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Author Alfio Ferlito

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High-grade Transformation/Dedifferentiation in Salivary Gland Carcinomas: Occurrence Across Subtypes and Clinical Significance.

Alena Skalova, Ilmo Leivo, Henrik Hellquist, Abbas Agaimy, Roderick H W Simpson, Göran Stenman, Vincent Vander Poorten, Justin A Bishop, Alessandro Franchi, Juan C Hernandez-Prera, David Slouka, Stefan M Willems, Kerry D Olsen, Alfio Ferlito,

High-grade transformation (HGT) or dedifferentiation has been described in a variety of salivary gland carcinomas, including acinic cell carcinoma, secretory carcinoma, adenoid cystic carcinoma, epithelial-myoepithelial carcinoma, polymorphous adenocarcinoma, low-grade mucoepidermoid carcinoma, and hyalinizing clear cell carcinoma. High-grade (HG) transformed tumors are composed of a conventional low-grade component characterized by specific ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(3):107-118]

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Emerging Entities and New Diagnostic Markers for Head and Neck Soft Tissue and Bone Tumors.

Alessandro Franchi, Lester D R Thompson, Juan C Hernandez-Prera, Abbas Agaimy, Michelle D Williams, Lauge H Mikkelsen, Justin A Bishop, Stefan M Willems, Henrik Hellquist, Alfio Ferlito,

Bone and soft tissue tumors of the head and neck are relatively uncommon tumors that often represent a diagnostic challenge because of the wide range of entities that must be considered in the differential diagnosis. Over the past few years, classification of bone and soft tissue tumors has evolved primarily ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(3):139-149]

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Transoral endoscopic vestibular approach for thyroidectomy and parathyroidectomy - From promise to practice.

Oded Cohen, Ralph P Tufano, AngKoon Anuwong, Ashok R Shaha, Kerry D Olsen, Mark Zafereo, Alessandra Rinaldo, Antti A Mäkitie, Iain J Nixon, Jonathon O Russell, Alfio Ferlito, Avi Khafif,

<h4>Objectives</h4>To describe the evolution and recent series on transoral endoscopic vestibular approach thyroidectomy and parathyroidectomy (TOET/PVA).<h4>Data sources</h4>PubMed, Google Scholar.<h4>Review methods</h4>Review of the available English literature.<h4>Results</h4>TOET/PVA may offer several advantages over other remote access thyroidectomy approaches and has been adopted by many centers worldwide with excellent success rates. Indications include benign ... Read more >>

Am J Otolaryngol (American journal of otolaryngology)
[2021, 42(5):103022]

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Contemporary management of the neck in nasopharyngeal carcinoma.

Wai Tong Ng, Raymond K Y Tsang, Jonathan J Beitler, Remco de Bree, Andrés Coca-Pelaz, Avraham Eisbruch, Orlando Guntinas-Lichius, Anne W M Lee, Antti A Mäkitie, William M Mendenhall, Sandra Nuyts, Alessandra Rinaldo, K Thomas Robbins, Juan P Rodrigo, Carl E Silver, Ricard Simo, Robert Smee, Primož Strojan, Robert P Takes, Alfio Ferlito,

Up to 85% of the patients with nasopharyngeal carcinoma present with regional nodal metastasis. Although excellent nodal control is achieved with radiotherapy, a thorough understanding of the current TNM staging criteria and pattern of nodal spread is essential to optimize target delineation and minimize unnecessary irradiation to adjacent normal tissue. ... Read more >>

Head Neck (Head & neck)
[2021, :]

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Occlusion of the internal jugular vein in differentiated thyroid carcinoma: Causes and diagnosis.

Dana M Hartl, Mark E Zafereo, Luiz P Kowalski, Gregory W Randolph, Kerry D Olsen, Veronica Fernandez-Alvarez, Iain J Nixon, Ashok R Shaha, Peter Angelos, Jatin P Shah, Alfio Ferlito,

Occlusion of the internal jugular vein (IJV) can be observed in thyroid cancer either on preoperative imaging with ultrasound or cross-sectional imaging, particularly contrast-enhanced CT-scan, and can be detected during follow-up when using these same imaging modalities. For thyroid cancer, four different causes of occlusion of the IJV can be ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2021, :]

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Determinants of delay and association with outcome in head and neck cancer: A systematic review.

