Full Text Journal Articles by
Author Alexander Kerner

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Surgical Drill Guide for Insertion of an Infra-Acetabular Screw Based on an Anatomically Precontoured Plate System: A Cadaveric Study.

Viola Freigang, Maximilian Gottsauner, Markus Rupp, Christian Pfeifer, Stephan Grechenig, Alexander Kerner, Volker Alt, Florian Baumann,

<h4>Purpose</h4>Due to the anatomic structure of the pelvis, free-hand placement of screws in the acetabular fracture management can be difficult. Infra-acetabular screw fixation increases acetabular stability by distal fixation of the cup. Aim of this cadaveric study is to investigate if a plate-referenced drill guide can provide save placement of ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:2321504]

Cited: 0 times

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MALDI versus ESI: The Impact of the Ion Source on Peptide Identification.

Wiebke Maria Nadler, Dietmar Waidelich, Alexander Kerner, Sabrina Hanke, Regina Berg, Andreas Trumpp, Christoph Rösli,

For mass spectrometry-based proteomic analyses, electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) are the commonly used ionization techniques. To investigate the influence of the ion source on peptide detection in large-scale proteomics, an optimized GeLC/MS workflow was developed and applied either with ESI/MS or with MALDI/MS for the proteomic ... Read more >>

J Proteome Res (Journal of proteome research)
[2017, 16(3):1207-1215]

Cited: 13 times

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Identification and Validation of Novel Subtype-Specific Protein Biomarkers in Pancreatic Ductal Adenocarcinoma.

Laura Kuhlmann, Wiebke M Nadler, Alexander Kerner, Sabrina A Hanke, Elisa M Noll, Christian Eisen, Elisa Espinet, Vanessa Vogel, Andreas Trumpp, Martin R Sprick, Christoph P Roesli,

<h4>Objectives</h4>Pancreatic ductal adenocarcinoma (PDAC) has been subclassified into 3 molecular subtypes: classical, quasi-mesenchymal, and exocrine-like. These subtypes exhibit differences in patient survival and drug resistance to conventional therapies. The aim of the current study is to identify novel subtype-specific protein biomarkers facilitating subtype stratification of patients with PDAC and novel ... Read more >>

Pancreas (Pancreas)
[2017, 46(3):311-322]

Cited: 12 times

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The pivotal role of reactivity in the design of novel biotinylation reagents for the chemical-proteomics-based identification of vascular accessible biomarkers.

Sabrina A Hanke, Alexander Kerner, Wiebke M Nadler, Andreas Trumpp, Yixin Zhang, Christoph P Rösli,

A promising approach for the development of novel therapeutics with fewer side effects in healthy tissues is the targeted delivery of bioactive molecules directly to the site of disease. Thus, one prerequisite is the identification of a robust, disease-specific, vascular accessible biomarker localized on the surface of diseased cells, in ... Read more >>

J Proteomics (Journal of proteomics)
[2016, 141:57-66]

Cited: 2 times

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Ion source-dependent performance of 4-vinylpyridine, iodoacetamide, and N-maleoyl derivatives for the detection of cysteine-containing peptides in complex proteomics.

Wiebke Nadler, Regina Berg, Philipp Walch, Sabrina Hanke, Mathis Baalmann, Alexander Kerner, Andreas Trumpp, Christoph Roesli,

Cysteine is unique among the proteinogenic amino acids due to its ability to form disulfide bonds. While this property is of vital importance for protein structures and biological processes, it causes difficulties for the mass spectrometric identification of cysteine-containing peptides. A common approach to overcome these problems in bottom-up proteomics ... Read more >>

Anal Bioanal Chem (Analytical and bioanalytical chemistry)
[2016, 408(8):2055-2067]

Cited: 0 times

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