Full Text Journal Articles by
Author Alexander H Hoon

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Why the Hips Remain Stable When the Spine Strays: A Deeper Analysis of the Relationship Between Hip Displacement and Severe Scoliosis in Patients With Cerebral Palsy.

Matthew J Hadad, Amy L Xu, Barry R Bryant, Nicholas S Andrade, Alexander H Hoon, Paul D Sponseller,

<h4>Background</h4>Many patients with spastic quadriplegic cerebral palsy (CP) and severe scoliosis develop hip displacement, whereas others do not. We investigated demographic characteristics, risk factors for CP, and imaging findings associated with nondisplaced hips in patients with CP and severe scoliosis.<h4>Methods</h4>We retrospectively analyzed records of 229 patients with spastic quadriplegic CP ... Read more >>

J Pediatr Orthop (Journal of pediatric orthopedics)
[2021, 41(5):261-266]

Cited: 0 times

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Principles of Medical and Surgical Treatment of Cerebral Palsy.

Eric M Chin, Hilary E Gwynn, Shenandoah Robinson, Alexander H Hoon,

Cerebral palsy is the most common cause of childhood motor disability, affecting 2 to 3/1000 children worldwide. Clinical abnormalities in tone, posture, and movement are the result of brain dysgenesis or injury early in life, and impairment varies in type, distribution, and in severity. The underlying brain disorder may also ... Read more >>

Neurol Clin (Neurologic clinics)
[2020, 38(2):397-416]

Cited: 0 times

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Case 236: Middle Interhemispheric Variant of Holoprosencephaly.

Noushin Yahyavi-Firouz-Abadi, Andrea Poretti, Oluwatoyin R Idowu, Alexander H Hoon, Thierry A Huisman, Izlem Izbudak,

History A 13-year-old girl presented for evaluation and further management of spastic diplegia cerebral palsy. Absence of the corpus callosum was noted at screening prenatal head ultrasonography. She was born at full term via spontaneous vaginal delivery. Physical examination revealed decreased axial muscle tone and increased muscle tone in her ... Read more >>

Radiology (Radiology)
[2016, 281(3):969-974]

Cited: 1 time

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Case 236.

Noushin Yahyavi-Firouz-Abadi, Andrea Poretti, Oluwatoyin R Idowu, Alexander H Hoon, Thierry A Huisman, Izlem Izbudak,

Radiology (Radiology)
[2016, 280(2):640-642]

Cited: 0 times

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Undecussated superior cerebellar peduncles and absence of the dorsal transverse pontine fibers: a new axonal guidance disorder?

Charlotte F Kweldam, Hilary Gwynn, Alpa Vashist, Alexander H Hoon, Thierry A G M Huisman, Andrea Poretti,

Axonal guidance disorders are a newly recognized group of diseases of the human central nervous system. These disorders are characterized by white matter tracts with abnormal course and failure to cross the midline or presence of ectopic white matter tracts. Diffusion tensor imaging (DTI) and fiber tractography are suitable neuroimaging ... Read more >>

Cerebellum (Cerebellum (London, England))
[2014, 13(4):536-540]

Cited: 4 times

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Quality of life in adolescents with cerebral palsy.

Alexander H Hoon, Elaine E Stashinko,

Lancet (Lancet (London, England))
[2015, 385(9969):670-672]

Cited: 0 times

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A diagnostic approach for cerebral palsy in the genomic era.

Ryan W Lee, Andrea Poretti, Julie S Cohen, Eric Levey, Hilary Gwynn, Michael V Johnston, Alexander H Hoon, Ali Fatemi,

An ongoing challenge in children presenting with motor delay/impairment early in life is to identify neurogenetic disorders with a clinical phenotype, which can be misdiagnosed as cerebral palsy (CP). To help distinguish patients in these two groups, conventional magnetic resonance imaging of the brain has been of great benefit in ... Read more >>

Neuromolecular Med (Neuromolecular medicine)
[2014, 16(4):821-844]

Cited: 21 times

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Severe auditory processing disorder secondary to viral meningoencephalitis.

