Full Text Journal Articles by
Author Alexandra Barratt

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Katy Bell, Jenny Doust, Kevin McGeechan, Andrea R Horvath, Alexandra Barratt, Andrew Hayen, Christopher Semsarian, Les Irwig,

J Hypertens (Journal of hypertension)
[2021, 39(5):1045-1046]

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Global Media Coverage of the Benefits and Harms of Early Detection Tests.

Mary O'Keeffe, Alexandra Barratt, Alice Fabbri, Joshua R Zadro, Giovanni E Ferreira, Sweekriti Sharma, Ray N Moynihan,

JAMA Intern Med (JAMA internal medicine)
[2021, :]

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Overdiagnosis of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents: A Systematic Scoping Review.

Luise Kazda, Katy Bell, Rae Thomas, Kevin McGeechan, Rebecca Sims, Alexandra Barratt,

<h4>Importance</h4>Reported increases in attention-deficit/hyperactivity disorder (ADHD) diagnoses are accompanied by growing debate about the underlying factors. Although overdiagnosis is often suggested, no comprehensive evaluation of evidence for or against overdiagnosis has ever been undertaken and is urgently needed to enable evidence-based, patient-centered diagnosis and treatment of ADHD in contemporary health ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(4):e215335]

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The potential for overdiagnosis and underdiagnosis because of blood pressure variability: a comparison of the 2017 ACC/AHA, 2018 ESC/ESH and 2019 NICE hypertension guidelines.

Katy Bell, Jenny Doust, Kevin McGeechan, Andrea Rita Horvath, Alexandra Barratt, Andrew Hayen, Christopher Semsarian, Les Irwig,

<h4>Objective</h4>To estimate the extent that BP measurement variability may drive over- and underdiagnosis of 'hypertension' when measurements are made according to current guidelines.<h4>Methods</h4>Using data from the National Health and Nutrition Examination Survey and empirical estimates of within-person variability, we simulated annual SBP measurement sets for 1 000 000 patients over 5 years. ... Read more >>

J Hypertens (Journal of hypertension)
[2021, 39(2):236-242]

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Research priorities for COVID-19 sensor technology.

Allison Tong, Tania C Sorrell, Andrew J Black, Corinne Caillaud, Wojciech Chrzanowski, Eugena Li, David Martinez-Martin, Alistair McEwan, Rex Wang, Alice Motion, Alvaro Casas Bedoya, Jun Huang, Lamiae Azizi, Benjamin J Eggleton, ,

Nat Biotechnol (Nature biotechnology)
[2021, 39(2):144-147]

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Impact of Full-Field Digital Mammography Versus Film-Screen Mammography in Population Screening: A Meta-Analysis.

Rachel Farber, Nehmat Houssami, Sally Wortley, Gemma Jacklyn, Michael L Marinovich, Kevin McGeechan, Alexandra Barratt, Katy Bell,

<h4>Background</h4>Breast screening programs replaced film mammography with digital mammography, and the effects of this practice shift in population screening on health outcomes can be measured through examination of cancer detection and interval cancer rates.<h4>Methods</h4>A systematic review and random effects meta-analysis were undertaken. Seven databases were searched for publications that compared ... Read more >>

J Natl Cancer Inst (Journal of the National Cancer Institute)
[2021, 113(1):16-26]

Cited: 1 time

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Genetic architecture of left ventricular noncompaction in adults.

Samantha Barratt Ross, Emma S Singer, Elizabeth Driscoll, Natalie Nowak, Laura Yeates, Rajesh Puranik, Raymond W Sy, Sulekha Rajagopalan, Alexandra Barratt, Jodie Ingles, Richard D Bagnall, Christopher Semsarian,

The genetic etiology and heritability of left ventricular noncompaction (LVNC) in adults is unclear. This study sought to assess the value of genetic testing in adults with LVNC. Adults diagnosed with LVNC while undergoing screening in the context of a family history of cardiomyopathy were excluded. Clinical data for 35 ... Read more >>

Hum Genome Var (Human genome variation)
[2020, 7:33]

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The carbon footprint of pathology testing.

Scott McAlister, Alexandra L Barratt, Forbes McGain,

Med J Aust (The Medical journal of Australia)
[2020, 213(10):477-477.e1]

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Mammography screening for breast cancer-the UK Age trial.

Katy J L Bell, Les Irwig, Brooke Nickel, Jolyn Hersch, Andrew Hayen, Alexandra Barratt,

Lancet Oncol (The Lancet. Oncology)
[2020, 21(11):e504]

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Views of healthcare professionals about the role of active monitoring in the management of ductal carcinoma in situ (DCIS): Qualitative interview study.

