Full Text Journal Articles by
Author Alexander Hansen

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Global Reach 2018: The adaptive phenotype to life with chronic mountain sickness and polycythaemia.

Alexander B Hansen, Gilbert Moralez, Sachin B Amin, Lydia L Simspon, Florian Hofstaetter, James D Anholm, Christopher Gasho, Mike Stembridge, Tony G Dawkins, Michael M Tymko, Philip N Ainslie, Francisco Villafuerte, Steven A Romero, Christopher M Hearon, Justin S Lawley,

<h4>Key points</h4>Humans suffering from polycythaemia undergo multiple circulatory adaptations including changes in blood rheology and structural and functional vascular adaptations to maintain normal blood pressure and vascular shear stresses, despite high blood viscosity. During exercise, several circulatory adaptations are observed, especially involving adrenergic and non-adrenergic mechanisms within non-active and active ... Read more >>

J Physiol (The Journal of physiology)
[2021, :]

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Commentaries on Viewpoint: Differential impact of shear rate in the cerebral and systemic circulation: implications for endothelial function.

Jay Carr, Joshua C. Tremblay, Stephen J. Ives, Gemma K. Lyall, Molly M. Baldwin, Karen M. Birch, Kaitlyn D. Lee, Dimitri W. Papadedes, Trevor J. King, Travis D. Gibbons, Kate N. Thomas, Brady E. Hanson, Joshua M. Bock, Darren P. Casey, Stefanie L. Ruediger, Tom G. Bailey, Sachin B. Amin, Alexander B. Hansen, Justin S. Lawley, Jennifer S. Williams, Jem L. Cheng, Maureen J. MacDonald,

J Appl Physiol (1985) (Journal of applied physiology (Bethesda, Md. : 1985))
[2021, 130(4):1155-1160]

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Provisional focal stenting of complex femoropopliteal lesions using the Multi-LOC multiple stent delivery system - 12-month results from the LOCOMOTIVE EXTENDED study.

Klaus Amendt, Thomas Zeller, Robert Proczka, Ulrich Beschorner, Nicola Troisi, Matthias Waliszewski, Ralf Langhoff, Hans Krankenberg, Andreas Hansch, Tomislav Krcmar, Vinko Vidjak, Claus Nolte-Ernsting, Alexander Hansen, Martin Sigl,

<i>Background</i>: This study aimed to evaluate a Multiple Stent Delivery System for provisional focal stenting of the femoropopliteal artery. <i>Patient and methods</i>: The LOCOMOTIVE EXTENDED study (Multi-<u>LOC</u> for fl<u>O</u>w li<u>M</u>iting <u>O</u>utcomes after plain old balloon angioplasty and/or drug-coated balloon <u>T</u>reatment in the infrainguinal position with the object<u>IVE</u> to implant multiple ... Read more >>

Vasa (VASA. Zeitschrift fur Gefasskrankheiten)
[2021, 50(3):209-216]

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Whole body passive heating versus dynamic lower body exercise: a comparison of peripheral hemodynamic profiles.

Sachin B Amin, Alexander B Hansen, Hendrik Mugele, Felix Willmer, Florian Gross, Benjamin Reimeir, William K Cornwell, Lydia L Simpson, Jonathan P Moore, Steven A Romero, Justin S Lawley,

Passive heating has emerged as a therapeutic intervention for the treatment and prevention of cardiovascular disease. Like exercise, heating increases peripheral artery blood flow and shear rate, which is thought to be a primary mechanism underpinning endothelium-mediated vascular adaptation. However, few studies have compared the increase in arterial blood flow ... Read more >>

J Appl Physiol (1985) (Journal of applied physiology (Bethesda, Md. : 1985))
[2021, 130(1):160-171]

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Reducing intracranial pressure by reducing central venous pressure: assessment of potential countermeasures to spaceflight-associated neuro-ocular syndrome.

