Full Text Journal Articles by
Author Alexandra Alexopoulou

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Letter: patients who have both sarcopenia and frailty have similar prognosis to those with either condition separately.

Theodoros Alexopoulos, Larisa Vasilieva, Meropi D Kontogianni, Iliana Mani, Alexandra Alexopoulou,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(7):981-982]

Cited: 0 times

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Myostatin in combination with creatine phosphokinase or albumin may differentiate patients with cirrhosis and sarcopenia.

Theodoros Alexopoulos, Larisa Vasilieva, Meropi D Kontogianni, Roxane Tenta, Alexandra Georgiou, Evangelia Stroumpouli, Iliana Mani, Alexandra Alexopoulou,

<h4>Background/objectives</h4>In patients with liver cirrhosis (LC), sarcopenia is correlated with frequent complications and increased mortality. Myostatin-a myokine-is a potential biomarker of skeletal mass and/or sarcopenia. The aim of this study was to examine the association between myostatin and muscle-mass and evaluate myostatin as a biomarker of sarcopenia in LC.<h4>Methods</h4>Skeletal-muscle-index (SMI) ... Read more >>

Am J Physiol Gastrointest Liver Physiol (American journal of physiology. Gastrointestinal and liver physiology)
[2021, :]

Cited: 0 times

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Thymic Carcinoma With Multiple Paraneoplastic Disorders.

Zoe Alexakou, George Liatsos, Nick Vasileiou, Ioannis Vamvakaris, Iliana Mani, Alexandra Alexopoulou,

Thymic neoplasms are rare and may run an indolent course. Among them, thymic epithelial carcinoma is exceptional as it may be presented with extensive local invasion and distant metastases. There is a wide spectrum of autoimmune/paraneoplastic syndromes associated with thymic tumors including autoimmune diseases, some of which may precede the ... Read more >>

Am J Med Sci (The American journal of the medical sciences)
[2021, 362(3):324-330]

Cited: 0 times

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Assessment of dietary habits and the adequacy of dietary intake of patients with cirrhosis-the KIRRHOS study.

Alexandra Georgiou, Mary Yannakoulia, Georgios V Papatheodoridis, Melanie Deutsch, Alexandra Alexopoulou, John Vlachogiannakos, Panagiota Ioannidou, Maria-Vasiliki Papageorgiou, Theodoros Voulgaris, Nikolaos Papadopoulos, Panagiotis Tsibouris, Meropi D Kontogianni,

<h4>Background & aims</h4>Undernutrition is widely prevalent in patients with cirrhosis and affects prognosis. Given the lack of data regarding the dietary intake (DI) and habits of patients with cirrhosis, the aim of the present study was to evaluate them by assessing diet's adequacy compared to the new guidelines, and the ... Read more >>

Clin Nutr (Clinical nutrition (Edinburgh, Scotland))
[2021, 40(6):3992-3998]

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Editorial: outcome prediction in patients with cirrhosis and acute-on-chronic liver failure.

Alexandra Alexopoulou, Larisa Vasilieva,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2020, 52(7):1225-1226]

Cited: 0 times

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Evaluation of the effectiveness of eight screening tools in detecting risk of malnutrition in cirrhotic patients: the KIRRHOS study.

Alexandra Georgiou, Georgios V Papatheodoridis, Alexandra Alexopoulou, Melanie Deutsch, Ioannis Vlachogiannakos, Panagiota Ioannidou, Maria-Vasiliki Papageorgiou, Nikolaos Papadopoulos, Panagiotis Tsibouris, Adamantia Prapa, Mary Yannakoulia, Meropi D Kontogianni,

Malnutrition risk screening in cirrhotic patients is crucial, as poor nutritional status negatively affects disease prognosis and survival. Given that a variety of malnutrition screening tools is usually used in routine clinical practice, the effectiveness of eight screening tools in detecting malnutrition risk in cirrhotic patients was sought. A total ... Read more >>

Br J Nutr (The British journal of nutrition)
[2019, 122(12):1368-1376]

Cited: 4 times

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Cardiac Imaging in Liver Transplantation Candidates: Current Knowledge and Future Perspectives.