Rosanne C Schoonbeek, Julia Zwertbroek, Boudewijn E C Plaat, Robert P Takes, John A Ridge, Primož Strojan, Alfio Ferlito, Boukje A C van Dijk, György B Halmos,

<h4>Introduction</h4>Head and neck cancers (HNC) are relatively fast-growing tumours, and delay in treatment initiation is associated with tumour progression and adverse outcome. An overview of factors contributing to delay can provide critical insights on necessary adjustments to optimize care pathways. This systematic review aims to identify factors associated with delay ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2021, :]

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Electrochemotherapy in Mucosal Cancer of the Head and Neck: A Systematic Review.

Primož Strojan, Aleš Grošelj, Gregor Serša, Christina Caroline Plaschke, Jan B Vermorken, Sandra Nuyts, Remco de Bree, Avraham Eisbruch, William M Mendenhall, Robert Smee, Alfio Ferlito,

Electrochemotherapy (ECT) is a local ablative treatment that is based on the reversible electroporation and intracellular accumulation of hydrophilic drug molecules, which greatly increases their cytotoxicity. In mucosal head and neck cancer (HNC), experience with ECT is limited due to the poor accessibility of tumors. In order to review the ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(6):]

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Pleomorphic Adenoma: The Great Mimicker of Malignancy.

Juan C Hernandez-Prera, Alena Skálová, Alessandro Franchi, Alessandra Rinaldo, Vincent Vander Poorten, Peter Zbären, Alfio Ferlito, Bruce M Wenig,

Pleomorphic adenoma is the most common salivary gland neoplasm and its diagnosis is straightforward in majority of cases. However; not infrequently PA exhibits unusual and uncommon histological findings that can erroneously be confused with malignancy. The diagnostic difficulties of PA arise from its ability of mimic invasion, show atypical or ... Read more >>

Histopathology (Histopathology)
[2020, :]

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Trends in the Management of Non-Vestibular Skull Base and Intracranial Schwannomas.

Carlos Suárez, Fernando López, William M Mendenhall, Simon Andreasen, Lauge Hjorth Mikkelsen, Johannes A Langendijk, Stefano Bondi, Juan P Rodrigo, Leif Bäck, Antti A Mäkitie, Verónica Fernández-Alvarez, Andrés Coca-Pelaz, Robert Smee, Alessandra Rinaldo, Alfio Ferlito,

The aim of this review is to analyze the latest trends in the management of non-vestibular skull base and intracranial schwannomas in order to optimize tumor control and quality of life. Non-vestibular cranial nerve schwannomas are rare lesions, representing 5-10% of cranial nerve schwannomas. Management decisions should be individualized depending ... Read more >>

Cancer Manag Res (Cancer management and research)
[2021, 13:463-478]

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Frozen section in thyroid gland follicular neoplasms: It's high time to abandon it!

Alvaro Sanabria, Mark Zafereo, Lester D R Thompson, Juan C Hernandez-Prera, Luiz P Kowalski, Iain J Nixon, Ashok Shaha, Juan P Rodrigo, Antti Mäkitie, Vincent Vander Poorten, Carlos Suarez, Peter Zbären, Alessandra Rinaldo, Alfio Ferlito,

Thyroid nodules are a very common clinical condition. The 2015 American Thyroid Association (ATA) guidelines recommend surgical excision for Bethesda IV nodules. The use of intraoperative frozen section (FS) has been recommended as a strategy to tailor the extent of the initial surgery. We critically evaluated the literature that discusses ... Read more >>

Surg Oncol (Surgical oncology)
[2021, 36:76-81]

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What is the role of sentinel lymph node biopsy in the management of oral cancer in 2020?