Alexander B Hansen, Justin S Lawley, Caroline A Rickards, Erin J Howden, Satyam Sarma, William K Cornwell, Sachin B Amin, Hendrik Mugele, Kyohei Marume, Carmen Possnig, Louis A Whitworth, Michael A Williams, Benjamin D Levine,

Spaceflight-associated neuro-ocular syndrome (SANS) involves unilateral or bilateral optic disc edema, widening of the optic nerve sheath, and posterior globe flattening. Owing to posterior globe flattening, it is hypothesized that microgravity causes a disproportionate change in intracranial pressure (ICP) relative to intraocular pressure. Countermeasures capable of reducing ICP include thigh ... Read more >>

J Appl Physiol (1985) (Journal of applied physiology (Bethesda, Md. : 1985))
[2021, 130(2):283-289]

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Reduction of inappropriate implantable cardioverter-defibrillator therapies using enhanced supraventricular tachycardia discriminators: the ReduceIT study.

Johann Christoph Geller, Armin Wöhrle, Mathias Busch, Albrecht Elsässer, Thomas Kleemann, Frank Birkenhauer, Peter Bramlage, Christian Veltmann, ,

<h4>Purpose</h4>Inappropriate implantable cardioverter-defibrillator (ICD) shocks are associated with greater healthcare resource utilization, poorer quality-of-life, and higher mortality. We aimed to investigate the performance of enhanced supraventricular tachycardia (SVT) discrimination algorithms (morphology discrimination, rate stability, and sudden or chamber onset) for reducing inappropriate ICD therapies in patients with ICD/cardiac resynchronization therapy ... Read more >>

J Interv Card Electrophysiol (Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing)
[2021, 61(2):339-348]

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Mechanisms of sympathetic restraint in human skeletal muscle during exercise: role of α-adrenergic and nonadrenergic mechanisms.

Alexander B Hansen, Gilbert Moralez, Steven A Romero, Christopher Gasho, Michael M Tymko, Philip N Ainslie, Florian Hofstätter, Simon L Rainer, Justin S Lawley, Christopher M Hearon,

Sympathetic vasoconstriction is mediated by α-adrenergic receptors under resting conditions. During exercise, increased sympathetic nerve activity (SNA) is directed to inactive and active skeletal muscle; however, it is unclear what mechanism(s) are responsible for vasoconstriction during large muscle mass exercise in humans. The aim of this study was to determine ... Read more >>

Am J Physiol Heart Circ Physiol (American journal of physiology. Heart and circulatory physiology)
[2020, 319(1):H192-H202]

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UBC-Nepal expedition: dynamic cerebral autoregulation is attenuated in lowlanders upon ascent to 5050 m.

Michael M Tymko, Alexander B Hansen, Joshua C Tremblay, Alexander Patrician, Ryan L Hoiland, Connor A Howe, Matthew G Rieger, Philip N Ainslie,

PURPOSE:We examined the effects of hypoxaemia on dynamic cerebral autoregulation (dCA) in lowlanders and Sherpa highlanders. We hypothesized that dCA in lowlanders would be reduced to a greater extent in the common carotid artery (CCA) compared to the internal carotid artery (ICA) during acute hypoxia at sea level and at ... Read more >>

Eur J Appl Physiol (European journal of applied physiology)
[2020, 120(3):675-686]

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Global Reach 2018 Heightened α-Adrenergic Signaling Impairs Endothelial Function During Chronic Exposure to Hypobaric Hypoxia.

Michael M Tymko, Justin S Lawley, Philip N Ainslie, Alexander B Hansen, Florian Hofstaetter, Simon Rainer, Sachin Amin, Gilbert Moralez, Christopher Gasho, Gustavo Vizcardo-Galindo, Daniela Bermudez, Francisco C Villafuerte, Christopher M Hearon,

<h4>Rationale</h4>Chronic exposure to hypoxia is associated with elevated sympathetic nervous activity and reduced vascular function in lowlanders, and Andean highlanders suffering from excessive erythrocytosis (EE); however, the mechanistic link between chronically elevated sympathetic nervous activity and hypoxia-induced vascular dysfunction has not been determined.<h4>Objective</h4>To determine the impact of heightened sympathetic nervous ... Read more >>

Circ Res (Circulation research)
[2020, 127(2):e1-e13]

Cited: 1 time

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Hearing in Schoolchildren After Neonatal Exposure to a High-Dose Gentamicin Regimen.