Yannis Dimitroglou, Constantina Aggeli, Alexandra Alexopoulou, Sophie Mavrogeni, Dimitris Tousoulis,

Cardiovascular dysfunction in cirrhotic patients is a recognized clinical entity commonly referred to as cirrhotic cardiomyopathy. Systematic inflammation, autonomic dysfunction, and activation of vasodilatory factors lead to hyperdynamic circulation with high cardiac output and low peripheral vascular resistance. Counter acting mechanisms as well as direct effects on cardiac cells led ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(12):]

Cited: 2 times

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Validation of cutoffs for skeletal muscle mass index based on computed tomography analysis against dual energy X-ray absorptiometry in patients with cirrhosis: the KIRRHOS study.

Alexandra Georgiou, Georgios V Papatheodoridis, Alexandra Alexopoulou, Melanie Deutsch, Ioannis Vlachogiannakos, Panagiota Ioannidou, Maria-Vasiliki Papageorgiou, Nikolaos Papadopoulos, Mary Yannakoulia, Meropi D Kontogianni,

Background:Accurate assessments of muscle mass in patients with cirrhosis are necessary in clinical practice. Computed tomography (CT) of the upper abdomen has been proposed as a useful method for quantifying muscle mass. Recently, Carey et al developed specific cutoffs for muscle wasting based on the skeletal muscle index at the ... Read more >>

Ann Gastroenterol (Annals of gastroenterology)
[2020, 33(1):80-86]

Cited: 2 times

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Successful treatment of noncirrhotic portal hypertension with eculizumab in paroxysmal nocturnal hemoglobinuria: A case report.

Alexandra Alexopoulou, Iliana Mani, Dina G Tiniakos, Flora Kontopidou, Ioanna Tsironi, Marina Noutsou, Helen Pantelidaki, Spyros P Dourakis,

<h4>Background</h4>Idiopathic non-cirrhotic portal hypertension (INCPH) is mainly associated with thrombophilia in Western countries. Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disease that manifests with hemolytic anemia, thrombosis, and peripheral blood cytopenias. Portal and hepatic venous thrombosis were reported in PNH. A rare case of INCPH complicating PNH is described.<h4>Case ... Read more >>

World J Hepatol (World journal of hepatology)
[2019, 11(5):483-488]

Cited: 0 times

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Letter: high ferritin to haemoglobin ratio is related to early mortality in patients with alcoholic hepatitis.

Eleana Gkamprela, Iliana Mani, Alexandra Alexopoulou, Larisa Vasilieva, Sophia Pouriki, Spyros P Dourakis,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2019, 49(11):1456-1457]

Cited: 0 times

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Evaluation of noninvasive markers for the diagnosis of cystic fibrosis liver disease.

Alexandra Alexopoulou, Sophia Pouriki, Larisa Vasilieva, Theodoros Alexopoulos, Vasiliki Filaditaki, Maria Gioka, Filia Diamantea, Spyros P Dourakis,

<h4>Objectives</h4>In cystic fibrosis (CF), liver disease (LD) is the third leading cause of mortality. As liver biopsy was considered inconsistent in CFLD diagnosis, a combination of modalities were utilized in the conventional Debray criteria (DC). More recently, noninvasive liver fibrosis biomarkers were applied by Koh et al (New criteria-NC). In the ... Read more >>

Scand J Gastroenterol (Scandinavian journal of gastroenterology)
[2018, 53(12):1547-1552]

Cited: 2 times

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Human beta-defensin-1 is a highly predictive marker of mortality in patients with acute-on-chronic liver failure.

Iliana Mani, Alexandra Alexopoulou, Larisa Vasilieva, Emilia Hadziyannis, Danai Agiasotelli, Myrianthi Bei, Theodoros Alexopoulos, Spyros P Dourakis,

<h4>Background & aim</h4>Human beta-defensin-1 (hBD-1) is a natural antimicrobial peptide expressed in the epithelia of multiple tissues including the digestive tract. In the current study, hBD-1 levels were determined in different subsets of patients with decompensated cirrhosis including acute-on-chronic liver failure (ACLF). In addition, the association with mortality of hBD-1, ... Read more >>

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2019, 39(2):299-306]

Cited: 1 time

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Pegylated interferon and ribavirin treatment for chronic hepatitis C deteriorates subclinical markers of vascular function.