Joseph P Pillion, Dorothy E Shiffler, Alexander H Hoon, Doris D M Lin,

<h4>Objective</h4>To describe auditory function in an individual with bilateral damage to the temporal and parietal cortex.<h4>Design</h4>Case report.<h4>Study sample</h4>A previously healthy 17-year old male is described who sustained extensive cortical injury following an episode of viral meningoencephalitis. He developed status epilepticus and required intubation and multiple anticonvulsants.<h4>Results</h4>Serial brain MRIs showed bilateral ... Read more >>

Int J Audiol (International journal of audiology)
[2014, 53(6):427-431]

Cited: 0 times

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Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy.

Yang He, Janice E Brunstrom-Hernandez, Liu Lin Thio, Shellie Lackey, Deborah Gaebler-Spira, Maxine M Kuroda, Elaine Stashinko, Alexander H Hoon, Jilda Vargus-Adams, Richard D Stevenson, Stephanie Lowenhaupt, John F McLaughlin, Ana Christensen, Nienke P Dosa, Maureen Butler, Aloysia Schwabe, Christina Lopez, Desiree Roge, Diane Kennedy, Ann Tilton, Linda E Krach, Andrew Lewandowski, Hongying Dai, Andrea Gaedigk, J Steven Leeder, William J Jusko,

<h4>Objective</h4>To characterize the population pharmacokinetics (PK) of oral baclofen and assess impact of patient-specific covariates in children with cerebral palsy (CP) in order to support its clinical use.<h4>Subjects design</h4>Children (2-17 years of age) with CP received a dose of titrated oral baclofen from 2.5 mg 3 times a day to ... Read more >>

J Pediatr (The Journal of pediatrics)
[2014, 164(5):1181-1188.e8]

Cited: 15 times

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Subthalamic nucleus involvement in children: a neuroimaging pattern-recognition approach.

Thangamadhan Bosemani, Cristina Anghelescu, Eugen Boltshauser, Alexander H Hoon, Phillip L Pearl, Dana Craiu, Michael V Johnston, Thierry A G M Huisman, Andrea Poretti,

A neuroimaging-based pattern-recognition approach has been shown to be very helpful in the diagnosis of a wide range of pediatric central nervous system diseases. Few disorders may selectively affect the subthalamic nucleus in children including Leigh syndrome, succinic semialdehyde dehydrogenase deficiency, kernicterus, chronic end-stage liver failure and near total hypoxic-ischemic ... Read more >>

Eur J Paediatr Neurol (European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society)
[2014, 18(3):249-256]

Cited: 5 times

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Inclusion--in whose best interest? How pediatricians can effectively advocate for children with neurodevelopmental disabilities.

Denise W Wilcox, Alexander H Hoon,

Dev Med Child Neurol (Developmental medicine and child neurology)
[2014, 56(3):206-209]

Cited: 0 times

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Sensory and motor deficits in children with cerebral palsy born preterm correlate with diffusion tensor imaging abnormalities in thalamocortical pathways.

Alexander H Hoon, Elaine E Stashinko, Lidia M Nagae, Doris D M Lin, Jennifer Keller, Amy Bastian, Michelle L Campbell, Eric Levey, Susumu Mori, Michael V Johnston,

<h4>Aim</h4>Cerebral palsy (CP) is frequently linked to white matter injury in children born preterm. Diffusion tensor imaging (DTI) is a powerful technique providing precise identification of white matter microstructure. We investigated the relationship between DTI-observed thalamocortical (posterior thalamic radiation) injury, motor (corticospinal tract) injury, and sensorimotor function.<h4>Method</h4>Twenty-eight children born preterm ... Read more >>

Dev Med Child Neurol (Developmental medicine and child neurology)
[2009, 51(9):697-704]

Cited: 147 times

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Neuroimaging: connecting the pixels.

Alexander H Hoon, Elaine E Stashinko,

Dev Med Child Neurol (Developmental medicine and child neurology)
[2011, 53(6):482]

Cited: 1 time

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Pathogenesis, neuroimaging and management in children with cerebral palsy born preterm.