Dagny Hemmingsen, Camilla Mikalsen, Alexander Rydland Hansen, Jon Widding Fjalstad, Niels Christian Stenklev, Claus Klingenberg,

OBJECTIVE:To assess the association between gentamicin exposure in the neonatal period and hearing in school age. METHODS:This study included children exposed to a high-dose (6 mg/kg) gentamicin regimen as neonates (2004-2012), invited for follow-up at school age, and a healthy age-matched control group. We assessed hearing with pure tone audiometry ... Read more >>

Pediatrics (Pediatrics)
[2020, 145(2):]

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High-Altitude Acclimatization Improves Recovery from Muscle Fatigue.

Luca Ruggiero, Ryan L Hoiland, Alexander B Hansen, Philip N Ainslie, Chris J McNeil,

<h4>Purpose</h4>We investigated the effect of high-altitude acclimatization on peripheral fatigue compared with sea level and acute hypoxia.<h4>Methods</h4>At sea level (350 m), acute hypoxia (environmental chamber), and chronic hypoxia (5050 m, 5-9 d) (partial pressure of inspired oxygen = 140, 74 and 76 mm Hg, respectively), 12 participants (11 in chronic ... Read more >>

Med Sci Sports Exerc (Medicine and science in sports and exercise)
[2020, 52(1):161-169]

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Weight gain velocity as a predictor of severe obstructive sleep apnea among obese adolescents.

Romaine F Johnson, Alexander Hansen, Ajay Narayanan, Ahana Yogesh, Gopi B Shah, Ron B Mitchell,

<h4>Objectives/hypothesis</h4>To evaluate a cohort of obese adolescents with obstructive sleep apnea (OSA) to determine if increased yearly weight gain was a predictor of severe OSA.<h4>Study design</h4>Retrospective cohort study.<h4>Methods</h4>Obese adolescents (body mass index percentile >95% for that age and sex based upon the Centers for Disease Control and Prevention weight classifications), ... Read more >>

Laryngoscope (The Laryngoscope)
[2020, 130(5):1339-1342]

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Functional Vs. Running Low-Volume High-Intensity Interval Training: Effects on VO2max and Muscular Endurance.

Verena Menz, Natalie Marterer, Sachin B Amin, Martin Faulhaber, Alexander B Hansen, Justin S Lawley,

The purpose of the study was to assess if high-intensity interval training (HIIT) using functional exercises is as effective as traditional running HIIT in improving maximum oxygen uptake (VO<sub>2</sub>max) and muscular endurance. Fifteen healthy, moderately trained female (n = 11) and male (n= 4) participants (age 25.6 ± 2.6 years) ... Read more >>

J Sports Sci Med (Journal of sports science & medicine)
[2019, 18(3):497-504]

Cited: 10 times

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UBC-Nepal expedition: peripheral fatigue recovers faster in Sherpa than lowlanders at high altitude.

Luca Ruggiero, Ryan L Hoiland, Alexander B Hansen, Philip N Ainslie, Chris J McNeil,

<h4>Key points</h4>The reduced oxygen tension of high altitude compromises performance in lowlanders. In this environment, Sherpa display superior performance, but little is known on this issue. Sherpa present unique genotypic and phenotypic characteristics at the muscular level, which may enhance resistance to peripheral fatigue at high altitude compared to lowlanders. ... Read more >>

J Physiol (The Journal of physiology)
[2018, 596(22):5365-5377]

Cited: 2 times

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UBC-Nepal expedition: The use of oral antioxidants does not alter cerebrovascular function at sea level or high altitude.