Georgios Georgiopoulos, Alexandra Alexopoulou, Sophia Pouriki, Larisa Vasilieva, Ageliki Laina, Dimitrios Bampatsias, Iliana Mani, Christos Kontogiannis, Dimitrios Tousoulis, Kimon Stamatelopoulos, Spyridon P Dourakis,

Hellenic J Cardiol (Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese)
[2019, 60(2):143-145]

Cited: 0 times

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Improvements in clinical characteristics of patients with non-alcoholic fatty liver disease, after an intervention based on the Mediterranean lifestyle: a randomised controlled clinical trial.

Christina N Katsagoni, George V Papatheodoridis, Panagiota Ioannidou, Melanie Deutsch, Alexandra Alexopoulou, Nikolaos Papadopoulos, Maria-Vasiliki Papageorgiou, Elizabeth Fragopoulou, Meropi D Kontogianni,

Lifestyle interventions remain the cornerstone therapy for non-alcoholic fatty liver disease (NAFLD). This randomised controlled single-blind clinical trial investigated the effect of Mediterranean diet (MD) or Mediterranean lifestyle, along with weight loss, in NAFLD patients. In all, sixty-three overweight/obese patients (50 (sd 11) years, BMI=31·8 (sd 4·5) kg/m2, 68 % ... Read more >>

Br J Nutr (The British journal of nutrition)
[2018, 120(2):164-175]

Cited: 23 times

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Single center validation of mortality scores in patients with acute decompensation of cirrhosis with and without acute-on-chronic liver failure.

Alexandra Alexopoulou, Larisa Vasilieva, Iliana Mani, Danai Agiasotelli, Helen Pantelidaki, Spyros P Dourakis,

<h4>Objectives</h4>Acute decompensation (AD) of cirrhosis is characterized by high mortality. We aimed to validate the performance in predicting mortality of both the chronic-liver-failure-consortium (CLIF-C) acute-on-chronic liver failure (ACLF) and CLIF-C AD scores in a cohort of patients admitted for AD.<h4>Methods</h4>In this prospective cohort study, patients were followed-up during their hospital ... Read more >>

Scand J Gastroenterol (Scandinavian journal of gastroenterology)
[2017, 52(12):1385-1390]

Cited: 3 times

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Bacterial translocation markers in liver cirrhosis.

Alexandra Alexopoulou, Danai Agiasotelli, Larisa E Vasilieva, Spyros P Dourakis,

Bacterial translocation (BT) is an important mechanism in the development of infection in liver cirrhosis. The migration and colonization of bacteria and/or bacterial products from the bowel to mesenteric lymph nodes is a controlled process in healthy persons. Increased intestinal permeability, bacterial overgrowth and defect of gut-associated lymphatic tissue promote ... Read more >>

Ann Gastroenterol (Annals of gastroenterology)
[2017, 30(5):486-497]

Cited: 20 times

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Response to Lipopolysaccharide binding protein predicts decompensated cirrhosis mortality? It is too early.

Danai Agiasotelli, Alexandra Alexopoulou, Larisa Vasilieva, Emilia Hadziyannis, Dimitris Goukos, George L Daikos, Spyros P Dourakis,

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2017, 37(7):1085-1086]

Cited: 0 times

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Clinical presentation, diagnosis, and survival in cholangiocarcinoma: A prospective study.

Larisa Vasilieva, Stefanos I Papadhimitriou, Alexandra Alexopoulou, Ioannis Kostopoulos, Konstantinos Papiris, Dimitrios Pavlidis, Dimitrios Xinopoulos, Andreas Romanos, Spyridon P Dourakis,

<h4>Background and study aims</h4>The diagnosis of cholangiocarcinoma (CCA) is difficult. The present study aimed to assess the clinical features, diagnosis, and survival in CCA.<h4>Patients and methods</h4>This is a prospective study on 46 patients with CCA who underwent endoscopic retrograde cholangiopancreatography (ERCP) or surgical resection and 20 controls with a clinical ... Read more >>

Arab J Gastroenterol (Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology)
[2016, 17(4):181-184]

Cited: 1 time

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Associations Between Lifestyle Characteristics and the Presence of Nonalcoholic Fatty Liver Disease: A Case-Control Study.

