Full Text Journal Articles by
Author Ali H Eid

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Beta-Caryophyllene Exhibits Anti-Proliferative Effects through Apoptosis Induction and Cell Cycle Modulation in Multiple Myeloma Cells.

Federica Mannino, Giovanni Pallio, Roberta Corsaro, Letteria Minutoli, Domenica Altavilla, Giovanna Vermiglio, Alessandro Allegra, Ali H Eid, Alessandra Bitto, Francesco Squadrito, Natasha Irrera,

Cannabinoid receptors, which are widely distributed in the body, have been considered as possible pharmacological targets for the management of several tumors. Cannabinoid type 2 receptors (CB2Rs) belong to the G protein-coupled receptor family and are mainly expressed in hematopoietic and immune cells, such as B-cells, T-cells, and macrophages; thus, ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(22):]

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Sex Differences in Cardiovascular Impact of Early Metabolic Impairment: Interplay between Dysbiosis and Adipose Inflammation.

Haneen S Dwaib, Ibrahim AlZaim, Ghina Ajouz, Ali H Eid, Ahmed F El-Yazbi,

The Evolving view of gut microbiota has shifted towards describing the colonic flora as a dynamic organ in continuous interaction with systemic physiological processes. Alterations of the normal gut bacterial profile, known as dysbiosis, has been linked to a wide array of pathologies. Of particular interest is the cardiovascular-metabolic disease ... Read more >>

Mol Pharmacol (Molecular pharmacology)
[2021, :]

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Retraction: Samaha et al. Effects of a Single Dose of Ivermectin on Viral and Clinical Outcomes in Asymptomatic SARS-CoV-2 Infected Subjects: A Pilot Clinical Trial in Lebanon. Viruses 2021, 13, 989.

Ali A Samaha, Hussein Mouawia, Mirna Fawaz, Hamad Hassan, Ali Salami, Ali Al Bazzal, Hamid Bou Saab, Mohamed Al-Wakeel, Ahmad Alsaabi, Mohamad Chouman, Mahmoud Al Moussawi, Hassan Ayoub, Ali Raad, Ola Hajjeh, Ali H Eid, Houssam Raad,

The journal retracts the article, Effects of a Single Dose of Ivermectin on Viral and Clinical Outcomes in Asymptomatic SARS-CoV-2 Infected Subjects: A Pilot Clinical Trial in Lebanon [...]. ... Read more >>

Viruses (Viruses)
[2021, 13(11):]

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Ziziphus nummularia Attenuates the Malignant Phenotype of Human Pancreatic Cancer Cells: Role of ROS.

Joelle Mesmar, Manal M Fardoun, Rola Abdallah, Yusra Al Dhaheri, Hadi M Yassine, Rabah Iratni, Adnan Badran, Ali H Eid, Elias Baydoun,

Pancreatic cancer (PC) is the fourth leading cause of all cancer-related deaths. Despite major improvements in treating PC, low survival rate remains a major challenge, indicating the need for alternative approaches, including herbal medicine. Among medicinal plants is <i>Ziziphus nummularia</i> (family <i>Rhamnaceae</i>), which is a thorny shrub rich in bioactive ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(14):]

Cited: 1 time

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COVID-19: potential therapeutics for pediatric patients.

Nour K Younis, Rana O Zareef, Ghina Fakhri, Fadi Bitar, Ali H Eid, Mariam Arabi,

The global spread of COVID-19 has imparted significant economic, medical, and social burdens. Like adults, children are affected by this pandemic. However, milder clinical symptoms are often experienced by them. Only a minimal proportion of the affected patients may develop severe and complicated COVID-19. Supportive treatment is recommended in all ... Read more >>

Pharmacol Rep (Pharmacological reports : PR)
[2021, 73(6):1520-1538]

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Perirenal Adipose Tissue Inflammation: Novel Insights Linking Metabolic Dysfunction to Renal Diseases.

Safaa H Hammoud, Ibrahim AlZaim, Yusra Al-Dhaheri, Ali H Eid, Ahmed F El-Yazbi,

A healthy adipose tissue (AT) is indispensable to human wellbeing. Among other roles, it contributes to energy homeostasis and provides insulation for internal organs. Adipocytes were previously thought to be a passive store of excess calories, however this view evolved to include an endocrine role. Adipose tissue was shown to ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2021, 12:707126]

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Modulation of preeclampsia by the cholinergic anti-inflammatory pathway: Therapeutic perspectives.