Brooke Nickel, Kirsten McCaffery, Nehmat Houssami, Jesse Jansen, Christobel Saunders, Andrew Spillane, Claudia Rutherford, Ann Dixon, Alexandra Barratt, Kirsty Stuart, Geraldine Robertson, Jolyn Hersch,

<h4>Background</h4>Ductal carcinoma in situ (DCIS) is an in-situ (pre-cancerous) breast malignancy whereby malignant cells are contained within the basement membrane of the breast ducts. Increasing awareness that some low-risk forms of DCIS might remain indolent for many years has led to concern about overtreatment, with at least 3 clinical trials ... Read more >>

Breast (Breast (Edinburgh, Scotland))
[2020, 54:99-105]

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Media coverage of calls to rename low-risk cancers: a content analysis.

Brooke Nickel, Ray Moynihan, Alexandra Barratt, Juan P Brito, Kirsten McCaffery,

<h4>Objectives</h4>The use of more medicalised labels can increase both concern about illness and the desire for more invasive treatment. This study analyses the media's coverage of an Analysis article in <i>The BMJ</i> which generated a large amount of high-profile international media coverage. It aims to understand how to better communicate ... Read more >>

BMJ Open (BMJ open)
[2020, 10(7):e038087]

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The carbon footprint of pathology testing.

Scott McAlister, Alexandra L Barratt, Katy Jl Bell, Forbes McGain,

<h4>Objectives</h4>To estimate the carbon footprint of five common hospital pathology tests: full blood examination; urea and electrolyte levels; coagulation profile; C-reactive protein concentration; and arterial blood gases.<h4>Design, setting</h4>Prospective life cycle assessment of five pathology tests in two university-affiliated health services in Melbourne. We included all consumables and associated waste for ... Read more >>

Med J Aust (The Medical journal of Australia)
[2020, 212(8):377-382]

Cited: 1 time

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A systematic review and meta-analysis of the prevalence of left ventricular non-compaction in adults.

Samantha B Ross, Katherine Jones, Bianca Blanch, Rajesh Puranik, Kevin McGeechan, Alexandra Barratt, Christopher Semsarian,

<h4>Aims</h4>To assess the reported prevalence of left ventricular non-compaction (LVNC) in different adult cohorts, taking in to consideration the role of diagnostic criteria and imaging modalities used.<h4>Methods and results</h4>A systematic review and meta-analysis of studies reporting LVNC prevalence in adults. Studies were sourced from Pre-Medline, Medline, and Embase and assessed ... Read more >>

Eur Heart J (European heart journal)
[2020, 41(14):1428-1436]

Cited: 8 times

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Estimating the magnitude of cancer overdiagnosis in Australia.

Paul P Glasziou, Katy Jl Bell, Alexandra L Barratt,

Med J Aust (The Medical journal of Australia)
[2020, 213(4):189-189.e1]

Cited: 0 times

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Overdiagnosis of lung cancer with low-dose computed tomography screening: meta-analysis of the randomised clinical trials.

John Brodersen, Theis Voss, Frederik Martiny, Volkert Siersma, Alexandra Barratt, Bruno Heleno,

In low-dose computed tomography (LDCT) screening for lung cancer, all three main conditions for overdiagnosis in cancer screening are present: 1) a reservoir of slowly or nongrowing lung cancer exists; 2) LDCT is a high-resolution imaging technology with the potential to identify this reservoir; and 3) eligible screening participants have ... Read more >>

Breathe (Sheff) (Breathe (Sheffield, England))
[2020, 16(1):200013]

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Trends in knee magnetic resonance imaging, arthroscopies and joint replacements in older Australians: still too much low-value care?

Leon Smith, Alexandra Barratt, Rachelle Buchbinder, Ian A Harris, Jenny Doust, Katy Bell,

<h4>Background</h4>The objective of the study is to describe temporal trends and regional variations in the use of knee magnetic resonance imaging (MRI), knee arthroscopy and total knee replacement surgery in Australians older than 55 years.<h4>Methods</h4>Design: A retrospective descriptive study using routinely collected administrative data.<h4>Main outcome measures</h4>Age-standardized rates of knee MRI, knee ... Read more >>

ANZ J Surg (ANZ journal of surgery)
[2020, 90(5):833-839]

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Evaluating two decision aids for Australian men supporting informed decisions about prostate cancer screening: A randomised controlled trial.

Kristen Pickles, Luise Kazda, Alexandra Barratt, Kevin McGeechan, Jolyn Hersch, Kirsten McCaffery,

BACKGROUND:Australian clinicians are advised to 'offer evidence-based decisional support to men considering whether or not to have a PSA test'. This randomised trial compared the performance and acceptability of two new decision aids (DAs) to aid men in making informed choices about PSA screening. METHODS:~3000 Australian men 45-60 years with ... Read more >>

PLoS One (PloS one)
[2020, 15(1):e0227304]

Cited: 1 time

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Estimating the magnitude of cancer overdiagnosis in Australia.

