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Author Alexandre Leclercq

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Large Nationwide Outbreak of Invasive Listeriosis Associated with Blood Sausage, Germany, 2018-2019.

Sven Halbedel, Hendrik Wilking, Alexandra Holzer, Sylvia Kleta, Martin A Fischer, Stefanie Lüth, Ariane Pietzka, Steliana Huhulescu, Raskit Lachmann, Amrei Krings, Werner Ruppitsch, Alexandre Leclercq, Rolf Kamphausen, Maylin Meincke, Christiane Wagner-Wiening, Matthias Contzen, Iris Barbara Kraemer, Sascha Al Dahouk, Franz Allerberger, Klaus Stark, Antje Flieger,

Invasive listeriosis is a severe foodborne infection in humans and is difficult to control. Listeriosis incidence is increasing worldwide, but some countries have implemented molecular surveillance programs to improve recognition and management of listeriosis outbreaks. In Germany, routine whole-genome sequencing, core genome multilocus sequence typing, and single nucleotide polymorphism calling ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2020, 26(7):1456-1464]

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Outbreak of Listeriosis in South Africa Associated with Processed Meat.

Juno Thomas, Nevashan Govender, Kerrigan M McCarthy, Linda K Erasmus, Timothy J Doyle, Mushal Allam, Arshad Ismail, Ntsieni Ramalwa, Phuti Sekwadi, Genevie Ntshoe, Andronica Shonhiwa, Vivien Essel, Nomsa Tau, Shannon Smouse, Hlengiwe M Ngomane, Bolele Disenyeng, Nicola A Page, Nelesh P Govender, Adriano G Duse, Rob Stewart, Teena Thomas, Deon Mahoney, Mathieu Tourdjman, Olivier Disson, Pierre Thouvenot, Mylène M Maury, Alexandre Leclercq, Marc Lecuit, Anthony M Smith, Lucille H Blumberg,

BACKGROUND:An outbreak of listeriosis was identified in South Africa in 2017. The source was unknown. METHODS:We conducted epidemiologic, trace-back, and environmental investigations and used whole-genome sequencing to type Listeria monocytogenes isolates. A case was defined as laboratory-confirmed L. monocytogenes infection during the period from June 11, 2017, to April 7, ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2020, 382(7):632-643]

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Critical Orientation in the Jungle of Currently Available Methods and Types of Data for Source Attribution of Foodborne Diseases.

Lapo Mughini-Gras, Pauline Kooh, Philippe Fravalo, Jean-Christophe Augustin, Laurent Guillier, Julie David, Anne Thébault, Frederic Carlin, Alexandre Leclercq, Nathalie Jourdan-Da-Silva, Nicole Pavio, Isabelle Villena, Moez Sanaa, Laurence Watier,

With increased interest in source attribution of foodborne pathogens, there is a need to sort and assess the applicability of currently available methods. Herewith we reviewed the most frequently applied methods for source attribution of foodborne diseases, discussing their main strengths and weaknesses to be considered when choosing the most ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2019, 10:2578]

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Cutaneous listeriosis, a case series of 16 consecutive patients over 25 years.

Benoit Pilmis, Alexandre Leclercq, Mylène M Maury, Alexandra Moura, Hélène Bracq-Dieye, Pierre Thouvenot, Guillaume Valès, Marc Lecuit, Caroline Charlier, ,

J. Infect. (The Journal of Infection)
[2020, 80(2):232-254]

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Author Correction: Hypervirulent Listeria monocytogenes clones' adaptation to mammalian gut accounts for their association with dairy products.

Mylène M Maury, Hélène Bracq-Dieye, Lei Huang, Guillaume Vales, Morgane Lavina, Pierre Thouvenot, Olivier Disson, Alexandre Leclercq, Sylvain Brisse, Marc Lecuit,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):3619]

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Listeria monocytogenes-associated endovascular infections: A study of 71 consecutive cases.

Michka Shoai-Tehrani, Benoit Pilmis, Mylène M Maury, Olivier Robineau, Olivier Disson, Gregory Jouvion, Gabrielle Coulpier, Pierre Thouvenot, Hélène Bracq-Dieye, Guillaume Valès, Alexandre Leclercq, Marc Lecuit, Caroline Charlier, ,

BACKGROUND:Listeria monocytogenes-associated endovascular infections are not well characterized. METHODS:Retrospective study of 71 culture-proven cases reported to the French National Reference Center for Listeria from 1993 to 2018. RESULTS:Seventy-one cases were identified: 42 with vascular aneurysms/prosthetic infections, 27 with endocarditis, 2 with both. Fifty-eight were men (82%); median age was 75 ... Read more >>

J. Infect. (The Journal of infection)
[2019, 79(4):322-331]

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Hypervirulent Listeria monocytogenes clones' adaption to mammalian gut accounts for their association with dairy products.