Abdalla M Wedn, Hany M El-Bassossy, Ali H Eid, Mahmoud M El-Mas,

The cholinergic anti-inflammatory pathway (CAP) is vital for the orchestration of the immune and inflammatory responses under normal and challenged conditions. Over the past two decades, peripheral and central circuits of CAP have been shown to be critically involved in dampening the inflammatory reaction in a wide array of inflammatory ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2021, 192:114703]

Cited: 1 time

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Effects of a Single Dose of Ivermectin on Viral and Clinical Outcomes in Asymptomatic SARS-CoV-2 Infected Subjects: A Pilot Clinical Trial in Lebanon.

Ali A Samaha, Hussein Mouawia, Mirna Fawaz, Hamad Hassan, Ali Salami, Ali Al Bazzal, Hamid Bou Saab, Mohamed Al-Wakeel, Ahmad Alsaabi, Mohamad Chouman, Mahmoud Al Moussawi, Hassan Ayoub, Ali Raad, Ola Hajjeh, Ali H Eid, Houssam Raad,

<h4>Objective</h4>This study was designed to determine the efficacy of ivermectin, an FDA-approved drug, in producing clinical benefits and decreasing the viral load of SARS-CoV-2 among asymptomatic subjects that tested positive for this virus in Lebanon.<h4>Methods</h4>A randomized controlled trial was conducted in 100 asymptomatic Lebanese subjects that have tested positive for ... Read more >>

Viruses (Viruses)
[2021, 13(6):]

Cited: 5 times

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Pathophysiological Aspects of the Development of Abdominal Aortic Aneurysm with a Special Focus on Mitochondrial Dysfunction and Genetic Associations.

Volha I Summerhill, Vasily N Sukhorukov, Ali H Eid, Ludmila V Nedosugova, Igor A Sobenin, Alexander N Orekhov,

Abdominal aortic aneurysm (AAA) is a complex degenerative vascular disease, with considerable morbidity and mortality rates among the elderly population. The mortality of AAA is related to aneurysm expansion (the enlargement of the aortic diameter up to 30 mm and above) and the subsequent rupture. The pathogenesis of AAA involves ... Read more >>

Biomol Concepts (Biomolecular concepts)
[2021, 12(1):55-67]

Cited: 1 time

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Metal-based nanoparticles: Promising tools for the management of cardiovascular diseases.

Nour K Younis, Joseph A Ghoubaira, Emmanuel P Bassil, Houda N Tantawi, Ali H Eid,

Cardiovascular disease (CVD) is the leading cause of death worldwide. A search for more effective treatments of CVD is increasingly needed. Major advances in nanotechnology opened new avenues in CVD therapeutics. Owing to their special properties, iron oxide, gold and silver nanoparticles (NPs) could exert various effects in the management ... Read more >>

Nanomedicine (Nanomedicine : nanotechnology, biology, and medicine)
[2021, 36:102433]

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Cannabinoids and myocardial ischemia: Novel insights, updated mechanisms, and implications for myocardial infarction.

Karim Seif El-Dahan, Dima Machtoub, Gaelle Massoud, Suzanne A Nasser, Bassam Hamam, Firas Kobeissy, Fouad A Zouein, Ali H Eid,

Cannabis is the most widely trafficked and abused illicit drug due to its calming psychoactive properties. It has been increasingly recognized as having potential health benefits and relatively less adverse health effects as compared to other illicit drugs; however, growing evidence clearly indicates that cannabis is associated with considerable adverse ... Read more >>

Curr Med Chem (Current medicinal chemistry)
[2021, :]

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ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis.

Anastasia V Poznyak, Evgeny E Bezsonov, Ali H Eid, Tatyana V Popkova, Ludmila V Nedosugova, Antonina V Starodubova, Alexander N Orekhov,

COVID-19 is a highly contagious new infection caused by the single-stranded RNA Sars-CoV-2 virus. For the first time, this infection was recorded in December 2019 in the Chinese province of Wuhan. The virus presumably crossed the interspecies barrier and passed to humans from a bat. Initially, the disease was considered ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(9):]

Cited: 1 time

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Carnosol Is a Novel Inhibitor of p300 Acetyltransferase in Breast Cancer.

