Full Text Journal Articles by
Author Alexis Bergsma

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Regulation of cytoskeleton and adhesion signaling in osteoclasts by tetraspanin CD82.

Alexis Bergsma, Sourik S Ganguly, Mollie E Wiegand, Daniel Dick, Bart O Williams, Cindy K Miranti,

We used a myeloid-specific Cre to conditionally delete CD82 in mouse osteoclasts and their precursors. In contrast to global loss of CD82 (gKO), conditional loss of CD82 (cKO) in osteoclasts does not affect cortical bone, osteoblasts, or adipocytes. CD82 loss results in greater trabecular volume and trabecular number but reduced ... Read more >>

(Bone reports)
[2019, 10:100196]

Cited: 0 times

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Global deletion of tetraspanin CD82 attenuates bone growth and enhances bone marrow adipogenesis.

Alexis Bergsma, Sourik S Ganguly, Daniel Dick, Bart O Williams, Cindy K Miranti,

CD82 is a widely expressed member of the tetraspanin family of transmembrane proteins known to control cell signaling, adhesion, and migration. Tetraspanin CD82 is induced over 9-fold during osteoclast differentiation in vitro; however, its role in bone homeostasis is unknown. A globally deleted CD82 mouse model was used to assess ... Read more >>

Bone (Bone)
[2018, 113:105-113]

Cited: 4 times

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Enhanced cortical bone expansion in Lgals3-deficient mice during aging.

Kevin A Maupin, Kevin Weaver, Alexis Bergsma, Cheryl Christie, Zhendong A Zhong, Tao Yang, Bart O Williams,

Imbalances between bone formation and bone resorption, which can occur due to aging or sex hormone deprivation, result in decreased bone mass and an increased risk of fracture. Previous studies have suggested that the β-galactoside binding lectin, galectin-3, is involved in bone remodeling. We compared bone parameters of mice having ... Read more >>

(Bone research)
[2018, 6:7]

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Aging causes decreased resistance to multiple stresses and a failure to activate specific stress response pathways.

Dylan J Dues, Emily K Andrews, Claire E Schaar, Alexis L Bergsma, Megan M Senchuk, Jeremy M Van Raamsdonk,

In this work, we examine the relationship between stress resistance and aging. We find that resistance to multiple types of stress peaks during early adulthood and then declines with age. To dissect the underlying mechanisms, we use C. elegans transcriptional reporter strains that measure the activation of different stress responses ... Read more >>

Aging (Albany NY) (Aging)
[2016, 8(4):777-795]

Cited: 32 times

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Homozygous loss of mouse tetraspanin CD82 enhances integrin αIIbβ3 expression and clot retraction in platelets.

Kristen Uchtmann, Electa R Park, Alexis Bergsma, Justin Segula, Mathew J Edick, Cindy K Miranti,

Integrin αIIbβ3 is critical for platelet-mediated blood clotting. Tetraspanins are well-established regulators of integrins and genetic loss of tetraspanin CD151 or TSSC6 in mice leads to increased bleeding due to inadequate integrin αIIbβ3 outside-in signaling. Conversely, mild but enhanced integrin αIIbβ3 activation and hyperaggregation is observed in CD9 and CD63 ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2015, 339(2):261-269]

Cited: 8 times

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