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Familial hemiplegic migraine type 2 due to a novel missense mutation in ATP1A2.

Fabio Antonaci, Sabrina Ravaglia, Gaetano S Grieco, Stella Gagliardi, Cristina Cereda, Alfredo Costa,

<h4>Background</h4>The mechanisms of genotype-phenotype interaction in Familiar Hemiplegic migraine type 2 (FHM2) are still far from clear. Different ATP1A2 mutations have been described, with a spectrum of phenotypes ranging from mild to severe. No genotype-phenotype correlations have been attempted.<h4>Case presentation</h4>We describe an Italian family with FHM and a missense ATP1A2 ... Read more >>

J Headache Pain (The journal of headache and pain)
[2021, 22(1):12]

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Correlation of Frontal Atrophy and CSF Tau Levels With Neuropsychiatric Symptoms in Patients With Cognitive Impairment: A Memory Clinic Experience.

Matteo Cotta Ramusino, Giulia Perini, Gloria Vaghi, Beatrice Dal Fabbro, Marco Capelli, Marta Picascia, Diego Franciotta, Lisa Farina, Elena Ballante, Alfredo Costa,

<b>Background</b>: Behavioral and psychological symptoms of dementia (BPSD) are a distressful condition. We aimed to investigate the BPSD distribution in subjects with cognitive impairment, and the potential correlations between BPSD and neurodegeneration in terms of cerebrospinal fluid (CSF) tau and brain atrophy. <b>Methods</b>: One-hundred patients with mild cognitive impairment (MCI) ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2021, 13:595758]

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Effects of Oral Administration of Alprazolam and Lorazepam as Hypnotics on Cardiovascular Parameters in Hypertensive Patients.

Alfredo Costa, Angela D'Angelo, Matteo Cotta Ramusino, Giulia Perini, Daniele Bosone, Giuseppe Derosa, Roberto Fogari,

<h4>Background</h4>Previous studies have suggested that evening intake of benzodiazepine affects blood pressure (BP) and/or heart rate (HR) in healthy and hypertensive subjects. The aim of this study was to compare the effect of chronic oral administration of alprazolam and lorazepam as hypnotics on ambulatory BP and HR in patients with ... Read more >>

J Clin Psychopharmacol (Journal of clinical psychopharmacology)
[2021, 41(2):191-195]

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Different miRNA Profiles in Plasma Derived Small and Large Extracellular Vesicles from Patients with Neurodegenerative Diseases.

Daisy Sproviero, Stella Gagliardi, Susanna Zucca, Maddalena Arigoni, Marta Giannini, Maria Garofalo, Martina Olivero, Michela Dell'Orco, Orietta Pansarasa, Stefano Bernuzzi, Micol Avenali, Matteo Cotta Ramusino, Luca Diamanti, Brigida Minafra, Giulia Perini, Roberta Zangaglia, Alfredo Costa, Mauro Ceroni, Nora I Perrone-Bizzozero, Raffaele A Calogero, Cristina Cereda,

Identifying biomarkers is essential for early diagnosis of neurodegenerative diseases (NDs). Large (LEVs) and small extracellular vesicles (SEVs) are extracellular vesicles (EVs) of different sizes and biological functions transported in blood and they may be valid biomarkers for NDs. The aim of our study was to investigate common and different ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(5):]

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Alzheimer's, Parkinson's Disease and Amyotrophic Lateral Sclerosis Gene Expression Patterns Divergence Reveals Different Grade of RNA Metabolism Involvement.

