Logan Zemp, Charles C Peyton, Jasreman Dhillon, Samantha Nealon, Richard R Reich, Biwei Cao, Roger Li, Brandon J Manley, Wade J Sexton, Scott M Gilbert,

<h4>Purpose</h4>Although neoadjuvant chemotherapy is associated with a survival advantage in pure urothelial, muscle invasive bladder cancer, the role of neoadjuvant chemotherapy is less clear in variant histology or urothelial carcinoma with divergent differentiation. We compared chemotherapy response and survival outcomes of patients with nonpure urothelial carcinoma histology who were managed ... Read more >>

J Urol (The Journal of urology)
[2021, 205(1):100-108]

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Leveraging innovative therapies with an evolving understanding of the molecular pathogenesis of penile squamous cell carcinoma.

Ali Hajiran, Taylor Bracco, Logan Zemp, Philippe E Spiess,

Penile squamous cell carcinoma is a rare condition that is associated with significant morbidity and mortality in its advanced stages. In today's rapidly evolving field of oncology, physicians and scientists are learning to harness the power of genomics to drive innovative targeted, immunotherapeutic, and multimodal strategies across different cancer types; ... Read more >>

Urol Oncol (Urologic oncology)
[2020, :]

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What you need to know: updates in penile cancer staging.

Mahmoud I Khalil, Mohamed H Kamel, Jasreman Dhillon, Viraj Master, Rodney Davis, Ali J Hajiran, Philippe E Spiess,

<h4>Purpose</h4>We sought to discuss the updates in the 8th edition (8E) of The American Joint Committee on Cancer (AJCC) staging for penile cancer and to provide relevant evidence associated with the major changes that occurred.<h4>Methods</h4>A comprehensive search of PubMed<sup>®</sup> and Web of Science<sup>®</sup> was performed for relevant English language articles ... Read more >>

World J Urol (World journal of urology)
[2021, 39(5):1413-1419]

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Editorial Comment.

Ali Hajiran, Julio Pow-Sang,

J Urol (The Journal of urology)
[2020, 204(2):266]

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Reply by Authors.

Mounsif Azizi, Ahmet M Aydin, Ali Hajiran, Andrew Lai, Ambuj Kumar, Charles C Peyton, Suks Minhas, Guru P Sonpavde, Jad Chahoud, Lance C Pagliaro, Andrea Necchi, Philippe E Spiess,

J Urol (The Journal of urology)
[2020, 203(6):1155]

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Re: Effect of Extended Pelvic Lymph Node Dissection on Oncologic Outcomes in Patients with D'Amico Intermediate and High Risk Prostate Cancer Treated with Radical Prostatectomy: A Multi-Institutional Study.

Ali Hajiran, Julio Pow-Sang,

J Urol (The Journal of urology)
[2020, 204(1):159]

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Robot-Assisted Laparoscopic Management of Persistent Mullerian Duct Structures in a Male Infant: A Novel Technique.

Alexandra Pearce, Chad Crigger, Ali Hajiran, Osama Al-Omar,

<b><i>Background:</i></b> Persistent Mullerian duct syndrome (PMDS) is a rare disorder of sexual development that results in the presence of internal female reproductive structures in male children who are otherwise phenotypically normal. The removal of the Mullerian structures is suggested, as they pose a risk for future malignancy. <b><i>Case Presentation:</i></b> In ... Read more >>

J Endourol Case Rep (Journal of endourology case reports)
[2020, 6(1):35-38]

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Urinary leak following partial nephrectomy: a contemporary review of 975 cases.

Charles C Peyton, Ali Hajiran, Kevin Morgan, Mounsif Azizi, Dominic Tang, Juan Chipollini, Scott M Gilbert, Michael Poch, Wade J Sexton, Philippe E Spiess,

<h4>Introduction</h4>To describe the incidence, contemporary management, risk factors and outcomes of urinary leak following open and robotic partial nephrectomy at a tertiary care, comprehensive cancer center.<h4>Materials and methods</h4>We reviewed 975 patients who underwent partial nephrectomy at Moffitt Cancer Center from January 2009 to May 2017. Patient demographic, perioperative and follow ... Read more >>

Can J Urol (The Canadian journal of urology)
[2020, 27(1):10118-10124]

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Systematic Review and Meta-Analysis-Is there a Benefit in Using Neoadjuvant Systemic Chemotherapy for Locally Advanced Penile Squamous Cell Carcinoma?

Mounsif Azizi, Ahmet M Aydin, Ali Hajiran, Andrew Lai, Ambuj Kumar, Charles C Peyton, Suks Minhas, Guru P Sonpavde, Jad Chahoud, Lance C Pagliaro, Andrea Necchi, Philippe E Spiess,

PURPOSE:Neoadjuvant chemotherapy is a recommended treatment for patients with penile cancer with bulky inguinal lymphadenopathy or unresectable primary tumors, although there is no evidence of its benefit from randomized trials. MATERIALS AND METHODS:We conducted a systematic search in Embase® and MEDLINE® for studies reporting on patients who received preoperative neoadjuvant ... Read more >>

J Urol (The Journal of urology)
[2020, 203(6):1147-1155]

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Aberrant Epidermal Growth Factor Receptor RNA Splice Products Are Among the Most Frequent Somatic Alterations in Clear Cell Renal Cell Carcinoma and Are Associated with a Poor Response to Immunotherapy.

Saif Zaman, Ali Hajiran, George A Coba, Timothy Robinson, Thushara W Madanayake, Daniel T Segarra, Boris I Chobrutskiy, Theresa A Boyle, Jun-Min Zhou, Youngchul Kim, James J Mulé, Jamie K Teer, Brandon J Manley,

<h4>Background</h4>Accumulating evidence suggests that alternative RNA splicing has an important role in cancer development and progression by driving the expression of a diverse array of RNA and protein isoforms from a handful of genes. However, our understanding of the clinical significance of cancer-specific RNA splicing in renal cell carcinoma (RCC) ... Read more >>

Eur Urol Focus (European urology focus)
[2021, 7(2):373-380]

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Use of SPY Elite Fluorescence Imaging in Creation of a Continent Urinary Diversion.

Ali Hajiran, David Zekan, Tyler Trump, Dylan Dangerfield, Adam Luchey,

The use of SPY Elite Fluorescence Imaging has recently grown popular among multiple surgical specialties, including colorectal, plastic, endocrine, ophthalmologic, and vascular surgery, due to its ability to quickly and accurately assess tissue perfusion and guide intraoperative decision making. To our knowledge, the use of SPY imaging in urologic reconstructive ... Read more >>

Case Rep Urol (Case reports in urology)
[2019, 2019:9069841]

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