Mylène M Maury, Hélène Bracq-Dieye, Lei Huang, Guillaume Vales, Morgane Lavina, Pierre Thouvenot, Olivier Disson, Alexandre Leclercq, Sylvain Brisse, Marc Lecuit,

Listeria monocytogenes (Lm) is a major human and animal foodborne pathogen. Here we show that hypervirulent Lm clones, particularly CC1, are strongly associated with dairy products, whereas hypovirulent clones, CC9 and CC121, are associated with meat products. Clone adaptation to distinct ecological niches and/or different food products contamination routes may ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):2488]

Cited: 3 times

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Atypical Hemolytic Listeria innocua Isolates Are Virulent, albeit Less than Listeria monocytogenes.

Alexandra Moura, Olivier Disson, Morgane Lavina, Pierre Thouvenot, Lei Huang, Alexandre Leclercq, Maria Fredriksson-Ahomaa, Athmanya K Eshwar, Roger Stephan, Marc Lecuit,

Listeria innocua is considered a nonpathogenic Listeria species. Natural atypical hemolytic L. innocua isolates have been reported but have not been characterized in detail. Here, we report the genomic and functional characterization of representative isolates from the two known natural hemolytic L. innocua clades. Whole-genome sequencing confirmed the presence of ... Read more >>

Infect. Immun. (Infection and immunity)
[2019, 87(4):]

Cited: 1 time

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European and International validation of 15 main reference methods in the microbiology of the food chain.

Alexandre Leclercq, Gwenola Hardouin, Bertrand Lombard,

Int. J. Food Microbiol. (International journal of food microbiology)
[2019, 288:1-2]

Cited: 0 times

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Imaging of Human Neurolisteriosis: A Prospective Study of 71 Cases.

Caroline Charlier, Sylvain Poirée, Christophe Delavaud, Gaby Khoury, Clémence Richaud, Alexandre Leclercq, Olivier Hélénon, Marc Lecuit, ,

Background:Neurolisteriosis ranks among the most severe neurological infections. Its radiological features have not been thoroughly studied. We describe here the neuroradiological features of neurolisteriosis and assess their prognostic value. Methods:Patients with microbiologically proven neurolisteriosis were enrolled from November 2009 to October 2013 in MONALISA study. Magnetic resonance and computed tomography ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2018, 67(9):1419-1426]

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Listeria thailandensis sp. nov.

Alexandre Leclercq, Alexandra Moura, Guillaume Vales, Nathalie Tessaud-Rita, Christine Aguilhon, Marc Lecuit,

During a screening of Listeria species in food samples in Thailand, a Listeria-like bacterium was recovered from fried chicken and could not be assigned to any known species. Phylogenetic analysis based on the 16S rRNA gene and on 243 Listeria core genes placed the novel taxon within the Listeria aquatica, ... Read more >>

Int. J. Syst. Evol. Microbiol. (International journal of systematic and evolutionary microbiology)
[2019, 69(1):74-81]

Cited: 4 times

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Correction: Epistatic control of intrinsic resistance by virulence genes in Listeria.

Mariela Scortti, Lei Han, Sonsiray Alvarez, Alexandre Leclercq, Alexandra Moura, Marc Lecuit, Jose Vazquez-Boland,

[This corrects the article DOI: 10.1371/journal.pgen.1007525.]. ... Read more >>

PLoS Genet. (PLoS genetics)
[2018, 14(10):e1007727]

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Epistatic control of intrinsic resistance by virulence genes in Listeria.

Mariela Scortti, Lei Han, Sonsiray Alvarez, Alexandre Leclercq, Alexandra Moura, Marc Lecuit, Jose Vazquez-Boland,

Elucidating the relationships between antimicrobial resistance and virulence is key to understanding the evolution and population dynamics of resistant pathogens. Here, we show that the susceptibility of the gram-positive bacterium Listeria monocytogenes to the antibiotic fosfomycin is a complex trait involving interactions between resistance and virulence genes and the environment. ... Read more >>

PLoS Genet. (PLoS genetics)
[2018, 14(9):e1007525]

Cited: 3 times

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Retrospective validation of whole genome sequencing-enhanced surveillance of listeriosis in Europe, 2010 to 2015.

Ivo Van Walle, Jonas Torgny Björkman, Martin Cormican, Timothy Dallman, Joël Mossong, Alexandra Moura, Ariane Pietzka, Werner Ruppitsch, Johanna Takkinen, ,

Background and aimThe trend in reported case counts of invasive Listeria monocytogenes (Lm), a potentially severe food-borne disease, has been increasing since 2008. In 2015, 2,224 cases were reported in the European Union/European Economic Area (EU/EEA). We aimed to validate the microbiological and epidemiological aspects of an envisaged EU/EEA-wide surveillance ... Read more >>

Euro Surveill. (Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin)
[2018, 23(33):]

Cited: 3 times

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Listeria costaricensis sp. nov.