Maria Garofalo, Cecilia Pandini, Matteo Bordoni, Orietta Pansarasa, Federica Rey, Alfredo Costa, Brigida Minafra, Luca Diamanti, Susanna Zucca, Stephana Carelli, Cristina Cereda, Stella Gagliardi,

Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by a progressive degeneration of the central or peripheral nervous systems. A central role of the RNA metabolism has emerged in these diseases, concerning mRNAs processing and non-coding RNAs biogenesis. We aimed to identify possible ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(24):]

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Different RNA profiles in plasma derived small and large extracellular vesicles of Neurodegenerative diseases patients

Daisy Sproviero, Stella Gagliardi, Susanna Zucca, Maddalena Arigoni, Marta Giannini, Maria Garofalo, Martina Olivero, Michela Dell’Orco, Orietta Pansarasa, Stefano Bernuzzi, Micol Avenali, Matteo Cotta Ramusino, Luca Diamanti, Brigida Minafra, Giulia Perini, Roberta Zangaglia, Alfredo Costa, Mauro Ceroni, Nora Perrone-Bizzozero, Raffaele Calogero, Cristina Cereda,

<h4>Background</h4> Identifying robust biomarkers is essential for early diagnosis of neurodegenerative diseases (NDs). Large (LEVs) and small extracellular vesicles (SEVs) are extracellular vesicles (EVs) of different sizes and biological functions transported in blood and they may be valid biomarkers for NDs. The aim of our study was to investigate common ... Read more >>

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Frontal and Cerebellar Atrophy Supports FTSD-ALS Clinical Continuum.

Beatrice Pizzarotti, Fulvia Palesi, Paolo Vitali, Gloria Castellazzi, Nicoletta Anzalone, Elena Alvisi, Daniele Martinelli, Sara Bernini, Matteo Cotta Ramusino, Mauro Ceroni, Giuseppe Micieli, Elena Sinforiani, Egidio D'Angelo, Alfredo Costa, Claudia A M Gandini Wheeler-Kingshott,

<h4>Background</h4>Frontotemporal Spectrum Disorder (FTSD) and Amyotrophic Lateral Sclerosis (ALS) are neurodegenerative diseases often considered as a continuum from clinical, epidemiologic, and genetic perspectives. We used localized brain volume alterations to evaluate common and specific features of FTSD, FTSD-ALS, and ALS patients to further understand this clinical continuum.<h4>Methods</h4>We used voxel-based morphometry ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2020, 12:593526]

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COVID-19 and Guillain-Barré Syndrome: A Case Report and Review of Literature.

Antonio Zito, Enrico Alfonsi, Diego Franciotta, Massimiliano Todisco, Matteo Gastaldi, Matteo Cotta Ramusino, Mauro Ceroni, Alfredo Costa,

During the recent coronavirus disease 2019 (COVID-19) outbreak in Northern Italy, we observed a 57-year-old man developing acute motor-sensory axonal neuropathy, a variant of Guillain-Barré syndrome (GBS), 12 days after severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. Similarly to other bacterial and viral infections, dysregulation of the immune system due to ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:909]

Cited: 8 times

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Mini Nutritional Assessment May Identify a Dual Pattern of Perturbed Plasma Amino Acids in Patients with Alzheimer's Disease: A Window to Metabolic and Physical Rehabilitation?

Roberto Aquilani, Alfredo Costa, Roberto Maestri, Matteo Cotta Ramusino, Antonia Pierobon, Maurizia Dossena, Sebastiano Bruno Solerte, Anna Maria Condino, Valeria Torlaschi, Paola Bini, Mirella Boselli, Mauro Ceroni, Daniela Buonocore, Federica Boschi, Mariella Bruni, Manuela Verri,

Conflicting results about alterations of plasma amino acid (AA) levels are reported in subjects with Alzheimer's disease (AD). The current study aimed to provide more homogeneous AA profiles and correlations between AAs and cognitive tests. Venous plasma AAs were measured in 54 fasting patients with AD (37 males, 17 females; ... Read more >>

Nutrients (Nutrients)
[2020, 12(6):]

Cited: 1 time

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Arrigo Moglia (1947-2020).

Alfredo Costa,

Neurol Sci (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2020, 41(6):1379-1380]

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A Machine Learning Approach for the Differential Diagnosis of Alzheimer and Vascular Dementia Fed by MRI Selected Features.