Alexander B Hansen, Ryan L Hoiland, Nia C S Lewis, Michael M Tymko, Joshua C Tremblay, Michael Stembridge, Daniela Nowak-Flück, Howard H Carter, Damian M Bailey, Philip N Ainslie,

NEW FINDINGS:What is the central question of the study? Does the use of antioxidants alter cerebrovascular function and blood flow at sea level (344 m) and/or high altitude (5050 m)? What is the main finding and its importance? This is the first study to investigate whether antioxidant administration alters cerebrovascular regulation and ... Read more >>

Exp Physiol (Experimental physiology)
[2018, 103(4):523-534]

Cited: 2 times

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Efficacy and Safety of Individualized Coaching After Stroke: the LAST Study (Life After Stroke): A Pragmatic Randomized Controlled Trial.

Torunn Askim, Birgitta Langhammer, Hege Ihle-Hansen, Mari Gunnes, Stian Lydersen, Bent Indredavik, ,

<h4>Background and purpose</h4>The evidence for interventions to prevent functional decline in the long term after stroke is lacking. The aim of this trial was to evaluate the efficacy and safety of an 18-month follow-up program of individualized regular coaching on physical activity and exercise.<h4>Methods</h4>This was a multicentre, pragmatic, single-blinded, randomized ... Read more >>

Stroke (Stroke)
[2018, 49(2):426-432]

Cited: 10 times

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Endoscopic Infracochlear Approach for Drainage of Petrous Apex Cholesterol Granulomas: A Case Series.

Cameron C Wick, Alexander R Hansen, Joe Walter Kutz, Brandon Isaacson,

<h4>Objective</h4>To describe the feasibility and technical nuances of a transcanal endoscopic infracochlear approach for drainage of petrous apex cholesterol granulomas.<h4>Study design</h4>Retrospective case review.<h4>Setting</h4>Tertiary care university hospital.<h4>Patients</h4>A 32-year-old man with bilateral petrous apex cholesterol granulomas and a 54-year-old man with a left-sided petrous apex granuloma each with symptoms necessitating surgical intervention.<h4>Interventions</h4>Transcanal ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2017, 38(6):876-881]

Cited: 8 times

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Predicting Plasma Glucose From Interstitial Glucose Observations Using Bayesian Methods.

Alexander Hildenbrand Hansen, Anne Katrine Duun-Henriksen, Rune Juhl, Signe Schmidt, Kirsten Nørgaard, John Bagterp Jørgensen, Henrik Madsen,

One way of constructing a control algorithm for an artificial pancreas is to identify a model capable of predicting plasma glucose (PG) from interstitial glucose (IG) observations. Stochastic differential equations (SDEs) make it possible to account both for the unknown influence of the continuous glucose monitor (CGM) and for unknown ... Read more >>

J Diabetes Sci Technol (Journal of diabetes science and technology)
[2014, 8(2):321-330]

Cited: 2 times

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Myocardial left ventricular dysfunction in patients with systemic lupus erythematosus: new insights from tissue Doppler and strain imaging.

Sebastian J Buss, David Wolf, Grigorios Korosoglou, Regina Max, Celine S Weiss, Christian Fischer, Dieter Schellberg, Christian Zugck, Helmut F Kuecherer, Hanns-Martin Lorenz, Hugo A Katus, Stefan E Hardt, Alexander Hansen,

<h4>Objective</h4>Systemic lupus erythematosus (SLE) is associated with high cardiovascular morbidity and mortality. Cardiovascular involvement is frequently underestimated by routine imaging techniques. Our aim was to determine if new echocardiographic imaging modalities like tissue Doppler (TDI), strain rate (SRR), and strain (SRI) imaging detect abnormalities in left ventricular (LV) function in ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2010, 37(1):79-86]

Cited: 28 times

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Effect of rosiglitazone on progression of coronary atherosclerosis in patients with type 2 diabetes mellitus and coronary artery disease: the assessment on the prevention of progression by rosiglitazone on atherosclerosis in diabetes patients with cardiovascular history trial.