Halima Alsamri, Hussain El Hasasna, Bincy Baby, Aysha Alneyadi, Yusra Al Dhaheri, Mohammed Akli Ayoub, Ali H Eid, Ranjit Vijayan, Rabah Iratni,

Carnosol, a natural polyphenol abundant in edible plants such as sage, rosemary, and oregano, has shown promising anticancer activity against various types of cancers. Nonetheless, very little is known about its molecular mechanism of action or its downstream target(s). We have previously shown that carnosol inhibits cellular proliferation, migration, invasion, ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:664403]

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Peri-renal adipose inflammation contributes to renal dysfunction in a non-obese prediabetic rat model: Role of anti-diabetic drugs.

Safaa H Hammoud, Ibrahim AlZaim, Nahed Mougharbil, Sahar Koubar, Ali H Eid, Assaad A Eid, Ahmed F El-Yazbi,

Diabetic nephropathy is a major health challenge with considerable economic burden and significant impact on patients' quality of life. Despite recent advances in diabetic patient care, current clinical practice guidelines fall short of halting the progression of diabetic nephropathy to end-stage renal disease. Moreover, prior literature reported manifestations of renal ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2021, 186:114491]

Cited: 2 times

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Visfatin: An emerging adipocytokine bridging the gap in the evolution of cardiovascular diseases.

Ali Dakroub, Suzanne A Nasser, Firas Kobeissy, Hadi M Yassine, Alexander Orekhov, Javad Sharifi-Rad, Rabah Iratni, Ahmed F El-Yazbi, Ali H Eid,

Visfatin/nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine expressed predominately in visceral fat tissues. High circulating levels of visfatin/NAMPT have been implicated in vascular remodeling, vascular inflammation, and atherosclerosis, all of which pose increased risks of cardiovascular events. In this context, increased levels of visfatin have been correlated with several upregulated pro-inflammatory ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2021, 236(9):6282-6296]

Cited: 1 time

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Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome.

Siarhei A Dabravolski, Nikita G Nikiforov, Ali H Eid, Ludmila V Nedosugova, Antonina V Starodubova, Tatyana V Popkova, Evgeny E Bezsonov, Alexander N Orekhov,

Polycystic ovarian syndrome (PCOS) is the most common endocrine-metabolic disorder affecting a vast population worldwide; it is linked with anovulation, mitochondrial dysfunctions and hormonal disbalance. Mutations in mtDNA have been identified in PCOS patients and likely play an important role in PCOS aetiology and pathogenesis; however, their causative role in ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(8):]

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Cucurbituril Ameliorates Liver Damage Induced by Microcystis aeruginosa in a Mouse Model.

Na'il Saleh, Saad Al-Jassabi, Ali H Eid, Werner M Nau,

<i>Microcystis aeruginosa</i> is a cyanobacterium that produces a variety of cyclic heptapeptide toxins in freshwater. The protective effects of the macromolecular container cucurbit[7]uril (CB7) were evaluated using mouse models of cyanotoxin-induced liver damage. Biochemical analysis of liver function was performed to gauge the extent of liver damage after exposure to ... Read more >>

Front Chem (Frontiers in chemistry)
[2021, 9:660927]

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The pleiotropic effects of antithrombotic drugs in the metabolic-cardiovascular-neurodegenerative disease continuum: impact beyond reduced clotting.

Rana A Alaaeddine, Ibrahim AlZaim, Safaa H Hammoud, Aya Arakji, Ali H Eid, Khaled S Abd-Elrahman, Ahmed F El-Yazbi,

Antithrombotic drugs are widely used for primary and secondary prevention, as well as treatment of many cardiovascular disorders. Over the past few decades, major advances in the pharmacology of these agents have been made with the introduction of new drug classes as novel therapeutic options. Accumulating evidence indicates that the ... Read more >>

Clin Sci (Lond) (Clinical science (London, England : 1979))
[2021, 135(8):1015-1051]

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Transforming growth factor-β1 inhibits interleukin-1β-induced expression of inflammatory genes and Cathepsin S activity in human vascular smooth muscle cells.