Gloria Castellazzi, Maria Giovanna Cuzzoni, Matteo Cotta Ramusino, Daniele Martinelli, Federica Denaro, Antonio Ricciardi, Paolo Vitali, Nicoletta Anzalone, Sara Bernini, Fulvia Palesi, Elena Sinforiani, Alfredo Costa, Giuseppe Micieli, Egidio D'Angelo, Giovanni Magenes, Claudia A M Gandini Wheeler-Kingshott,

Among dementia-like diseases, Alzheimer disease (AD) and vascular dementia (VD) are two of the most frequent. AD and VD may share multiple neurological symptoms that may lead to controversial diagnoses when using conventional clinical and MRI criteria. Therefore, other approaches are needed to overcome this issue. Machine learning (ML) combined ... Read more >>

Front Neuroinform (Frontiers in neuroinformatics)
[2020, 14:25]

Cited: 2 times

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Understanding Factors Associated With Psychomotor Subtypes of Delirium in Older Inpatients With Dementia.

Alessandro Morandi, Antonella Zambon, Simona G Di Santo, Andrea Mazzone, Antonio Cherubini, Enrico Mossello, Mario Bo, Alessandra Marengoni, Giuseppe Bellelli, ,

<h4>Objectives</h4>Few studies have analyzed factors associated with delirium subtypes. In this study, we investigate factors associated with subtypes of delirium only in patients with dementia to provide insights on the possible prevention and treatments.<h4>Design</h4>This is a cross-sectional study nested in the "Delirium Day" study, a nationwide Italian point-prevalence study.<h4>Setting and ... Read more >>

J Am Med Dir Assoc (Journal of the American Medical Directors Association)
[2020, 21(4):486-492.e7]

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Unsuspected Involvement of Spinal Cord in Alzheimer Disease.

Roberta Maria Lorenzi, Fulvia Palesi, Gloria Castellazzi, Paolo Vitali, Nicoletta Anzalone, Sara Bernini, Matteo Cotta Ramusino, Elena Sinforiani, Giuseppe Micieli, Alfredo Costa, Egidio D'Angelo, Claudia A M Gandini Wheeler-Kingshott,

Objective: Brain atrophy is an established biomarker for dementia, yet spinal cord involvement has not been investigated to date. As the spinal cord is relaying sensorimotor control signals from the cortex to the peripheral nervous system and vice-versa, it is indeed a very interesting question to assess whether it is ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2020, 14:6]

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Diagnostic and Therapeutic Errors in Classical Trigeminal Neuralgia: a Multicenter Survey

Fabio Antonaci, Sebastiano Arceri, Martin Rakusa, Dimos Mitsikostas, Ivan Milanov, Vasil Todorov, Matteo Cotta Ramusino, Alfredo Costa,

<h4>Background: </h4> Classical Trigeminal neuralgia (CTN) is a severe, disabling form of painful cranial neuropathy. Even though CTN has a typical clinical picture, diagnosis it is often missed or delayed in clinical practice. This study was carried over to investigate the occurrence of diagnostic and therapeutic errors in CNT. Methods ... Read more >>

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The Impact of COVID-19 Quarantine on Patients With Dementia and Family Caregivers: A Nation-Wide Survey.

Innocenzo Rainero, Amalia C Bruni, Camillo Marra, Annachiara Cagnin, Laura Bonanni, Chiara Cupidi, Valentina Laganà, Elisa Rubino, Alessandro Vacca, Raffaele Di Lorenzo, Paolo Provero, Valeria Isella, Nicola Vanacore, Federica Agosta, Ildebrando Appollonio, Paolo Caffarra, Cinzia Bussè, Renato Sambati, Davide Quaranta, Valeria Guglielmi, Giancarlo Logroscino, Massimo Filippi, Gioacchino Tedeschi, Carlo Ferrarese, ,

<h4>Introduction</h4>Previous studies showed that quarantine for pandemic diseases is associated with several psychological and medical effects. The consequences of quarantine for COVID-19 pandemic in patients with dementia are unknown. We investigated the clinical changes in patients with Alzheimer's disease and other dementias, and evaluated caregivers' distress during COVID-19 quarantine.<h4>Methods</h4>The study ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2020, 12:625781]

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The Treatment of Trigeminal Autonomic Cephalalgias: An Overview.