Remco de Bree, Bart de Keizer, Francisco J Civantos, Robert P Takes, Juan P Rodrigo, Juan C Hernandez-Prera, Gyorgy B Halmos, Alessandra Rinaldo, Alfio Ferlito,

Approximately 70-80% of patients with cT1-2N0 oral squamous cell carcinoma (OSCC) ultimately prove to have no cancer in the cervical lymphatics on final pathology after selective neck dissection. As a result, sentinel lymph node biopsy (SLNB) has been adopted during the last decade as a diagnostic staging method to intelligently identify ... Read more >>

Eur Arch Otorhinolaryngol (European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery)
[2020, :]

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Endonasal endoscopic surgery for sinonasal squamous cell carcinoma from an oncological perspective.

Akihiro Homma, Yuji Nakamaru, Valerie J Lund, Ehab Y Hanna, Luiz Paulo Kowalski, Ronaldo Nunes Toledo, Antti A Mäkitie, Juan Pablo Rodrigo, Alessandra Rinaldo, Carl H Snyderman, Alfio Ferlito,

Endonasal endoscopic surgery (EES) has been applied to the management of sinonasal (SN) tumors based on recent advances in endoscopic surgical techniques and technologies over the past three decades. EES has been mainly indicated for benign tumors and less aggressive malignant tumors. Notwithstanding this, EES has been gradually adopted for ... Read more >>

Auris Nasus Larynx (Auris, nasus, larynx)
[2021, 48(1):41-49]

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Management of the Neck in Well-Differentiated Thyroid Cancer.

Panagiotis Asimakopoulos, Ashok R Shaha, Iain J Nixon, Jatin P Shah, Gregory W Randolph, Peter Angelos, Mark E Zafereo, Luiz P Kowalski, Dana M Hartl, Kerry D Olsen, Juan P Rodrigo, Vincent Vander Poorten, Antti A Mäkitie, Alvaro Sanabria, Carlos Suárez, Miquel Quer, Francisco J Civantos, K Thomas Robbins, Orlando Guntinas-Lichius, Marc Hamoir, Alessandra Rinaldo, Alfio Ferlito,

<h4>Purpose of review</h4>In this narrative review, we discuss the indications for elective and therapeutic neck dissections and the postoperative surveillance and treatment options for recurrent nodal disease in patients with well-differentiated thyroid cancer.<h4>Recent findings</h4>Increased availability of advanced imaging modalities has led to an increased detection rate of previously occult nodal ... Read more >>

Curr Oncol Rep (Current oncology reports)
[2020, 23(1):1]

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Metastatic Squamous Cell Carcinoma to the Cervical Lymph Nodes From an Unknown Primary Cancer: Management in the HPV Era.

Francisco J Civantos, Jan B Vermorken, Jatin P Shah, Alessandra Rinaldo, Carlos Suárez, Luiz P Kowalski, Juan P Rodrigo, Kerry Olsen, Primoz Strojan, Antti A Mäkitie, Robert P Takes, Remco de Bree, June Corry, Vinidh Paleri, Ashok R Shaha, Dana M Hartl, William Mendenhall, Cesare Piazza, Michael Hinni, K Thomas Robbins, Ng Wai Tong, Alvaro Sanabria, Andres Coca-Pelaz, Johannes A Langendijk, Juan Hernandez-Prera, Alfio Ferlito,

<h4>Background</h4>Patients with metastases in the lymph nodes of the neck and no obvious primary tumor, neck cancer with unknown primary (NCUP), represent a management challenge. A majority of patients have metastatic squamous cell carcinoma (SCC), although other histologies do occur.<h4>Methods</h4>We comprehensively reviewed the literature, compared available guidelines, and conferred with ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:593164]

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Prognostic role of intraparotid lymph node metastasis in primary parotid cancer: Systematic review.

Orlando Guntinas-Lichius, Jovanna Thielker, K Thomas Robbins, Kerry D Olsen, Ashok R Shaha, Antti A Mäkitie, Remco de Bree, Vincent Vander Poorten, Miquel Quer, Alessandra Rinaldo, Luiz Paulo Kowalski, Juan Pablo Rodrigo, Marc Hamoir, Alfio Ferlito,

<h4>Background</h4>The prognostic importance of intraparotid lymph node metastasis (P+) in patients with primary parotid gland carcinoma is unclear.<h4>Methods</h4>Nineteen retrospective and noncomparative cohort studies, published between 1992 and 2020, met the inclusion criteria and included 2202 patients for this systematic review.<h4>Results</h4>The pooled prevalence of the P in adult patients in the ... Read more >>

Head Neck (Head & neck)
[2021, 43(3):997-1008]

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Vitamin D in Head and Neck Cancer: a Systematic Review.