Kattia Núñez-Montero, Alexandre Leclercq, Alexandra Moura, Guillaume Vales, Johnny Peraza, Javier Pizarro-Cerdá, Marc Lecuit,

A bacterial strain isolated from a food processing drainage system in Costa Rica fulfilled the criteria as belonging to the genus Listeria, but could not be assigned to any of the known species. Phylogenetic analysis based on the 16S rRNA gene revealed highest sequence similarity with the type strain of ... Read more >>

Int. J. Syst. Evol. Microbiol. (International journal of systematic and evolutionary microbiology)
[2018, 68(3):844-850]

Cited: 1 time

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MALDI-TOF mass spectrometry-based identification of Listeria species in surveillance: A prospective study.

Pierre Thouvenot, Guillaume Vales, Hélène Bracq-Dieye, Nathalie Tessaud-Rita, Mylène M Maury, Alexandra Moura, Marc Lecuit, Alexandre Leclercq,

This study aimed to evaluate MALDI-TOF MS for species discrimination of Listeria in the context of routine surveillance. MALDI-TOF MS yielded 100% accuracy for the identification of L. monocytogenes, L. innocua, L. ivanovii, L. fleischmannii, L. grayi, L. seeligeri, L. weihenstephanensis and L. welshimeri, as confirmed by whole genome sequence ... Read more >>

J. Microbiol. Methods (Journal of microbiological methods)
[2018, 144:29-32]

Cited: 4 times

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Cross-border outbreak of listeriosis caused by cold-smoked salmon, revealed by integrated surveillance and whole genome sequencing (WGS), Denmark and France, 2015 to 2017.

Susanne Schjørring, Sofie Gillesberg Lassen, Tenna Jensen, Alexandra Moura, Jette S Kjeldgaard, Luise Müller, Stine Thielke, Alexandre Leclercq, Mylene M Maury, Mathieu Tourdjman, Marie-Pierre Donguy, Marc Lecuit, Steen Ethelberg, Eva M Nielsen,

In August 2017, an outbreak of six listeriosis cases in Denmark was traced to cold-smoked salmon, using epidemiological investigations and whole-genome sequencing (WGS) analyses. Exchange of genome sequences allowed identification in France of a food isolate from a salmon-derived product and a human isolate from 2016 within the same cgMLST ... Read more >>

Euro Surveill. (Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin)
[2017, 22(50):]

Cited: 6 times

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Spontaneous Loss of Virulence in Natural Populations of Listeria monocytogenes.

Mylène M Maury, Viviane Chenal-Francisque, Hélène Bracq-Dieye, Lei Han, Alexandre Leclercq, Guillaume Vales, Alexandra Moura, Edith Gouin, Mariela Scortti, Olivier Disson, José A Vázquez-Boland, Marc Lecuit,

The pathogenesis of Listeria monocytogenes depends on the ability of this bacterium to escape from the phagosome of the host cells via the action of the pore-forming toxin listeriolysin O (LLO). Expression of the LLO-encoding gene (hly) requires the transcriptional activator PrfA, and both hly and prfA genes are essential ... Read more >>

Infect. Immun. (Infection and immunity)
[2017, 85(11):]

Cited: 7 times

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Real-Time Whole-Genome Sequencing for Surveillance of Listeria monocytogenes, France.

Alexandra Moura, Mathieu Tourdjman, Alexandre Leclercq, Estelle Hamelin, Edith Laurent, Nathalie Fredriksen, Dieter Van Cauteren, Hélène Bracq-Dieye, Pierre Thouvenot, Guillaume Vales, Nathalie Tessaud-Rita, Mylène M Maury, Andreea Alexandru, Alexis Criscuolo, Emmanuel Quevillon, Marie-Pierre Donguy, Vincent Enouf, Henriette de Valk, Sylvain Brisse, Marc Lecuit,

During 2015-2016, we evaluated the performance of whole-genome sequencing (WGS) as a routine typing tool. Its added value for microbiological and epidemiologic surveillance of listeriosis was compared with that for pulsed-field gel electrophoresis (PFGE), the current standard method. A total of 2,743 Listeria monocytogenes isolates collected as part of routine ... Read more >>

Emerging Infect. Dis. (Emerging Infectious Diseases)
[2017, 23(9):1462-1470]

Cited: 24 times

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Draft Genome Sequences of Listeria monocytogenes, Isolated from Fresh Leaf Vegetables in Owerri City, Nigeria.