Nedra Dhaouadi, Ali Nehme, Wissam H Faour, Patrick Feugier, Catherine Cerutti, Kamel Kacem, Ali H Eid, Jacques-Yuan Li, Kazem Zibara,

<h4>Objective and design</h4>This study investigated the opposite mechanisms by which IL-1β and TGF-β1 modulated the inflammatory and migratory phenotypes in cultured human intimal vascular smooth muscle cells vSMCs.<h4>Materials and treatment</h4>Primary human vSMCs, obtained from twelve hypertensive patients who underwent carotid endarterectomy, were incubated for 24 hours with either 40 pM TGF-β1, or ... Read more >>

Fundam Clin Pharmacol (Fundamental & clinical pharmacology)
[2021, 35(6):979-988]

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Lipid-Lowering Therapies for Atherosclerosis: Statins, Fibrates, Ezetimibe and PCSK9 Monoclonal Antibodies.

Adel Hajj Ali, Nour Younis, Rola Abdallah, Farah Shaer, Ali Dakroub, Mohammed Akli Ayoub, Rabah Iratni, Hadi Mohamad Yassine, Kazem Zibara, Alexander Orekhov, Ahmed Fawzy El-Yazbi, Ali H Eid,

Cardiovascular disease (CVD) remains the primary cause of global morbidity and mortality. CVD includes various life-threatening conditions such as myocardial infarction, stroke and peripheral arterial diseases. In this context, atherosclerosis continues to play the principal role in the pathogenesis of these conditions. Atherosclerosis emanates from a set of modifiable and ... Read more >>

Curr Med Chem (Current medicinal chemistry)
[2021, 28(36):7427-7445]

Cited: 1 time

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Drug Repurposing in Cancer: Now and Beyond.

Ali H Eid,

Curr Med Chem (Current medicinal chemistry)
[2021, 28(11):2083-2084]

Cited: 0 times

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Inflammatory Basis of Atherosclerosis: Modulation by Sex Hormones.

Suzanne A Nasser, Elham A Afify, Firas Kobeissy, Bassam Hamam, Ali H Eid, Mahmoud M El-Mas,

Atherosclerosis-related cardiovascular diseases (CVDs) are the leading cause of death globally. Several lines of evidence are supportive of the contributory role of vascular inflammation in atherosclerosis. Diverse immune cell types, including monocytes/macrophages, T-cells and neutrophils, as well as specialized proresolving lipid mediators, have been successfully characterized as key players in ... Read more >>

Curr Pharm Des (Current pharmaceutical design)
[2021, 27(18):2099-2111]

Cited: 1 time

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Pharmacological and Antioxidant Activities of Rhus coriaria L. (Sumac).

Halima Alsamri, Khawlah Athamneh, Gianfranco Pintus, Ali H Eid, Rabah Iratni,

<i>Rhus coriaria</i> L. (Anacardiaceae), commonly known as sumac, is a commonly used spice, condiment, and flavoring agent, especially in the Mediterranean region. Owing to its bountiful beneficial values, sumac has been used in traditional medicine for the management and treatment of many ailments including hemorrhoids, wound healing, diarrhea, ulcer, and ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2021, 10(1):]

Cited: 4 times

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Drug Repurposing in Neurodegenerative and Cardiovascular Diseases.

Ali H Eid,

Curr Med Chem (Current medicinal chemistry)
[2021, 28(12):2303-2304]

Cited: 0 times

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Cardiac Autonomic Neuropathy: A Progressive Consequence of Chronic Low-Grade Inflammation in Type 2 Diabetes and Related Metabolic Disorders.

Nour-Mounira Z Bakkar, Haneen S Dwaib, Souha Fares, Ali H Eid, Yusra Al-Dhaheri, Ahmed F El-Yazbi,

Cardiac autonomic neuropathy (CAN) is one of the earliest complications of type 2 diabetes (T2D), presenting a silent cause of cardiovascular morbidity and mortality. Recent research relates the pathogenesis of cardiovascular disease in T2D to an ensuing chronic, low-grade proinflammatory and pro-oxidative environment, being the hallmark of the metabolic syndrome. ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(23):]

Cited: 4 times

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