Antti Mäkitie, Iida Tuokkola, Göran Laurell, Outi Mäkitie, Kerry Olsen, Robert P Takes, Ewa Florek, Krzysztof Szyfter, Cornelis F M Sier, Alfio Ferlito,

<h4>Purpose of review</h4>Observational studies have shown that serum 25-OH vitamin D [25(OH)D] is inversely associated with overall cancer risk in many malignancies. We performed a systematic literature review to determine whether vitamin D deficiency is related to head and neck cancer (HNC) etiology and outcome.<h4>Recent findings</h4>The search yielded five prospective ... Read more >>

Curr Oncol Rep (Current oncology reports)
[2020, 23(1):5]

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Immediate Intraoperative Repair of the Recurrent Laryngeal Nerve in Thyroid Surgery.

Ricard Simó, Iain J Nixon, Aleix Rovira, Vincent Vander Poorten, Alvaro Sanabria, Mark Zafereo, Dana M Hartl, Luiz P Kowalski, Gregory W Randolph, Dipti Kamani, Ashok R Shaha, Jatin Shah, Jean-Paul Marie, Alessandra Rinaldo, Alfio Ferlito,

<h4>Objectives</h4>Recurrent laryngeal nerve (RLN) injury is a recognized risk during thyroid and parathyroid surgery and can result in significant morbidity. The aim of this review paper is to consider the optimal approach to the immediate intraoperative repair of the RLN during thyroid surgery.<h4>Methods</h4>A PubMed literature search was performed from inception ... Read more >>

Laryngoscope (The Laryngoscope)
[2020, :]

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Radiation-Induced Sarcomas of the Head and Neck: A Systematic Review.

Andrés Coca-Pelaz, Antti A Mäkitie, Primož Strojan, June Corry, Avraham Eisbruch, Jonathan J Beitler, Sandra Nuyts, Robert Smee, Johannes A Langendijk, William M Mendenhall, Cesare Piazza, Alessandra Rinaldo, Alfio Ferlito,

<h4>Introduction</h4>As a result of the increased use of radiotherapy (RT) and improved long-term overall survival of patients with cancers of the head and neck (HN), the frequency of radiation-induced sarcomas of the head and neck (RISHN) may be increasing. The main objective of this systematic review was to determine the ... Read more >>

Adv Ther (Advances in therapy)
[2021, 38(1):90-108]

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Considerations for environmentally sustainable head and neck surgical oncology practice.

Alvaro Sanabria, Luiz P Kowalski, Iain J Nixon, Ashok Shaha, Remco De Bree, Antti A Mäkitie, Alessandra Rinaldo, Alfio Ferlito,

<h4>Objective</h4>To evaluate the potential role of head and neck oncologic surgeons in environmental protection, sustainability of health-care systems and avoidance of procedures contributing to climate change in the future.<h4>Review methods</h4>This literature review searched for relevant literature about the relevance of waste in surgical head and neck oncology practice and the ... Read more >>

Am J Otolaryngol (American journal of otolaryngology)
[2020, 41(6):102719]

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Radiotherapy in the management of glottic squamous cell carcinoma.

William M Mendenhall, Primož Strojan, Anne W M Lee, Alessandra Rinaldo, Avraham Eisbruch, Wai Tong Ng, Robert Smee, Alfio Ferlito,

<h4>Introduction</h4>Our purpose is to review the role radiotherapy (RT) in the treatment of glottic squamous cell carcinoma (SCC).<h4>Methods</h4>A concise review of the pertinent literature.<h4>Results</h4>RT cure rates are Tis- T1N0, 90% to 95%; T2N0, 70% to 80%; low-volume T3-T4a, 65% to 70%. Concomitant cisplatin is given for T3-T4a SCCs. Severe complications ... Read more >>

Head Neck (Head & neck)
[2020, 42(12):3558-3567]

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Value and Quality of Care in Head and Neck Oncology.