Ogueri Nwaiwu, Alexandra Moura, Pierre Thouvenot, Catherine Rees, Alexandre Leclercq, Marc Lecuit,

Here, we report the draft genome sequences of three Listeria monocytogenes isolates from fresh leaves collected in Nigeria, belonging to sequence types ST5 and ST155 (sublineages SL5 and SL155, respectively). ... Read more >>

Genome Announc (Genome announcements)
[2017, 5(22):]

Cited: 1 time

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Erratum: Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity.

Mylène M Maury, Yu-Huan Tsai, Caroline Charlier, Marie Touchon, Viviane Chenal-Francisque, Alexandre Leclercq, Alexis Criscuolo, Charlotte Gaultier, Sophie Roussel, Anne Brisabois, Olivier Disson, Eduardo P C Rocha, Sylvain Brisse, Marc Lecuit,

Nat. Genet. (Nature genetics)
[2017, 49(6):970]

Cited: 1 time

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Corrigendum: Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity.

Mylène M Maury, Yu-Huan Tsai, Caroline Charlier, Marie Touchon, Viviane Chenal-Francisque, Alexandre Leclercq, Alexis Criscuolo, Charlotte Gaultier, Sophie Roussel, Anne Brisabois, Olivier Disson, Eduardo P C Rocha, Sylvain Brisse, Marc Lecuit,

Nat. Genet. (Nature genetics)
[2017, 49(4):651]

Cited: 0 times

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Diagnosis and Treatment of Listeria monocytogenes Endophthalmitis: A Systematic Review.

Matthew F Chersich, Johanna Takkinen, Caroline Charlier, Alexandre Leclercq, Paul E Adams, Gauri Godbole, Ursula Altmeyer, Ingrid H M Friesema, Lisa Labbé Sandelin, Lorna Jenkin, Luigi Fontana, Raffaella Aldigeri, Francois Venter, Stanley M F Luchters, Marc Lecuit, Luca Cimino,

Describe patient characteristics, treatment, and vision outcomes of Listeria monocytogenes endophthalmitis, an exceedingly rare form of listeriosis.L. monocytogenes endophthalmitis cases in human adults, located through Medline (32) and from disease surveillance centers (11). L. monocytogenes conjunctivitis and keratitis were excluded.Most cases occurred in 2000-2015 (22/43), and almost all in Europe ... Read more >>

Ocul. Immunol. Inflamm. (Ocular immunology and inflammation)
[2018, 26(4):508-517]

Cited: 1 time

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Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study.

Caroline Charlier, Élodie Perrodeau, Alexandre Leclercq, Benoît Cazenave, Benoît Pilmis, Benoît Henry, Amanda Lopes, Mylène M Maury, Alexandra Moura, François Goffinet, Hélène Bracq Dieye, Pierre Thouvenot, Marie-Noëlle Ungeheuer, Mathieu Tourdjman, Véronique Goulet, Henriette de Valk, Olivier Lortholary, Philippe Ravaud, Marc Lecuit, ,

BACKGROUND:Listeriosis is a severe foodborne infection and a notifiable disease in France. We did a nationwide prospective study to characterise its clinical features and prognostic factors. METHODS:MONALISA was a national prospective observational cohort study. We enrolled eligible cases declared to the National Reference Center for Listeria (all microbiologically proven) between ... Read more >>

Lancet Infect Dis (The Lancet. Infectious Diseases)
[2017, 17(5):510-519]

Cited: 47 times

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Whole genome-based population biology and epidemiological surveillance of Listeria monocytogenes.

Alexandra Moura, Alexis Criscuolo, Hannes Pouseele, Mylène M Maury, Alexandre Leclercq, Cheryl Tarr, Jonas T Björkman, Timothy Dallman, Aleisha Reimer, Vincent Enouf, Elise Larsonneur, Heather Carleton, Hélène Bracq-Dieye, Lee S Katz, Louis Jones, Marie Touchon, Mathieu Tourdjman, Matthew Walker, Steven Stroika, Thomas Cantinelli, Viviane Chenal-Francisque, Zuzana Kucerova, Eduardo P C Rocha, Celine Nadon, Kathie Grant, Eva M Nielsen, Bruno Pot, Peter Gerner-Smidt, Marc Lecuit, Sylvain Brisse,

Listeria monocytogenes (Lm) is a major human foodborne pathogen. Numerous Lm outbreaks have been reported worldwide and associated with a high case fatality rate, reinforcing the need for strongly coordinated surveillance and outbreak control. We developed a universally applicable genome-wide strain genotyping approach and investigated the population diversity of Lm ... Read more >>

Nat Microbiol (Nature microbiology)
[2016, 2:16185]

Cited: 98 times

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