Hertzel C Gerstein, Robert E Ratner, Christopher P Cannon, Patrick W Serruys, Héctor M García-García, Gerrit-Anne van Es, Nikheel S Kolatkar, Barbara G Kravitz, Diane M Miller, Chun Huang, Peter J Fitzgerald, Richard W Nesto, ,

<h4>Background</h4>Rosiglitazone has several properties that may affect progression of atherosclerosis. The Assessment on the Prevention of Progression by Rosiglitazone on Atherosclerosis in Diabetes Patients With Cardiovascular History (APPROACH) study was undertaken to determine the effect of the thiazolidinedione rosiglitazone on coronary atherosclerosis as assessed by intravascular ultrasound compared with the ... Read more >>

Circulation (Circulation)
[2010, 121(10):1176-1187]

Cited: 51 times

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Dose-dependent effects of intravenous allogeneic mesenchymal stem cells in the infarcted porcine heart.

David Wolf, Adrian Reinhard, Anja Seckinger, Hugo A Katus, Helmut Kuecherer, Alexander Hansen,

Intravenous delivery of mesenchymal stem cells (MSCs) preserves myocardial function after infarction. This dose-escalating study was performed to examine pathologic remodeling and scar formation in a pig model of permanent coronary occlusion without restoration of reperfusion. MSCs labeled with fluorescent dye 48 h or saline (negative control, n = 8) ... Read more >>

Stem Cells Dev (Stem cells and development)
[2009, 18(2):321-329]

Cited: 24 times

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Aortic valve fibroelastoma causing cerebral infarction.

Alexander Hansen, Werner Oel,

We report incidental findings of aortic valve fibroelastoma in a patient with embolic complications during routine transthoracic echocardiography. ... Read more >>

Eur J Echocardiogr (European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology)
[2008, 9(3):414]

Cited: 1 time

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Cardiac complications in Whipple's disease.

Alexander Hansen, Derliz Mereles,

Whipple's disease or intestinal lipodystrophy is an infection induced by Tropheryma whipplei. It is rare with an estimated incidence of 0.4 per million. Symptoms are arthropathy, weight loss, and diarrhoea, but other organs notably the central nervous system may be affected. We demonstrate a case of cardiac complications in Whipple's ... Read more >>

Eur J Echocardiogr (European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology)
[2008, 9(3):426-427]

Cited: 1 time

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Regenerative capacity of intravenous autologous, allogeneic and human mesenchymal stem cells in the infarcted pig myocardium-complicated by myocardial tumor formation.

David Wolf, Adrian Reinhard, Anja Seckinger, Lisa Gross, Hugo A Katus, Alexander Hansen,

OBJECTIVES: Intravenous delivery of mesenchymal stem cells (MSCs) is an attractive approach for regeneration of infarcted myocardium. However, its efficacy is not well-defined in large animals. METHODS: Pigs (n =8) received intravenously autologous, allogeneic porcine or human MSCs (1 x 10(6) per kg bodyweight) labeled with fluorescent dye 48 hours ... Read more >>

Scand Cardiovasc J (Scandinavian cardiovascular journal : SCJ)
[2009, 43(1):39-45]

Cited: 15 times

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Caught in the act: entrapped embolus through a patent foramen ovale.

Alexander Hansen, Helmut Kuecherer,

A patent foramen ovale (PFO) is detected frequently by transesophageal echocardiography. The diagnosis of paradoxical embolism is usually presumptive when arterial emboli occur in the appropriate clinical setting. Presumably, paradoxical embolism of small thrombi arise in the venous system and pass through the PFO during a transient right-to-left shunt; however, ... Read more >>

Eur J Echocardiogr (European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology)
[2008, 9(5):692-693]

Cited: 6 times

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