Paul P Glasziou, Mark A Jones, Thanya Pathirana, Alexandra L Barratt, Katy Jl Bell,

<h4>Objectives</h4>To estimate the proportion of cancer diagnoses in Australia that might reasonably be attributed to overdiagnosis by comparing current and past lifetime risks of cancer.<h4>Design, setting, and participants</h4>Routinely collected Australian Institute of Health and Welfare national data were analysed to estimate recent (2012) and historical (1982) lifetime risks (adjusted for ... Read more >>

Med J Aust (The Medical journal of Australia)
[2020, 212(4):163-168]

Cited: 7 times

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Is the risk of cancer in Australia overstated? The importance of competing mortality for estimating lifetime risk.

Anthea C Bach, Kelvin Se Lo, Thanya Pathirana, Paul P Glasziou, Alexandra L Barratt, Mark A Jones, Katy Jl Bell,

OBJECTIVES:To calculate lifetime risks of cancer diagnosis and cancer-specific death, adjusted for competing mortality, and to compare these estimates with the corresponding risks published by the Australian Institute of Health and Welfare (AIHW). DESIGN, SETTING:Analysis of publicly available annual AIHW data on age-specific cancer incidence and mortality - for breast ... Read more >>

Med J Aust (The Medical journal of Australia)
[2020, 212(1):17-22]

Cited: 1 time

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Evidence of potential overdiagnosis and overtreatment of attention deficit hyperactivity disorder (ADHD) in children and adolescents: protocol for a scoping review.

Luise Kazda, Katy Bell, Rae Thomas, Kevin McGeechan, Alexandra Barratt,

INTRODUCTION:Worldwide, attention deficit hyperactivity disorder (ADHD) diagnosis rates in children and adolescents have been increasing consistently over the past decades, fuelling a debate about the underlying reasons for this trend. While many hypothesise that a substantial number of these additional cases are overdiagnosed, to date there has been no comprehensive ... Read more >>

BMJ Open (BMJ open)
[2019, 9(11):e032327]

Cited: 0 times

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Overdiagnosis of left ventricular non-compaction in adults: the data tells the story.

Samantha B Ross, Kevin McGeechan, Alexandra Barratt, Christopher Semsarian,

Eur Heart J (European heart journal)
[2019, 40(38):3206]

Cited: 1 time

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Media Coverage of the Benefits and Harms of Testing the Healthy: a protocol for a descriptive study.

Mary O'Keeffe, Alexandra Barratt, Christopher Maher, Joshua Zadro, Alice Fabbri, Mark Jones, Ray Moynihan,

<h4>Introduction</h4>Much testing in medicine is aimed at healthy people to facilitate the early detection of health conditions. However, there is growing evidence that early detection is a double-edged sword that may cause harm in the form of overdiagnosis. The media can be seen as a major generator of consumer demand ... Read more >>

BMJ Open (BMJ open)
[2019, 9(8):e029532]

Cited: 0 times

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The association between induction of labour at 38 to 39 weeks pregnancy and indication for caesarean delivery: An observational study.

Bradley Stephen de Vries, Kevin McGeechan, Alexandra Barratt, Jane Tooher, Ebony Wong, Hala Phipps, Adrienne Gordon, Jon Anthony Hyett,

<h4>Background</h4>Induction of labour is associated with a reduction in caesarean delivery, but the mechanism of action and which groups of women might benefit remain unknown.<h4>Aims</h4>To assess the association between induction of labour at 38-39 weeks pregnancy, and caesarean delivery: (i) overall; (ii) for slow progress in labour; and (iii) for suspected ... Read more >>

Aust N Z J Obstet Gynaecol (The Australian & New Zealand journal of obstetrics & gynaecology)
[2019, 59(6):791-798]

Cited: 0 times

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Resisting recommended treatment for prostate cancer: a qualitative analysis of the lived experience of possible overdiagnosis.

Kirsten McCaffery, Brooke Nickel, Kristen Pickles, Ray Moynihan, Barnett Kramer, Alexandra Barratt, Jolyn Hersch,

<h4>Objective</h4>To describe the lived experience of a possible prostate cancer overdiagnosis in men who resisted recommended treatment.<h4>Design</h4>Qualitative interview study SETTING: Australia PARTICIPANTS: 11 men (aged 59-78 years) who resisted recommended prostate cancer treatment because of concerns about overdiagnosis and overtreatment.<h4>Outcomes</h4>Reported experience of screening, diagnosis and treatment decision making, and its ... Read more >>

BMJ Open (BMJ open)
[2019, 9(5):e026960]

Cited: 1 time

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Australia is responding to the complex challenge of overdiagnosis.

Raymond Moynihan, Alexandra L Barratt, Paul P Glasziou,

Med J Aust (The Medical journal of Australia)
[2019, 210(11):525-525.e1]

Cited: 0 times

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