Christina N Katsagoni, Michael Georgoulis, George V Papatheodoridis, Elisabeth Fragopoulou, Panagiota Ioannidou, Mariviki Papageorgiou, Alexandra Alexopoulou, Nikolaos Papadopoulos, Melanie Deutsch, Meropi D Kontogianni,

<h4>Background</h4>Dietary and physical activity (PA) habits have been suggested as important factors for nonalcoholic fatty liver disease (NAFLD). Published data are mainly focused on the effect of either diet or exercise, whereas data on other aspects like sleep remain sparse. The aim of this study was to explore potential associations ... Read more >>

Metab Syndr Relat Disord (Metabolic syndrome and related disorders)
[2017, 15(2):72-79]

Cited: 17 times

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A "healthy diet-optimal sleep" lifestyle pattern is inversely associated with liver stiffness and insulin resistance in patients with nonalcoholic fatty liver disease.

Christina N Katsagoni, George V Papatheodoridis, Maria-Vasiliki Papageorgiou, Panagiota Ioannidou, Melanie Deutsch, Alexandra Alexopoulou, Nikolaos Papadopoulos, Elisabeth Fragopoulou, Meropi D Kontogianni,

Several lifestyle habits have been described as risk factors for nonalcoholic fatty liver disease (NAFLD). Given that both healthy and unhealthy habits tend to cluster, the aim of this study was to identify lifestyle patterns and explore their potential associations with clinical characteristics of individuals with NAFLD. One hundred and ... Read more >>

Appl Physiol Nutr Metab (Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme)
[2017, 42(3):250-256]

Cited: 11 times

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High serum lipopolysaccharide binding protein is associated with increased mortality in patients with decompensated cirrhosis.

Danai Agiasotelli, Alexandra Alexopoulou, Larisa Vasilieva, Emilia Hadziyannis, Dimitris Goukos, George L Daikos, Spyros P Dourakis,

<h4>Background & aims</h4>Lipopolysaccharide-binding-protein (LBP) is an acute-phase-protein produced by hepatocytes. Changes in LBP are associated with the dynamics of bacterial translocation and intestinal permeability in decompensated cirrhosis (DC). We assessed serum and ascitic-fluid (AF) LBP and examined their association with mortality in patients with DC.<h4>Methods</h4>Eighty-eight consecutive patients (73.9% males) underwent ... Read more >>

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2017, 37(4):576-582]

Cited: 7 times

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Extensively drug-resistant bacteria are an independent predictive factor of mortality in 130 patients with spontaneous bacterial peritonitis or spontaneous bacteremia.

Alexandra Alexopoulou, Larisa Vasilieva, Danai Agiasotelli, Kyriaki Siranidi, Sophia Pouriki, Athanasia Tsiriga, Marina Toutouza, Spyridon P Dourakis,

<h4>Aim</h4>To evaluate the epidemiology and outcomes of culture-positive spontaneous bacterial peritonitis (SBP) and spontaneous bacteremia (SB) in decompensated cirrhosis.<h4>Methods</h4>We prospectively collected clinical, laboratory characteristics, type of administered antibiotic, susceptibility and resistance of bacteria to antibiotics in one hundred thirty cases (68.5% males) with positive ascitic fluid and/or blood cultures during ... Read more >>

World J Gastroenterol (World journal of gastroenterology)
[2016, 22(15):4049-4056]

Cited: 21 times

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Reply to "Prognosis of cirrhotic patients with fungiascites and spontaneous fungal peritonitis".

Alexandra Alexopoulou, Larisa Vasilieva, Danai Agiasotelli, Spyros P Dourakis,

J Hepatol (Journal of hepatology)
[2016, 64(6):1454-1455]

Cited: 0 times

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Evaluation of neutrophil/leukocyte ratio and organ failure score as predictors of reversibility and survival following an acute-on-chronic liver failure event.

Danai Agiasotelli, Alexandra Alexopoulou, Larisa Vasilieva, Georgia Kalpakou, Sotiria Papadaki, Spyros P Dourakis,

AIM:Acute-on-chronic liver failure (ACLF) is defined as an acute deterioration of liver disease with high mortality in patients with cirrhosis. The early mortality in ACLF is associated with organ failure and high leukocyte count. The time needed to reverse this condition and the factors affecting mortality after the early 30-day-period ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2016, 46(6):514-520]

Cited: 5 times

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Fungal infections in patients with cirrhosis.

Alexandra Alexopoulou, Larisa Vasilieva, Danai Agiasotelli, Spyros P Dourakis,

J Hepatol (Journal of hepatology)
[2015, 63(4):1043-1045]

Cited: 15 times

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