Matteo Cotta Ramusino, Giulia Perini, Fabio Antonaci, Alfredo Costa,

Trigeminal autonomic cephalalgias (TACs) are primary headaches that include cluster headache (CH), paroxysmal hemicrania (PH), and short-lasting unilateral neuralgiform headache attacks (SUNHAs) with conjunctival injection and tearing (SUNCT) or cranial autonomic features (SUNA). Hemicrania continua (HC) is another form that has been ascribed to TACs for clinical and pathophysiologic reasons. ... Read more >>

J Oral Facial Pain Headache (Journal of oral & facial pain and headache)
[2019, 33(1):89-104]

Cited: 1 time

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Frontal and cerebellar atrophy supports FTSD-ALS clinical continuum

Beatrice Pizzarotti, Fulvia Palesi, Paolo Vitali, Gloria Castellazzi, Nicoletta Anzalone, Elena Alvisi, Daniele Martinelli, Sara Bernini, Matteo Cotta Ramusino, Mauro Ceroni, Giuseppe Micieli, Elena Sinforiani, Egidio D’Angelo, Alfredo Costa, Claudia AM Gandini Wheeler-Kingshott,

<h4>Background</h4> Frontotemporal Spectrum Disorder (FTSD) and Amyotrophic Lateral Sclerosis (ALS) are neurodegenerative diseases often considered as a continuum from clinical, epidemiologic and genetic perspectives. We used localized brain volume alterations to evaluate common and specific features of FTSD, FTSD-ALS and ALS patients to further understand this clinical continuum. <h4>Methods</h4> We ... Read more >>

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Medial temporal lobe atrophy and posterior atrophy scales normative values.

Matteo Cotta Ramusino, Daniele Altomare, Ruggero Bacchin, Silvia Ingala, Claudio Bnà, Matteo Bonetti, Alfredo Costa, Frederik Barkhof, Valentina Nicolosi, Cristina Festari, Giovanni B Frisoni, Marina Boccardi,

<h4>Objectives</h4>The medial temporal lobe atrophy (MTA) and the posterior atrophy (PA) scales allow to assess the degree hippocampal and parietal atrophy from magnetic resonance imaging (MRI) scans. Despite reliable, easy and widespread employment, appropriate normative values are still missing. We aim to provide norms for the Italian population.<h4>Methods</h4>Two independent raters ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2019, 24:101936]

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Incremental value of amyloid-PET versus CSF in the diagnosis of Alzheimer's disease.

Matteo Cotta Ramusino, Valentina Garibotto, Ruggero Bacchin, Daniele Altomare, Alessandra Dodich, Frederic Assal, Aline Mendes, Alfredo Costa, Michele Tinazzi, Silvia D Morbelli, Matteo Bauckneht, Agnese Picco, Massimo E Dottorini, Cristina Tranfaglia, Lucia Farotti, Nicola Salvadori, Davide Moretti, Giordano Savelli, Anna Tarallo, Flavio Nobili, Maura Parapini, Carlo Cavaliere, Elena Salvatore, Marco Salvatore, Marina Boccardi, Giovanni B Frisoni,

<h4>Purpose</h4>To compare the incremental diagnostic value of amyloid-PET and CSF (Aβ42, tau, and phospho-tau) in AD diagnosis in patients with mild cognitive impairment (MCI) or mild dementia, in order to improve the definition of diagnostic algorithm.<h4>Methods</h4>Two independent dementia experts provided etiological diagnosis and relative diagnostic confidence in 71 patients on ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2020, 47(2):270-280]

Cited: 7 times

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Role of Cerebrospinal Fluid Biomarkers and (18)F-florbetapir PET Imaging in the Diagnosis of Primary Progressive Aphasia: A Retrospective Analysis.