Robert P Takes, Gyorgy B Halmos, John A Ridge, Paolo Bossi, Matthias A W Merkx, Alessandra Rinaldo, Alvaro Sanabria, Ludi E Smeele, Antti A Mäkitie, Alfio Ferlito,

<h4>Purpose of review</h4>The concept of value-based health care (VBHC) was articulated more than a decade ago. However, its clinical implementation remains an on-going process and a particularly demanding one for the domain of head and neck cancer (HNC). These cancers often present with fast growing tumors in functionally and cosmetically ... Read more >>

Curr Oncol Rep (Current oncology reports)
[2020, 22(9):92]

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Case for staged thyroidectomy.

Ohad Ronen, K Thomas Robbins, Kerry D Olsen, Ashok R Shaha, Gregory W Randolph, Iain J Nixon, Mark E Zafereo, Dana M Hartl, Luiz P Kowalski, Juan P Rodrigo, Andrés Coca-Pelaz, Antti A Mäkitie, Vincent Vander Poorten, Alvaro Sanabria, Peter Angelos, Alessandra Rinaldo, Alfio Ferlito,

Recent modifications in the management of well-differentiated thyroid cancer have resulted in significant alterations in clinical approach. Utilizing a series of preoperative and postoperative risk factors involving both the patient and the disease pathology, we offer the term "staged thyroidectomy" to help organize these risk factors for patients and the ... Read more >>

Head Neck (Head & neck)
[2020, 42(10):3061-3071]

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Papillary Thyroid Cancer-Aggressive Variants and Impact on Management: A Narrative Review.

Andrés Coca-Pelaz, Jatin P Shah, Juan C Hernandez-Prera, Ronald A Ghossein, Juan P Rodrigo, Dana M Hartl, Kerry D Olsen, Ashok R Shaha, Mark Zafereo, Carlos Suarez, Iain J Nixon, Gregory W Randolph, Antti A Mäkitie, Luiz P Kowalski, Vincent Vander Poorten, Alvaro Sanabria, Orlando Guntinas-Lichius, Ricard Simo, Peter Zbären, Peter Angelos, Avi Khafif, Alessandra Rinaldo, Alfio Ferlito,

<h4>Introduction</h4>Aggressive variants of papillary thyroid cancer (PTC) have been described with increasing frequency. These variants include diffuse sclerosing variant, tall cell variant, columnar cell variant, solid variant, and hobnail variant.<h4>Methods</h4>We have performed a review of the more aggressive variants of PTC with respect to main characteristics, histological and molecular features, ... Read more >>

Adv Ther (Advances in therapy)
[2020, 37(7):3112-3128]

Cited: 2 times

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Staging and grading of oral squamous cell carcinoma: An update.

Alhadi Almangush, Antti A Mäkitie, Asterios Triantafyllou, Remco de Bree, Primož Strojan, Alessandra Rinaldo, Juan C Hernandez-Prera, Carlos Suárez, Luiz P Kowalski, Alfio Ferlito, Ilmo Leivo,

Oral squamous cell carcinoma (OSCC) is a common malignancy of the head and neck region. OSCC has a relatively low survival rate and the incidence of the disease is increasing in some geographic areas. Staging and grading of OSCC are established prerequisites for management, as they influence risk stratification and ... Read more >>

Oral Oncol (Oral oncology)
[2020, 107:104799]

Cited: 3 times

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Developing Classifications of Laryngeal Dysplasia: The Historical Basis.

Henrik Hellquist, Alfio Ferlito, Antti A Mäkitie, Lester D R Thompson, Justin A Bishop, Abbas Agaimy, Juan C Hernandez-Prera, Douglas R Gnepp, Stefan M Willems, Pieter J Slootweg, Alessandra Rinaldo,

During the last 60 years numerous significant attempts have been made to achieve a widely acceptable terminology and histological grading for laryngeal squamous intraepithelial lesions. While dysplasia was included in the pathology of the uterine cervix already in 1953, the term dysplasia was accepted in laryngeal pathology first after the Toronto ... Read more >>

Adv Ther (Advances in therapy)
[2020, 37(6):2667-2677]

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