Alexander H Hoon, Andreia Vasconcellos Faria,

With advances in obstetric and perinatal management, the incidence of intraventricular hemorrhage in premature infants has declined, while periventricular leukomalacia remains a significant concern. It is now known that brain injury in children born preterm also involves neuronal-axonal disease in supratentorial and infratentorial structures. The developing brain is especially vulnerable ... Read more >>

Dev Disabil Res Rev (Developmental disabilities research reviews)
[2010, 16(4):302-312]

Cited: 11 times

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The challenge of cerebral palsy classification: the ELGAN study.

Pasquale J Accardo, Alexander H Hoon,

J Pediatr (The Journal of pediatrics)
[2008, 153(4):451-452]

Cited: 2 times

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Cerebral palsy.

Michael V Johnston, Alexander H Hoon,

Cerebral palsy (CP) is a group of disorders of movement and posture resulting from nonprogressive disturbances of the fetal or neonatal brain. More than 80% of cases of CP in term infants originate in the prenatal period; in premature infants, both prenatal or postnatal causes contribute. The most prevalent pathological ... Read more >>

Neuromolecular Med (Neuromolecular medicine)
[2006, 8(4):435-450]

Cited: 28 times

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Neuroimaging in cerebral palsy: Patterns of brain dysgenesis and injury.

Alexander H Hoon,

Despite advances in obstetric and neonatal care, the overall prevalence of cerebral palsy has remained stable, supporting the belief that pathogenesis is primarily due to prenatal brain dysgenesis and injury. Neuroimaging studies have consistently shown abnormalities in 70% to 90% of affected children, facilitating clinical classification into groups with early ... Read more >>

J Child Neurol (Journal of child neurology)
[2005, 20(12):936-939]

Cited: 25 times

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Oral baclofen in cerebral palsy: possible seizure potentiation?

Donna E Hansel, Christian R W Hansel, Michael K Shindle, Elsie M Reinhardt, LaVerne Madden, Eric B Levey, Michael V Johnston, Alexander H Hoon,

Baclofen, a gamma-aminobutyric acid agonist, is widely used to treat spasticity of cerebral and spinal origin. Patients with both acute baclofen overdose and withdrawal have developed seizures. After several reports of new-onset seizures in children treated with oral baclofen at our institution, we reviewed our experience regarding possible effects of ... Read more >>

Pediatr Neurol (Pediatric neurology)
[2003, 29(3):203-206]

Cited: 14 times

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Neuroimaging in cerebral palsy.

Jennifer Accardo, Heather Kammann, Alexander H Hoon,

Parents and clinicians concerned about high-risk infants and children with motor delay or cerebral palsy seek information on cause, treatment, prognosis, and recurrence risk. Used in combination with history and examination, neuroimaging studies can improve diagnosis and management. In premature infants, cranial ultrasound is a reliable, noninvasive diagnostic modality. Nuclear ... Read more >>

J Pediatr (The Journal of pediatrics)
[2004, 145(2 Suppl):S19-27]

Cited: 25 times

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Neuroimaging in spasticity and movement disorders.

Alexander H Hoon, Karin M Belsito, Lidia M Nagae-Poetscher,

Advances in neuroimaging provide unique opportunities to evaluate brain structure, biochemistry, and function. Although a number of imaging techniques have been used in newborns, cranial ultrasonography in premature infants and nuclear magnetic resonance modalities, including magnetic resonance imaging and diffusion-weighted imaging, in high-risk term infants are of foremost benefit. Interpretation ... Read more >>

J Child Neurol (Journal of child neurology)
[2003, 18 Suppl 1:S25-39]

Cited: 9 times

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Unusual migration of the distal catheter of a ventriculoperitoneal shunt into the heart: case report.

James L Frazier, Paul P Wang, Salil H Patel, Jane E Benson, Duke E Cameron, Alexander H Hoon, Anthony M Avellino,

<h4>Objective and importance</h4>Placement of a ventriculoperitoneal (VP) shunt is the most common form of treatment for hydrocephalus. Thoracic complications with VP shunts are rare, but we present the second documented case of the distal migration of the distal catheter of a VP shunt into the heart.<h4>Clinical presentation</h4>A 14-year-old boy, who ... Read more >>

Neurosurgery (Neurosurgery)
[2002, 51(3):819-22; discussion 822]

Cited: 25 times

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