Giulia Perini, Matteo Cotta Ramusino, Elena Sinforiani, Diego Franciotta, Giusppe Trifirò, Mauro Ceroni, Alfredo Costa,

The use of biomarkers has recently supported the association between Alzheimer disease (AD) pathology and the logopenic variant of primary progressive aphasia (PPA). We aim to investigate possible differences in cerebrospinal fluid (CSF) biomarker concentrations in the three PPA variants, and to assess any agreement between CSF biomarkers and (18)F-florbetapir ... Read more >>

Alzheimer Dis Assoc Disord (Alzheimer disease and associated disorders)
[2019, 33(3):282-284]

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Impact of Medical Care on Symptomatic Drug Consumption and Quality of Life in Headache: A One-Year Population Study.

Matteo Cotta Ramusino, Ilaria De Cillis, Alfredo Costa, Fabio Antonaci,

Background: Chronic headache is one of the most common pain conditions, often leading to symptomatic drug overuse. The aim of this study was to provide data on symptomatic drug consumption in an Italian outpatient population and to describe how the clinical picture of headache may change after headache experts take ... Read more >>

Front Neurol (Frontiers in neurology)
[2019, 10:629]

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Unsuspected involvement of spinal cord in Alzheimer Disease

Roberta Maria Lorenzi, Fulvia Palesi, Gloria Castellazzi, Paolo Vitali, Nicoletta Anzalone, Sara Bernini, Elena Sinforiani, Giuseppe Micieli, Alfredo Costa, Egidio D’Angelo, Claudia A.M. Gandini Wheeler-Kingshott,

<h4>Objective</h4> Brain atrophy is an established biomarker for dementia, yet spinal cord involvement has not been investigated to date. As the spinal cord is relaying sensorimotor control signals from the cortex to the peripheral nervous system and viceversa, it is indeed a very interesting question to assess whether it is ... Read more >>

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Leukocyte Derived Microvesicles as Disease Progression Biomarkers in Slow Progressing Amyotrophic Lateral Sclerosis Patients.

Daisy Sproviero, Sabrina La Salvia, Federico Colombo, Susanna Zucca, Orietta Pansarasa, Luca Diamanti, Alfredo Costa, Luca Lova, Marta Giannini, Stella Gagliardi, Eliana Lauranzano, Michela Matteoli, Mauro Ceroni, Andrea Malaspina, Cristina Cereda,

The lack of biomarkers in Amyotrophic Lateral Sclerosis (ALS) makes it difficult to determine the stage of the disease in patients and, therefore, it delays therapeutic trials. Microvesicles (MVs) are possible biomarkers implicated in physiological and pathological functions, however, their role in ALS remains unclear. We investigated whether plasma derived ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2019, 13:344]

Cited: 3 times

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Cognitive impairment in depression: recent advances and novel treatments.

Giulia Perini, Matteo Cotta Ramusino, Elena Sinforiani, Sara Bernini, Roberto Petrachi, Alfredo Costa,

In the past, little or no attention was paid to cognitive disorders associated with depression (a condition sometimes termed pseudodementia). However, recent years have seen a growing interest in these changes, not only because of their high frequency in acute-stage depression, but also because they have been found to persist, ... Read more >>

Neuropsychiatr Dis Treat (Neuropsychiatric disease and treatment)
[2019, 15:1249-1258]

Cited: 6 times

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Effect of Evening Bromazepam Administration on Blood Pressure and Heart Rate in Mild Hypertensive Patients.

Alfredo Costa, Daniele Bosone, Matteo Cotta Ramusino, Giulia Perini, Natascia Ghiotto, Annalisa Zoppi, Angela D Apos Angelo, Roberto Fogari,

<h4>Aim</h4>To assess the effects of chronic evening oral administration of bromazepam alone or in combination with propranolol on ambulatory blood pressure (BP) and heart rate (HR) in mild hypertensive subjects.<h4>Methods</h4>Thirty-seven mild hypertensive patients after a 2-week placebo period were randomized to bromazepam 3 mg, propranolol 40 mg, bromazepam 3 mg ... Read more >>

Pharmacology (Pharmacology)
[2019, 104(1-2):1-6]

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