Full Text Journal Articles by
Author Alexander Scheiter

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Morphology Matters: A Critical Reappraisal of the Clinical Relevance of Morphologic Criteria From the 2019 WHO Classification in a Large Colorectal Cancer Cohort Comprising 1004 Cases.

Moritz Jesinghaus, Maxime Schmitt, Corinna Lang, Marianne Reiser, Alexander Scheiter, Björn Konukiewitz, Katja Steiger, Miguel Silva, Markus Tschurtschenthaler, Sebastian Lange, Sebastian Foersch, Karl F Becker, Dieter Saur, Helmut Friess, Kathrin Halfter, Jutta Engel, Melanie Boxberg, Nicole Pfarr, Dirk Wilhelm, Wilko Weichert,

The 2019 World Health Organization (WHO) classification of colorectal carcinoma (CRC) profoundly reclassified CRC subtypes and introduces tumor budding as a second major grading criterion, while condensing conventional grade into a 2-tiered system. So far it remains largely unexplored how these parameters interact with each other and whether they truly ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2021, 45(7):969-978]

Cited: 0 times

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Identification and In-Depth Analysis of the Novel FGFR2-NDC80 Fusion in a Cholangiocarcinoma Patient: Implication for Therapy.

Alexander Scheiter, Felix Keil, Florian Lüke, Jirka Grosse, Niklas Verloh, Sabine Opitz, Sophie Schlosser, Arne Kandulski, Tobias Pukrop, Wolfgang Dietmaier, Matthias Evert, Diego F Calvisi, Kirsten Utpatel,

Fibroblast growth factor receptor 2 (FGFR2) fusions have emerged as a new therapeutic target for cholangiocarcinoma in clinical practice following the United States Food and Drug Administration (FDA) approval of Pemigatinib in May 2020. FGFR2 fusions can result in a ligand-independent constitutive activation of FGFR2 signaling with a downstream activation ... Read more >>

Curr Oncol (Current oncology (Toronto, Ont.))
[2021, 28(2):1161-1169]

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Cellular Dissociation Grading Based on the Parameters Tumor Budding and Cell Nest Size in Pretherapeutic Biopsy Specimens Allows for Prognostic Patient Stratification in Esophageal Squamous Cell Carcinoma Independent From Clinical Staging.

Moritz Jesinghaus, Frido Brühl, Katja Steiger, Peter Klare, Marianne Reiser, Alexander Scheiter, Björn Konukiewitz, Peer Kuhn, Stefan Münch, Michael Quante, Roland M Schmid, Dirk Wilhelm, Markus Feith, Helmut Friess, Stephanie E Combs, Dieter Saur, Melanie Boxberg, Wilko Weichert,

Initial treatment planning in esophageal squamous cell carcinoma mainly relies on clinical staging. Recently, a highly prognostic grading system based on the cellular dissociation parameters Tumor Budding and Cell Nest Size has been proposed for resected esophageal squamous cell carcinoma. To probe for the transferability and relevance of this established ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2019, 43(5):618-627]

Cited: 6 times

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Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis.

Maarten E Witte, Adrian-Minh Schumacher, Christoph F Mahler, Jan P Bewersdorf, Jonas Lehmitz, Alexander Scheiter, Paula Sánchez, Philip R Williams, Oliver Griesbeck, Ronald Naumann, Thomas Misgeld, Martin Kerschensteiner,

Axon loss determines persistent disability in multiple sclerosis patients. Here, we use in vivo calcium imaging in a multiple sclerosis model to show that cytoplasmic calcium levels determine the choice between axon loss and survival. We rule out the endoplasmic reticulum, glutamate excitotoxicity, and the reversal of the sodium-calcium exchanger as ... Read more >>

Neuron (Neuron)
[2019, 101(4):615-624.e5]

Cited: 15 times

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